Hoppel Charles L

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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping

Hoppel Charles L

MitoPedia topics: EAGLE

COST: Member COST WG1: WG1

Name	Hoppel Charles L, Prof., MD Professor, Pharmacology and Medicine Chief, Clinical Pharmacology Director, the Center for Mitochondrial Diseases
Institution	Department of Pharmacology, Case Western Reserve University School of Medicine, US Annual Charles L. Hoppel, M.D. Award for Outstanding Contributions in Mitochondrial Research
Address	W147 Wood Building, 10900 Euclid Avenue, 44106-4981
City	Cleveland
State/Province	Ohio (OH)
Country	USA
Email	charles.hoppel@case.edu
Weblink	Department of Pharmacology
O2k-Network Lab	US OH Cleveland Hoppel CL

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Publications

	Published	Reference
Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research 2022	2022-11-14	Cleveland, OH , 2022 Nov 14. The Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research.
Akinbiyi 2021 Sci Rep	2021	Akinbiyi EO, Abramowitz LK, Bauer BL, Stoll MSK, Hoppel CL, Hsiao CP, Hanover JA, Mears JA (2021) Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass. Sci Rep 11:22106.
Zunica 2021 Cancer Metab	2021	Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP (2021) Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. Cancer Metab 9:36.
King 2021 J Biol Chem	2021	King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP (2021) Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem 297:101196.
Axelrod 2021 EMBO Mol Med	2021	Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med 12:12088.
BEC 2020.1 doi10.26124bec2020-0001.v1	2020	Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1
Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research 2019	2019-11-09	Cleveland, OH , 2019 Nov 09. The Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research.
Lai 2019 Acta Physiol (Oxf)	2019	Lai N, Kummitha CM, Rosca MG, Fujioka H, Tandler B, Hoppel CL (2019) Isolation of mitochondrial subpopulations from skeletal muscle: Optimizing recovery and preserving integrity. Acta Physiol (Oxf) 225:13182.
Kumar 2019 Free Radic Biol Med	2019	Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy. Free Radic Biol Med 145:284-99.
Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research 2018	2018-11-09	Cleveland, OH , 2018 Nov 09. The Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research.
Chen 2018 Hum Mol Genet	2018	Chen A, Tiosano D, Guran T, Baris HN, Bayram Y, Mory A, Shapiro-Kulnane L, Hodges CA, Coban Akdemir Z, Turan S, Jhangiani SN, van den Akker F, Hoppel CL, Salz HK, Lupski JR, Buchner DA (2018) Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency. Hum Mol Genet 27:1913-26.
Hsiao 2018 Anal Biochem	2018	Hsiao CP, Hoppel C (2018) Analyzing mitochondrial function in human peripheral blood mononuclear cells. Anal Biochem 549:12-20.
Lai 2018 Acta Physiol (Oxf)	2018	Lai N, M Kummitha C, Rosca MG, Fujioka H, Tandler B, Hoppel CL (2018) Isolation of mitochondrial subpopulations from skeletal muscle: optimizing recovery and preserving integrity. Acta Physiol (Oxf) e13182. doi: 10.1111/apha.13182.
The Hoppel Prize Lectureship in Mitochondrial Biology	2017-10-05	Cleveland, OH , 2017 Oct 05. The Hoppel Prize Lectureship in Mitochondrial Biology.
Zhou 2017 Biochim Biophys Acta	2017	Zhou L, Wang W, Hoppel C, Liu J, Zhu X (2017) Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits. Biochim Biophys Acta 1863:2791-5.
Davuluri 2016 J Physiol	2016	Davuluri G, Allawy A, Thapaliya S, Rennison JH, Singh D, Kumar A, Sandlers Y, Van Wagoner DR, Flask CA, Hoppel C, Kasumov T, Dasarathy S (2016) Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress. J Physiol 594:7341-60.
Solinas 2014 Mech Ageing Dev	2014	Solinas P, Fujioka H, Radivoyevitch T, Tandler B, Hoppel CL (2014) Aging effects on oxidative phosphorylation in rat adrenocortical 3 mitochondria. Mech Ageing Dev 138:10-4.
Ye 2013 Anal Biochem	2013	Ye F, Hoppel CL (2013) Measuring oxidative phosphorylation in human skin fibroblasts. https://doi.org/10.1016/j.ab.2013.02.010
Rosca 2012 Diabetes	2012	Rosca MG, Vazquez EJ, Chen Q, Kerner J, Kern TS, Hoppel CL (2012) Oxidation of fatty acids is the source of increased mitochondrial reactive oxygen species production in kidney cortical tubules in early diabetes. Diabetes 61:2074-83. https://doi.org/10.2337/db11-1437
Ye 2011 J Biol Chem	2011	Ye F, Lemieux H, Hoppel CL, Hanson RW, Hakimi P, Croniger CM, Puchowicz M, Anderson VE, Fujioka H, Stavnezer E (2011) Peroxisome proliferator-activated receptor γ (PPARγ) mediates a Ski-induced shift from glycolysis to oxidative energy metabolism. J Biol Chem 286:40013-24.
Rosca 2011 Biochim Biophys Acta	2011	Rosca M, Minkler P, Hoppel CL (2011) Cardiac mitochondria in heart failure: Normal cardiolipin profile and increased threonine phosphorylation of Complex IV. Biochim Biophys Acta 1807:1373-82.
Lemieux 2010 J Gerontol A Biol Sci Med Sci	2010	Lemieux H, Vazquez EJ, Fujioka H, Hoppel CL (2010) Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype. J Gerontol A Biol Sci Med Sci 65:1157-64.
Lemieux 2009 JBB	2009	Lemieux H, Hoppel CL (2009) Mitochondria in the human heart. J. Bioenerg. Biomembr. 41:99-106.
Rosca 2008 Cardiovasc Res	2008	Rosca MG, Vazquez EJ, Kerner J, Parland W, Chandler MP, Stanley W, Sabbah HN, Hoppel CL (2008) Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation. Cardiovasc Res 80:30-39.
Puchowicz 2004 Mitochondrion	2004	Puchowicz MA, Varnes ME, Cohen BH, Friedman NR, Kerr DS, Hoppel CL (2004) Oxidative phosphorylation analysis: assessing the integrated functional activity of human skeletal muscle mitochondria-case studies. Mitochondrion 4:377-85.
Kerner 2000 Biochim Biophys Acta	2000	Kerner J, Hoppel C (2000) Fatty acid import into mitochondria. Biochim Biophys Acta 1486:1-17.
Palmer 1977 J Biol Chem	1977	Palmer JW, Tandler B, Hoppel CL (1977) Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle. J Biol Chem 252:8731-9.
Tomec 1975 Arch Biochem Biophys	1975	Tomec RJ, Hoppel CL (1975) Carnitine palmitoyltransferase in bovine fetal heart mitochondria. Arch Biochem Biophys 170:716-23.

Abstracts

	Published	Reference
Lai 2022 Abstract Bioblast	2022	5.6. «5 min» Lai Nicola, Kummitha CM, Hoppel CL (2022) Effect of isolation protocol of skeletal muscle mitochondrial subpopulations on bioenergetic function. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001
Axelrod 2019 Abstract IOC141	2019	Axelrod CL, Davuluri G, Zunica ERM, Noland RC, Hoppel CL, Kirwan JP (2019) Administration of BAM15 to obese C57BL/6J mice increases skeletal muscle fatty acid oxidation independent of OXPHOS or ETC capacity. Mitochondr Physiol Network 24.02.
Hoppel 2018 MiPschool Tromso D2	2018	Mitochondrial function during ischemia/reperfusion injury.
Hoppel 2018 MiPschool Tromso D1	2018	Two populations of muscle mitochondria: heart and skeletal muscle.
Hoppel 2017 MiP2017	2017	Pathways of mitochondrial fatty acid oxidation. Hoppel_Presentation
Hoppel 2017 MiPschool Obergurgl E1	2017	The challenges of functional mitochondrial diagnosis.
Hoppel 2017 MiPschool Obergurgl A	2017	Biochemical coupling efficiency and ATP/O₂ ratios.
Hsiao 2016 Abstract MitoFit Science Camp 2016	2016	Association between mitochondrial bioenergetics and radiation-related fatigue: a possible mechanism and novel target.
Hoppel 2016a Abstract MitoFit Science Camp 2016	2016	Skeletal muscle mitochondria in diagnostic studies.
Hoppel 2016b Abstract MitoFit Science Camp 2016	2016	Comparison of permeabilized skeletal muscle fibers or isolated mitochondria for the detection of oxidative phosphorylation defects.
Hoppel 2016c Abstract MitoFit Science Camp 2016	2016	Mitochondrial respiration in permeabilized skin fibroblasts.
Lai 2014 Abstract1 MiP2014	2014	Improved isolation of high quality subsarcolemmal and interfibrillar mitochondria from skeletal muscle.
Lai 2014 Abstract2 MiP2014	2014	Bioenergetic differences between permeabilized red and white fibers of a non-obese model of type II diabetes.
Hoppel 2012 Abstract Bioblast	2012	Hoppel CL (2012) Mitochondrial functional testing – muscle biopsy, isolated mitochondria and others. Mitochondr Physiol Network 17.12.
Rosca MiP2010	2010	Rosca MG, Hoppel CL (2010) Activation of distinct mitochondrial cAMP-PKA compartments induces different effects on mitochondrial function.