Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Braganza 2019 Mol Aspects Med

From Bioblast
Publications in the MiPMap
Braganza A, Annarapu GK, Shiva S (2019) Blood-based bioenergetics: An emerging translational and clinical tool. Mol Aspects Med 2019:100835.

» PMID: 31864667 Open Access

Braganza Andrea, Annarapu Gowtham K, Shiva Sruti (2019) Mol Aspects Med

Abstract: Accumulating studies demonstrate that mitochondrial genetics and function are central to determining the susceptibility to, and prognosis of numerous diseases across all organ systems. Despite this recognition, mitochondrial function remains poorly characterized in humans primarily due to the invasiveness of obtaining viable tissue for mitochondrial studies. Recent studies have begun to test the hypothesis that circulating blood cells, which can be obtained by minimally invasive methodology, can be utilized as a biomarker of systemic bioenergetic function in human populations. Here we present the available methodologies for assessing blood cell bioenergetics and review studies that have applied these techniques to healthy and disease populations. We focus on the validation of this methodology in healthy subjects, as well as studies testing whether blood cell bioenergetics are altered in disease, correlate with clinical parameters, and compare with other methodology for assessing human mitochondrial function. Finally, we present the challenges and goals for the development of this emerging approach into a tool for translational research and personalized medicine.

Copyright © 2019 Elsevier Ltd. All rights reserved. Keywords: Bioenergetics, Biomarker, Blood cell, Mitochondria, Platelets, Precision medicine Bioblast editor: Plangger M

Selected quotes

  • .. a wide range of metabolic diseases .. affect multiple organs and have slow and progressive chronic symptoms that vary in onset from birth to late adulthood (Cohen and Gold, 2001; Pieczenik and Neustadt, 2007; Wallace, 1994,2010; Finsterer, 2008). Since mitochondrial function underlies the pathogenesis of these diseases, the systems that are frequently affected are those that require high energy and give rise to symptoms that include vision, hearing and respiratory problems, cardiovascular abnormalities, neurological and learning problems, and gastrointestinal disorders (Pieczenik and Neustadt, 2007; Finsterer, 2004; Stork and Renshaw,2005; Nierenberg et al., 2013).
An interesting reference (p 11)
  • Polarographic, E.G., 2008. Oxygen sensors, the oxygraph, and high-resolution respirometry to assess mitochondrial function. In: Dykens, J.A., Will, Y. (Eds.), Drug‐Induced Mitochondrial Dysfunction. John Wiley & Sons, pp. 327–352. - »Bioblast link«

Labels: MiParea: Respiration, Instruments;methods 

Organism: Human  Tissue;cell: Blood cells, Platelet 

HRR: Oxygraph-2k 

Labels, 2020-01, MitoEAGLE blood cells reviews