Jacobs Howard T
| Name | Jacobs Howard T., Prof.Dr. |
|---|---|
| Institution | Academy Professor
Institute of Biotechnology, P.O.Box. 56 University of Helsinki |
| Address | Viikinkaari 9, Biocenter 1, 00014 |
| City | Helsinki |
| State/Province | |
| Country | Finland |
| howard.jacobs@helsinki.fi | |
| Weblink | |
| O2k-Network Lab | FI Helsinki Jacobs HT, FI Tampere Dufour E |
Labels:
Publications
| Published | Reference | |
|---|---|---|
| Szibor 2020 J Cell Mol Med | 2020 | Szibor Marten, Schreckenberg Rolf, Gizatullina Zemfira, Dufour Eric, Wiesnet Marion, Dhandapani Praveen Kumar, Debska-Vielhaber Grazyna, Heidler Juliana, Wittig Ilka, Nyman Tuula A, Gaertner Ulrich, Hall Andrew R, Pell Victoria, Viscomi Carlo, Krieg Thomas, Murphy Michael P, Braun Thomas, Gellerich Frank Norbert, Schlueter Klaus-Dieter, Jacobs Howard T(2020) Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. J Cell Mol Med 24:3534-48. |
| Sommer 2020 Sci Adv | 2020 | Sommer N, Alebrahimdehkordi N, Pak O, Knoepp F, Strielkov I, Scheibe S, Dufour E, Andjelekovic A, Sydykov A, Saraji A, Petrovic A, Quanz K, Hecker M, Kumar M, Wahl J, Kraut S, Seeger W, Schermuly RT, Ghofrani HA, Ramser K, Braun T, Jacobs HT, Weissmann N, Szibor M (2020) Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing. Sci Adv 6:eaba0694. |
| Rajendran 2019 EMBO Mol Med | 2019 | Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Auvinen P, Mervaala E, Jacobs HT, Szibor M, Fellman V, Kallijärvi J (2019) Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Mol Med 11:e9456. |
| Bahhir 2019 PLoS Genet | 2019 | Bahhir D, Yalgin C, Ots L, Jaervinen S, George J, Naudi A, Krama T, Krams I, Tamm M, Andjelkovic A, Dufour E, Gonzalez de Cozar JM, Gerards M, Parhiala M, Pamplona R, Jacobs HT, Joers P (2019) Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms. PLoS Genet 15:e1008410. |
| Rodrigues 2018 Sci Rep | 2018 | Rodrigues APC, Camargo AF, Andjelkovic A, Jacobs HT, Oliveira MT (2018) Developmental arrest in Drosophila melanogaster caused by mitochondrial DNA replication defects cannot be rescued by the alternative oxidase. Sci Rep 8:10882. |
| Dogan 2018 Cell Metab | 2018 | Dogan SA, Cerutti R, Benincá C, Brea-Calvo G, Jacobs HT, Zeviani M, Szibor M, Viscomi C (2018) Perturbed redox signaling exacerbates a mitochondrial myopathy. Cell Metab 28:764-77. |
| Giordano 2018 Am J Respir Cell Mol Biol | 2018 | Giordano L, Farnham A, Dhandapani PK, Salminen L, Bhaskaran J, Voswinckel R, Rauschkolb P, Scheibe S, Sommer N, Beisswenger C, Weissmann N, Braun T, Jacobs HT, Bals R, Herr C, Szibor M (2018) Alternative oxidase attenuates cigarette smoke-induced lung dysfunction and tissue damage. Am J Respir Cell Mol Biol 60:515-22. |
| Chretien 2017 bioRxiv | 2017 | Chretien D, Benit P, Ha HH, Keipert S, El-Khoury R, Chang YT, Jastroch M, Jacobs H, Rustin P, Rak M (2017) Mitochondria are physiologically maintained at close to 50 C. bioRxiv doi: https://doi.org/10.1101/133223 . |
| Syrjanen 2015 Front Zool | 2015 | Syrjanen L, Valanne S, Kuuslahti M, Tuomela T, Sriram A, Sanz A, Jacobs HT, Ramet M, Parkkila S. (2015) β carbonic anhydrase is required for female fertility in Drosophila melanogaster. Front Zool 12:19. |
| Kemppainen 2014 Hum Mol Genet | 2014 | Kemppainen KK, Rinne J, Sriram A, Lakanmaa M, Zeb A, Tuomela T, Popplestone A, Singh S, Sanz A, Rustin P, Jacobs HT (2014) Expression of alternative oxidase in Drosophila ameliorates diverse phenotypes due to cytochrome oxidase deficiency. Hum Mol Genet 23:2078-93. |
| Stefanatos 2012 Cell Cycle | 2012 | Stefanatos R, Sriram A, Kiviranta E, Mohan A, Ayala V, Jacobs HT, Pamplona R, Sanz A (2012) dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster. Cell Cycle 11:3876-86. |
Abstracts
| Published | Reference | |
|---|---|---|
| Oliveira 2015 Abstract IOC100 | 2015 | Oliveira MT, Saari S, Andjelkovic A, Jacobs HT (2015) Investigating the metabolic alterations caused by the transgenic expression of the mitochondrial alternative oxidase of Ciona intestinalis in Drosophila melanogaster. Mitochondr Physiol Network 20.01. |
| Dhandapani 2014 Abstract IOC 2014-04 Schroecken | 2014 | Dhandapani PK, Dufour E, Jacobs HT, Szibor M (2014) Alternative oxidase-based therapy for heart failure. Mitochondr Physiol Network 19.02. |
NextGen-O2k
- Prof. Howard T Jacobs is Key Opinion Leader (KOL) in the NextGen-O2k project.
