Huetter 2002 Mol Biol Rep

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Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Mol Biol Rep 29:83-7.

» PMID: 12241081

Huetter E, Renner K, Jansen-Duerr P, Gnaiger E (2002) Mol Biol Rep

Abstract: Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone- and antimycin A- inhibited oxygen consumption in the high-oxygen range. This suggest an increased production of reactive oxygen species and oxidative stress at elevated, air-level oxygen concentrations. The high oxygen activity of mitochondrial respiration provides the basis for the maintenance of a high aerobic scope at physiological low-oxygen levels, whereas further pronounced depression induces energetic stress under hypoxia.

O2k-Network Lab: AT Innsbruck Gnaiger E, AT Innsbruck Jansen-Duerr P, AT Innsbruck Oroboros, DE Regensburg Renner-Sattler K

Labels: MiParea: Respiration 

Organism: Human  Tissue;cell: Fibroblast  Preparation: Intact cells 

Regulation: Oxygen kinetics  Coupling state: ROUTINE  Pathway: ROX  HRR: Oxygraph-2k