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Konjar 2010 FEBS Lett

From Bioblast
Publications in the MiPMap
Konjar S, Yin F, Bogyo M, Turk B, Kopitar-Jerala N (2010) Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages. FEBS Lett 584:2201-6.

Β» PMID: 20338168 Open Access

Konjar S, Yin F, Bogyo M, Turk B, Kopitar-Jerala N (2010) FEBS Lett

Abstract: Macrophages play a key role in innate immune response to pathogens and in tissue homeostasis, inflammation and repair. A serpin A3G (SpiA3G) is highly induced in classically activated macrophages. We show increased localization of SpiA3G in the nucleolus and co-localization with cathepsin L, upon classical, but not alternative activation of macrophages. Despite the increased expression of cathepsin L in the nuclei of classically activated macrophages, no cathepsin activity was detected. Since only pro-inflammatory, but not anti-inflammatory stimuli induce increased nucleolar localization of SpiA3G, we propose that SpiA3g translocation into the nucleolus is important in host defense against pathogens.

Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.


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