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Donnelly 2022 BEC

From Bioblast

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Bioenergetics Communications        
Gnaiger 2020 BEC MitoPathways
Gnaiger Erich et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1.
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Bioenergetics Communications
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Donnelly C, Schmitt S, Cecatto C, Cardoso LHD, Komlódi T, Place N, Kayser B, Gnaiger E (2022) The ABC of hypoxia – what is the norm. Bioenerg Commun 2022.12.

» Bioenerg Commun 2022.12. Open Access pdf
published online 2022-11-14 »Watch the presentation«

Donnelly Chris, Schmitt Sabine, Cecatto Cristiane, Cardoso Luiza HD, Komlodi Timea, Place Nicolas, Kayser Bengt, Gnaiger Erich (BEC 2022.12) Bioenerg Commun

Abstract: BEC.png

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Hypoxia is a condition of oxygen levels below normoxia and opposite to hyperoxia. We here define the normoxic reference state by three complementary precepts: (A) ambient normoxia at sea level in the contemporary atmosphere and corresponding dissolved O2 concentration at air saturation of aqueous environments; (B) biological compartmental O2 levels at ambient normoxia under physiological activity of healthy organisms in the absence of environmental stress (e.g. in a diving human, a stranded whale, a thermally stressed animal); and (C) control of respiration i.e., O2 levels above the region, where the capacity for O2 consumption is not compromised by partial O2 pressure as evaluated by its kinetics. The concept of the ABC of hypoxia is extended by addressing deviations from these reference points caused by different mechanisms: ∆A: ambient alterations of oxygen levels; ∆B: biological O2 demand exceeding O2 supply under pathological or experimental limitations of convective O2 transport or O2 diffusion; and ∆C: critical oxygen pressure in oxygen kinetics shifted by pathological and toxicological effects or environmental stress. The ABC of hypoxia may be of help in the design and interpretation of in vitro and in vivo experimental studies. Keywords: ambient, anoxia, critical O2 pressure pc, functional hypoxia, hyperoxia, hypoxia, limiting O2 pressure pl, normoxia, oxygen O2, O2 concentration cO2 [µM], O2 pressure pO2 [kPa] Bioblast editor: Tindle-Solomon L O2k-Network Lab: AT Innsbruck Oroboros, IE Dublin Porter RK

ORCID: ORCID.png Donnelly Chris, Schmitt Sabine, ORCID.png Cecatto Cristiane, ORCID.png Cardoso Luiza HD, ORCID.png Komlodi Timea, ORCID.png Place Nicolas, ORCID.png Kayser Bengt, ORCID.png Gnaiger Erich


» Donnelly 2022 MitoFit Hypoxia

Labels: MiParea: Respiration, Comparative MiP;environmental MiP, Exercise physiology;nutrition;life style 

Stress:Oxidative stress;RONS, Hypoxia 

Regulation: Aerobic glycolysis, Flux control, Temperature  Coupling state: ROUTINE 

HRR: Oxygraph-2k 

Tissue normoxia, BEC