Harmonization is the process of minimizing redundant or conflicting standards which may have evolved independently. To obtain a common basis in reaching a defined objective, critical requirements are identified that need to be retained.
- Harmonization of some terms in mitochondrial physiology links separate 'subcultures' in publication. Ambiguities are pointed out for clarification of concepts. A platform-independent terminology is preferred. See also Table 2. Harmonization of terminology on respiratory states.
- Table 1. Some platform-independent and platform-specific or outdated terms in mitochondrial physiology
Symbol Platform-independent terms Platform-specific or outdated terms ce living cells intact cells R ROUTINE respiration, in ROUTINE state basal respiration, in basal state P OXPHOS capacity, in OXPHOS state of mt-preparations State 3 L LEAK respiration proton leak; State 4 E ET capacity, electron transfer capacity maximum respiration; State 3u L/E L/E coupling-control ratio 1/UCR = L/E (ambiguous) L/P L/P coupling-control ratio 1/RCR = L/P R/E R/E control ratio 1/UCR = E/R R-L R-L net ROUTINE capacity, net ROUTINE respiration ATP production, ATP-linked respiration E-R E-R reserve capacity spare capacity Rox residual oxygen consumption, in ROX state nonmitochondrial respiration; State 2
MitoPedia O2k and high-resolution respirometry: Oroboros QM
- ↑ Zdrazilova L, Hansikova H, Gnaiger E (2022) Comparable respiratory activity in attached and suspended human fibroblasts. PLoS ONE 17:e0264496. https://doi.org/10.1371/journal.pone.0264496