Brown David A

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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping


 

Brown David A


MitoPedia topics: EAGLE 

COST: Member COST WG1: WG1


Name Brown David A, PhD.

Senior Director of Scientific and Technical Innovation

Institution
David A Brown
Stealth BioTherapeutics, US
Address 140 Kendrick Street, Building C-West, 02494
City Needham
State/Province Massachusetts (MA)
Country USA
Email david.brown@stealthbt.com
Weblink www.StealthBT.com
O2k-Network Lab US NC Greenville Brown DA, US NC Greenville Neufer PD


Labels: Field of research: Basic, Clinical, Pharmacological 



Publications

 PublishedReference
BEC 2020.1 doi10.26124bec2020-0001.v1BEC 2020.1Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. https://doi.org/10.26124/bec:2020-0001.v1
Bandara 2021 Mitochondrion2021Bandara AB, Drake JC, James CC, Smyth JW, Brown DA (2021) Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics. Mitochondrion 58:160-68.
Allen 2020 Commun Biol2020Allen ME, Pennington ER, Perry JB, Dadoo S, Makrecka-Kuka M, Dambrova M, Moukdar F, Patel HD, Han X, Kidd GK, Benson EK, Raisch TB, Poelzing S, Brown DA, Shaikh SR (2020) The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats. Commun Biol 3:389.
Perry 2019 J Mol Cell Cardiol2019Perry JB, Davis GN, Allen ME, Makrecka-Kuka M, Dambrova M, Grange RW, Shaikh SR, Brown DA (2019) Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury. J Mol Cell Cardiol 135:160-171.
Goswami 2018 Biophys J2018Goswami I, Perry JB, Allen ME, Brown DA, von Spakovsky MR, Verbridge SS (2018) Influence of pulsed electric fields and mitochondria-cytoskeleton interactions on cell respiration. Biophys J 114:2951-64.
Alleman 2016 Am J Physiol Heart Circ Physiol2016Alleman RJ, Tsang AM, Ryan TE, Patteson DJ, McClung JM, Spangenburg EE, Shaikh SR, Neufer PD, Brown DA (2016) Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics. Am J Physiol Heart Circ Physiol 310:H1360-70.
Ryan 2016 J Mol Cell Cardiol2016Ryan TE, Schmidt CA, Alleman RJ, Tsang AM, Green TD, Neufer PD, Brown DA, McClung JM (2016) Mitochondrial therapy improves limb perfusion and myopathy following hindlimb ischemia. J Mol Cell Cardiol 97:191-6.
Brown 2016 Nat Rev Cardiol2016Brown DA, Perry JB, Allen ME, Sabbah HN, Stauffer BL, Shaikh SR, Cleland JG, Colucci WS, Butler J, Voors AA, Anker SD, Pitt B, Pieske B, Filippatos G, Greene SJ, Gheorghiade M (2016) Expert consensus document: Mitochondrial function as a therapeutic target in heart failure. Nat Rev Cardiol 14:238-50.
Brown 2014 J Cardiovasc Pharmacol Ther2014Brown DA, Hale SL, Baines CP, del Rio CL, Hamlin RL, Yueyama Y, Kijtawornrat A, Yeh ST, Frasier CR, Stewart LM, Moukdar F, Shaikh SR, Fisher-Wellman KH, Neufer PD, Kloner RA (2014) Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia. J Cardiovasc Pharmacol Ther 19:121-32.

Abstracts

 PublishedReference
Wilson 2018 Virginia Tech2018Wilson ZT, Perry JB, Brow DA (2018) High-resolution respirometry of heart mitochondria in healthy and stressed states. Virginia Tech.
Sullivan 2015 Abstract MiPschool Greenville 20152015Lipid microdomains containing supercomplexes are enriched with multiple phospholipids including cardiolipin: A detergent extraction study.
Brown 2015 Abstract MiPschool Cape Town 20152015Protection of post-ischemic mitochondrial bioenergetics by targeting cardiolipin-dependent membrane fluidity.
Brown DA 2014 Abstract MiP20142014The cardiolipin-targeting peptide Bendavia preserves post-ischemic mitochondrial energetics by sustaining respiratory supercomplexes.
Shaikh 2014 Circulation2014Shaikh SR, Moukdar F, Alleman RJ, Lark DS, Neufer PD, Brown D (2014) The cardiolipin-targeting peptide Bendavia improves post-ischemic mitochondrial energetics by sustaining native respiratory protein complexes. Am Heart Assoc 130:A17592.

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