Houben 2015 Mitochondrion
|Houben R, Leleu C, Fraipont A, Serteyn D, Votion DM (2015) Determination of muscle mitochondrial respiratory capacity in Standardbred racehorses as an aid to predicting exertional rhabdomyolysis. Mitochondrion 24:99-104.|
Abstract: This prospective cohort study evaluated the potential of high-resolution respirometry applied to permeabilized muscle fibers for fitness evaluation in French Standardbred racehorses. Fitness evaluation by means of respirometric parameters did not correlate with racing performance registered over the following racing season. However, altered mitochondrial energy metabolism was associated with higher risk of developing exertional rhabdomyolysis, a common cause of exercise intolerance in racehorses. These data represent a first step towards establishing reference values for muscle OXPHOS capacity in this breed.
• Keywords: Horse, Muscle, Mitochondria, High-resolution respirometry, OXPHOS, Exertional rhabdomyolysis
• O2k-Network Lab: BE Liege Votion DM
Labels: MiParea: Respiration, Exercise physiology;nutrition;life style Pathology: Other
Organism: Horse Tissue;cell: Skeletal muscle Preparation: Permeabilized tissue
Coupling state: OXPHOS, ET Pathway: N, S, NS, ROX HRR: Oxygraph-2k