Dreher 2023 Int J Obes (Lond)

From Bioblast
Publications in the MiPMap
Dreher SI, Irmler M, Pivovarova-Ramich O, Kessler K, JΓΌrchott K, Sticht C, Fritsche L, Schneeweiss P, Machann J, Pfeiffer AFH, HrabΔ› de Angelis M, Beckers J, Birkenfeld AL, Peter A, Niess AM, Weigert C, Moller A (2023) Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: a matched transcriptomics approach after 8-week training-intervention. https://doi.org/10.1038/s41366-023-01271-y

Β» Int J Obes (Lond) 47:313-24. PMID: 36774413 Open Access

Dreher Simon I, Irmler Martin, Pivovarova-Ramich Olga, Kessler Katharina, Juerchott Karsten, Sticht Carsten, Fritsche Louise, Schneeweiss Patrick, Machann Juergen, Pfeiffer Andreas FH, Hrabe de Angelis Martin, Beckers Johannes, Birkenfeld Andreas L, Peter Andreas, Niess Andreas M, Weigert Cora, Moller Anja (2023) Int J Obes (Lond)

Abstract: Exercise exerts many health benefits by directly inducing molecular alterations in physically utilized skeletal muscle. Molecular adaptations of subcutaneous adipose tissue (SCAT) might also contribute to the prevention of metabolic diseases.

The aim of this study was to characterize the response of human SCAT based on changes in transcripts and mitochondrial respiration to acute and repeated bouts of exercise in comparison to skeletal muscle.

Sedentary participants (27 Β± 4 yrs) with overweight or obesity underwent 8-week supervised endurance exercise 3Γ—1h/week at 80% VO2peak. Before, 60 min after the first and last exercise bout and 5 days post intervention, biopsies were taken for transcriptomic analyses and high-resolution respirometry (n = 14, 8 female/6 male).

In SCAT, we found 37 acutely regulated transcripts (FC > 1.2, FDR < 10%) after the first exercise bout compared to 394, respectively, in skeletal muscle. Regulation of only 5 transcripts overlapped between tissues highlighting their differential response. Upstream and enrichment analyses revealed reduced transcripts of lipid uptake, storage and lipogenesis directly after exercise in SCAT and point to Ξ²-adrenergic regulation as potential major driver. The data also suggest an exercise-induced modulation of the circadian clock in SCAT. Neither term was associated with transcriptomic changes in skeletal muscle. No evidence for beigeing/browning was found in SCAT along with unchanged respiration.

Adipose tissue responds completely distinct from adaptations of skeletal muscle to exercise. The acute and repeated reduction in transcripts of lipid storage and lipogenesis, interconnected with a modulated circadian rhythm, can counteract metabolic syndrome progression toward diabetes.

β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: DE Tuebingen Weigert C

Labels: MiParea: Respiration, nDNA;cell genetics, Comparative MiP;environmental MiP, Exercise physiology;nutrition;life style  Pathology: Obesity 

Organism: Human  Tissue;cell: Skeletal muscle, Fat  Preparation: Permeabilized tissue 

Coupling state: OXPHOS, ET  Pathway: F, N, NS  HRR: Oxygraph-2k 


Cookies help us deliver our services. By using our services, you agree to our use of cookies.