Cerwenka 2016 Mol Cell Oncol
|Cerwenka A, Kopitz J, Schirmacher P, Roth W, Gdynia G (2016) HMGB1: The metabolic weapon in the arsenal of NK cells. Mol Cell Oncol 3:e1175538.|
Abstract: Targeting tumor glycolysis would hit the main energy source of cancer. We show that natural killer (NK) cells pursue this strategy by employing high mobility group box 1 (HMGB1) protein-a well-known proinflammatory cytokine-to specifically target glycolysis in cancer cells. This opens up new perspectives for cancer immunotherapy.
• Keywords: Cancer, HMGB1, NK cells, Natural killer cells, Cell death, Immunotherapy, Innate immunity, Metabolism, HT29 colon carcinoma cells
Labels: MiParea: Respiration Pathology: Cancer
Organism: Human Tissue;cell: Endothelial;epithelial;mesothelial cell, Other cell lines