Harmonization

From Bioblast


high-resolution terminology - matching measurements at high-resolution


Harmonization

Description

Harmonization is the process of minimizing redundant or conflicting standards which may have evolved independently. To obtain a common basis in reaching a defined objective, critical requirements are identified that need to be retained.


Harmonization of some terms in mitochondrial physiology links separate 'subcultures' in publication. Ambiguities are pointed out for clarification of concepts. A platform-independent terminology is preferred. See also Table 2. Harmonization of terminology on respiratory states[1].
Table 1. Some platform-independent and platform-specific or outdated terms in mitochondrial physiology
Symbol Platform-independent terms Platform-specific or outdated terms
ce living cells intact cells
R ROUTINE respiration, in ROUTINE state basal respiration, in basal state
P OXPHOS capacity, in OXPHOS state of mt-preparations State 3
L LEAK respiration proton leak; State 4
E ET capacity, electron transfer capacity maximum respiration; State 3u
L/E L/E coupling-control ratio 1/UCR = L/E (ambiguous)
L/P L/P coupling-control ratio 1/RCR = L/P
R/E R/E control ratio 1/UCR = E/R
R-L R-L net ROUTINE capacity, net ROUTINE respiration ATP production, ATP-linked respiration
E-R E-R reserve capacity spare capacity
Rox residual oxygen consumption, in ROX state nonmitochondrial respiration; State 2


MitoPedia O2k and high-resolution respirometry: Oroboros QM 

  1. ↑ Zdrazilova L, Hansikova H, Gnaiger E (2022) Comparable respiratory activity in attached and suspended human fibroblasts. PLoS ONE 17:e0264496. https://doi.org/10.1371/journal.pone.0264496
Cookies help us deliver our services. By using our services, you agree to our use of cookies.