Difference between revisions of "Gnaiger 2015 Scand J Med Sci Sports"
(26 intermediate revisions by 6 users not shown) | |||
Line 1: | Line 1: | ||
{{Publication | {{Publication | ||
|title=Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports | |title=Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126–34. | ||
|info=[http://www.ncbi.nlm.nih.gov/pubmed/26589126 PMID: 26589126] [http://onlinelibrary.wiley.com/doi/10.1111/sms.12612/abstract Open Access] | |info=[http://www.ncbi.nlm.nih.gov/pubmed/26589126 PMID: 26589126] [http://onlinelibrary.wiley.com/doi/10.1111/sms.12612/abstract Open Access] »[[File:O2k-brief.png|36px|link=http://wiki.oroboros.at/images/5/5f/Gnaiger_2015_Scand_J_Med_Sci_Sports_O2k-brief.pdf |O2k-brief]] | ||
|authors=Gnaiger E, Boushel R, | |authors=Gnaiger E, Boushel R, Soendergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Diez-Sanchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JA, Christiansen M, Helge JW, Saltin B | ||
|year=2015 | |year=2015 | ||
|journal=Scand J Med Sci Sports | |journal=Scand J Med Sci Sports | ||
|abstract=[[File: | |abstract=[[Image:O2k-Publications.jpg|80px|link=O2k-Publications: Topics|O2k-Publications: Topics]][http://www.bioblast.at/images/5/5f/Gnaiger_2015_Scand_J_Med_Sci_Sports_O2k-brief.pdf O2k-''in brief''] | ||
[[File:1OctM;2D;3G;4S;5Rot;6Omy;7U;7c-8Ama.jpg|right|300px|link=1OctM;2D;3G;4S;5Rot;6Omy;7U-]] | |||
During evolution, mtDNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fibre type and uncoupling protein-3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from ''V''<sub>O2max</sub> and maximum capacities of oxidative phosphorylation. | During evolution, mtDNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fibre type and uncoupling protein-3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from ''V''<sub>O2max</sub> and maximum capacities of oxidative phosphorylation. | ||
|keywords=BMI, VO2max | |||
|editor=[[Gnaiger E]] | |||
|mipnetlab=AT Innsbruck Gnaiger E, AT Innsbruck | |mipnetlab=AT Innsbruck Gnaiger E, AT Innsbruck Oroboros, CA Vancouver Boushel RC, NL Maastricht Schrauwen P, DK Copenhagen Christiansen M, ES CN Las Palmas Calbet JA | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|area=Respiration, mt-Biogenesis;mt-density, mtDNA;mt-genetics, Comparative MiP;environmental MiP, Gender, Exercise physiology;nutrition;life style | |area=Respiration, mt-Biogenesis;mt-density, mtDNA;mt-genetics, Comparative MiP;environmental MiP, Gender, Exercise physiology;nutrition;life style | ||
|injuries=Temperature | |||
|organism=Human | |organism=Human | ||
|tissues=Skeletal muscle | |tissues=Skeletal muscle | ||
|preparations=Permeabilized tissue | |preparations=Permeabilized tissue | ||
|enzymes=Marker enzyme, TCA cycle and matrix dehydrogenases | |enzymes=Marker enzyme, TCA cycle and matrix dehydrogenases | ||
|topics=Coupling efficiency;uncoupling, Cyt c | |topics=Coupling efficiency;uncoupling, Cyt c | ||
|couplingstates=LEAK, OXPHOS, | |couplingstates=LEAK, OXPHOS, ET | ||
| | |pathways=F, N, S, ROX | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k, O2k-Protocol | ||
|additional=MitoFitPublication | |additional=MitoFitPublication, BMI, VO2max, 1OctM;2D;3G;4S;5Rot;6Omy;7U-, SUIT-016, SUIT-016 O2 pfi D044, | ||
}} | }} | ||
__TOC__ | __TOC__ | ||
== SUIT protocol == | |||
****: [[SUIT-016 |1OctM;2D;3G;4S;5Rot;6Omy;7U-]] | |||
[[Image:The world as a laboratory.jpg|right|120px|link=http://wiki.oroboros.at/index.php/The_world_as_a_laboratory|Science and adventure]] | [[Image:The world as a laboratory.jpg|right|120px|link=http://wiki.oroboros.at/index.php/The_world_as_a_laboratory|Science and adventure]] | ||
[[File:Overview1.jpg|left|100px|Project of the Copenhagen Muscle Research Centre (CMRC), Rigshospitalet, Copenhagen, Denmark (Prof. Dr. Bengt Saltin). Logo of the CMRC Greenland 2004 Expedition, designed by Crownprince Frederik of Denmark.]] | [[File:Overview1.jpg|left|100px|Project of the Copenhagen Muscle Research Centre (CMRC), Rigshospitalet, Copenhagen, Denmark (Prof. Dr. Bengt Saltin). Logo of the CMRC Greenland 2004 Expedition, designed by Crownprince Frederik of Denmark.]] | ||
== Greenland expedition CMRC: science and adventure == | == Greenland expedition CMRC: science and adventure == | ||
::» [[Greenland Expedition CMRC 2004 |'''Greenland Expedition CMRC''']] | ::::» [[Greenland Expedition CMRC 2004 |'''Greenland Expedition CMRC''']] | ||
::» [http://onlinelibrary.wiley.com/doi/10.1111/sms.2015.25.issue-S4/issuetoc '''The Saltin Symposium: Exercise and Integrative Physiology (2015)'''] | ::::» [http://onlinelibrary.wiley.com/doi/10.1111/sms.2015.25.issue-S4/issuetoc '''The Saltin Symposium: Exercise and Integrative Physiology (2015)'''] | ||
[[Image:Logo MitoFit.jpg|right|120px|link=http://www.mitofit.org/index.php/MitoFit|MitoFit]] | [[Image:Logo MitoFit.jpg|right|120px|link=http://www.mitofit.org/index.php/MitoFit|MitoFit]] | ||
== MitoFit news 2015#18 == | == MitoFit news 2015#18 == | ||
* 2015-11-25: Performance tests on skeletal muscle mitochondria of the Inuit haplogroup reveal fitness information beyond the uncoupling hypothesis for adaptations to the arctic climate. » [[MitoFit news]] - a contribution to [[K-Regio MitoFit]]. | ::::* 2015-11-25: Performance tests on skeletal muscle mitochondria of the Inuit haplogroup reveal fitness information beyond the uncoupling hypothesis for adaptations to the arctic climate. » [[K-Regio_MitoFit#2015 |MitoFit news]] - a contribution to [[K-Regio MitoFit]]. | ||
== Bengt Saltin - a Gentle Scientist == | == Bengt Saltin - a Gentle Scientist == | ||
Line 42: | Line 45: | ||
== Additional references == | == Additional references == | ||
* Marconi C, Marzorati M, Cerretelli P (2006) Work capacity of permanent residents of high altitude. High Alt Med Biol 7:105-115. - [[Marconi_2006_High Alt Med Biol |»Bioblast link«]] | ::::* Marconi C, Marzorati M, Cerretelli P (2006) Work capacity of permanent residents of high altitude. High Alt Med Biol 7:105-115. - [[Marconi_2006_High Alt Med Biol |»Bioblast link«]] | ||
* Tam E, Bruseghini P, Calabria E, Sacco LD, Doria C, Grassi B, Pietrangelo T, Pogliaghi S, Reggiani C, Salvadego D, Schena F, Toniolo L, Verratti V, Vernillo G, Capelli C (2015) Gokyo Khumbu/Ama Dablam Trek 2012: effects of physical training and high-altitude exposure on oxidative metabolism, muscle composition, and metabolic cost of walking in women. Eur J Appl Physiol | ::::* Tam E, Bruseghini P, Calabria E, Sacco LD, Doria C, Grassi B, Pietrangelo T, Pogliaghi S, Reggiani C, Salvadego D, Schena F, Toniolo L, Verratti V, Vernillo G, Capelli C (2015) Gokyo Khumbu/Ama Dablam Trek 2012: effects of physical training and high-altitude exposure on oxidative metabolism, muscle composition, and metabolic cost of walking in women. Eur J Appl Physiol. - [[Tam 2015 Eur J Appl Physiol |»Bioblast link«]] | ||
[[File:O2k-brief.png|36px|left]] | |||
== O2k-brief == | |||
::::» [[O2k-brief |List of O2k-Publications presented as O2k-brief]] |
Revision as of 11:55, 10 April 2019
Gnaiger E, Boushel R, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126–34. |
» PMID: 26589126 Open Access »
Gnaiger E, Boushel R, Soendergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Diez-Sanchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JA, Christiansen M, Helge JW, Saltin B (2015) Scand J Med Sci Sports
Abstract: O2k-in brief
During evolution, mtDNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fibre type and uncoupling protein-3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from VO2max and maximum capacities of oxidative phosphorylation. • Keywords: BMI, VO2max • Bioblast editor: Gnaiger E • O2k-Network Lab: AT Innsbruck Gnaiger E, AT Innsbruck Oroboros, CA Vancouver Boushel RC, NL Maastricht Schrauwen P, DK Copenhagen Christiansen M, ES CN Las Palmas Calbet JA
Labels: MiParea: Respiration, mt-Biogenesis;mt-density, mtDNA;mt-genetics, Comparative MiP;environmental MiP, Gender, Exercise physiology;nutrition;life style
Stress:Temperature Organism: Human Tissue;cell: Skeletal muscle Preparation: Permeabilized tissue Enzyme: Marker enzyme, TCA cycle and matrix dehydrogenases Regulation: Coupling efficiency;uncoupling, Cyt c Coupling state: LEAK, OXPHOS, ET Pathway: F, N, S, ROX HRR: Oxygraph-2k, O2k-Protocol
MitoFitPublication, BMI, VO2max, 1OctM;2D;3G;4S;5Rot;6Omy;7U-, SUIT-016, SUIT-016 O2 pfi D044
SUIT protocol
Greenland expedition CMRC: science and adventure
MitoFit news 2015#18
- 2015-11-25: Performance tests on skeletal muscle mitochondria of the Inuit haplogroup reveal fitness information beyond the uncoupling hypothesis for adaptations to the arctic climate. » MitoFit news - a contribution to K-Regio MitoFit.
Bengt Saltin - a Gentle Scientist
Additional references
- Marconi C, Marzorati M, Cerretelli P (2006) Work capacity of permanent residents of high altitude. High Alt Med Biol 7:105-115. - »Bioblast link«
- Tam E, Bruseghini P, Calabria E, Sacco LD, Doria C, Grassi B, Pietrangelo T, Pogliaghi S, Reggiani C, Salvadego D, Schena F, Toniolo L, Verratti V, Vernillo G, Capelli C (2015) Gokyo Khumbu/Ama Dablam Trek 2012: effects of physical training and high-altitude exposure on oxidative metabolism, muscle composition, and metabolic cost of walking in women. Eur J Appl Physiol. - »Bioblast link«