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Desler 2017 Abstract MITOEAGLE Barcelona

From Bioblast

Bioenergetic changes of differentiating human embryonic cells.

Link: MitoEAGLE

Desler C, Hopkinson BM, Kalisz M, Vestentoft PS, Bisgaard HC, Rasmussen LJ (2017)

Event: MitoEAGLE Barcelona 2017


Mitochondrial dysfunction has been demonstrated to result in premature aging due to its effects on stem cells. Nevertheless, a full understanding of the role of mitochondrial bioenergetics through differentiation is still lacking. We show the bioenergetics profile of human stem cells of embryonic origin differentiating along the hepatic lineage. Our study reveals especially the transition between hepatic specification and hepatic maturation, as dependent of mitochondrial respiration and demonstrates that even though differentiating cells are primarily dependent on glycolysis until induction of hepatocyte maturation, oxidative phosphorylation is essential at all stages of differentiation.

β€’ Bioblast editor: Bitschnaub B

Labels: MiParea: Respiration  Pathology: Aging;senescence 

Organism: Human  Tissue;cell: Liver, Stem cells 

Event: A4 


Desler C(1,2), Hopkinson BM(1), Kalisz M(3), Vestentoft PS(1), Bisgaard HC(1), Rasmussen LJ(1,2)
  1. Dept Cellular Molecular Med
  2. Center Healthy Aging
  3. Danish Stem Cell Center, Fac Health Sciences; Univ Copenhagen, Denmark