Krako 2021 Int J Mol Sci

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Krako Jakovljevic N, Pavlovic K, Jotic A, Lalic K, Stoiljkovic M, Lukic L, Milicic T, Macesic M, Stanarcic Gajovic J, Lalic NM (2021) Targeting mitochondria in diabetes. Int J Mol Sci 22:6642.

» PMID: 34205752 Open Access

Krako Jakovljevic Nina, Pavlovic Kasja, Jotic Aleksandra, Lalic Katarina, Stoiljkovic Milica, Lukic Ljiljana, Milicic Tanja, Macesic Marija, Stanarcic Gajovic Jelena, Lalic Nebojsa M (2021) Int J Mol Sci

Abstract: Type 2 diabetes (T2D), one of the most prevalent noncommunicable diseases, is often preceded by insulin resistance (IR), which underlies the inability of tissues to respond to insulin and leads to disturbed metabolic homeostasis. Mitochondria, as a central player in the cellular energy metabolism, are involved in the mechanisms of IR and T2D. Mitochondrial function is affected by insulin resistance in different tissues, among which skeletal muscle and liver have the highest impact on whole-body glucose homeostasis. This review focuses on human studies that assess mitochondrial function in liver, muscle and blood cells in the context of T2D. Furthermore, different interventions targeting mitochondria in IR and T2D are listed, with a selection of studies using respirometry as a measure of mitochondrial function, for better data comparison. Altogether, mitochondrial respiratory capacity appears to be a metabolic indicator since it decreases as the disease progresses but increases after lifestyle (exercise) and pharmacological interventions, together with the improvement in metabolic health. Finally, novel therapeutics developed to target mitochondria have potential for a more integrative therapeutic approach, treating both causative and secondary defects of diabetes. Keywords: Blood cells, Diabetes therapy, Exercise, Insulin resistance, Liver, Mitochondria, Respiration, Respiratory capacity, Skeletal muscle, Type 2 diabetes Bioblast editor: Reiswig R O2k-Network Lab: RS Belgrade Lalic NM


Labels: MiParea: Respiration, Exercise physiology;nutrition;life style, Pharmacology;toxicology  Pathology: Diabetes 

Organism: Human  Tissue;cell: Skeletal muscle, Liver, Blood cells  Preparation: Permeabilized tissue 


Coupling state: LEAK, OXPHOS, ET  Pathway: F, N, S  HRR: Oxygraph-2k 

2021-07