Krumschnabel 1994 Experientia

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Krumschnabel G, Wieser W (1994) Inhibition of the sodium pump does not cause a stoichiometric decrease of ATP-production in energy limited fish hepatocytes. Experientia 50:483-5.

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Krumschnabel G, Wieser W (1994) Experientia

Abstract: In isolated goldfish hepatocytes underaerobic conditions the energy requirement for the sodium pump (calculated from Rb+ flux) is closely matched by the ouabain-sensitive fraction of oxygen consumption, whereas during in vitroanoxia (cyanide inhibition of the electron transport chain) the measured ATP demand of the sodium pump clearly exceeds ouabain-sensitive ATP production by anaerobic glycolysis. We conclude that when the energy status of cells is low, part or all of the ATP spared by the inhibition of a particular function may be used for fuelling other ATP-consuming functions.

Keywords: goldfish, hepatocyte, sodium pump, protein synthesis, membrane-metabolic coupling, lactate, ouabain

O2k-Network Lab: AT Innsbruck Oroboros


Labels: MiParea: Respiration 

Stress:Ischemia-reperfusion  Organism: Fishes  Tissue;cell: Liver  Preparation: Intact cells 


Coupling state: ROUTINE 

HRR: Oxygraph-2k