Aisenberg 1961 Academic Press

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Aisenberg AC (1961) The glycolysis and respiration of tumors. Academic Press 224 pp.


Aisenberg Alan C (1961) Academic Press

Abstract: One of the basic aspects of the cancer problem, the energy metabolism of neoplastic tissue, is presented in this monograph which covers the anaerobic and aerobic glycolysis of normal and tumor tissue, the oxidative metabolism of the tumors, and the regulatory mechanism in respiration and glycolysis. Almost 40 years after Warburg's fundamental studies, the present state of our knowledge of metabolism and biochemistry of tumors has found a competent and critical evaluation in this book

Bioblast editor: Gnaiger E

Table of contents

  1. The aerobic and anaerobic glycolysis of normal and tumor tissues
    1. Anaerobic and aerobic glycolysis in the surviving tissue slice and in ascites cells
    2. Tumor glycolysis in vitro
    3. Tumor glycolysis in extracts and homogenates
    4. Metabolic inhibitors of glycolysis
    5. Glycolytic enzymes in the blood
  2. The oxidative metabolism of tumors
    1. The over-all respiratory rate of the tumor slice
    2. Nature of the substrate of tumor respiration
    3. Carbohydrate oxidation in tumor tissue
    4. The metabolism of fatty acids by tumor tissue
    5. The hexose monophosphate shunt in tumors
    6. The requirement for DPN and other nucleotide additions in the oxidative metabolism of tumors
    7. Oxidative phosphorylation in tumor mitochondria
    8. Number and nitrogen content of tumor mitochondria
    9. Miscellaneous studies on tumor mitochondria
    10. The levels of specific oxidative components in tumors
    11. Warburg's theory of a damaged tumor respiration
  3. Regulatory mechanisms in respiration and glycolysis
    1. The Pasteur effect
    2. The Crabtree effect
  4. The dependence of tumors on oxidative and glycolytic energy
    1. The dependence of synthetic processes on oxidative and glycolytic energy
    2. The nature of the energy supply for cell division
    3. The relationship of tumor survival to glycolysis and respiration
  5. Summary and conclusions

Labels: MiParea: Respiration, mt-Medicine  Pathology: Cancer  Stress:Hypoxia  Organism: Human, Mouse  Tissue;cell: Fibroblast  Preparation: Homogenate, Isolated mitochondria, Intact cells  Enzyme: TCA cycle and matrix dehydrogenases  Regulation: Aerobic glycolysis, Cyt c  Coupling state: ROUTINE 

Crabtree effect, Pasteur effect