Hoffmann 2020 J Clin Endocrinol Metab

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Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, Schick F, Fritsche A, Heni M, Birkenfeld A, Niess AM, Häring HU, Weigert C, Moller A (2020) Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects. J Clin Endocrinol Metab 105:dgaa571.

» PMID: 32827042 Open Access

Hoffmann Christoph, Schneeweiss Patrick, Randrianarisoa Elko, Schnauder Guenter, Kappler Lisa, Machann Juergen, Schick Fritz, Fritsche Andreas, Heni Martin, Birkenfeld Andreas, Niess Andreas M, Haering Hans-Ulrich, Weigert Cora, Moller Anja (2020) J Clin Endocrinol Metab

Abstract: Exercise training improves glycemic control and increases mitochondrial content and respiration capacity in skeletal muscle. Rodent studies suggest that training increases mitochondrial respiration in adipose tissue.

The Objective was to assess the effects of endurance training on respiratory capacities of human skeletal muscle and abdominal subcutaneous adipose tissue and to study the correlation with improvement in insulin sensitivity.

Using high resolution respirometry, we analyzed biopsies from 25 sedentary (VO2 peak 25.1 ± 4.0 VO2 ml/(kg*min)) subjects (16 females, 9 males; 29.8 ± 8.4 yrs) with obesity (BMI 31.5 ± 4.3 kg/m2), who did not have diabetes. They performed a supervised endurance training over 8 weeks (3 x 1 hour/week at 80% VO2 peak).

Based on change in insulin sensitivity after intervention, subjects were grouped in responders (>15% increase in ISIMatsuda) and low responders. The response in ISIMatsuda was correlated to a reduction of subcutaneous and visceral adipose tissue volume. Both groups exhibited similar increases in fitness, respiratory capacity, and in abundance of mitochondrial enzymes in skeletal muscle fibers. Respiratory capacities in subcutaneous adipose tissue were not altered by the intervention. Compared to muscle fibers, adipose tissue respiration showed a preference for β-oxidation and complex II substrates. Respiratory capacities were higher in adipose tissue from females.

Our data show that the improvement of peripheral insulin sensitivity after endurance training is not directly related to an increase in mitochondrial respiratory capacities in skeletal muscle and occurs without an increase in the respiratory capacity of subcutaneous adipose tissue.

© Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Keywords: Respiratory chain complex, VO2peak, Diabetes prevention, Sex-differences Bioblast editor: Plangger M O2k-Network Lab: DE Tuebingen Weigert C

Labels: MiParea: Respiration, Exercise physiology;nutrition;life style  Pathology: Obesity 

Organism: Human  Tissue;cell: Skeletal muscle  Preparation: Permeabilized tissue 

Coupling state: LEAK, OXPHOS, ET  Pathway: F, N, S, NS, ROX  HRR: Oxygraph-2k