Goldstein 1990 Nature

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Goldstein JL, Brown MS (1990) Regulation of the mevalonate pathway. Nature 343:425-30.

» PMID:1967820

Goldstein JL, Brown MS (1990) Nature

Abstract: The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.

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