Iglesias-Gonzalez 2014 PhD Thesis
|Iglesias-Gonzalez J (2014) Neurotoxicity induced by oxidative stress and aluminium in relation to Parkinson’s disease: a mitochondrial bioenergetic approach by high-resolution respirometry. PhD Thesis 1-242.|
Abstract: The study of mitochondria during the last years has revealed that this organelle plays an important role in the development and onset of neurodegenerative disorders such as Parkinson's disease. The main hallmarks found in post‐mortem studies remark the importance of brain free radicals levels, the alteration in brain metabolic parameters and the presence of xenobiotics like metals for the neurodegenerative processes. Also, any energetic deficit related with the metabolic impairment due to an exposition to toxics or an...
Labels: MiParea: Respiration, Patients Pathology: Parkinson's
Organism: Rat Tissue;cell: Nervous system Preparation: Isolated mitochondria
Coupling state: LEAK, OXPHOS, ET Pathway: N, S, NS, ROX HRR: Oxygraph-2k, Theory