Herbst 2016 Appl Physiol Nutr Metab

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Herbst EA, Holloway GP (2016) Exercise increases mitochondrial glutamate oxidation in the mouse cerebral cortex. Appl Physiol Nutr Metab 41:799-801.

» PMID: 27184881 Open Access

Herbst EA, Holloway GP (2016) Appl Physiol Nutr Metab

Abstract: The present study investigated the impact of acute exercise on stimulating mitochondrial respiratory function in mouse cerebral cortex. Where pyruvate-stimulated respiration was not affected by acute exercise, glutamate respiration was enhanced following the exercise bout. Additional assessment revealed that this affect was dependent on the presence of malate and did not occur when substituting glutamine for glutamate. As such, our results suggest that glutamate oxidation is enhanced with acute exercise through activation of the malate-aspartate shuttle.

Keywords: Brain mitochondria, Cerebral cortex, Cortex cérébral, Exercice physique, Exercise, Glutamate metabolism, Mitochondrie cérébrale, Métabolisme du glutamate

O2k-Network Lab: CA Guelph Holloway GP


Labels: MiParea: Respiration, Exercise physiology;nutrition;life style 


Organism: Mouse  Tissue;cell: Nervous system  Preparation: Permeabilized tissue 


Coupling state: LEAK, OXPHOS  Pathway:HRR: Oxygraph-2k 

2016-07