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Ivarsson 2016 Physiol Behav

From Bioblast
Publications in the MiPMap
Ivarsson N, Schiffer TA, Hernández A, Lanner JT, Weitzberg E, Lundberg JO, Westerblad H (2016) Dietary nitrate markedly improves voluntary running in mice. Physiol Behav 168:55-61.

» PMID: 27794435

Ivarsson N, Schiffer TA, Hernandez A, Lanner JT, Weitzberg E, Lundberg JO, Westerblad H (2016) Physiol Behav

Abstract: Nitrate supplementation is shown to increase submaximal force in human and mouse skeletal muscles. In this study, we test the hypothesis that the increased submaximal force induced by nitrate supplementation reduces the effort of submaximal voluntary running, resulting in increased running speed and distance. C57Bl/6N male mice were fed nitrate in the drinking water and housed with or without access to an in-cage running wheel. Nitrate supplementation in sedentary mice had no effect on endurance in a treadmill test, nor did it enhance mitochondrial function. However, after three weeks with in-cage running wheel, mice fed nitrate ran on average 20% faster and 30% further than controls (p<0.01). Compared to running controls, this resulted in ~13% improved endurance on a subsequent treadmill test (p<0.05) and increased mitochondrial oxidative capacity, as judged from a mean increase in citrate synthase activity of 14% (p<0.05). After six weeks with nitrate, the mice were running 58% longer distances per night. When nitrate supplementation was removed from the diet, the running distance and speed decreased to the control level, despite the improved endurance achieved during nitrate supplementation. In conclusion, low-frequency force improvement due to nitrate supplementation facilitates submaximal exercise such as voluntary running.

Copyright © 2016 Elsevier Inc. All rights reserved. Keywords: Endurance, Excitation-contraction coupling, Exercise, Oxidative capacity

O2k-Network Lab: SE Stockholm Weitzberg E


Labels: MiParea: Respiration, Exercise physiology;nutrition;life style 


Organism: Mouse  Tissue;cell: Skeletal muscle  Preparation: Isolated mitochondria 


Coupling state: LEAK, OXPHOS 

HRR: Oxygraph-2k, TIP2k