Chinopoulos 2011 J Neurosci Res

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Chinopoulos C (2011) The "B space" of mitochondrial phosphorylation. J Neurosci Res 89:1897-904.

Β» PMID: 21541983 Open Access

Chinopoulos C (2011) J Neurosci Res

Abstract: It was recently shown that, in progressively depolarizing mitochondria, the F(0) -F(1) ATP synthase and the adenine nucleotide translocase (ANT) may change directionality independently from each other (Chinopoulos et al. [2010] FASEB J. 24:2405). When the membrane potentials at which these two molecular entities reverse directionality, termed reversal potential (Erev), are plotted as a function of matrix ATP/ADP ratio, an area of the plot is bracketed by the Erev_ATPase and the Erev_ANT, which we call "B space". Both reversal potentials are dynamic, in that they depend on the fluctuating values of the participating reactants; however, Erev_ATPase is almost always more negative than Erev_ANT. Here we review the conditions that define the boundaries of the "B space". Emphasis is placed on the role of matrix substrate-level phosphorylation, because during metabolic compromise this mechanism could maintain mitochondrial membrane potential and prevent the influx of cytosolic ATP destined for hydrolysis by the reversed F(0) -F(1) ATP synthase.

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  • KomlΓ³di et al (2022) The protonmotive force - not merely membrane potential. MitoFit Preprints 2022 (in prep)


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