Duicu 2015 Biomed Res Int

From Bioblast
Jump to: navigation, search
Publications in the MiPMap
Duicu OM, Lighezan R, Sturza A, Ceausu RA, Borza C, Vaduva A, Noveanu L, Gaspar M, Ionac A, Feier H, Muntean DM, Mornos C (2015) Monoamine oxidases as potential contributors to oxidative stress in diabetes: time for a study in patients undergoing heart surgery. Biomed Res Int 2015:515437.

» PMID: 26101773 Open Access

Duicu OM, Lighezan R, Sturza A, Ceausu RA, Borza C, Vaduva A, Noveanu L, Gaspar M, Ionac A, Feier H, Muntean DM, Mornos C (2015) Biomed Res Int

Abstract: Oxidative stress is a pathomechanism causally linked to the progression of chronic cardiovascular diseases and diabetes. Mitochondria have emerged as the most relevant source of reactive oxygen species, the major culprit being classically considered the respiratory chain at the inner mitochondrial membrane. In the past decade, several experimental studies unequivocally demonstrated the contribution of monoamine oxidases (MAOs) at the outer mitochondrial membrane to the maladaptative ventricular hypertrophy and endothelial dysfunction. This paper addresses the contribution of mitochondrial dysfunction to the pathogenesis of heart failure and diabetes together with the mounting evidence for an emerging role of MAO inhibition as putative cardioprotective strategy in both conditions.

Keywords: Monoamine oxidases, Oxidative stress, Mitochondrial dysfunction, Coronary heart disease, Diabetes mellitus

O2k-Network Lab: RO Timisoara Muntean DM


Labels: MiParea: Respiration, Patients  Pathology: Cardiovascular, Diabetes  Stress:Oxidative stress;RONS  Organism: Human  Tissue;cell: Heart  Preparation: Permeabilized tissue 


Coupling state: LEAK, OXPHOS, ET  Pathway: N, S, ROX  HRR: Oxygraph-2k 

2016-03