Hunter 2019 J Appl Physiol (1985)

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Hunter GR, Moellering DR, Windham ST, Mathis SL, Bamman MM, Fisher G (2019) Relationship between VO2max, cycle economy & mitochondrial respiration in untrained/trained. J Appl Physiol (1985) 127:1562-68.

» PMID: 31556836

Hunter GR, Moellering DR, Windham ST, Mathis SL, Bamman MM, Fisher G (2019) J Appl Physiol (1985)

Abstract: Aerobic capacity is negatively related to locomotion economy. The purpose of the paper is to determine what effects aerobic exercise training has on the relationship between net cycling oxygen uptake (inverse of economy) and aerobic capacity (VO2peak) as well as what role mitochondrial coupled and uncoupled respiration may play in whole body aerobic capacity and cycling economy.

Cycling net oxygen uptake and VO2peak were evaluated on 52 subjects prior to exercise training (baseline) and 31 subjects after 8-16 weeks of aerobic training. Muscle tissue was collected from 25 subjects at baseline and 15 post training. Mitochondrial respiration assays were performed using High Resolution Respirometry.

Pre (r=0.34, p<0.05) and post exercise training (r=0.62, p<0.01) VO2peak and cycling net oxygen uptake were related. In addition, uncoupled and coupled fat respiration were related both baseline (r=0.89, p<0.01) and post training (r=0.89, p<01). Post training coupled (r=0.74, p<0.01) and uncoupled carbohydrate respiration (r=0.52, p<05) were related to cycle net oxygen uptake. In addition, correlations between changes in VO2peak and changes in cycle net oxygen uptake persist after training, even after adjusting for changes in RQ (an index of fat oxidation).

These results suggest that the negative relationship between locomotion economy and aerobic capacity is increased following exercise training. In addition, it is proposed that at least one of the primary factors influencing this relationship has its foundation within the mitochondria. Strong relationships between coupled and uncoupled respiration appear to be contributing factors for this relationship.

Keywords: Peak oxygen uptake, State 3 mitochondrial respiration, State 4 mitochondrial respiration, Submaximal oxygen uptake Bioblast editor: Plangger M O2k-Network Lab: US AL Birmingham Moellering DR


Labels: MiParea: Respiration, Exercise physiology;nutrition;life style 


Organism: Human  Tissue;cell: Skeletal muscle  Preparation: Permeabilized tissue 


Coupling state: LEAK, OXPHOS  Pathway: F, N, NS  HRR: Oxygraph-2k 

Labels, 2019-10, VO2max