Furihata 2021 Commun Biol

From Bioblast
Publications in the MiPMap
Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S (2021) Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure. Commun Biol 4:138.

Β» PMID: 33514783 Open Access

Furihata Takaaki, Takada Shingo, Kakutani Naoya, Maekawa Satoshi, Tsuda Masaya, Matsumoto Junichi, Mizushima Wataru, Fukushima Arata, Yokota Takashi, Enzan Nobuyuki, Matsushima Shouji, Handa Haruka, Fumoto Yoshizuki, Nio-Kobayashi Junko, Iwanaga Toshihiko, Tanaka Shinya, Tsutsui Hiroyuki, Sabe Hisataka, Kinugawa Shintaro (2021) Commun Biol

Abstract: Heart failure (HF) occurs frequently among older individuals, and dysfunction of cardiac mitochondria is often observed. We here show the cardiac-specific downregulation of a certain mitochondrial component during the chronological aging of mice, which is detrimental to the heart. MitoNEET is a mitochondrial outer membrane protein, encoded by CDGSH iron sulfur domain 1 (CISD1). Expression of mitoNEET was specifically downregulated in the heart and kidney of chronologically aged mice. Mice with a constitutive cardiac-specific deletion of CISD1 on the C57BL/6J background showed cardiac dysfunction only after 12 months of age and developed HF after 16 months; whereas irregular morphology and higher levels of reactive oxygen species in their cardiac mitochondria were observed at earlier time points. Our results suggest a possible mechanism by which cardiac mitochondria may gradually lose their integrity during natural aging, and shed light on an uncharted molecular basis closely related to age-associated HF.

β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: JP Sapporo Yokota T

Labels: MiParea: Respiration, Genetic knockout;overexpression  Pathology: Aging;senescence, Cardiovascular 

Organism: Mouse  Tissue;cell: Heart  Preparation: Isolated mitochondria 

Coupling state: LEAK, OXPHOS, ET  Pathway: N, S, NS, ROX  HRR: Oxygraph-2k, O2k-Fluorometer 

2021-02, AmR, JP 

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