Farrar 2015 US Patent

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Farrar GJ, Millington-Ward S, Chadderton N (2015) Variants of yeast ndi1 gene, and uses thereof in the treatment of disease associated with mitochondrial dysfunction. US Patent WO 2013093029 A3.

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Farrar GJ, Millington-Ward S, Chadderton N (2015) US Patent

Abstract: A nucleic acid sequence encoding the yeast NDI1 protein of SEQ ID NO: 542 or a functional variant thereof having at least 90% sequence identity with SEQ ID NO: 2 is described. The nucleic acid sequence comprises at least 50 codons which are codon optimised compared with the sequence of yeast NDI1 gene of SEQ ID NO: 1. An immune optimised functional variant of the yeast NDI1 protein of SEQ ID NO: 542 having at least 90% sequence identity with SEQ ID NO: 542 is also described, and includes at least one amino acid change selected from the group consisting of L194F, K283E, K9R, S142N, L501M, L402I, A386S, S85K, F89H, L93M, K195E, L18M, K213E, K372E, L258F, K510E, L158M, R478Q, L482M.

Keywords: Patent


Labels: MiParea: Respiration, nDNA;cell genetics, Genetic knockout;overexpression, mt-Medicine  Pathology: Neurodegenerative 

Organism: Human  Tissue;cell: HeLa 

Enzyme: Complex I 

Coupling state: ROUTINE  Pathway: ROX  HRR: Oxygraph-2k