Jacobs HT

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Name Jacobs Howard T., Prof.Dr.
Institution Academy Professor

Institute of Biotechnology, P.O.Box. 56 University of Helsinki

Address Viikinkaari 9, Biocenter 1, 00014
City Helsinki
State/Province
Country Finland
Email howard.jacobs@helsinki.fi
Weblink
O2k-Network Lab FI Helsinki Jacobs HT, FI Tampere Dufour E


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Publications

 PublishedReference
Szibor 2020 J Cell Mol Med2020Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gärtner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich FN, Schlüter KD, Jacobs HT (2020) Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. J Cell Mol Med [Epub ahead of print].
Rajendran 2019 EMBO Mol Med2019Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Auvinen P, Mervaala E, Jacobs HT, Szibor M, Fellman V, Kallijärvi J (2019) Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Mol Med 11:e9456.
Bahhir 2019 PLoS Genet2019Bahhir D, Yalgin C, Ots L, Jaervinen S, George J, Naudi A, Krama T, Krams I, Tamm M, Andjelkovic A, Dufour E, Gonzalez de Cozar JM, Gerards M, Parhiala M, Pamplona R, Jacobs HT, Joers P (2019) Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms. PLoS Genet [Epub ahead of print].
Giordano 2018 Am J Respir Cell Mol Biol2018Giordano L, Farnham A, Dhandapani PK, Salminen L, Bhaskaran J, Voswinckel R, Rauschkolb P, Scheibe S, Sommer N, Beisswenger C, Weissmann N, Braun T, Jacobs HT, Bals R, Herr C, Szibor M (2018) Alternative oxidase attenuates cigarette smoke-induced lung dysfunction and tissue damage. Am J Respir Cell Mol Biol 60:515-22.
Rodrigues 2018 Sci Rep2018Rodrigues APC, Camargo AF, Andjelkovic A, Jacobs HT, Oliveira MT (2018) Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase. Sci Rep 8:10882.
Dogan 2018 Cell Metab2018Dogan SA, Cerutti R, Benincá C, Brea-Calvo G, Jacobs HT, Zeviani M, Szibor M, Viscomi C (2018) Perturbed redox signaling exacerbates a mitochondrial myopathy. Cell Metab 28:764-77.
Chretien 2017 bioRxiv2017Chretien D, Benit P, Ha HH, Keipert S, El-Khoury R, Chang YT, Jastroch M, Jacobs H, Rustin P, Rak M (2017) Mitochondria are physiologically maintained at close to 50 C. bioRxiv doi: https://doi.org/10.1101/133223 .
Syrjanen 2015 Front Zool2015Syrjanen L, Valanne S, Kuuslahti M, Tuomela T, Sriram A, Sanz A, Jacobs HT, Ramet M, Parkkila S. (2015) β carbonic anhydrase is required for female fertility in Drosophila melanogaster. Front Zool 12:19.
Kemppainen 2014 Hum Mol Genet2014Kemppainen KK, Rinne J, Sriram A, Lakanmaa M, Zeb A, Tuomela T, Popplestone A, Singh S, Sanz A, Rustin P, Jacobs HT (2014) Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Hum Mol Genet 23:2078-93.
Stefanatos 2012 Cell Cycle2012Stefanatos R, Sriram A, Kiviranta E, Mohan A, Ayala V, Jacobs HT, Pamplona R, Sanz A (2012) dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster. Cell Cycle 11:3876-86.

Abstracts

 PublishedReference
Oliveira 2015 Abstract IOC1002015Oliveira MT, Saari S, Andjelkovic A, Jacobs HT (2015) Investigating the metabolic alterations caused by the transgenic expression of the mitochondrial alternative oxidase of Ciona intestinalis in Drosophila melanogaster. Mitochondr Physiol Network 20.01.
Dhandapani 2014 Abstract IOC 2014-04 Schroecken2014Dhandapani PK, Dufour E, Jacobs HT, Szibor M (2014) Alternative oxidase-based therapy for heart failure. Mitochondr Physiol Network 19.02.