Fliri 2015 US Patent
|Fliri HG, Ford RL, Scowen DA, Batcheller DG, Ehinger J, Elmér E, Hansson MJ, Sjövall F (2015) Protected succinates for enhancing mitochondrial atp-production. US Patent US20150259317 A1.|
Abstract: Disclosed herein are mono or di-succinate compounds where one or both of the acid groups in the succinate core are protected in the form of biologically labile moieties, and the use of said compounds to enhance mitochondrial function. The compounds may be of formula (I) wherein R1 is H or an optionally substituted alkyl group or a group of formula (II) and R2 is independently a group according to formula (II) where formula (II) is as defined 10 herein.
Labels: MiParea: Respiration, Pharmacology;toxicology
Organism: Human Tissue;cell: Blood cells, Platelet Preparation: Intact cells, Permeabilized cells
Coupling state: ET Pathway: S, NS, ROX HRR: Oxygraph-2k