Glombik 2019 Neurotox Res

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Głombik K, Detka J, Góralska J, Kurek A, Solnica B, Budziszewska B (2019) Brain metabolic alterations in rats showing depression-like and obesity phenotypes. Neurotox Res 37:406-24.

» PMID: 31782099 Open Access

Glombik K, Detka J, Goralska J, Kurek A, Solnica B, Budziszewska B (2019) Neurotox Res

Abstract: Current data suggest an important role of brain metabolic disturbances in the pathogenesis of depression and obesity, diseases that frequently co-occur. Our aim was to determine whether there are changes in markers characterizing glucose metabolism in prenatal stress (PS; animal model of depression), in rats fed a high-fat diet (HFD), and especially in the model of depression and obesity co-occurrence. The changes in glucose-6-phosphate, glycogen, glucose transporters (GLUT1, GLUT4), glucagon-like peptide-1 receptor (GLP-1R), and mitochondrial complexes levels in the frontal cortex and/or hippocampus were observed. In the case of the coexistence of depression and obesity, the most important changes were (1) the decrease in the membrane form of GLUT4, which may suggest weaker insulin action in the frontal cortex, and (2) the diminished GLP-1R, which could cause neurodegenerative changes in the hippocampus. However, presented results suggested that HFD weakened the PS effect of uncoupling oxidative phosphorylation in the frontal cortex.

Keywords: Brain, Depression, Glucose, High-fat diet, Mitochondria, Oxidative phosphorylation Bioblast editor: Plangger M

Labels: MiParea: Respiration, Developmental biology, Exercise physiology;nutrition;life style  Pathology: Obesity, Other 

Organism: Rat  Tissue;cell: Nervous system  Preparation: Isolated mitochondria  Enzyme: TCA cycle and matrix dehydrogenases 

Coupling state: LEAK, OXPHOS, ET  Pathway: N, S, NS, ROX  HRR: Oxygraph-2k 

Labels, 2019-12