Zouhar 2023 MiP2023

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Zouhar 2023 MiP2023

Zouhar Petr
Major site of non-shivering thermogenesis: brown fat or skeletal muscle?

Link: MiP2023 Obergurgl AT

Zouhar Petr (2023)

Event: MiP2023 Obergurgl AT

Authors: Kopecky Jan, Zouhar Petr, Janovska Petra, Bardova K, Otahal J, Vrbacky Marek, Mracek Tomas, Adamcova K, Lenkova L, Funda J, Cajka T, Drahota Zdenek, Stanic S, Rustan Arild C, Horakova Olga, Houstek Josef, Rosmeissl M

Heat production is essential for maintaining a constant body temperature, and is an important component of energy balance. Well-described mechanisms involved in heat generation include shivering of muscle and non-shivering thermogenesis (NST) in brown adipose tissue (BAT). Thermogenesis in BAT, which is dependent on the presence of the mitochondrial protein UCP1, is the focus of interest for its potential use in the treatment of obesity. Other mechanisms of NST and their significance are relatively poorly understood. We have shown [1] that obesity-resistant A/J mice acclimated to cold failed to increase adrenergically stimulated NST in BAT and activated NST in skeletal muscle instead. Heat generation in muscle involved increased calcium ion cycling in the endoplasmic reticulum associated with higher mitochondrial oxidative activity. The involvement of different thermogenic mechanisms could be related to the different susceptibility to obesity. The resistance of A/J mice to obesity may result, at least in part, from their ability to activate NST in muscle. Such mechanism may provide a more promising way to treat obesity than potential therapies based on increasing thermogenesis in BAT, as the capacity of skeletal muscle of adult human to burn fat energy stores is several fold greater than in BAT. Thus, only a relatively small increase in thermogenesis in muscle could significantly reduce adipose tissue deposition. How to achieve such an increase is a challenge for further research.

  1. Janovska P et al., 2023, Mol Metab. https://doi.org/10.1016/j.molmet.2023.101683

β€’ Keywords: Non-shivering thermogenesis, Calcium cycling, cold acclimation

β€’ O2k-Network Lab: CZ Prague Kopecky J

Affiliations and acknowledgments

Kopecky J1, Zouhar P1, Janovska P1, Bardova K1, Otahal J2, Vrbacky M3, Mracek T3, Adamcova K1, Lenkova L1, Funda J1, Cajka T4, Drahota Z3, Stanic S1, Rustan AC5, Horakova O1, Houstek J3, Rosmeissl M1
  1. Lab. of Adipose Tissue Biology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
  2. Lab. of Developmental Epileptology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
  3. Lab. of Bioenergetics, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
  4. Lab. of Translational Metabolism of the Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
  5. Section for Pharmacology and Pharmaceutical Biosciences, Dept. of Pharmacy, Univ. of Oslo, Oslo, Norway
Corresponding author: jan.kopecky@fgu.cas.cz
Funding: Supported by project no. LX22NPO5104 - funded by the European Union Next Generation EU


Organism: Mouse  Tissue;cell: Skeletal muscle, Fat 

Regulation: Temperature 

Event: Oral 

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