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Chance 1955 J Biol Chem

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Publications in the MiPMap
Chance B, Williams GR, Holmes WF, Higgins J (1955) Respiratory enzymes in oxidative phosphorylation. V. Mechanism for oxidative phosphorylation. J Biol Chem 217:439-51.

Β» PMID: 13271406 Open Access

Chance B, Williams GR, Holmes WF, Higgins J (1955) J Biol Chem

Abstract: In a preceding paper (1) we have used, as an explanation of spectroscopic changes observed in oxidative phosphorylation, an analogy between antimycin A inhibition of the respiratory chain and the inhibition of mitochondrial respiration which is brought about by the exhaustion of added ADP. The latter process causes a 10-fold decrease of respiration rate and, in addition, changes in the steady state oxidation-reduction levels of spectroscopically detectable members of the respiratory chain involved in oxidative phosphorylation. In this paper we describe three types of inhibiting reactions that can affect steady state levels in the respiratory chain and analyze one of these mechanisms in detail by analytical and analogue computer methods. It has been possible to formulate a few general relationships between changes in steady state oxidation-reduction levels caused by the State 3 to 4 transition and the sites involved in oxidative phosphorylation.

β€’ Bioblast editor: Doerrier C


Labels: MiParea: Respiration