CZ Prague Neuzil J

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CZ Prague Neuzil J

Oroboros O2k-Network

O2k-Network
O2k-Network Lab Molecular Therapy Group

Institute of Biotechnology

Academy of Sciences

Address Videnska 1083

See also AU Queensland Neuzil J, 142 20

City Prague
State/Prov
Country Czech Republic
Weblink
Contact Neuzil Jiri
Team Bajzikova Martina, Davidova Eliska, Ezrova Zuzana, Rohlena Jakub, Novotna Jana, Vondrusova Magdalena, Zobalova Renata
Team previous Kluckova Katarina
Status 2 Power-O2k 2011-
Oroboros Events MiPschool 2018, IOC134, MitoEAGLE 2017 CZ, MiP2014, IOC93, IOC79, MiPsummer 2012, IOC68
Topics


O2k-Publications

 PublishedReference
Bajzikova 2018 Cell Metab2018Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman WJH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2018) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab S1550-4131(18)30646-6 [Epub ahead of print].
Blecha 2017 Free Radic Biol Med2017Blecha J, Novais SM, Rohlenova K, Novotna E, Lettlova S, Schmitt S, Zischka H, Neuzil J, Rohlena J (2017) Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death. Free Radic Biol Med 112:253-66.
Rohlenova 2016 Antioxid Redox Signal2016Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer. Antioxid Redox Signal 26:84-103.
Pasdar 2015 PLoS One2015Pasdar EA, Smits M, Stapelberg M, Bajzikova M, Stantic M, Goodwin J, Yan B, Stursa J, Kovarova J, Sachaphibulkij K, Bezawork-Geleta A, Sobol M, Filimonenko A, Tomasetti M, Zobalova R, Hozak P, Dong LF, Neuzil J (2015) Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents. PLoS One 10:e0119549.
Kluckova 2015 Cell Death Dis2015Kluckova K, Sticha M, Cerny J, Mracek T, Dong L, Drahota Z, Gottlieb E, Neuzil J, Rohlena J (2015) Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. Cell Death Dis 6:e1749.
Yan 2015 BMC Cancer2015Yan B, Stantic M, Zobalova R, Bezawork-Geleta A, Stapelberg M, Stursa J, Prokopova K, Dong L, Neuzil J (2015) Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner. BMC Cancer 15:401.
Tan 2015 Cell Metab2015Tan AS, Baty JW, Dong L, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, Pesdar EA, Sobol M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K, Sachaphibulkij K, Rohlena J, Hozak P, Truksa J, Eccles D, Haupt LM, Griffiths LR, Neuzil J, Berridge MV (2015) Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab 21:81-94.
Khera 2015 Placenta2015Khera A, Dong LF, Holland OJ, Vanderlelie J, Pasdar EA, Neuzil J, Perkins AV (2015) Selenium supplementation induces mitochondrial biogenesis in trophoblasts. Placenta 36:863-9.
Truksa 2015 Antioxid Redox Signal2015Truksa J, Dong L, Rohlena J, Stursa J, Vondrusova M, Goodwin J, Nguyen M, Kluckova K, Rychtarcikova Z, Lettlova S, Spacilova J, Stapelberg M, Zoratti M, Neuzil J (2015) Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis. Antioxid Redox Signal 22:883-900.
Kluckova 2015 Methods Mol Biol2015Kluckova K, Dong L, Bajzikova M, Rohlena J, Neuzil J (2015) Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents. Methods Mol Biol 1265:181-94.

O2k-Abstracts

 PublishedReference
Blecha 2015 Abstract MiP20152015Modulation of mitochondrial electron transport chain activity differentially regulates cell death in proliferating and quiescent cells.
Rohlena 2015 Abstract MiP20152015Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.
Kluckova 2014 Abstract MiP20142014Proximal ubiquinone binding site in mitochondrial respiratory Complex II is a target for vitamin E analog MitoVES, an experimental anti-cancer agent. Mitochondr Physiol Network 19.13.
Bajzikova 2013 Abstract IOC792013Bajzikova M (2013) Mitochondrially targeted vitamin E succinate and its effects on mitochondrial oxidative phosphorylation system. Mitochondr Physiol Network 18.07.


O2k-Feedback
  • I am really happy that we have a very good working relationship. The Oxygraphs, certainly, helped us get superb results and get our work published in Cell Metabolism. I hope we keep this relationship into the future! Jirka Neuzil (2015-11-09)
  • We are more than happy with the O2k. In fact, it is one of the most useful instruments we have in both our laboratories. Jirka Neuzil (2014-06-10)
  • We just ordered the fluorescence attachment and are excited about the new options that it will allow us to explore. Jirka Neuzil (2012-10-09)