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Eynon 2011 Physiol Genomics

From Bioblast
Publications in the MiPMap
Eynon N, Morán M, Birk R, Lucia A (2011) The champions' mitochondria: is it genetically determined? A review on mitochondrial DNA and elite athletic performance. Physiol Genomics 43:789-98.

» PMID: 21540298 Open Access

Eynon N, Moran M, Birk R, Lucia A (2011) Physiol Genomics

Abstract: Aerobic ATP generation by the mitochondrial respiratory oxidative phosphorylation system (OXPHOS) is a vital metabolic process for endurance exercise. Notably, mitochondrial DNA (mtDNA) codifies 13 of the 83 polypeptides implied in the respiratory chain. As such, there is a strong rationale for identifying an association between mtDNA variants and "aerobic" (endurance) exercise phenotypes. The aim of this review is to summarize current knowledge on the association between mtDNA, nuclear genes involved in mitochondriogenesis, and elite endurance athletic status. Several studies in nonathletic people have demonstrated an association between certain mtDNA lineages and aerobic performance, characterized by maximal oxygen uptake (VO2max). Whether mtDNA haplogroups are also associated with the status of being an elite endurance athlete is more controversial, with differences between studies arising from the different ethnic backgrounds of the athletic cohorts (Caucasian of mixed geographic origin, Asiatic, or East African).

Labels: MiParea: mtDNA;mt-genetics, Exercise physiology;nutrition;life style 

Organism: Human 

Preparation: Intact organism