Wang 2017 Mol Cell
| Wang X, Auwerx J (2017) Systems phytohormone responses to mitochondrial proteotoxic stress. Mol Cell 68:540-51. |
Wang X*, Auwerx J (2017) Mol Cell
Abstract: Mitochondrial function is controlled by two separate genomes. This feature makes mitochondria prone to proteotoxic stress when a stoichiometric imbalance occurs in the protein complexes that perform oxidative phosphorylation, which consist of both nuclear- and mitochondrial-encoded proteins. Such a proteotoxic stress is known to induce the mitochondrial unfolded protein response (UPRmt) in animals. It is unknown whether UPRmt occurs in plants. Here, we induced a mitonuclear protein imbalance in Arabidopsis through chemical or genetic interference. Mitochondrial proteotoxic stress activated a plant-specific UPRmt and impaired plant growth and development. The plant UPRmt pathway is triggered by a transient oxidative burst, activating MAPK and hormonal (involving ethylene and auxin) signaling, which are all geared to repair proteostasis. This also establishes phytohormones as bona fide plant mitokines. Our data ascertain that mitochondrial protein quality control pathways, such as the UPRmt, are conserved in plants and that hormone signaling is an essential mediator that regulates mitochondrial proteostasis.
• Bioblast editor: Kandolf G • O2k-Network Lab: CH Lausanne Auwerx J
Labels: MiParea: Respiration
Organism: Plants
Preparation: Isolated mitochondria
Coupling state: OXPHOS
Pathway: N, NS
HRR: Oxygraph-2k
Labels, 2018-01
