Apostolopoulou 2021 Sci Adv

Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Straßburger K, de Filippo E, Jelenik T, Karusheva Y, Gancheva S, Markgraf D, Herder C, Nair KS, Reichert AS, Lehr S, Müssig K, Al-Hasani H, Szendroedi J, Roden M (2021) Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. https://doi.org/10.1126/sciadv.abi9551

» Sci Adv 7:eabi9551. PMID: 34623918 Open Access

Apostolopoulou Maria, Mastrototaro Lucia, Hartwig Sonja, Pesta Dominik, Straßburger Klaus, de Filippo Elisabetta, Jelenik Tomas, Karusheva Yanislava, Gancheva Sofiya, Markgraf Daniel, Herder Christian, Nair K Sreekumaran, Reichert Andreas S, Lehr Stefan, Muessig Karsten, Al-Hasani Hadi, Szendroedi Julia, Roden Michael (2021) Sci Adv

Abstract: High-intensity interval training (HIIT) improves cardiorespiratory fitness (VO₂max), but its impact on metabolism remains unclear. We hypothesized that 12-week HIIT increases insulin sensitivity in males with or without type 2 diabetes [T2D and NDM (nondiabetic humans)]. However, despite identically higher VO₂max, mainly insulin-resistant (IR) persons (T2D and IR NDM) showed distinct alterations of circulating small extracellular vesicles (SEVs) along with lower inhibitory metabolic (protein kinase Ce activity) or inflammatory (nuclear factor kB) signaling in muscle of T2D or IR NDM, respectively. This is related to the specific alterations in SEV proteome reflecting down-regulation of the phospholipase C pathway (T2D) and up-regulated antioxidant capacity (IR NDM). Thus, SEV cargo may contribute to modulating the individual metabolic responsiveness to exercise training in humans.

• Bioblast editor: Plangger M • O2k-Network Lab: DE Duesseldorf Roden M, US MN Rochester Nair KS, DE Cologne Pesta D

Labels: MiParea: Respiration, Exercise physiology;nutrition;life style  Pathology: Diabetes 

Organism: Human  Tissue;cell: Skeletal muscle  Preparation: Permeabilized tissue 

Coupling state: LEAK, OXPHOS, ET  Pathway: N, NS, ROX  HRR: Oxygraph-2k, O2k-Fluorometer 

2021-10, AmR