Cerwenka 2016 Mol Cell Oncol

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Cerwenka A, Kopitz J, Schirmacher P, Roth W, Gdynia G (2016) HMGB1: The metabolic weapon in the arsenal of NK cells. Mol Cell Oncol 3:e1175538.

» PMID: 27652323

Cerwenka A, Kopitz J, Schirmacher P, Roth W, Gdynia G (2016) Mol Cell Oncol

Abstract: Targeting tumor glycolysis would hit the main energy source of cancer. We show that natural killer (NK) cells pursue this strategy by employing high mobility group box 1 (HMGB1) protein-a well-known proinflammatory cytokine-to specifically target glycolysis in cancer cells. This opens up new perspectives for cancer immunotherapy.

Keywords: Cancer, HMGB1, NK cells, Natural killer cells, Cell death, Immunotherapy, Innate immunity, Metabolism, HT29 colon carcinoma cells


Labels: MiParea: Respiration  Pathology: Cancer 

Organism: Human  Tissue;cell: Endothelial;epithelial;mesothelial cell, Other cell lines 



HRR: Oxygraph-2k 

2016-11