Holloway 2023 MiP2023

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Holloway 2023 MiP2023

Holloway Graham P
Mitochondrial bioenergetics as a nexus-point for the beneficial effects of nitrate in diverse tissues.

Link: MiP2023 Obergurgl AT

Holloway Graham P (2023)

Event: MiP2023 Obergurgl AT

Authors: Holloway Graham P, Petrick Heather L, van Loon LJC

Mitochondria play a key role in metabolic homeostasis, with impaired mitochondrial biology directly linked with numerous pathological conditions, including skeletal muscle atrophy, insulin resistance and heart dysfunction. Our team has focused on identifying nutritional approaches that preserve mitochondrial bioenergetics as a preventative medicine approach. In particular, we have studied dietary nitrate, which can be consumed through foods such as beets and green leafy vegetables or supplementation, as this compound appears to positively affect mitochondrial bioenergetics in diverse tissues. Additionally, we have shown that dietary nitrate can prevent high-fat diet-induced cardiac dysfunction, whole-body insulin resistance, dyslipidemia, and hepatic dysfunction. Moreover, we have recently uncovered that nitrate prevents skeletal muscle disuse-mediated reductions in mitochondrial protein synthesis rates (FSR), mitochondrial protein content, respiration and prevented the normal increase mitochondrial reactive oxygen species (ROS) emission during limb immobilization. While these physiological outcomes are likely in part linked to the serial reduction of nitrate to systemic nitric oxide (NO)-mediated vasodilation, we have also utilized fecal microbial transplantation from nitrate-fed donors to prevent HFD-induced cardiac dysfunction in the absence of increasing serum nitrate or reducing blood pressure. Given these systemic, reproducible, and consistent effects, nitrate appears to represent a viable therapeutic approach to improve mitochondrial bioenergetics to combat compromised cardiometabolic health in diverse situations.


β€’ O2k-Network Lab: CA Guelph Holloway GP


Affiliations

Holloway Graham P1, Petrick Heather L1,2, van Loon LJC2
  1. Dept Human Health and Nutritional Sciences, Univ Guelph, Canada
  2. Dept Human Biology, Maastricht Univ, the Netherlands


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Event: Oral 


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