CA Montreal Hepple RT

CA Montreal Hepple RT

O2k-Network Lab	Department of Kinesiology and Dep. of Critical Care Medicine McGill University Health Center - Meakins Christie Laboratories Royal Victoria Hospital
Address	687 Pine Ave W, H3A 1A1
City	Montreal
State/Prov	Quebec (QC)
Country	Canada
Weblink	MAD Lab
Contact
Team
Team previous	Darmyn Ritchie, Gouspillou Gilles, Hepple Russell T, Kane Constance, Miguez Kayla, Minozzo Fabio, Perez Anna, Picard Martin, Romestaing Caroline, Spendiff Sally, Taivassalo Tanja, Zadeh Zahra E
Status	O2k 2007-2016; present: US FL Gainesville Hepple RT
Oroboros Events	IOC95, MiP2014, IOC72, Bioblast 2012, IOC54, IOC51, IOC50, IOC49, IOC44
Topics	Aging, permeabilized muscle fibers, isolated mitochondria

O2k-Publications

	Published	Reference
Newell 2016 Physiol Entomol	2016	Newell C, Kane CL, Kane DC (2016) Mitochondrial substrate specificity in beetle flight muscle: assessing respiratory oxygen flux in small samples from Dermestes maculatus and Tenebrio molitor. Physiol Entomol p7.
Spendiff 2016 J Physiol	2016	Spendiff S, Vuda M, Gouspillou G, Aare S, Perez A, Morais JA, Jagoe RT, Filion ME, Glicksman R, Kapchinsky S, MacMillan NJ, Pion CH, Aubertin-Leheudre M, Hettwer S, Correa JA, Taivassalo T, Hepple RT (2016) Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians. J Physiol 594:7361-79.
Desprat 2015 Thesis	2015	Desprat JL, Teulier L, Puijalon S, Romestaing C, Dumet A, Lengagne T, Mondy N (2015) Caloric restriction and testosterone affect mitochondrial functioning and contractile properties of calling muscles in Hyla arborea.. Doctoral Thesis p153.
Gouspillou 2015 Sci Rep	2015	Gouspillou G, Scheede-Bergdahl C, Spendiff S, Vuda M, Meehan B, Mlynarski H, Archer-Lahlou E, Sgarioto N, Purves-Smith FM, Konokhova Y, Rak J, Chevalier S, Taivassalo T, Hepple RT, Jagoe RT (2015) Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle. Sci Rep 5:8717.
Elustondo 2014 Biochim Biophys Acta	2014	Elustondo PA, Negoda A, Kane CL, Kane DA, Pavlov EV (2014) Spermine selectively inhibits high-conductance, but not low-conductance calcium-induced permeability transition pore. Biochim Biophys Acta 1847:231–40.
Picard 2012 PLoS One	2012	Picard M, Wright KJ, Ritchie D, Thomas MM, Hepple RT (2012) Mitochondrial function in permeabilized cardiomyocytes is largely preserved in the senescent rat myocardium. PLoS One 7:e43003.
Picard 2011 PLoS One	2011	Picard M, Taivassalo T, Ritchie D, Wright KJ, Thomas MM, Romestaing C, Hepple RT (2011) Mitochondrial structure and function are disrupted by standard isolation methods. PLoS One 6:e18317.
Picard 2011 Aging Cell	2011	Picard M, Ritchie D, Wright KJ, Romestaing C, Thomas MM, Rowan SL, Taivassalo T, Hepple RT (2011) Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers. Aging Cell 9:1032–46.
Naimi 2011 Clin Physiol Funct Imaging	2011	Naimi AI, Bourbeau J, Perrault H, Baril J, Wright-Paradis C, Rossi A, Taivassalo T, Sheel AW, Rabøl R, Dela F, Boushel RC (2011) Altered mitochondrial regulation in quadriceps muscles of patients with COPD. Clin Physiol Funct Imaging 31:124-31.
Tweedie 2011 Am J Physiol Regul Integr Comp Physiol	2011	Kane C, Romestaing C, Burelle Y, Safdar A, Tarnopolsky MA, Seadon S, Britton SL, Koch LG, Hepple RT (2011) Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity. Am J Physiol Regul Integr Comp Physiol 300:R544-53.

O2k-Abstracts

	Published	Reference
Muguiz 2017 J Cachexia Sarcopenia Muscle	2017	Chronic tobacco smoke exposure induces aryl hydrocarbon receptor-dependent neuromuscular junction degeneration.
Spendiff 2014 Abstract MiP2014	2014	Lessons from the master athlete: mitochondrial contributions to aging.
Hepple 2014 Abstract MiP2014	2014	Denervation modulates mitochondrial function when aging muscle atrophy becomes severe: implications for therapeutic intervention.
Hepple 2012 Abstract Bioblast	2012	Hepple RT, Picard M, Taivassalo T (2012) Is latent mitochondrial dysfunction in aging muscle exposed through mitochondrial isolation? Mitochondr Physiol Network 17.12.