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BR Sao Paulo Silber AM

From Bioblast


BR Sao Paulo Silber AM

Oroboros O2k-Network

O2k-Network Lab Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo
Address ,
City Sao Paulo
Country Brazil
Contact Silber Ariel Mariano
Team Alencar Mayke Bezerra
Team previous
Status O2k 2014-
Oroboros Events


Luevano-Martinez 2020 FEBS Lett2020Luévano-Martínez LA, Girard RMBM, Alencar MB, Silber AM (2020) ATP regulates the activity of an alternative oxidase in Trypanosoma brucei. FEBS Lett [Epub ahead of print].
Girard 2018 mSphere2018Girard RMBM, Crispim M, Alencar MB, Silber AM (2018) Uptake of L-alanine and its distinct roles in the bioenergetics of Trypanosoma cruzi. mSphere pii:e00338-18.
Mantilla 2017 PLOS Pathog2017Mantilla BS, Marchese L, Casas-Sánchez A, Dyer NA, Ejeh N, Biran M, Bringaud F, Lehane MJ, Acosta-Serrano A, Silber AM (2017) Proline metabolism is essential for Trypanosoma brucei brucei survival in the tsetse vector. PLOS Pathog 13:e1006158.
Barison 2016 J Bioenerg Biomembr2016Barisón MJ, Damasceno FS, Mantilla BS, Silber AM (2016) The active transport of histidine and its role in ATP production in Trypanosoma cruzi. J Bioenerg Biomembr 48:437-49.


update please

Field of research

Our research group is interested in different issues related to the biochemistry of protozoan, with focus on that of interest for human health. Among them, we stress our interest on trypanosomatids, which includes two genus with species that are pathogenic to man: Trypanosoma and Leishmania. The biochemical peculiarities of this group are a reason for our interest, mainly in the area of bioenergetics and metabolism. Our group has been studying the role of the metabolism of amino acids in trypanosomatids, intending to unveil critical pathways for energy obtainment and managing environmental challenges affecting these cells during their complex life cycle. The inhibition of some of these metabolic pathways studied by our group, led to the definition of possible therapeutic targets against pathogenic trypanosomes. Ariel M Silber