Alencar 2022 MitoFit

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Alencar 2022 MitoFit

Publications in the MiPMap
Alencar MB, Ramos EV, Silber AM, ZΓ­kovΓ‘ A, Oliveira MF (2022) The extraordinary energy metabolism of the bloodstream Trypanosoma brucei forms: a critical review and a hypothesis. β€” 2022-12-05 published in Bioenerg Commun 2022.17.

Β» MitoFit Preprints 2022.09.v2.

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A unifying hypothesis for the extraordinary energy metabolism of bloodstream Trypanosoma brucei

Alencar Mayke Bezerra, Ramos Emily V, Silber Ariel M, Zikova Alena, Oliveira Marcus F (2022) MitoFit Prep


Version 2 (v2) 2022-07-07 doi:10.26124/mitofit:2022-0009.v2
Version 1 (v1) 2022-04-07 doi:10.26124/mitofit:2022-0009.v1 - Β»Link to all versionsΒ«

Oliveira 2022 Abstract Bioblast: The parasite Trypanosoma brucei is the causative agent of sleeping sickness and involves an insect vector and a mammalian host through its complex life-cycle. T. brucei mammalian bloodstream forms (BSF) exhibit unique metabolic features including: i) reduced expression and activity of mitochondrial enzymes; ii) respiration mediated by the glycerol phosphate shuttle (GPSh) and the Trypanosome alternative oxidase (TAO) that is intrinsically uncoupled from generation of mitochondrial membrane potential; iii) maintenance of mitochondrial membrane potential by ATP hydrolysis through the reversal of F1Fo ATP synthase activity; iv) strong reliance on glycolysis to meet their energy demands; v) high susceptibility to oxidants. Here, we critically review the main metabolic features of BSF and provide a hypothesis to explain the unusual metabolic network and its biological significance for this parasite form. We postulate that intrinsically uncoupled respiration provided by GPSh-TAO system would act as a preventive antioxidant defense by limiting mitochondrial superoxide production and complementing the NADPH-dependent scavenging antioxidant defenses to maintain parasite redox balance. Given the uncoupled nature of the GPSh-TAO system, BSF would avoid programmed cell death processes by maintaining mitochondrial membrane potential through the reversal of ATP synthase activity using the ATP generated by glycolysis. This unique β€œmetabolic design” in BSF has no biological parallel outside of Trypanosomatids and highlights the enormous diversity of the parasite mitochondrial processes to adapt to distinct environments.

β€’ Keywords: Alternative oxidase; glycerol phosphate; reactive oxygen species; cell death; Trypanosoma brucei; mitophagy; antioxidant β€’ Bioblast editor: Tindle-Solomon L β€’ O2k-Network Lab: BR Sao Paulo Silber AM, BR Rio de Janeiro Oliveira MF

ORCID: ORCID.png Alencar MB, ORCID.png Silber Ariel M, ORCID.png Zikova Alena, ORCID.png Oliveira Marcus F


Organism: Protists 

Pathway: Gp 

AOX, Trypanosoma brucei, glycerophosphate shuttle, Bioblast 2022 

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