CA Montreal Hepple RT

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CA Montreal Hepple RT

Oroboros O2k-Network

O2k-Network
O2k-Network Lab Department of Kinesiology and Dep. of Critical Care Medicine

McGill University Health Center - Meakins Christie Laboratories

Royal Victoria Hospital

Address 687 Pine Ave W, H3A 1A1
City Montreal
State/Prov Quebec (QC)
Country Canada
Weblink MAD Lab
Contact
Team
Team previous Darmyn Ritchie, Gouspillou Gilles, Hepple Russell T, Kane Constance, Miguez Kayla, Minozzo Fabio, Perez Anna, Picard Martin, Romestaing Caroline, Spendiff Sally, Taivassalo Tanja, Zadeh Zahra E
Status O2k 2007-2016; present: US FL Gainesville Hepple RT
Oroboros Events IOC95, MiP2014, IOC72, Bioblast 2012, IOC54, IOC51, IOC50, IOC49, IOC44
Topics Aging, permeabilized muscle fibers, isolated mitochondria


O2k-Publications

 PublishedReference
Spendiff 2016 J Physiol2016Spendiff S, Vuda M, Gouspillou G, Aare S, Perez A, Morais JA, Jagoe RT, Filion ME, Glicksman R, Kapchinsky S, MacMillan NJ, Pion CH, Aubertin-Leheudre M, Hettwer S, Correa JA, Taivassalo T, Hepple RT (2016) Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians. J Physiol 594:7361-79.
Newell 2016 Physiol Entomol2016Newell C, Kane CL, Kane DC (2016) Mitochondrial substrate specificity in beetle flight muscle: assessing respiratory oxygen flux in small samples from Dermestes maculatus and Tenebrio molitor. Physiol Entomol p7.
Desprat 2015 Thesis2015Desprat JL, Teulier L, Puijalon S, Romestaing C, Dumet A, Lengagne T, Mondy N (2015) Caloric restriction and testosterone affect mitochondrial functioning and contractile properties of calling muscles in Hyla arborea.. Doctoral Thesis p153.
Elustondo 2014 Biochim Biophys Acta2014Elustondo PA, Negoda A, Kane CL, Kane DA, Pavlov EV (2014) Spermine selectively inhibits high-conductance, but not low-conductance calcium-induced permeability transition pore. Biochim Biophys Acta 1847:231–40.
Picard 2012 PLoS One2012Picard M, Wright KJ, Ritchie D, Thomas MM, Hepple RT (2012) Mitochondrial function in permeabilized cardiomyocytes is largely preserved in the senescent rat myocardium. PLoS One 7:e43003.
Picard 2011 Aging Cell2011Picard M, Ritchie D, Wright KJ, Romestaing C, Thomas MM, Rowan SL, Taivassalo T, Hepple RT (2011) Mitochondrial functional impairment with aging is exaggerated in isolated mitochondria compared to permeabilized myofibers. Aging Cell 9:1032–46.
Naimi 2011 Clin Physiol Funct Imaging2011Naimi AI, Bourbeau J, Perrault H, Baril J, Wright-Paradis C, Rossi A, Taivassalo T, Sheel AW, Rabøl R, Dela F, Boushel RC (2011) Altered mitochondrial regulation in quadriceps muscles of patients with COPD. Clin Physiol Funct Imaging 31:124-31.
Tweedie 2011 Am J Physiol Regul Integr Comp Physiol2011Kane C, Romestaing C, Burelle Y, Safdar A, Tarnopolsky MA, Seadon S, Britton SL, Koch LG, Hepple RT (2011) Lower oxidative DNA damage despite greater ROS production in muscles from rats selectively bred for high running capacity. Am J Physiol Regul Integr Comp Physiol 300:R544-53.
Picard 2011 PLoS One2011Picard M, Taivassalo T, Ritchie D, Wright KJ, Thomas MM, Romestaing C, Hepple RT (2011) Mitochondrial structure and function are disrupted by standard isolation methods. PLoS One 6:e18317.

O2k-Abstracts

 PublishedReference
Muguiz 2017 J Cachexia Sarcopenia Muscle2017Chronic tobacco smoke exposure induces aryl hydrocarbon receptor-dependent neuromuscular junction degeneration.
Spendiff 2014 Abstract MiP20142014Lessons from the master athlete: mitochondrial contributions to aging.
Hepple 2014 Abstract MiP20142014Denervation modulates mitochondrial function when aging muscle atrophy becomes severe: implications for therapeutic intervention.
Hepple 2012 Abstract Bioblast2012Hepple RT, Picard M, Taivassalo T (2012) Is latent mitochondrial dysfunction in aging muscle exposed through mitochondrial isolation? Mitochondr Physiol Network 17.12.