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Gonzalez-Franquesa 2022 Redox Biol

From Bioblast
Publications in the MiPMap
Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, Fernández-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Samino S, Miró-Blanch J, Oemer G, Duran X, Sanchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, Fernández-Veledo S, Enríquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, Guimerà R, Blüher M, Martín-Subero JI, Garcia-Roves PM (2022) Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. https://doi.org/10.1016/j.redox.2022.102353

» Redox Biol 54:102353. PMID: 35777200 Open Access

Gonzalez-Franquesa Alba, Gama-Perez Pau, Kulis Marta, Szczepanowska Karolina, Dahdah Norma, Moreno-Gomez Sonia, Latorre-Pellicer Ana, Fernandez-Ruiz Rebeca, Aguilar-Mogas Antoni, Hoffman Anne, Monelli Erika, Samino Sara, Miro-Blanch Joan, Oemer Gregor, Duran Xavier, Sanchez-Rebordelo Estrella, Schneeberger Marc, Obach Merce, Montane Joel, Castellano Giancarlo, Chapaprieta Vicente, Sun Wenfei, Navarro Lourdes, Prieto Ignacio, Castano Carlos, Novials Anna, Gomis Ramon, Monsalve Maria, Claret Marc, Graupera Mariona, Soria Guadalupe, Wolfrum Christian, Vendrell Joan, Fernandez-Veledo Sonia, Enriquez Jose Antonio, Carracedo Angel, Perales Jose Carlos, Nogueiras Ruben, Herrero Laura, Trifunovic Aleksandra, Keller Markus A, Yanes Oscar, Sales-Pardo Marta, Guimera Roger, Blueher Matthias, Martín-Subero Jose Ignacio, Garcia-Roves Pablo M (2022) Redox Biol

Abstract: Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue.

Bioblast editor: Plangger M O2k-Network Lab: ES Barcelona Garcia-Roves PM, ES Barcelona Claret M, DE Cologne Trifunovic A


Labels: MiParea: Respiration  Pathology: Obesity 

Organism: Mouse  Tissue;cell: Skeletal muscle, Nervous system, Liver, Fat  Preparation: Permeabilized tissue, Homogenate 


Coupling state: LEAK, OXPHOS, ET  Pathway: N, S, NS, ROX  HRR: Oxygraph-2k 

2022-09