Coen 2017 Abstract MITOEAGLE Barcelona
To bring MitoEAGLE and MoTrPAC together.
Event: MitoEAGLE Barcelona 2017
Regular physical activity imparts many physical and mental health benefits. However, the cellular and molecular mechanisms by which exercise has this effect are not completely understood. To identify major gaps in knowledge and potential strategies for catalyzing progress in the field, the National Institutes of Health (NIH) in the US convened a workshop in October 2014 entitled ‘‘Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits.’’ Presentations and discussions emphasized the challenges imposed by the integrative and intermittent nature of PA, the tremendous discovery potential of applying ‘‘-omics’’ technologies to understand inter organ crosstalk and biological networking systems during PA. It was agreed upon that the identification of the mechanisms that underlie the link between PA and improved health holds extraordinary promise for discovery of novel therapeutic targets and development of personalized exercise medicine. Following on from the workshop, the NIH common fund announced support of a program called: “The Molecular Transducers of Physical Activity Consortium” or MoTrPAC. The goal of MoTrPAC is to catalogue the biological molecules affected by acute and chronic exercise in a cohort of ~3000 individuals, to assemble a comprehensive map of the molecular changes that occur in response to physical activity and, when possible, relate these changes to the subsequent health benefits. This molecular map will contain the many molecular signals that transmit the health effects of physical activity, and indicate how they are altered by age, sex, body composition, fitness level, and exposure to exercise.
MoTrPAC also represents an opportunity for those of us interested in mitochondrial function as it relates to exercise and health. The program coordinators of MoTrPAC are keen to support ancillary studies that bring cutting edge science to the initiative. Our group is currently at the early stages of planning an ancillary proposal to study mitochondrial respiration in bio specimens from MoTrPAC. We hope that there may be opportunity for MitoEAGLE and MoTrPAC to come together and synergize within the framework of an ancillary study of mitochondrial function in response in response to physical activity and, when possible, relate these changes to the subsequent health benefits.
Labels: MiParea: Gender, Exercise physiology;nutrition;life style Pathology: Aging;senescence
Event: A1 MitoEAGLEPublication
- Translational Research Inst Metabolism Diabetes, Florida Hospital, Orlando, USA
- Neufer PD, Bamman MM, Muoio DM, Bouchard C, Cooper DM, Goodpaster BH, Booth FW, Kohrt WM, Gerszten RE, Mattson MP, Hepple RT, Kraus WE, Reid MB, Bodine SC, Jakicic JM, Fleg JL, Williams JP, Joseph L, Evans M, Maruvada P, Rodgers M, Roary M, Boyce AT, Drugan JK, Koenig JI, Ingraham RH, Krotoski D, Garcia-Cazarin M, McGowan JA, Laughlin MR (2015) Understanding the cellular and molecular mechanisms of physical activity-induced health benefits. Cell Metab 22:4-11.