Aspirin

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Aspirin

Description

Aspirin is a widely applied drug that requires dosage adjusted to individual body mass. It is a non-selective COX inhibitor and exerts an effect on long-chain fatty acid transport into mitochondria.


Reference: Uppala 2017 Biochem Biophys Res Commun

Aspirin and mitObesity

Work in progress by Gnaiger E 2023-09-24 linked to a preprint in preparation on mitObesity drugs - mitObesity.

References: Aspirin

 YearReferenceOrganismTissue;cellPathology
Chen 2023 Front Oncol2023Chen L, Zhu C, Pan F, Chen Y, Xiong L, Li Y, Chu X, Huang G (2023) Platelets in the tumor microenvironment and their biological effects on cancer hallmarks. Front Oncol 13:1121401. https://doi.org/10.3389/fonc.2023.1121401HumanBlood cells
Platelet
Cancer
Ravera 2023 Cells2023Ravera S, Signorello MG, Panfoli I (2023) Platelet metabolic flexibility: a matter of substrate and location. Cells 12:1802. https://doi.org/10.3390/cells12131802HumanBlood cells
Platelet
Cancer
Cardiovascular
Diabetes
Obesity
Bian 2022 Heliyon2022Bian X, Yin S, Yang S, Jiang X, Wang J, Zhang M, Zhang L (2022) Roles of platelets in tumor invasion and metastasis: a review. Heliyon 8:e12072. https://doi.org/10.1016/j.heliyon.2022.e12072HumanBlood cells
Platelet
Cancer
Tao 2021 Blood2021Tao DL, Tassi Yunga S, Williams CD, McCarty OJT (2021) Aspirin and antiplatelet treatments in cancer. Blood 137:3201-11. https://doi.org/10.1182/blood.2019003977HumanBlood cells
Platelet
Cancer
John 2021 Life (Basel)2021John A, Amiri L, Shafarin J, Howarth FC, Raza H (2021) Effect of aspirin on mitochondrial dysfunction and stress in the pancreas and heart of Goto-Kakizaki diabetic rats. Life (Basel) 11:902. https://doi.org/10.3390/life11090902RatHeart
Islet cell;pancreas;thymus
Diabetes
Lichtenberger 2019 Cancer Res2019Lichtenberger LM, Vijayan KV (2019) Are platelets the primary target of aspirin's remarkable anticancer activity? Cancer Res 79:3820-3. https://doi.org/10.1158/0008-5472.CAN-19-0762HumanPlateletCancer
Farrugia 2019 Sci Rep2019Farrugia G, Azzopardi M, Saliba C, Grech G, Gross AS, Pistolic J, Benes V, Vassallo N, Borg J, Madeo F, Eisenberg T, Balzan R (2019) Aspirin impairs acetyl-coenzyme A metabolism in redox-compromised yeast cells. Sci Rep 9:6152. https://doi.org/10.1038/s41598-019-39489-4Saccharomyces cerevisiaeCancer
Sowton 2018 Biochem Biophys Res Commun2018Sowton AP, Millington-Burgess SL, Murray AJ, Harper MT (2018) Rapid kinetics of changes in oxygen consumption rate in thrombin-stimulated platelets measured by high-resolution respirometry. Biochem Biophys Res Commun 503:2721-27.HumanPlatelet
Blood cells
Uppala 2017 Biochem Biophys Res Commun2017Uppala R, Dudiak B, Beck ME, Bharathi SS, Zhang Y, Stolz DB, Goetzman ES (2017) Aspirin increases mitochondrial fatty acid oxidation. Biochem Biophys Res Commun 482:346-51.Human
Mouse
HEK
Fibroblast
Other
Ornelas 2017 Cancer Metastasis Rev2017Ornelas A, Zacharias-Millward N, Menter DG, Davis JS, Lichtenberger L, Hawke D, Hawk E, Vilar E, Bhattacharya P, Millward S (2017) Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention. Cancer Metastasis Rev 36:289-303. https://doi.org/10.1007/s10555-017-9675-zHumanBlood cells
Platelet
Cancer
Kassassir 2016 Chem Biol Interact2016Kassassir H, Siewiera K, Talar M, Stec-Martyna E, Pawlowska Z, Watala C (2016) Non-enzymatic modifications of prostaglandin H synthase 1 affect bifunctional enzyme activity - Implications for the sensitivity of blood platelets to acetylsalicylic acid. Chem Biol Interact 253:78-92.Other mammalsDiabetes
Alfonso 2014 Br J Cancer2014Alfonso L, Ai G, Spitale RC, Bhat GJ (2014) Molecular targets of aspirin and cancer prevention. Br J Cancer 111:61-7. https://doi.org/10.1038/bjc.2014.271HumanBlood cells
Platelet
Cancer
Gottfried 2013 PLoS One2013Gottfried E, Lang SA, Renner K, Bosserhoff A, Gronwald W, Rehli M, Einhell S, Gedig I, Singer K, Seilbeck A, Mackensen A, Grauer O, Hau P, Dettmer K, Andreesen R, Oefner PJ, Kreutz M (2013) New aspects of an old drug - Diclofenac targets MYC and glucose metabolism in tumor cells. PLoS One 8:e66987.Human
Mouse
Endothelial;epithelial;mesothelial cell
Blood cells
Other cell lines
Lymphocyte
Cancer
Santilli 2012 Obes Rev2012Santilli F, Vazzana N, Liani R, Guagnano MT, Davì G (2012) Platelet activation in obesity and metabolic syndrome. Obes Rev 13:27-42. https://doi.org/10.1111/j.1467-789X.2011.00930.xHumanBlood cells
Platelet
Diabetes
Obesity


MitoPedia: mitObesity drugs

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TermAbbreviationDescription
AspirinAspirin is a widely applied drug that requires dosage adjusted to individual body mass. It is a non-selective COX inhibitor and exerts an effect on long-chain fatty acid transport into mitochondria.
CurcuminCurcumin has been shown to possess significant anti-inflammatory, anti-oxidant, anti-carcinogenic, anti-mutagenic, anti-coagulant and anti-infective effects. The protective effects of curcumin on rat heart mitochondrial injuries induced by in vitro anoxia–reoxygenation were evaluated by Xu et al 2013. It was found that curcumin added before anoxia or immediately prior to reoxygenation exhibited remarkable protective effects against anoxia–reoxygenation induced oxidative damage to mitochondria.
ElamipretideBendaviaBendavia (Elamipretide) was developed as a mitochondria-targeted drug against degenerative diseases, including cardiac ischemia-reperfusion injury. Clinical trials showed variable results. It is a cationic tetrapeptide which readily passes cell membranes, associates with cardiolipin in the mitochondrial inner membrane. Supercomplex-associated CIV activity significantly improved in response to elamipretide treatment in the failing human heart.
FlavonoidsFlavonoids are a group of bioactive polyphenols with potential antioxidant and anti-inflammatory effects, abundant in fruits and vegetables, and in some medicinal herbs. Flavonoids are synthesized in plants from phenylalanine. Dietary intake of flavonoids as nutraceuticals is discussed for targeting T2D and other degenerative diseases.
MelatoninaMTMelatonin (N-acetyl-5-methoxytryptamine, aMT) is a highly conserved molecule present in unicellular to vertebrate organisms. Melatonin is synthesized from tryptophan in the pinealocytes by the pineal gland and also is produced in other organs, tissues and fluids (extrapineal melatonin). Melatonin has lipophilic and hydrophilic nature which allows it to cross biological membranes. Therefore, melatonin is present in all subcellular compartments predominantly in the nucleus and mitochondria. Melatonin has pleiotropic functions with powerful antioxidant, anti-inflammatory and oncostatic effects with a wide spectrum of action particularly at the level of mitochondria. Β» MiPNet article
MetforminMetformin (dimethylbiguanide) is mainly known as an important antidiabetic drug which is effective, however, in a wide spectrum of degenerative diseases. It is an inhibitor of Complex I and glycerophosphate dehydrogenase complex.
RapamycinRapamycin is an inhibitor of the mammalian/mechanistic target of rapamycin, complex 1 (mTORC1). Rapamycin induces autophagy and dyscouples mitochondrial respiration. Rapamycin delays senescence in human cells, and extends lifespan in mice without detrimental effects on mitochondrial fitness in skeletal muscle.
ResveratrolResveratrol is a natural bioactive phenol prouced by several plants with antioxidant and anti-inflammatory effects. Dietary intake as nutraceutical is discussed for targeting mitochondria with a wide spectrum of action in degenerative diseases.
SpermidineSpermidine is a polycationic bioactive polyamine mainly found in wheat germ, soybean and various vegetables, involved in the regulation of mitophagy, cell growth and cell death. Like other caloric restriction mimetics, spermidine is effective in cardioprotection, neuroprotection and anticancer immunosuppression by preserving mitochondrial function and control of autophagy.
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