Krumschnabel 2009 Oncogene

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Krumschnabel G, Manzl C, Villunger A (2009) Caspase-2: killer, savior and safeguard--emerging versatile roles for an ill-defined caspase. Oncogene 28:3093-6.

» PMID: 19581929 Open Access

Krumschnabel G, Manzl C, Villunger A (2009) Oncogene

Abstract: Despite the early discovery of caspase-2, its physiological function has long remained an enigma. A number of recent publications now suggest not just one, but multiple functions, including roles in apoptosis, DNA repair and tumor suppression. How can one enzyme have so many talents? Considering the diversity of interaction partners and the specific mode of pro-apoptotic action proposed in these studies, caspase-2 might in fact represent a primordial protease serving numerous pathways, established before the advent of a more elaborate functionally diversified caspases system.

Keywords: Caspase, Apoptosis, DNA repair, Tumor suppression