Koopman Werner JH

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Short-Term Scientific Missions

Management Committee

Members

COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping

Koopman Werner JH

MitoPedia topics: EAGLE

COST: Member

COST WG4: WG4 COST Mentor: Mentor

MC Member - Management Committee MitoEAGLE

Name	Koopman Werner JH, PhD ORCID ID
Institution	Department of Pediatrics, Cellular Bioenergetics group, RIMLS, RCMM, Radboud University Nijmegen Medical Centre, NL Human and Animal Physiology, Wageningen University & Research, NL
Address	PO Box 9101, 6500,
City	Nijmegen
State/Province
Country	Netherlands
Email	Werner.Koopman@radboudumc.nl
Weblink	Nijmegen Centre for Molecular Life Sciences; https://www.radboudumc.nl/en/people/werner-koopman
O2k-Network Lab	NL Nijmegen Koopman WJH

Bioenergetics Communications

Werner Koopman is Associate Editor of the journal Bioenergetics Communications

Keywords: mitochondrial morphofunction, redox metabolism, mitochondrial disorders, quantitative microscopy, intervention

Participated at

Bioblast 2022: BEC Inaugural Conference

MiPschool 2017 Obergurgl AT

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Publications

	Published	Reference
Hoogstraten 2023 Arch Toxicol	2023	Hoogstraten CA, Jacobs MME, de Boer G, van de Wal MAE, Koopman WJH, Smeitink JAM, Russel FGM, Schirris TJJ (2023) Metabolic impact of genetic and chemical ADP/ATP carrier inhibition in renal proximal tubule epithelial cells. https://doi.org/10.1007/s00204-023-03510-7
Krabbendam 2020 Cell Death Dis	2020	Krabbendam IE, Honrath B, Dilberger B, Iannetti EF, Branicky RS, Meyer T, Evers B, Dekker FJ, Koopman WJH, Beyrath J, Bano D, Schmidt M, Bakker BM, Hekimi S, Culmsee C, Eckert GP, Dolga AM (2020) SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans. Cell Death Dis 11:263.
BEC 2020.1 doi10.26124bec2020-0001.v1	2020	Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1
Bajzikova 2019 Cell Metab	2019	Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman Werner JH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416. 10.1016/j.cmet.2018.10.014
Koopman 2016 EMBO Mol Med	2016	Koopman WJ, Beyrath J, Fung CW, Koene S, Rodenburg RJ, Willems PH, Smeitink JA (2016) Mitochondrial disorders in children: toward development of small-molecule treatment strategies. EMBO Mol Med 8:311-27.
Iannetti 2016 Nat Protoc	2016	Iannetti EF, Smeitink JA, Beyrath J, Willems PH, Koopman WJ (2016) Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy. Nat Protoc 11:1693-710.
Willems 2015 Cell Metab	2015	Willems PH, Rossignol R, Dieteren CE, Murphy MP, Koopman WJH (2015) Redox homeostasis and mitochondrial dynamics. Cell Metab 22:207-18.
Schirris 2015 Cell Metab	2015	Schirris TJ, Renkema GH, Ritschel T, Voermans NC, Bilos A, van Engelen BG, Brandt U, Koopman WJ, Beyrath JD, Rodenburg RJ, Willems PH, Smeitink JA, Russel FG (2015) Statin-induced myopathy is associated with mitochondrial complex III inhibition. Cell Metab 22:399-407.
Grefte 2015 Biochim Biophys Acta	2015	Grefte S, Wagenaars JA, Jansen R, Willems PH, Koopman WJ (2015) Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2. Biochim Biophys Acta 1853:1606-14.
Schoeckel 2015 Cancer Metab	2015	Schöckel L, Glasauer A, Basit F, Bitschar K, Truong H, Erdmann G, Algire C, Hägebarth A, Willems PH, Kopitz C, Koopman WJ, Héroult M (2015) Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth. Cancer Metab 3:11.
Liemburg-Apers 2015 Biophys J	2015	Liemburg-Apers DC, Schirris TJ, Russel FG, Willems PH, Koopman WJ (2015) Mitoenergetic dysfunction triggers a rapid compensatory increase in steady-state glucose flux. Biophys J 109:1372-86.
Blanchet 2015 Sci Rep	2015	Blanchet L, Smeitink JA, van Emst-de Vries SE, Vogels C, Pellegrini M, Jonckheere AI, Rodenburg RJ, Buydens LM, Beyrath J, Willems PH, Koopman WJ (2015) Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning. Sci Rep 5:8035.
Forkink 2014 Biochim Biophys Acta	2014	Forkink M, Manjeri GR, Liemburg-Apers DC, Nibbeling E, Blanchard M, Wojtala A, Smeitink JA, Wieckowski MR, Willems PH, Koopman WJ (2014) Mitochondrial hyperpolarization during chronic Complex I inhibition is sustained by low activity of Complex II, III, IV and V. Biochim Biophys Acta 1837:1247-56.
Willems 2013 Antioxid Redox Signal	2013	Willems P, Wanschers BF, Esseling J, Szklarczyk R, Kudla U, Duarte I, Forkink M, Nooteboom M, Swarts H, Gloerich J, Nijtmans L, Koopman W, Huynen MA (2013) BOLA1 is an aerobic protein that prevents mitochondrial morphology changes induced by glutathione depletion. Antioxid Redox Signal 18:129-38.
Breuer 2013 Neurobiol Dis	2013	Breuer ME, Koopman WJ, Koene S, Nooteboom M, Rodenburg RJ, Willems PH, Smeitink JA (2013) The role of mitochondrial OXPHOS dysfunction in the development of neurologic diseases. Neurobiol Dis 51:27-34. https://doi.org/10.1016/j.nbd.2012.03.007
Koopman 2012 N Engl J Med	2012	Koopman WJ, Willems PH, Smeitink JA (2012) Monogenic mitochondrial disorders. N Engl J Med 366:1132-41.
Distelmaier 2012 Antioxid Redox Signal	2012	Distelmaier F, Valsecchi F, Forkink M, van Emst-de Vries S, Swarts HG, Rodenburg RJ, Verwiel ET, Smeitink JA, Willems PH, Koopman WJ (2012) Trolox-sensitive reactive oxygen species regulate mitochondrial morphology, oxidative phosphorylation and cytosolic calcium handling in healthy cells. Antioxid Redox Signal 17:1657-69.
Dieteren 2011 Proc Natl Acad Sci U S A	2011	Dieteren CE, Gielen SC, Nijtmans LG, Smeitink JA, Swarts HG, Brock R, Willems PH, Koopman WJ (2011) Solute diffusion is hindered in the mitochondrial matrix. Proc Natl Acad Sci U S A 108:8657-62.
Heeman 2011 J Cell Sci	2011	Heeman B, Van den Haute C, Aelvoet SA, Valsecchi F, Rodenburg RJ, Reumers V, Debyser Z, Callewaert G, Koopman WJ, Willems PH, Baekelandt V (2011) Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance. J Cell Sci 124:1115-25.
Koene 2011 J Inherit Metab Dis	2011	Koene S, Willems PH, Roestenberg P, Koopman WJ, Smeitink JA (2011) Mouse models for nuclear DNA-encoded mitochondrial complex I deficiency. J Inherit Metab Dis 34:293-307. https://doi.org/10.1007/s10545-009-9005-x
Koopman 2010 Antioxid Redox Signal	2010	Koopman WJ, Nijtmans LG, Dieteren CE, Roestenberg P, Valsecchi F, Smeitink JA, Willems PH (2010) Mammalian mitochondrial complex I: biogenesis, regulation, and reactive oxygen species generation. Antioxid Redox Signal 12:1431-70.
Distelmaier 2009 Brain	2009	Distelmaier F, Koopman WJ, van den Heuvel LP, Rodenburg RJ, Mayatepek E, Willems PH, Smeitink JA (2009) Mitochondrial Complex I deficiency: from organelle dysfunction to clinical disease. Brain 132:833-42.
Eisenberg 2008 Hum Mol Genet	2008	Eisenberg I, Novershtern N, Itzhaki Z, Becker-Cohen M, Sadeh M, Willems PH, Friedman N, Koopman WJ, Mitrani-Rosenbaum S (2008) Mitochondrial processes are impaired in hereditary inclusion body myopathy. Hum Mol Genet 17:3663-74.
Mortiboys 2008 Ann Neurol	2008	Mortiboys H, Thomas KJ, Koopman WJ, Klaffke S, Abou-Sleiman P, Olpin S, Wood NW, Willems PH, Smeitink JA, Cookson MR, Bandmann O (2008) Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts. Ann Neurol 64:555-65.
Boxma 2005 Nature	2005	Boxma B, de Graaf RM, van der Staay GW, van Alen TA, Ricard G, Gabaldón T, van Hoek AH, Moon-van der Staay SY, Koopman WJ, van Hellemond JJ, Tielens AG, Friedrich T, Veenhuis M, Huynen MA, Hackstein JH (2005) An anaerobic mitochondrion that produces hydrogen. Nature 434:74-9..

Abstracts

	Published	Reference
Koopman 2022 Abstract Bioblast	2022	7.7. «10+5» Bulthuis EP, Einer C, Distelmaier F, Groh L, van Emst-de Vries SE, van de Westerlo E, van de Wal M, Wagenaars J, Rodenburg RJ, Smeitink JAM, Riksen NP, Willems PGHM, Adjobo-Hermans MJW, Zischka H, Koopman Werner JH (2022) The decylTPP mitochondria-targeting moiety lowers electron transport system supercomplex levels in primary human skin fibroblasts. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001
Koopman 2017 Abstract MITOEAGLE Barcelona	2017	Standardized quantification of mitochondrial morphology and function in living patient fibroblasts using microscopy. Koopman_Presentation
Koopman 2017 MiPschool Obergurgl	2017	Mitochondrial function and dysfunction: ROS detection and redox analysis. Koopman_Presenation
Iannetti 2015 Abstract MiP2015	2015	High-Content Screening of mitochondrial morphofunction in living cells.
Koopman 2015 Abstract MiP2015	2015	Mitoenergetic dysfunction triggers a rapid compensatory increase in steady-state glucose flux.
Wojtala 2014 Abstract MiP2014	2014	Proteomic analysis of mitochondrial Complex I deficient mouse model - impact of Complex I deficiency on p66Shc-Ser36 phosphorylation pathway in NDUFS4^-/- mouse tissues.
Koopman 2014 Abstract MiP2014	2014	Redox regulation of mitochondrial dynamics and function.
Wagenaars 2014 Abstract IOC 2014-04 Schroecken	2014	Wagenaars J, Willems PHGM, Koopman WJ (2014) Oxygen consumption in OXPHOS-deficient cells. Mitochondr Physiol Network 19.02.
Grefte 2014 Abstract MiP2014	2014	Myotube formation does not require mitochondrial ATP production but is inhibited by rotenone via the Rho-associated, coiled-coil containing protein kinase II.
Koopman 2013 Abstract MiP2013	2013	Koopman WJH (2013) Developing novel treatment strategies for mitochondrial disease. Mitochondr Physiol Network 18.08.
Tronstad 2012 Abstract Bioblast	2012	Nikolaisen J, Nilsson LIH, Hagland HR, Koopman WJ, Tronstad KJ (2012) Mitochondrial morphology and biogenesis in cellular stress. Mitochondr Physiol Network 17.12.
Koopman 2012 Abstract Bioblast	2012	Koopman WJ (2012) Cellular consequences of mitochondrial dysfunction. Mitochondr Physiol Network 17.12.