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Ebanks 2022 Abstract Bioblast

From Bioblast

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P09.
Brad Ebanks
Ebanks Brad, Wang Y, Katyal G, Sargent C, Ingram TL, Bowman A, Moisoi N, Chakrabarti L (2022) Exercise alters mitochondrial physiology and has age-specific impacts on the fitness and lifespan of D. melanogaster.
Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001

Link: Bioblast 2022: BEC Inaugural Conference

Ebanks Brad, Wang Y, Katyal G, Sargent C, Ingram TL, Bowman A, Moisoi Nicoleta, Chakrabarti Lisa (2022)

Event: Bioblast 2022

Biological ageing is one of the biggest risk factors for a range of diseases, including cancers, neurodegenerative disease, and heart disease. Mitochondrial dysfunction is associated with both ageing and diseases of ageing. As exercise is increasingly being viewed as a potential anti-ageing therapy, we sought to assess the impact of exercise on the fitness and lifespan of D. melanogaster[1]. In addition, we assessed the exercise-induced changes to mitochondrial physiology through high-resolution respirometry and label-free mass spectrometry. Exercise in late life extends the lifespan of male and female D. melanogaster compared with those exercised throughout their entire lifetime. Exercise also increases Complex-II-linked respiration and upregulates the expression of proteins from the electron transfer Complexes I, III, IV.

  1. Ebanks B, Wang Y, Katyal G, Sargent C, Ingram TL, Bowman A, Moisoi N, Chakrabarti L (2021) Exercising D. melanogaster modulates the mitochondrial proteome and physiology. The effect on lifespan depends upon age and sex. https://doi.org/10.3390/ijms222111606

โ€ข Keywords: Drosophila; ageing; exercise; lifespan; mitochondria; proteomics; respirometry


Affiliation

University of Nottingham, UK - mbybdpo@nottingham.ac.uk

List of abbreviations, terms and definitions - MitoPedia

ยป MitoPedia: Terms and abbreviations


Labels: MiParea: Exercise physiology;nutrition;life style  Pathology: Aging;senescence 

Organism: Drosophila 




HRR: Oxygraph-2k  Event: Poster