LEAK-respiration

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LEAK-respiration

Description

L.jpg EAK-respiration or LEAK oxygen flux, L, compensating for proton leak, proton slip, cation cycling and electron leak, is a dissipative component of respiration which is not available for performing biochemical work and thus related to heat production. LEAK-respiration is measured in the LEAK state, in the presence of reducing substrate(s), but absence of ADP - abbreviated as L(n) (theoretically, absence of inorganic phosphate presents an alternative), or after enzymatic inhibition of the phosphorylation system, which can be reached with the use of oligomycin - abbreviated as L(Omy). The LEAK state is the non-phosphorylating resting state of intrinsic uncoupled or dyscoupled respiration when oxygen flux is maintained mainly to compensate for the proton leak at a high chemiosmotic potential, when ATP synthase is not active. In this non-phosphorylating resting state, the electrochemical proton gradient is increased to a maximum, exerting feedback control by depressing oxygen flux to a level determined mainly by the proton leak and the H+/O2 ratio. In this state of maximum protonmotive force, LEAK-respiration, L, is higher than the LEAK component of OXPHOS capacity, P. The conditions for measurement and expression of respiration vary (oxygen flux in the LEAK state, JO2L, or oxygen flow, IO2L). If these conditions are defined and remain consistent within a given context, then the simple symbol L for respiratory rate can be used as a substitute for the more explicit expression for respiratory activity. » MiPNet article

Abbreviation: L

Reference: Gnaiger 2019 MitoFit Preprint Arch, Gnaiger 2014 MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol
Questions.jpg


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LEAK-respiration: concept-linked terminology of respiratory states

LEAK-respiration corresponds to resting, non-phosphorylating electron transfer with a shortcircuit of the proton cycle across the inner mt-membrane due to intrinsic uncoupling or dyscoupling. 2[H] indicates the reduced hydrogen equivalents of CHO substrates and electron transfer to oxygen. H+out are protons pumped out of the matrix phase. Proton leaks (a property of the inner mt-membrane) dissipate energy of translocated protons, and proton slip prevents full translocation of protons across the inner mt-membrane (a property of the proton pumps). Measurement of LEAK-respiration is possible in intact cells by inhibition of the phosphorylation system and in mt-preparations supported by an ET-pathway competent substrate state, exemplifed as the NS-pathway (CI&II-linked substrate supply). Modified after Gnaiger 2014 MitoPathways.
Publications in the MiPMap
Gnaiger E (2019) LEAK-respiration: concept-linked terminology of respiratory states. Mitochondr Physiol Network 2019-01-24.

» Gnaiger 2014 MitoPathways

Oroboros (2019) MiPNet

Abstract: L.jpg Mitochondrial respiratory states have been defined originally by Chance and Williams (1955) as a sequence (from 1 to 5) of titrations and transitions in a respiratory protocol, including State 4 as a LEAK state of respiration obtained after exhaustion of the added ADP. The second state (State 2) is induced by addition of 'high ADP'. Confusion persists in the current literature as to the meaning of State 2, which can be resolved by a transition from a specific protocol-linked to a generalized concept-linked terminology.


O2k-Network Lab: AT Innsbruck Gnaiger E


Labels:




Regulation: Coupling efficiency;uncoupling  Coupling state: LEAK, ET 

HRR: Theory 



The LEAK state

LEAK states of respiration are frequently called State 4, State 4o, basal state, or inactive state. Importantly, State 2 is not a LEAK state according to the classical definition.
Respiration compensating for the proton leak is the main component of LEAK-respiration. If proton leak were the only component involved, it would make sense to simply write leak respiration for the compensatory oxygen flux. Proton slip and cation cycling, however, are also involved to a larger or smaller extent to stimulate LEAK-respiration. The upper case 'LEAK', therefore, should make us aware that this is more accurately considered as an acronym, and cannot be taken as a definitive delineation of the stimulatory mechanism in the LEAK state of respiration.
  • Note: The distinction between LEAK and ET-capacity helps to clarify the important difference between physiologically uncoupled or pathologically dyscoupled respiration (LEAK) in contrast to noncoupled respiration (ET-capacity).


Protocols for measurement of LEAK-respiration

The LEAK state can be induced experimentally in various ways, which may yield idential estimates of LEAK-respiration, or may show deviations that help to critically assess the proper protocol to be applied in specific cases:

a) LEAK state with ATP

LEAK-respiration in the presence of ATP, L(T), and absence of ATPase activity.
LEAK state with ATP: classical State 4 in isolated mitochondria), LEAK respiration, L(T), after phosphorylation of ADP to ATP is completed, or when a high concentration of ATP is added in the absence of ADP (Gnaiger 2000 Proc Natl Acad Sci U S A).
In contradiction to the original definition of State 2 (ROX), yet with reference to Chance and Williams (1956), 'State 2' has later been used for describing this functionally different LEAK state:
State 2: substrate added, respiration low due to lack of ADP. .. the controlled respiration prior to addition of ADP, which is strictly termed “state 2”, is functionally the same as state 4, and the latter term is usually used for both states’ (Nicholls & Ferguson 1992).
Thus State 2 was re-defined as functionally the same as State 4. State 2 (Chance and Williams 1955, 1956), however, is substrate-limited residual oxygen consumption at high ADP (ROXD), whereas L(n) and L(T) (State 4) are LEAK-respiration in the absence of adenylates, L(n) (no ADP, no ATP) or presence of ATP, L(T).
To overcome the termonological confusion persisting in the scientific literature, the respiratory coupling states of LEAK-respiration, OXPHOS-capacity and ET-capacity are distinguished from residual oxygen consumption (ROX; Gnaiger 2009).



b) LEAK state with oligomycin

LEAK-respiration induced by inhibition of ATP synthase by oligomycin, L(Omy).
LEAK-respiration with oligomycin: L(Omy) (in isolated mitochondria or other mitochondrial preparations, and non-permeabilized cells).








c) LEAK state without adenylates

LEAK-respiration without adenylates, L(n).
LEAK-respiration without adenylates: L(n) (in isolated mitochondria or other mitochondrial preparations, using a protocol different from the classical State 2-3-4 sequence).
Sequential addition of (1) mitochondria, (2) ADP, and (3) reduced substrates is the basis of the original State 1-2-3 definitions of respiratory states (Chance and Williams 1955 part III, 1956), where State 2 is zero respiration or residual oxygen consumption in the absence of substrate. An alternative protocol is well established, as shown, e.g., by the classical Fig. 5A (Chance and Williams 1955 part I): 600 µM ADP is added after a state described as ‘Aerobic mitochondria plus succinate’. That state was never defined as ‘State 2’ by Brit Chance. Later Estabrook (1967) made this protocol more popular, with addition of substrate before any ADP or ATP was added.
In this alternative protocol, a respiratory LEAK state is induced in isolated mitochondria, permeabilized tissues, or permeabilized cells, adding the mitochondrial preparation to respiration medium containing inorganic phosphate (State 1), then adding reduced substrate (no external adenylates). This second state (Estabrook 1967) is a non-phosphorylating LEAK state, with respiration L(n) (n for no adenylates; Gnaiger 2009), when substrate-saturated respiration compensates for the proton leak (mainly) in the absence of ADP.



Related terms in MitoPedia

State 4 versus State 2

Static head

State 4 is frequently referred to as 'static head' of isolated mitochondria. Equivalence requires testing, if at State 4 (in a protocol defined by Chance and Williams 1955) ATPase activity is actually zero, such that respiration at State 4 is not partially stimulated by partial recycling of ATP to ADP. In the latter case, State 4 respiration would be higher than LEAK-respiration and thus higher than respiration at static head.
OXPHOS-coupled energy cycles. Source: The Blue Book

Respiratory coupling states

P.jpg OXPHOS, P
R.jpg ROUTINE, R
E.jpg ET-capacity, E
L.jpg LEAK, L


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References

  1. Caplan SR, Essig A (1983) Bioenergetics and linear nonequilibrium thermodynamics. The steady state. Harvard Univ. Press, Cambridge:435 pp.
  2. Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization. J Biol Chem 217:383-93.
  3. Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation. III. The steady state. J Biol Chem 217:409-27.
  4. Chance B, Williams GR (1956) The respiratory chain and oxidative phosphorylation. Adv Enzymol 17:65-134.
  5. Estabrook R (1967) Mitochondrial respiratory control and the polarographic measurement of ADP:O ratios. Methods Enzymol 10:41-7.
  6. Gnaiger E (1993a) Efficiency and power strategies under hypoxia. Is low efficiency at high glycolytic ATP production a paradox? In: Surviving Hypoxia: Mechanisms of Control and Adaptation. Hochachka PW, Lutz PL, Sick T, Rosenthal M, Van den Thillart G (eds) CRC Press, Boca Raton, Ann Arbor, London, Tokyo:77-109. - »Bioblast link«
  7. Gnaiger E (1993b) Nonequilibrium thermodynamics of energy transformations. Pure Appl Chem 65: 1983-2002. - »Bioblast link«
  8. Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41: 1837–45. - »Bioblast link«
  9. Gnaiger E (2014) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 4th ed. Mitochondr Physiol Network 19.12. Oroboros MiPNet Publications, Innsbruck:80 pp. - »Bioblast link«
  10. Gnaiger E, Aasander Frostner E, Abdul Karim N, Abumrad NA, Acuna-Castroviejo D, Adiele RC et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001. - »Bioblast link«
  11. Nicholls DG, Ferguson SJ (2002) Bioenergetics 3. Academic Press, London:287 pp.


Publications in the MiPMap


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» List of publications: LEAK
Sort in ascending/descending order by a click on one of the small symbols in squares below.
Default sorting: chronological. Empty fields appear first in ascending order. 
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
MiPNet20.14 AmplexRed H2O2-production2019-06-24
O2k-Protocols
O2k-FluoRespirometry: HRR and simultaneous determination of H2O2 production with Amplex UltraRed.
LEAK
OXPHOS
ET
SIsolated mitochondriaMouseHeart
MiPNet20.13 Safranin mt-membranepotential2019-06-24
O2k-Protocols
O2k-FluoRespirometry: HRR and simultaneous determination of mt-membrane potential with safranin or TMRM.
LEAK
ET
S
ROX
HomogenateMouseNervous system
MiPNet18.05 Amplex-Mouse-heart2019-06-24
O2k-Protocols
O2k-Fluorometry: HRR and H2O2 production in mouse cardiac tissue homogenate.
LEAK
OXPHOS
ET
N
S
NS
HomogenateMouseHeart
MiPNet12.23 FiberRespiration2019-01-10
O2k-Protocols contents
Mitochondrial respiration in permeabilized fibers: Needle biopsies from horse skeletal muscle.
LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueHorseSkeletal muscle
Hafen 2019 J Appl Physiol (1985)2019Hafen PS, Abbott K, Bowden JA, Lopiano R, Hancock CR, Hyldahl RD (2019) Daily heat treatment maintains mitochondrial function and attenuates atrophy in human skeletal muscle subjected to immobilization. J Appl Physiol (1985) 127:47-57.ET
LEAK
OXPHOS
N
NS
ROX
S
Permeabilized tissueHumanSkeletal muscle
Oliveira 2019 Mol Nutr Food Res2019Oliveira TE, Castro É, Belchior T, Andrade ML, Chaves-Filho AB, Peixoto AS, Moreno MF, Ortiz Silva M, Moreira RJ, Inague A, Yoshinaga MY, Miyamoto S, Moustaid-Moussa N, Festuccia WT (2019) Fish oil protects wild type and uncoupling protein 1 deficient mice from obesity and glucose intolerance by increasing energy expenditure. Mol Nutr Food Res 63:e1800813.ET
LEAK
NIsolated mitochondriaMouseFat
Zhang 2019 Biochem Biophys Res Commun2019Zhang WY, Hu XF, Wan N, Zhang JF, Yang P, Wen Q, Chen WJ, Zhu F, Liang ML, Cheng LX, Shu YW (2019) Protective effect of the glucagon-like peptide-1 analogue liraglutide on carbon tetrachloride-induced acute liver injury in mice. Biochem Biophys Res Commun 514:386-92.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseLiver
Carteri 2019 Toxicol Lett2019Carteri RB, Kopzynski A, Menegassi LN, Rodolphi MS, Strogulski NR, Portela LV (2019) Anabolic-androgen steroids effects on bioenergetics responsiveness of synaptic and extrasynaptic mitochondria. Toxicol Lett 307:72-80.LEAK
OXPHOS
ET
N
NS
ROX
Isolated mitochondriaMouseNervous system
Jansen 2019 Am J Physiol Heart Circ Physiol2019Jansen KM, Moreno S, Garcia-Roves PM, Larsen TS (2019) Dietary Calanus oil recovers metabolic flexibility and rescues post-ischemic cardiac function in obese female mice. Am J Physiol Heart Circ Physiol [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseHeart
Zverova 2019 Neuropsychiatr Dis Treat2019Zvěřová M, Hroudová J, Fišar Z, Hansíková H, Kališová L, Kitzlerová E, Lambertová A, Raboch J (2019) Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder. Neuropsychiatr Dis Treat 15:233-40.LEAK
ROUTINE
ET
ROXIntact cellsHumanPlatelet
Johansen 2019 Comp Biochem Physiol C Toxicol Pharmacol2019Johansen JL, Esbaugh AJ (2019) Oil-induced responses of cardiac and red muscle mitochondria in red drum (Sciaenops ocellatus). Comp Biochem Physiol C Toxicol Pharmacol 219:35-41.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueFishesHeart
Skeletal muscle
Kakimoto 2019 PLoS One2019Kakimoto PA, Chausse B, Caldeira da Silva CC, Donato Júnior J, Kowaltowski AJ (2019) Resilient hepatic mitochondrial function and lack of iNOS dependence in diet-induced insulin resistance. PLoS One 14:e0211733.LEAK
OXPHOS
F
NS
Isolated mitochondriaMouseLiver
Tetsi 2019 Antioxidants (Basel)2019Tetsi L, Charles AL, Georg I, Goupilleau F, Lejay A, Talha S, Maumy-Bertrand M, Lugnier C, Geny B (2019) Effect of the phosphodiesterase 5 inhibitor sildenafil on ischemia-reperfusion-induced muscle mitochondrial dysfunction and oxidative stress. Antioxidants (Basel) 8:E93.LEAK
OXPHOS
N
CIV
NS
Permeabilized tissueMouseSkeletal muscle
Kopinski 2019 Proc Natl Acad Sci U S A2019Kopinski PK, Janssen KA, Schaefer PM, Trefely S, Perry CE, Potluri P, Tintos-Hernandez JA, Singh LN, Karch KR, Campbell SL, Doan MT, Jiang H, Nissim I, Nakamaru-Ogiso E, Wellen KE, Snyder NW, Garcia BA, Wallace DC (2019) Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy. Proc Natl Acad Sci U S A [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanOther cell lines
Devaux 2019 Front Physiol2019Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2019) Acidosis Maintains the Function of Brain Mitochondria in Hypoxia-Tolerant Triplefin Fish: A Strategy to Survive Acute Hypoxic Exposure? Front Physiol 9:1941.LEAK
OXPHOS
ET
Other combinations
N
NS
Permeabilized tissue
Isolated mitochondria
FishesNervous system
Germain 2019 Int J Med Sci2019Germain N, Dessein AF, Vienne JC, Dobbelaere D, Mention K, Joncquel M, Dekiouk S, Laine W, Kluza J, Marchetti P (2019) First-line screening of OXPHOS deficiencies using microscale oxygraphy in human skin fibroblasts: A preliminary study. Int J Med Sci 16:931-38.LEAK
ET
ROX
N
Intact cellsHumanFibroblast
Petrick 2019 Biochem J2019Petrick HL, Holloway GP (2019) High intensity exercise inhibits carnitine palmitoyltransferase-I sensitivity to L-carnitine. Biochem J 476:547-58.OXPHOS
LEAK
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Ling 2019 Am J Clin Nutr2019Ling Y, Carayol J, Galusca B, Canto C, Montaurier C, Matone A, Vassallo I, Minehira K, Alexandre V, Cominetti O, Núñez Galindo A, Corthésy J, Dayon L, Charpagne A, Métairon S, Raymond F, Descombes P, Casteillo F, Peoc'h M, Palaghiu R, Féasson L, Boirie Y, Estour B, Hager J, Germain N, Gheldof N (2019) Persistent low body weight in humans is associated with higher mitochondrial activity in white adipose tissue. Am J Clin Nutr [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Fat
Trefts 2019 Am J Physiol Endocrinol Metab2019Trefts E, Hughey CC, Lantier L, Lark DS, Boyd KL, Pozzi A, Zent R, Wasserman DH (2019) Energy metabolism couples hepatocyte integrin-linked kinase to liver glucoregulation and the postabsorptive response of mice in an age-dependent manner. Am J Physiol Endocrinol Metab 316:1118-35.LEAK
ROUTINE
ET
Intact cellsMouseLiver
Lerchner 2019 Anal Bioanal Chem2019Lerchner J, Sartori MR, Volpe POL, Lander N, Mertens F, Vercesi AE (2019) Direct determination of anaerobe contributions to the energy metabolism of Trypanosoma cruzi by chip calorimetry. Anal Bioanal Chem 411:3763-68.LEAK
OXPHOS
ET
ROXIntact cellsProtists
Paumelle 2019 J Hepatol2019Paumelle R, Haas J, Hennuyer N, Bauge E, Deleye Y, Mesotten D, Langouche L, Vanhoutte J, Cudejko C, Wouters K, Hannou SA, Legry V, Lancel S, Lalloyer F, Polizzi A, Smati S, Gourdy P, Vallez E, Bouchaert E, Derudas B, Dehondt H, Gheeraert C, Fleury S, Tailleux A, Montagner A, Wahli W, Van Den Berghe G, Guillou H, Dombrowicz D, Staels B (2019) Hepatic PPARα is critical in the metabolic adaptation to sepsis. J Hepatol 70:963-73.OXPHOS
LEAK
F
N
HomogenateHumanLiver
Yan 2019 Int Immunopharmacol2019Yan M, Yu Y, Mao X, Feng J, Wang Y, Chen H, Xie K, Yu Y (2019) Hydrogen gas inhalation attenuates sepsis-induced liver injury in a FUNDC1-dependent manner. Int Immunopharmacol 71:61-7.LEAK
OXPHOS
SIsolated mitochondriaMouseLiver
Desquiret-Dumas 2019 Biochim Biophys Acta Mol Basis Dis2019Desquiret-Dumas V, Leman G, Wetterwald C, Chupin S, Lebert A, Khiati S, Le Mao M, Geffroy G, Kane MS, Chevrollier A, Goudenege D, Gadras C, Tessier L, Barth M, Leruez S, Amati-Bonneau P, Henrion D, Bonneau D, Procaccio V, Reynier P, Lenaers G, Gueguen N (2019) Warburg-like effect is a hallmark of complex I assembly defects. Biochim Biophys Acta Mol Basis Dis 1865:2475-89.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Woodman 2019 Cardiovasc Res2019Woodman AG, Mah R, Keddie DL, Noble RMN, Holody CD, Panahi S, Gragasin FS, Lemieux H, Bourque SL (2019) Perinatal iron deficiency and a high salt diet cause long-term kidney mitochondrial dysfunction and oxidative stress. Cardiovasc Res [Epub ahead of print].LEAK
OXPHOS
ET
N
S
CIV
NS
HomogenateRatKidney
Kwak 2019 Int J Environ Res Public Health2019Kwak HB, Woodlief TL, Green TD, Cox JH, Hickner RC, Neufer PD, Cortright RN (2019) Overexpression of long-chain acyl-CoA synthetase 5 increases fatty acid oxidation and free radical formation while attenuating insulin signaling in primary human skeletal myotubes. Int J Environ Res Public Health 16:E1157.LEAK
OXPHOS
ET
F
N
NS
Permeabilized cellsHumanSkeletal muscle
Dlaskova 2019 Biochim Biophys Acta Bioenerg2019Dlasková A, Špaček T, Engstová H, Špačková J, Schröfel A, Holendová B, Smolková K, Plecitá-Hlavatá L, Ježek P (2019) Mitochondrial cristae narrowing upon higher 2-oxoglutarate load. Biochim Biophys Acta Bioenerg [Epub ahead of print].LEAK
ET
N
ROX
Intact cellsHumanLiver
Li 2019 Int Urol Nephrol2019Li Z, Zhou J, Li Y, Yang F, Lian X, Liu W (2019) Mitochondrial TRPC3 promotes cell proliferation by regulating the mitochondrial calcium and metabolism in renal polycystin-2 knockdown cells. Int Urol Nephrol 51:1059-70.ROUTINE
OXPHOS
ET
LEAK
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanEndothelial;epithelial;mesothelial cell
Stepanova 2019 Antioxid Redox Signal2019Stepanova A, Sosunov S, Niatsetskaya Z, Konrad C, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin A (2019) Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury. Antioxid Redox Signal [Epub ahead of print].LEAK
OXPHOS
N
NS
Isolated mitochondriaMouseNervous system
Ferreira 2019 Nat Commun2019Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D (2019) A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat Commun 10:329.LEAK
OXPHOS
ET
NSIsolated mitochondriaRatHeart
Garnham 2019 J Cachexia Sarcopenia Muscle2019Garnham JO, Roberts LD, Caspi T, Al-Owais MM, Bullock M, Swoboda PP, Koshy A, Gierula J, Paton MF, Cubbon RM, Kearney MT, Bowen TS, Witte KK (2019) Divergent skeletal muscle mitochondrial phenotype between male and female patients with chronic heart failure. J Cachexia Sarcopenia Muscle [Epub ahead of print].LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Anderson 2019 Acta Neuropathol2019Anderson CJ, Bredvik K, Burstein SR, Davis C, Meadows SM, Dash J, Case L, Milner TA, Kawamata H, Zuberi A, Piersigilli A, Lutz C, Manfredi G (2019) ALS/FTD mutant CHCHD10 mice reveal a tissue-specific toxic gain-of-function and mitochondrial stress response. Acta Neuropathol 138:103-21.LEAKN
S
Isolated mitochondriaMouseHeart
Schoepf 2019 MitoFit Preprint Arch2019Schöpf B, Weissensteiner H, Schäfer G, Fazzini F, Charoentong P, Naschberger A, Rupp B, Fendt L, Bukur V, Eichelbrönner I, Sorn P, Sahin U, Kronenberg F, Gnaiger E, Klocker H (2019) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and a prognostic gene expression signature. MitoFit Preprint Arch doi:10.26124/mitofit:190003.ET
LEAK
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueHumanGenital
Powers 2019 Neurourol Urodyn2019Powers SA, Ryan TE, Pak ES, Fraser MO, McClung JM, Hannan JL (2019) Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions. Neurourol Urodyn [Epub ahead of print].LEAK
OXPHOS
N
S
CIV
NS
HomogenateMouseOther cell lines
Bettinazzi 2019 Proc Biol Sci2019Bettinazzi S, Rodríguez E, Milani L, Blier PU, Breton S (2019) Metabolic remodelling associated with mtDNA: insights into the adaptive value of doubly uniparental inheritance of mitochondria. Proc Biol Sci 286:20182708.LEAK
OXPHOS
ET
N
Gp
CIV
NS
ROX
Permeabilized cellsMolluscsLung;gill
Genital
Diebold 2019 Nat Metab2019Diebold LP, Gil HJ, Gao P, Martinez CA, Weinberg SE, Chandel NS (2019) Mitochondrial Complex III is necessary for endothelial cell proliferation during angiogenesis. Nat Metab 1:158–71.LEAK
ROUTINE
ROXIntact cellsHumanHUVEC
Hirschi 2019 Biol Reprod2019Hirschi KM, Tsai KYF, Davis T, Clark JC, Knowlton MN, Bikman BT, Reynolds PR, Arroyo JA (2019) Growth arrest specific protein (Gas)-6/AXL signaling induces preeclampsia (PE) in rats. Biol Reprod [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
Permeabilized cells
Permeabilized tissue
RatGenital
McCoin 2019 Am J Physiol Endocrinol Metab2019McCoin CS, Von Schulze A, Allen J, Fuller KN, Xia Q, Koestler DC, Houchen CJ, Maurer A, Dorn Ii GW, Shankar K, Morris EM, Thyfault JP (2019) Sex modulates hepatic mitochondrial adaptations to high fat diet and physical activity. Am J Physiol Endocrinol Metab [Epub ahead of print].LEAK
OXPHOS
ET
F
N
NS
Isolated mitochondriaMouseLiver
LEAK-respiration2019Gnaiger E (2019) LEAK-respiration: concept-linked terminology of respiratory states. Mitochondr Physiol Network 2019-01-24.LEAK
ET
Dannheisig 2019 Cells2019Dannheisig DP, Beck E, Calzia E, Walther P, Behrends C, Pfister AS (2019) Loss of Peter Pan (PPAN) affects mitochondrial homeostasis and autophagic flux. Cells 8:E894.LEAK
ROUTINE
ET
N
S
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanHeLa
Wiberg 2019 Eur Heart J Acute Cardiovasc Care2019Wiberg S, Stride N, Bro-Jeppesen J, Holmberg MJ, Kjærgaard J, Larsen S, Donnino MW, Hassager C, Dela F (2019) Mitochondrial dysfunction in adults after out-of-hospital cardiac arrest. Eur Heart J Acute Cardiovasc Care [Epub ahead of print].OXPHOS
ET
LEAK
N
NS
Permeabilized tissueHumanSkeletal muscle
Goldberg 2019 Biochem J2019Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH (2019) Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J 476:1521-37.ET
LEAK
F
N
NS
Other combinations
ROX
S
Isolated mitochondriaMouseHeart
Hughes 2019 J Physiol2019Hughes MC, Ramos SV, Turnbull PC, Edgett BA, Huber JS, Polidovitch N, Schlattner U, Backx PH, Simpson JA, Perry CGR (2019) Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodelling in Duchenne muscular dystrophy. J Physiol [Epub ahead of print].OXPHOS
LEAK
N
NS
Permeabilized tissueMouseHeart
Petrick 2019 J Physiol2019Petrick HL, Pignanelli C, Barbeau PA, Churchward-Venne TA, Dennis KMJH, van Loon LJC, Burr JF, Goossens GH, Holloway GP (2019) Blood flow restricted resistance exercise and reductions in oxygen tension attenuate mitochondrial H2O2 emission rates in human skeletal muscle. J Physiol [Epub ahead of print].LEAK
OXPHOS
N
NS
Permeabilized tissueHumanSkeletal muscle
Gaviraghi 2019 Anal Biochem2019Gaviraghi A, Oliveira MF (2019) A method for assessing mitochondrial physiology using mechanically permeabilized flight muscle of Aedes aegypti mosquitoes. Anal Biochem 576:33-41.LEAK
OXPHOS
ET
N
Gp
CIV
ROX
Permeabilized tissueHexapodsSkeletal muscle
Sanchez-de-Diego 2019 iScience2019Sánchez-de-Diego C, Artigas N, Pimenta-Lopes C, Valer JA, Torrejon B, Gama-Pérez P, Villena JA, Garcia-Roves PM, Rosa JL, Ventura F (2019) Glucose restriction promotes osteocyte specification by activating a PGC-1α-dependent transcriptional program. iScience 15:79-94.LEAK
ROUTINE
ET
ROXIntact cellsMouseOther cell lines
Nold 2019 Psychoneuroendocrinology2019Nold V, Sweatman C, Karabatsiakis A, Böck C, Bretschneider T, Lawless N, Fundel-Clemens K, Kolassa IT, Allers KA (2019) Activation of the kynurenine pathway and mitochondrial respiration to face allostatic load in a double-hit model of stress. Psychoneuroendocrinology 107:148-59.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Lefranc 2019 Hypertension2019Lefranc C, Friederich-Persson M, Braud L, Palacios-Ramirez R, Karlsson S, Boujardine N, Motterlini R, Jaisser F, Nguyen Dinh Cat A (2019) MR (mineralocorticoid receptor) induces adipose tissue senescence and mitochondrial dysfunction leading to vascular dysfunction in obesity. Hypertension 73:458-68.OXPHOS
LEAK
NIsolated mitochondriaMouseFat
Lemieux 2019 bioRxiv2019Lemieux H, Subarsky P, Doblander C, Wurm M, Troppmair J, Gnaiger E (2019) Mitochondrial respiratory function as an early biomarker of apoptosis induced by growth factor removal. bioRxiv doi: https://doi.org/10.1101/151480 .LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
MouseBlood cells
Thomas 2019 Redox Biol2019Thomas NO, Shay KP, Hagen TM (2019) Age-related loss of mitochondrial glutathione exacerbates menadione-induced inhibition of Complex I. Redox Biol 22:101155.LEAK
OXPHOS
ET
N
S
NS
ROX
Intact cellsRatLiver
Hedges 2019 Comp Biochem Physiol A Mol Integr Physiol2019Hedges CP, Wilkinson RT, Devaux JBL, Hickey AJR (2019) Hymenoptera flight muscle mitochondrial function: Increasing metabolic power increases oxidative stress. Comp Biochem Physiol A Mol Integr Physiol 230:115-21.OXPHOS
ET
LEAK
N
S
Gp
CIV
NS
ROX
Permeabilized tissueOther invertebratesSkeletal muscle
Cadiz 2019 Comp Biochem Physiol B Biochem Mol Biol2019Cadiz L, Bundgaard A, Malte H, Fago A (2019) Hypoxia enhances blood O2 affinity and depresses skeletal muscle O2 consumption in zebrafish (Danio rerio). Comp Biochem Physiol B Biochem Mol Biol 234:18-25.LEAK
OXPHOS
ET
N
NS
Permeabilized tissueZebrafishSkeletal muscle
Gregg 2019 J Biol Chem2019Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Lewandowski SL, Pagliarini DJ, Denu JM, Merrins MJ (2019) Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at complex I in pancreatic β-cells. J Biol Chem 294:4656-66.OXPHOS
ET
LEAK
N
S
NS
ROX
Permeabilized tissueMouseIslet cell;pancreas;thymus
Blais-Lecours 2019 Am J Respir Cell Mol Biol2019Blais-Lecours P, Laouafa S, Arias-Reyes C, Santos WL, Joseph V, Burgess JK, Halayko AJ, Soliz J, Marsolais D (2019) Metabolic adaptation of airway smooth muscle cells to a SPHK2 substrate precedes cytostasis. Am J Respir Cell Mol Biol [Epub ahead of print].LEAK
ROUTINE
OXPHOS
ET
ROXIntact cellsHumanOther cell lines
Rojas-Morales 2019 Free Radic Biol Med2019Rojas-Morales P, León-Contreras JC, Aparicio-Trejo OE, Reyes- Ocampo JG, Medina-Campos ON, Jiménez-Osorio AS, González-Reyes S, Marquina- Castillo B, Hernández-Pando R, Barrera-Oviedo D, Sánchez-Lozada LG, Pedraza-Chaverri J, Tapia E (2019) Fasting reduces oxidative stress, mitochondrial dysfunction and fibrosis induced by renal ischemia-reperfusion injury. Free Radic Biol Med 135:60-67.LEAK
OXPHOS
NIsolated mitochondriaRatKidney
Majiene 2019 Nutrients2019Majiene D, Kuseliauskyte J, Stimbirys A, Jekabsone A (2019) Comparison of the effect of native 1,4-naphthoquinones plumbagin, menadione, and lawsone on viability, redox status, and mitochondrial functions of C6 glioblastoma cells. Nutrients 11:E1294.LEAK
OXPHOS
ET
N
NS
Permeabilized cellsRatNervous system
Teh 2019 Mol Cancer Ther2019Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M (2019) Respiratory capacity and reserve predict cell sensitivity to mitochondria inhibitors: mechanism-based markers to identify metformin-responsive cancers. Mol Cancer Ther 18:693-705.LEAK
ROUTINE
OXPHOS
ET
N
S
DQ
ROX
Intact cells
Permeabilized cells
Permeabilized tissue
Human
Mouse
Other cell lines
Crescenzo 2019 Mol Neurobiol2019Crescenzo R, Spagnuolo MS, Cancelliere R, Iannotta L, Mazzoli A, Gatto C, Iossa S, Cigliano L (2019) Effect of initial aging and high-fat/high-fructose diet on mitochondrial bioenergetics and oxidative status in rat brain. Mol Neurobiol [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Wang 2019 Free Radic Biol Med2019Wang SQ, Yang XY, Cui SX, Gao ZH, Qu XJ (2019) Heterozygous knockout insulin-like growth factor-1 receptor (IGF-1R) regulates mitochondrial functions and prevents colitis and colorectal cancer. Free Radic Biol Med 134:87-98.OXPHOS
LEAK
Isolated mitochondriaMouseHeart
Liver
Endothelial;epithelial;mesothelial cell
Jaiswal 2019 Mol Metab2019Jaiswal N, Gavin MG, Quinn WJ 3rd, Luongo TS, Gelfer RG, Baur JA, Titchenell PM (2019) The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis. Mol Metab [Epub ahead of print].LEAK
OXPHOS
NIsolated mitochondriaMouseSkeletal muscle
Christian 2019 Respir Physiol Neurobiol2019Christian AR, Losantos-Ramos K, Marcelino G, Daniela F, Jorge S (2019) NADH-linked mitochondrial respiration in the developing mouse brain is sex-, age- and tissue-dependent. Respir Physiol Neurobiol 266:156-62.LEAK
OXPHOS
NPermeabilized tissueMouseNervous system
Mayer 2019 Lipids2019Mayer K, Sommer N, Hache K, Hecker A, Reiche S, Schneck E, Weissmann N, Seeger W, Hecker M (2019) Resolvin E1 improves mitochondrial function in human alveolar epithelial cells during severe inflammation. Lipids 54:53-65.LEAK
ROUTINE
ET
ROXIntact cellsHumanLung;gill
Endothelial;epithelial;mesothelial cell
Other cell lines
Doerrier 2019 MitoFit Preprint Arch EA2019Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. MitoFit Preprint Arch doi:10.26124/mitofit:ea19.MiPSchool.0009.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Ahn 2019 J Cachexia Sarcopenia Muscle2019Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H (2019) Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fiber branching. J Cachexia Sarcopenia Muscle 10:411-28.OXPHOS
LEAK
N
S
CIV
NS
ROX
Isolated mitochondriaMouseSkeletal muscle
Trefts 2019 Thesis2019Trefts E (2019) Integrin linked kinase is critical for hepatic cellular organization, metabolism, and glucoregulation. PhD Thesis 164.LEAK
ROUTINE
ET
Intact cellsMouseLiver
Chatfield 2019 JACC Basic Transl Sci2019Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL (2019) Elamipretide improves mitochondrial function in the failing human heart. JACC Basic Transl Sci 4:147-57.ET
LEAK
OXPHOS
N
NS
S
Permeabilized tissueHumanHeart
Laouafa 2019 Acta Physiol (Oxf)2019Laouafa S, Roussel D, Marcouiller F, Soliz J, Gozal D, Bairam A, Joseph V (2019) Roles of oestradiol receptor alpha and beta against hypertension and brain mitochondrial dysfunction under intermittent hypoxia in female rats. Acta Physiol (Oxf) 226:e13255.LEAK
OXPHOS
ET
N
S
NS
ROX
CIV
Permeabilized tissueRatNervous system
Benoist 2019 Sci Rep2019Benoist L, Chadet S, Genet T, Lefort C, Heraud A, Danila MD, Muntean DM, Baron C, Angoulvant D, Babuty D, Bourguignon T, Ivanes F (2019) Stimulation of P2Y11 receptor protects human cardiomyocytes against hypoxia/reoxygenation injury and involves PKCε signaling pathway. Sci Rep 9:11613.LEAK
ROUTINE
ET
ROXIntact cellsHumanHeart
Electron transfer-pathway state2019Gnaiger E (2019) ET-pathway states. Mitochondr Physiol Network 2019-06-11 (last edit since 2016-11-08).LEAK
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
SMP
Sonjak 2019 J Gerontol A Biol Sci Med Sci2019Sonjak V, Jacob KJ, Spendiff S, Vuda M, Perez A, Miguez K, Minozzo FC, Spake C, Morais JA, Hepple RT (2019) Reduced mitochondrial content, elevated ROS, and modulation by denervation in skeletal muscle of pre-frail/frail elderly women. J Gerontol A Biol Sci Med Sci [Epub ahead of print].LEAK
OXPHOS
N
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Halbach 2019 Am J Physiol Regul Integr Comp Physiol2019Halbach JL, Prieto JM, Wang AW, Hawisher D, Cauvi DM, Reyes T, Okerblom J, Ramirez-Sanchez I, Villarreal F, Patel HH, Bickler SW, Perdrizet GA, De Maio A (2019) Early hyperbaric oxygen therapy improves survival in a model of severe sepsis. Am J Physiol Regul Integr Comp Physiol 317:R160-R168.LEAK
OXPHOS
N
NS
Intact cellsMouseLiver
Veyrat-Durebex 2019 Mol Neurobiol2019Veyrat-Durebex C, Bris C, Codron P, Bocca C, Chupin S, Corcia P, Vourc'h P, Hergesheimer R, Cassereau J, Funalot B, Andres CR, Lenaers G, Couratier P, Reynier P, Blasco H (2019) Metabo-lipidomics of fibroblasts and mitochondrial-endoplasmic reticulum extracts from ALS patients shows alterations in purine, pyrimidine, energetic, and phospholipid metabolisms. Mol Neurobiol [Epub ahead of print].LEAK
ET
ROUTINE
ROXIntact cellsHumanFibroblast
Miranda Mendonca 2019 Neurochem Int2019Miranda Mendonça AP, Hoppe LY, Gaviraghi A, Araújo-Jorge TC, de Oliveira GM, Felippe RM, Oliveira MF, da Silva Fragoso VM (2019) Highly aggressive behavior induced by social stress is associated to reduced cytochrome c oxidase activity in mice brain cortex. Neurochem Int 126:210-17.LEAK
OXPHOS
ET
N
CIV
ROX
Permeabilized tissueMouseNervous system
Kappler 2019 Am J Physiol Endocrinol Metab2019Kappler L, Hoene M, Hu C, von Toerne C, Li J, Bleher D, Hoffmann C, Böhm A, Kollipara L, Zischka H, Königsrainer A, Häring HU, Peter A, Xu G, Sickmann A, Hauck SM, Weigert C, Lehmann R (2019) Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints. Am J Physiol Endocrinol Metab [Epub ahead of print].LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissue
Isolated mitochondria
Human
Mouse
Skeletal muscle
Liver
Maresch 2019 Hepatol Commun2019Maresch LK, Benedikt P, Feiler U, Eder S, Zierler KA, Taschler U, Kolleritsch S, Eichmann TO, Schoiswohl G, Leopold C, Wieser B, Lackner C, Rülicke T, van Klinken J, Kratky D, Moustafa T, Hoefler G, Haemmerle G (2019) Intestine‐specific overexpression of carboxylesterase 2c protects mice from diet‐induced liver steatosis and obesity. Hepatol Commun 3:227-45.LEAK
OXPHOS
FHomogenateMouseEndothelial;epithelial;mesothelial cell
Miotto 2019 FASEB J2019Miotto PM, McGlory C, Bahniwal R, Kamal M, Phillips SM, Holloway GP (2019) Supplementation with dietary ω-3 mitigates immobilization-induced reductions in skeletal muscle mitochondrial respiration in young women. FASEB J 33:8232-40.LEAK
OXPHOS
N
NS
F
Permeabilized tissueHumanSkeletal muscle
Rose 2019 Am J Physiol Endocrinol Metab2019Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Børsheim E (2019) A Comparative Study of Mitochondrial Respiration in Circulating Blood Cells and Skeletal Muscle Fibers in Women. Am J Physiol Endocrinol Metab [Epub ahead of print].ET
LEAK
OXPHOS
F
N
NS
ROX
S
Intact cells
Permeabilized cells
Permeabilized tissue
HumanBlood cells
Platelet
Skeletal muscle
Munro 2019 Aging Cell2019Munro D, Baldy C, Pamenter ME, Treberg JR (2019) The exceptional longevity of the naked mole-rat may be explained by mitochondrial antioxidant defenses. Aging Cell 18:e12916.LEAK
OXPHOS
N
NS
S
Isolated mitochondriaMouse
Other mammals
Heart
Skeletal muscle
Halle 2019 Am J Physiol Regul Integr Comp Physiol2019Halle JL, Pena GS, Paez HG, Castro AJ, Rossiter HB, Visavadiya NP, Whitehurst MA, Khamoui AV (2019) Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. Am J Physiol Regul Integr Comp Physiol 317:R68-R82.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissue
Intact cells
MouseSkeletal muscle
Liver
Fat
Devaux 2019 J Exp Biol2019Devaux JBL, Hickey AJR, Renshaw GMC (2019) Mitochondrial plasticity in the cerebellum of two anoxia-tolerant sharks: contrasting responses to anoxia/reoxygenation. J Exp Biol 222:jeb191353.ET
LEAK
OXPHOS
ROUTINE
N
NS
S
HomogenateFishesNervous system
Gonzalez-Armenta 2019 J Nutr2019Gonzalez-Armenta JL, Gao Z, Appt SE, Vitolins MZ, Michalson KT, Register TC, Shively CA, Molina AJA (2019) Skeletal muscle mitochondrial respiration is elevated in female cynomolgus macaques fed a western compared with a mediterranean diet. J Nutr [Epub ahead of print].LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Permeabilized tissueOther mammalsSkeletal muscle
Larsen 2019 Appl Physiol Nutr Metab2019Larsen S, Dandanell S, Kristensen KB, Jørgensen SD, Dela F, Helge JW (2019) Influence of exercise amount and intensity on long-term weight loss maintenance and skeletal muscle mitochondrial ROS production in humans. Appl Physiol Nutr Metab [Epub ahead of print].OXPHOS
ET
LEAK
N
NS
Permeabilized tissueHumanSkeletal muscle
Driescher 2019 Heliyon2019Driescher N, Joseph DE, Human VR, Ojuka E, Cour M, Hadebe N, Bester D, Marnewick JL, Lecour S, Lochner A, Essop MF (2019) The impact of sugar-sweetened beverage intake on rat cardiac function. Heliyon 5:e01357.LEAK
OXPHOS
ET
F
N
CIV
ROX
Permeabilized tissueRatHeart
Silva Ramos 2019 PLoS Genet2019Silva Ramos E, Motori E, Brüser C, Kühl I, Yeroslaviz A, Ruzzenente B, Kauppila JHK, Busch JD, Hultenby K, Habermann BH, Jakobs S, Larsson NG, Mourier A (2019) Mitochondrial fusion is required for regulation of mitochondrial DNA replication. PLoS Genet 15:e1008085.LEAK
OXPHOS
ET
N
S
Gp
Permeabilized cells
Isolated mitochondria
MouseHeart
Fibroblast
Desmoulins 2019 Mol Metab2019Desmoulins L, Chrétien C, Paccoud R, Collins S, Cruciani-Guglielmacci C, Galinier A, Liénard F, Quinault A, Grall S, Allard C, Fenech C, Carneiro L, Mouillot T, Fournel A, Knauf C, Magnan C, Fioramonti X, Pénicaud L, Leloup C (2019) Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing. Mol Metab 20:166-77.OXPHOS
ET
LEAK
N
NS
HomogenateRatNervous system
Fisar 2019 Clin Biochem2019Fišar Z, Jirák R, Zvěřová M, Setnička V, Habartová L, Hroudová J, Vaníčková Z, Raboch J (2019) Plasma amyloid beta levels and platelet mitochondrial respiration in patients with Alzheimer's disease. Clin Biochem [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanPlatelet
Teulier 2019 Comp Biochem Physiol A Mol Integr Physiol2019Teulier L, Thoral E, Queiros Q, McKenzie DJ, Roussel D, Dutto G, Gasset E, Bourjea J, Saraux C (2019) Muscle bioenergetics of two emblematic Mediterranean fish species: Sardina pilchardus and Sparus aurata. Comp Biochem Physiol A Mol Integr Physiol 235:174-79.LEAK
OXPHOS
ET
F
N
NS
ROX
Intact cellsFishesSkeletal muscle
Gaglianone 2019 Sci Rep2019Gaglianone RB, Santos AT, Bloise FF, Ortiga-Carvalho TM, Costa ML, Quirico-Santos T, da Silva WS, Mermelstein C (2019) Reduced mitochondrial respiration and increased calcium deposits in the EDL muscle, but not in soleus, from 12-week-old dystrophic mdx mice. Sci Rep 9:1986.LEAK
OXPHOS
ET
N
CIV
NS
Permeabilized tissueMouseSkeletal muscle
Bundgaard 2019 Sci Rep2019Bundgaard A, James AM, Gruszczyk AV, Martin J, Murphy MP, Fago A (2019) Metabolic adaptations during extreme anoxia in the turtle heart and their implications for ischemia-reperfusion injury. Sci Rep 9:2850.LEAK
OXPHOS
SIsolated mitochondriaMouse
Reptiles
Heart
Okoye 2019 Aquat Toxicol2019Okoye CN, MacDonald-Jay N, Kamunde C (2019) Effects of bioenergetics, temperature and cadmium on liver mitochondria reactive oxygen species production and consumption. Aquat Toxicol [Epub ahead of print].LEAK
OXPHOS
NIsolated mitochondriaFishesLiver
Bousseau 2019 FASEB J2019Bousseau S, Marchand M, Soleti R, Vergori L, Hilairet G, Recoquillon S, Le Mao M, Gueguen N, Khiati S, Clarion L, Bakalara N, Martinez MC, Germain S, Lenaers G, Andriantsitohaina R (2019) Phostine 3.1a as a pharmacological compound with antiangiogenic properties against diseases with excess vascularization. FASEB J 33:5864-75.LEAK
ET
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Callegari 2019 J Mol Biol2019Callegari S, Müller T, Schulz C, Lenz C, Jans DC, Wissel M, Opazo F, Rizzoli SO, Jakobs S, Urlaub H, Rehling P, Deckers M (2019) A MICOS-TIM22 association promotes carrier import into human mitochondria. J Mol Biol 431:2835-51.LEAK
ET
ROUTINE
Intact cellsHumanHEK
Malyala 2019 PLoS Comput Biol2019Malyala S, Zhang Y, Strubbe JO, Bazil JN (2019) Calcium phosphate precipitation inhibits mitochondrial energy metabolism. PLoS Comput Biol 15:e1006719.OXPHOS
LEAK
N
S
Isolated mitochondriaGuinea pigHeart
Papadimitriou 2019 Sci Rep2019Papadimitriou ID, Eynon N, Yan X, Munson F, Jacques M, Kuang J, Voisin S, North KN, Bishop DJ (2019) A "human knockout" model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations. Sci Rep 9:12688.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Rodriguez-Enriquez 2019 Toxicol Appl Pharmacol2019Rodríguez-Enríquez S, Pacheco-Velázquez SC, Marín-Hernández Á, Gallardo-Pérez JC, Robledo-Cadena DX, Hernández-Reséndiz I, García-García JD, Belmont-Díaz J, López-Marure R, Hernández-Esquivel L, Sánchez-Thomas R, Moreno-Sánchez R (2019) Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress. Toxicol Appl Pharmacol 370:65-77.LEAK
OXPHOS
N
S
Isolated mitochondriaRatHeart
Liver
Long 2019 Methods Mol Biol2019Long Q, Huang L, Huang K, Yang Q (2019) Assessing mitochondrial bioenergetics in isolated mitochondria from mouse heart tissues using Oroboros Oxygraph-2k. Methods Mol Biol 1966:237-46.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaMouseHeart
Zhang 2019 Redox Biol2019Zhang Y, Bharathi SS, Beck ME, Goetzman ES (2019) The fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase can be a source of mitochondrial hydrogen peroxide. Redox Biol [Epub ahead of print].LEAK
OXPHOS
N
NS
F
Isolated mitochondriaMouseLiver
Magga 2019 Mol Ther2019Magga J, Vainio L, Kilpiö T, Hulmi JJ, Taponen S, Lin R, Räsänen M, Szabó Z, Gao E, Rahtu-Korpela L, Alakoski T, Ulvila J, Laitinen M, Pasternack A, Koch WJ, Alitalo K, Kivelä R, Ritvos O, Kerkelä R (2019) Systemic blockade of ACVR2B ligands protects myocardium from acute ischemia-reperfusion injury. Mol Ther 27:600-10.LEAK
OXPHOS
ET
N
S
NS
HomogenateMouseHeart
De-Souza-Ferreira 2019 J Neurochem2019de-Souza-Ferreira E, Rios-Neto IM, Martins EL, Galina A (2019) Mitochondria-coupled glucose phosphorylation develops after birth to modulate H2O2 release and calcium handling in rat brain. J Neurochem 149:624-40.LEAK
OXPHOS
ET
N
Gp
CIV
NS
Isolated mitochondriaRatNervous system
Lauridsen 2019 Mitochondrion2019Lauridsen PE, Rasmussen LJ, Desler C (2019) Mitochondrial oxidative phosphorylation capacity of cryopreserved cells. Mitochondrion 47:47-53.LEAK
ROUTINE
ET
ROXIntact cellsHumanOther cell lines
Zhu 2019 Aging Cell2019Zhu B, Li Y, Xiang L, Zhang J, Wang L, Guo B, Liang M, Chen L, Xiang L, Dong J, Liu M, Mei W, Li H, Xiang G (2019) Alogliptin improves survival and health of mice on a high-fat diet. Aging Cell 18:e12883.LEAK
OXPHOS
ET
N
NS
S
ROX
Isolated mitochondriaMouseLiver
Grauso 2019 Sci Rep2019Grauso M, Lan A, Andriamihaja M, Bouillaud F, Blachier F (2019) Hyperosmolar environment and intestinal epithelial cells: impact on mitochondrial oxygen consumption, proliferation, and barrier function in vitro. Sci Rep 9:11360.LEAK
ROUTINE
OXPHOS
ET
N
NS
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Oses 2019 Epilepsy Res2019Oses JP, Müller AP, Strogulski NR, Moreira JD, Böhmer AE, Hansel G, Carteri RB, Busnello JV, Kopczynski A, Rodolphi MS, Souza DO, Portela LV (2019) Sustained elevation of cerebrospinal fluid glucose and lactate after a single seizure does not parallel with mitochondria energy production. Epilepsy Res 152:35-41.LEAK
OXPHOS
ROUTINE
N
CIV
NS
HomogenateRatNervous system
Fiorenza 2019 FASEB J2019Fiorenza M, Lemminger AK, Marker M, Eibye K, Iaia FM, Bangsbo J, Hostrup M (2019) High-intensity exercise training enhances mitochondrial oxidative phosphorylation efficiency in a temperature-dependent manner in human skeletal muscle: implications for exercise performance. FASEB J [Epub ahead of print].LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Chang 2019 Br J Anaesth2019Chang L, Daly C, Miller DM, Allen PD, Boyle JP, Hopkins PM, Shaw MA (2019) Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals. Br J Anaesth 122:613-21.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HumanSkeletal muscle
Belosludtsev 2019 Biochim Biophys Acta Biomembr2019Belosludtsev KN, Belosludtseva NV, Talanov EY, Tenkov KS, Starinets VS, Agafonov AV, Pavlik LL, Dubinin MV (2019) Effect of bedaquiline on the functions of rat liver mitochondria. Biochim Biophys Acta Biomembr 1861:288-97.LEAK
OXPHOS
N
S
NS
Isolated mitochondriaRatLiver
Sundstroem 2019 Acta Neuropathol Commun2019Sundstrøm T, Prestegarden L, Azuaje F, Aasen SN, Røsland GV, Varughese JK, Bahador M, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Ingham ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Beschorner R, Bjerkvig R, Thorsen F (2019) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Commun 7:55.ET
LEAK
N
NS
ROX
S
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Azevedo 2019 Food Chem Toxicol2019Azevedo LF, Porto Dechandt CR, Cristina de Souza Rocha C, Hornos Carneiro MF, Alberici LC, Barbosa F Jr (2019) Long-term exposure to bisphenol A or S promotes glucose intolerance and changes hepatic mitochondrial metabolism in male Wistar rats. Food Chem Toxicol [Epub ahead of print].LEAK
OXPHOS
ET
N
S
ROX
Permeabilized tissueRatLiver
Gnaiger 2019 MitoFit Preprint Arch2019Gnaiger E, Aasander Frostner E, Abdul Karim N, Abdel-Rahman EA, Abumrad NA, Acuna-Castroviejo D, Adiele RC, et al (2019) Mitochondrial respiratory states and rates. MitoFit Preprint Arch doi:10.26124/mitofit:190001.v6.LEAK
OXPHOS
ET
F
N
S
Gp
DQ
CIV
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Bertolini 2019 MBio2019Bertolini MS, Chiurillo MA, Lander N, Vercesi AE, Docampo R (2019) MICU1 and MICU2 play an essential role in mitochondrial Ca2+ uptake, growth, and infectivity of the human pathogen Trypanosoma cruzi. MBio 10:e00348-19.LEAK
OXPHOS
ET
Permeabilized cellsProtists
Rajendran 2019 EMBO Mol Med2019Rajendran J, Purhonen J, Tegelberg S, Smolander OP, Mörgelin M, Rozman J, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Auvinen P, Mervaala E, Jacobs HT, Szibor M, Fellman V, Kallijärvi J (2019) Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy. EMBO Mol Med 11:e9456.LEAK
OXPHOS
ET
N
S
CIV
NS
Isolated mitochondriaMouseLiver
Kidney
Heart
McManus 2019 Cell Metab2019McManus MJ, Picard M, Chen HW, De Haas HJ, Potluri P, Leipzig J, Towheed A, Angelin A, Sengupta P, Morrow RM, Kauffman BA, Vermulst M, Narula J, Wallace DC (2019) Mitochondrial DNA variation dictates expressivity and progression of nuclear DNA mutations causing cardiomyopathy. Cell Metab 29:78-90.LEAK
OXPHOS
N
ROX
Isolated mitochondriaMouseHeart
Shuvo 2019 J Bioenerg Biomembr2019Shuvo SR, Wiens LM, Subramaniam S, Treberg JR, Court DA (2019) Increased reactive oxygen species production and maintenance of membrane potential in VDAC-less Neurospora crassa mitochondria. J Bioenerg Biomembr [Epub ahead of print].LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaFungi
Nakajima 2019 Sci Rep2019Nakajima T, Yokota T, Shingu Y, Yamada A, Iba Y, Ujihira K, Wakasa S, Ooka T, Takada S, Shirakawa R, Katayama T, Furihata T, Fukushima A, Matsuoka R, Nishihara H, Dela F, Nakanishi K, Matsui Y, Kinugawa S (2019) Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis. Sci Rep 9:3535.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanFat
Robinson 2019 Am J Physiol Cell Physiol2019Robinson MM, Sather BK, Burney ER, Ehrlicher SE, Stierwalt HD, Franco MC, Newsom SA (2019) Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells. Am J Physiol Cell Physiol [Epub ahead of print].LEAK
OXPHOS
ET
F
N
S
Gp
NS
Other combinations
ROX
Permeabilized cellsMouse
Rat
Skeletal muscle
Castellano-Gonzalez 2019 Neurotox Res2019Castellano-Gonzalez G, Jacobs KR, Don E, Cole NJ, Adams S, Lim CK, Lovejoy DB, Guillemin GJ (2019) Kynurenine 3-monooxygenase activity in human primary neurons and effect on cellular bioenergetics identifies new neurotoxic mechanisms. Neurotox Res 35:530-41.LEAK
ET
ROUTINE
ROXIntact cellsHumanHEK
Ferey 2019 Am J Physiol Heart Circ Physiol2019Ferey J, Boudoures AL, Reid M, Drury A, Scheaffer S, Modi Z, Kovacs A, Pietka T, DeBosch BJ, Thompson MD, Diwan A, Moley KH (2019) Maternal high-fat, high-sucrose diet induces transgenerational cardiac mitochondrial dysfunction independent of maternal mitochondrial inheritance. Am J Physiol Heart Circ Physiol 316:H1202-H1210.LEAK
OXPHOS
N
S
NS
Permeabilized tissueMouseHeart
Zhao 2019 Pharmacol Res2019Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, Yin L, Peng J (2019) MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1. Pharmacol Res [Epub ahead of print].LEAK
ROUTINE
ET
ROXIntact cellsMouseLiver
Other cell lines
Monteiro 2019 Thesis2019Monteiro ARB (2019) Effects of resistance training on mitochondrial function and gene expression of UCP-3 in muscles of ovariectomized rats. Dissertation 82.LEAK
OXPHOS
ET
NPermeabilized tissueRatSkeletal muscle
Kunz 2019 Am J Physiol Endocrinol Metab2019Kunz HE, Dasari S, Lanza IR (2019) EPA and DHA elicit distinct transcriptional responses to high-fat feeding in skeletal muscle and liver. Am J Physiol Endocrinol Metab [Epub ahead of print].LEAK
OXPHOS
F
N
S
NS
ROX
Isolated mitochondriaMouseSkeletal muscle
Liver
Zhao 2019 Basic Res Cardiol2019Zhao J, Gao JL, Zhu JX, Zhu HB, Peng X, Jiang M, Fu Y, Xu J, Mao XH, Hu N, Ma MH, Dong DL (2019) The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3. Basic Res Cardiol 114:12.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact cells
Permeabilized cells
RatHeart
Fibroblast
Flis 2019 Int J Mol Sci2019Flis DJ, Dzik K, Kaczor JJ, Cieminski K, Halon-Golabek M, Antosiewicz J, Wieckowski MR, Ziolkowski W (2019) Swim training modulates mouse skeletal muscle energy metabolism and ameliorates reduction in grip strength in a mouse model of amyotrophic lateral sclerosis. Int J Mol Sci 20:E233.LEAK
OXPHOS
NIsolated mitochondriaMouseSkeletal muscle
Pichaud 2019 Front Genet2019Pichaud N, Bérubé R, Côté G, Belzile C, Dufresne F, Morrow G, Tanguay RM, Rand DM, Blier PU (2019) Age dependent dysfunction of mitochondrial and ROS metabolism induced by mitonuclear mismatch. Front Genet 10:130.LEAK
OXPHOS
ET
N
Gp
CIV
ROX
Permeabilized tissueDrosophilaSkeletal muscle
Pajak 2019 PLoS Genet2019Pajak A, Laine I, Clemente P, El-Fissi N, Schober FA, Maffezzini C, Calvo-Garrido J, Wibom R, Filograna R, Dhir A, Wedell A, Freyer C, Wredenberg A (2019) Defects of mitochondrial RNA turnover lead to the accumulation of double-stranded RNA in vivo. PLoS Genet 15:e1008240.LEAK
OXPHOS
CIV
N
S
Permeabilized tissueDrosophila
Vaka 2019 Am J Physiol Regul Integr Comp Physiol2019Vaka VR, Mcmasters KM, Cornelius DC, Ibrahim T, Jayaram A, Usry N, Cunningham MW Jr, Amaral LM, LaMarca BD (2019) Natural killer cells contribute to mitochondrial dysfunction in response to placental ischemia in Reduced Uterine Perfusion Pressure (RUPP) rats. Am J Physiol Regul Integr Comp Physiol 316:R441-R447.LEAK
OXPHOS
ET
N
CIV
ROX
Intact cells
Isolated mitochondria
Human
Rat
Endothelial;epithelial;mesothelial cell
Genital
Chiurillo 2019 Mol Biol Cell2019Chiurillo MA, Lander N, Bertolini MS, Vercesi AE, Docampo R (2019) Functional analysis and importance for host cell infection of the Ca2+-conducting subunits of the mitochondrial calcium uniporter of Trypanosoma cruzi. Mol Biol Cell 30:1676-90.LEAK
OXPHOS
ET
SPermeabilized cellsProtists
Cormier 2019 Sci Rep2019Cormier RPJ, Champigny CM, Simard CJ, St-Coeur PD, Pichaud N (2019) Dynamic mitochondrial responses to a high-fat diet in Drosophila melanogaster. Sci Rep 9:4531.LEAK
OXPHOS
ET
N
Gp
NS
ROX
CIV
Permeabilized tissueDrosophilaSkeletal muscle
Cardinale 2019 Front Physiol2019Cardinale DA, Larsen FJ, Lännerström J, Manselin T, Södergård O, Mijwel S, Lindholm P, Ekblom B, Boushel R (2019) Influence of hyperoxic-supplemented high-intensity interval training on hemotological and muscle mitochondrial adaptations in trained cyclists. Front Physiol 10:730.LEAK
OXPHOS
ET
F
N
CIV
NS
ROX
Permeabilized tissue
Isolated mitochondria
HumanSkeletal muscle
Kharechkina 2019 Biochim Biophys Acta Gen Subj2019Kharechkina ES, Nikiforova AB, Teplova VV, Odinokova IV, Krestinina OV, Baburina YL, Kruglova SA, Kruglov AG (2019) Regulation of permeability transition pore opening in mitochondria by external NAD(H). Biochim Biophys Acta Gen Subj 1863:771-83.LEAK
OXPHOS
ET
SIsolated mitochondriaRatLiver
Pedrotti 2019 Sci Adv2019Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D (2019) The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli. Sci Adv 5:eaav1472.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Intact cellsMouseFat
Jaskiewicz 2019 J Clin Med2019Jaśkiewicz A, Pająk B, Łabieniec-Watała M, De Palma C, Orzechowski A (2019) Diverse action of selected statins on skeletal muscle cells - An attempt to explain the protective effect of geranylgeraniol (GGOH) in statin-associated myopathy (SAM). J Clin Med 8:694.ROUTINE
OXPHOS
ET
LEAK
N
S
NS
ROX
Permeabilized cells
Intact cells
MouseSkeletal muscle
Other cell lines
Mann 2019 Oncogene2019Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS (2019) Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism. Oncogene 38:3325-39.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
F
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Dilberger 2019 Nutrients2019Dilberger B, Passon M, Asseburg H, Silaidos CV, Schmitt F, Schmiedl T, Schieber A, Eckert GP (2019) Polyphenols and metabolites enhance survival in rodents and nematodes-impact of mitochondria. Nutrients 11:E1886.LEAK
OXPHOS
ET
N
S
CIV
NS
Isolated mitochondriaCaenorhabditis elegans
Hall 2019 Methods Mol Biol2019Hall A, Moghimi SM (2019) Determination of polycation-mediated perturbation of mitochondrial respiration in intact cells by high-resolution respirometry (Oxygraph-2k, OROBOROS). Methods Mol Biol 1943:313-22.LEAK
ROUTINE
ET
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Chroeis 2019 Eur J Sport Sci2019Chrøis KM, Dohlmann TL, Søgaard D, Hansen CV, Dela F, Helge JW, Larsen S (2019) Mitochondrial adaptations to high intensity interval training in older females and males. Eur J Sport Sci [Epub ahead of print].LEAK
OXPHOS
ET
N
NS
Permeabilized tissueHumanSkeletal muscle
Wessels 2019 Obesity (Silver Spring)2019Wessels B, Honecker J, Schöttl T, Stecher L, Klingenspor M, Hauner H, Skurk T (2019) Adipose mitochondrial respiratory capacity in obesity is impaired independently of glycemic status of tissue donors. Obesity (Silver Spring) 27:756-66.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized cellsHumanFat
Park 2019 Behav Brain Res2019Park SS, Park HS, Kim CJ, Baek SS, Kim TW (2019) Exercise attenuates maternal separation-induced mood disorder-like behaviors by enhancing mitochondrial functions and neuroplasticity in the dorsal raphe. Behav Brain Res 372:112049.LEAK
OXPHOS
N
NS
RatNervous system
Gonzalez-Mariscal 2019 FASEB J2019González-Mariscal I, Montoro RA, O'Connell JF, Kim Y, Gonzalez-Freire M, Liu QR, Alfaras I, Carlson OD, Lehrmann E, Zhang Y, Becker KG, Hardivillé S, Ghosh P, Egan JM (2019) Muscle cannabinoid 1 receptor regulates Il-6 and myostatin expression, governing physical performance and whole-body metabolism. FASEB J 33:5850-63.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Itkis 2019 Mitochondrion2019Itkis Y, Krylova T, Pechatnikova NL, De Grassi A, Tabakov VY, Pierri CL, Aleshin V, Boyko A, Bunik VI, Zakharova EY (2019) A novel variant m.641A>T in the mitochondrial MT-TF gene is associated with epileptic encephalopathy in adolescent. Mitochondrion 47:10-17.LEAK
ROUTINE
OXPHOS
ET
N
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanFibroblast
Sukovas 2019 J Bioenerg Biomembr2019Sukovas A, Silkuniene G, Trumbeckaite S, Jasukaitiene A, Degutyte-Fomins L, Mildaziene V, Gulbinas A, Baniene R, Dambrauskas Z, Paskauskas S (2019) Hyperthermia potentiates cisplatin cytotoxicity and negative effects on mitochondrial functions in OVCAR-3 cells. J Bioenerg Biomembr [Epub ahead of print].LEAK
OXPHOS
NPermeabilized cellsHumanGenital
Douros 2019 JCI Insight2019Douros JD, Niu J, Sdao SM, Gregg T, Fisher-Wellman KH, Bharadwaj MS, Molina A, Arumugam R, Martin MD, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell JE, D'Alessio D (2019) Sleeve gastrectomy rapidly enhances islet function independently of body weight. JCI Insight 4:126688.ET
LEAK
OXPHOS
Gp
N
NS
Permeabilized tissueMouseIslet cell;pancreas;thymus
Roux 2019 PLoS Pathog2019Roux A, Leroy H, De Muylder B, Bracq L, Oussous S, Dusanter-Fourt I, Chougui G, Tacine R, Randriamampita C, Desjardins D, Le Grand R, Bouillaud F, Benichou S, Margottin-Goguet F, Cheynier R, Bismuth G, Mangeney M (2019) FOXO1 transcription factor plays a key role in T cell-HIV-1 interaction. PLoS Pathog 15:e1007669.LEAK
ROUTINE
ET
Intact cellsHumanLymphocyte
Gururaja Rao 2019 Cells2019Gururaja Rao S, Bednarczyk P, Towheed A, Shah K, Karekar P, Ponnalagu D, Jensen HN, Addya S, Reyes BAS, Van Bockstaele EJ, Szewczyk A, Wallace DC, Singh H (2019) BKCa (Slo) channel regulates mitochondrial function and lifespan in Drosophila melanogaster. Cells 8:E945.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaDrosophila
Doig 2019 bioRxiv2019Doig CD, Zelinska AE, Oakey LA, Fletcher RS, El Hassan Y, Garten A, Cartwright D, Heising S, Tennant DA, Watson D, Adamski J, Lavery GG (2019) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in skeletal muscle of H6PDH KO mice. bioRxiv doi: https://doi.org/10.1101/567297 .ET
LEAK
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueMouseSkeletal muscle
Reyes-Fermin 2019 Antioxidants (Basel)2019Reyes-Fermín LM, Avila-Rojas SH, Aparicio-Trejo OE, Tapia E, Rivero I, Pedraza-Chaverri J (2019) The protective effect of alpha-mangostin against cisplatin-induced cell death in LLC-PK1 cells is associated to mitochondrial function preservation. Antioxidants (Basel) 8:E133.LEAK
ROUTINE
ET
CIV
ROX
Intact cellsPigKidney
Ruegsegger 2019 FASEB J2019Ruegsegger GN, Manjunatha S, Summer P, Gopala S, Zabeilski P, Dasari S, Vanderboom PM, Lanza IR, Klaus KA, Nair KS (2019) Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes. FASEB J 33:4458-72.LEAK
OXPHOS
N
NS
ROX
Isolated mitochondriaMouseNervous system
Fernando 2019 Exp Gerontol2019Fernando R, Drescher C, Deubel S, Jung T, Ost M, Klaus S, Grune T, Castro JP (2019) Low proteasomal activity in fast skeletal muscle fibers is not associated with increased age-related oxidative damage. Exp Gerontol 117:45-52.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Gnaiger 2019 MitoPathways2019
O2k-Protocols
Gnaiger E (2019) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Mitochondr Physiol Network 24.05. Oroboros MiPNet Publications, Innsbruck:112 pp.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Intact cells
Human
Mouse
Heart
Skeletal muscle
Fibroblast
Fisher-Wellman 2019 Cell Rep2019Fisher-Wellman KH, Draper JA, Davidson MT, Williams AS, Narowski TM, Slentz DH, Ilkayeva OR, Stevens RD, Wagner GR, Najjar R, Hirschey MD, Thompson JW, Olson DP, Kelly DP, Koves TR, Grimsrud PA, Muoio DM (2019) Respiratory phenomics across multiple models of protein hyperacylation in cardiac mitochondria reveals a marginal impact on bioenergetics. Cell Rep 26:1557-72.LEAK
OXPHOS
ET
F
N
S
Gp
Isolated mitochondriaMouseHeart
Skeletal muscle
Power 2019 PLoS One2019Power AS, Norman R, Jones TLM, Hickey AJ, Ward ML (2019) Mitochondrial function remains impaired in the hypertrophied right ventricle of pulmonary hypertensive rats following short duration metoprolol treatment. PLoS One 14:e0214740.LEAK
OXPHOS
N
NS
Permeabilized tissueRatHeart
Bianco 2019 PLoS One2019Bianco M, Lopes JA, Beiral HJV, Filho JDD, Frankenfeld SP, Fortunato RS, Gattass CR, Vieyra A, Takiya CM (2019) The contralateral kidney presents with impaired mitochondrial functions and disrupted redox homeostasis after 14 days of unilateral ureteral obstruction in mice. PLoS One 14:e0218986.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseKidney
Scheiber 2019 Exp Mol Med2019Scheiber D, Jelenik T, Zweck E, Horn P, Schultheiss HP, Lassner D, Boeken U, Saeed D, Kelm M, Roden M, Westenfeld R, Szendroedi J (2019) High-resolution respirometry in human endomyocardial biopsies shows reduced ventricular oxidative capacity related to heart failure. Exp Mol Med 51:16.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissue
Isolated mitochondria
HumanHeart
Scavuzzo 2019 J Neurophysiol2019Scavuzzo CJ, Leblancq MJ, Nargang F, Lemieux H, Hamilton TJ, Dickson CT (2019) The amnestic agent anisomycin disrupts intrinsic membrane properties of hippocampal neurons via a loss of cellular energetics. J Neurophysiol [Epub ahead of print].LEAK
OXPHOS
N
S
CIV
NS
ROX
HomogenateRatNervous system
Rodinova 2019 Dis Model Mech2019Rodinova M, Krizova J, Stufkova H, Bohuslavova B, Askeland G, Dosoudilova Z, Juhas S, Juhasova J, Ellederova Z, Zeman J, Eide L, Motlik J, Hansikova H (2019) Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease. Dis Model Mech 12:dmm038737.LEAK
OXPHOS
ET
N
S
CIV
ROX
Isolated mitochondriaPigSkeletal muscle
Rawat 2019 J Mol Biol2019Rawat S, Anusha V, Jha M, Sreedurgalakshmi K, Raychaudhuri S (2019) Aggregation of respiratory complex subunits marks the onset of proteotoxicity in proteasome inhibited cells. J Mol Biol 431:996-1015.LEAK
OXPHOS
CIV
N
ROX
S
Permeabilized cellsMouseNervous system
Other cell lines
Garcia-Roche 2019 PLoS One2019García-Roche M, Casal A, Mattiauda DA, Ceriani M, Jasinsky A, Mastrogiovanni M, Trostchansky A, Carriquiry M, Cassina A, Quijano C (2019) Impaired hepatic mitochondrial function during early lactation in dairy cows: Association with protein lysine acetylation. PLoS One 14:e0213780.LEAK
OXPHOS
ET
N
S
NS
ROX
Intact cellsBovinesLiver
Paradis 2019 Antioxidants (Basel)2019Paradis S, Charles AL, Georg I, Goupilleau F, Meyer A, Kindo M, Laverny G, Metzger D, Geny B (2019) Aging exacerbates ischemia-reperfusion-induced mitochondrial respiration impairment in skeletal muscle. Antioxidants (Basel) 8:E168.LEAK
OXPHOS
N
S
CIV
Permeabilized tissueMouseSkeletal muscle
Courtes 2019 Biomed Pharmacother2019Courtes AA, de Carvalho NR, Gonçalves DF, Hartmann DD, da Rosa PC, Dobrachinski F, Franco JL, de Souza DOG, Soares FAA (2019) Guanosine protects against Ca2+-induced mitochondrial dysfunction in rats. Biomed Pharmacother 111: 1438-46.OXPHOS
LEAK
N
S
NS
ROX
Isolated mitochondriaRatLiver
Baekkerud 2019 Cardiovasc Toxicol2019Bækkerud FH, Salerno S, Ceriotti P, Morland C, Storm-Mathisen J, Bergersen LH, Høydal MA, Catalucci D, Stølen TO (2019) High intensity interval training ameliorates mitochondrial dysfunction in the left ventricle of mice with type 2 diabetes. Cardiovasc Toxicol [Epub ahead of print].LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseHeart
Halling 2019 Am J Physiol Endocrinol Metab2019Halling JF, Jessen H, Nøhr-Meldgaard J, Thiellesen Buch B, Masselkhi Christensen N, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H (2019) PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training. Am J Physiol Endocrinol Metab [Epub ahead of print].ET
LEAK
OXPHOS
N
NS
ROX
S
Permeabilized tissueMouseSkeletal muscle
Spinazzi 2019 Proc Natl Acad Sci U S A2019Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B (2019) PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proc Natl Acad Sci U S A 116:277-86.ET
LEAK
OXPHOS
CIV
N
NS
ROX
S
Intact cells
Isolated mitochondria
Permeabilized cells
MouseNervous system
Bettinazzi 2019 Cryobiology2019Bettinazzi S, Gendron AD, Breton S (2019) The effect of cryopreservation on mitochondrial function in freshwater mussel tissue samples (Bivalvia: Unionida). Cryobiology 88:106-109.LEAK
OXPHOS
ET
N
Gp
CIV
NS
ROX
S
Other combinations
Permeabilized tissueMolluscsLung;gill
Detaille 2019 PLoS One2019Detaille D, Pasdois P, Sémont A, Dos Santos P, Diolez P (2019) An old medicine as a new drug to prevent mitochondrial complex I from producing oxygen radicals. PLoS One 14:e0216385.LEAK
OXPHOS
N
S
NS
ROX
Isolated mitochondriaRatHeart
McBride 2019 Arch Biochem Biophys2019McBride S, Wei-LaPierre L, McMurray F, MacFarlane M, Qiu X, Patten DA, Dirksen RT, Harper ME (2019) Skeletal muscle mitoflashes, pH, and the role of uncoupling protein-3. Arch Biochem Biophys 663:239-48.LEAK
OXPHOS
CIV
F
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Bouitbir 2019 Toxicology2019Bouitbir J, Alshaikhali A, Panajatovic MV, Abegg VF, Paech F, Krähenbühl S (2019) Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib. Toxicology [Epub ahead of print].LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Rat
Mouse
Heart
Gaiser 2019 Adv Ther (Weinh)2019Gaiser A, Hafner S, Schmiech M, Büchele B, Schäfer P, Arnim CA, Calzia, E, Feuring‐Buske M, Buske C, Vick B, Jeremias I, Syrovets T, Simmet T (2019) Gold nanoparticles with selective antileukemic activity in vitro and in vivo target mitochondrial respiration. Adv Ther (Weinh) doi:10.1002/adtp.201800149.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Braganza 2019 JCI Insight2019Braganza AC, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S (2019) Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight 5:128248.LEAK
OXPHOS
ET
N
NS
Permeabilized tissueHumanSkeletal muscle
Chao 2019 J Appl Physiol (1985)2019Chao T, Burmeister DM, Corona BT, Greising SM (2019) Oxidative pathophysiology following volumetric muscle loss injury in a porcine model. J Appl Physiol (1985) 126:1541-49.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissuePigSkeletal muscle
Havird 2019 Mitochondrion2019Havird JC, Noe GR, Link L, Torres A, Logan DC, Sloan DB, Chicco AJ (2019) Do angiosperms with highly divergent mitochondrial genomes have altered mitochondrial function? Mitochondrion 49:1-11.LEAK
OXPHOS
N
S
CIV
NS
ROX
Isolated mitochondriaPlants
Alvarez 2019 Chem Biol Interact2019Álvarez Santos MR, Duarte YB, Güiza FM, Romero Bohórquez AR, Mendez-Sanchez SC (2019) Effects of new tetrahydroquinoline-isoxazole hybrides on bioenergetics of hepatocarcinoma Hep-G2 cells and rat liver mitochondria. Chem Biol Interact 302:164-71.LEAK
ROUTINE
ET
ROXIntact cellsHumanLiver
Ng 2019 J Biol Chem2019Ng J, Kaur H, Collier T, Chang K, Brooks AES, Allison JR, Brimble MA, Hickey A, Birch NP (2019) Site-specific glycations of Aβ1-42 affect fibril formation and are neurotoxic. J Biol Chem 294:8806-18.ET
LEAK
OXPHOS
CIV
N
NS
ROX
S
Permeabilized cellsHumanNeuroblastoma
Dall 2019 J Biol Chem2019Dall M, Trammell SAJ, Asping M, Hassing AS, Agerholm M, Vienberg SG, Gillum MP, Larsen S, Treebak JT (2019) Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity. J Biol Chem [Epub ahead of print].LEAK
OXPHOS
ET
F
N
S
Intact cellsMouseLiver
MiPNet12.01 Suppl T-issue2018-11-18
O2k-Protocols contents
MitoPathways at the Q-junction: mouse skeletal muscle fibers.
LEAK
ROUTINE
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
MiPNet21.06 SUIT RP2018-06-25
O2k-Protocols
SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.
LEAK
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
MiPNet21.17 BloodCellsIsolation2018-04-09
O2k-Protocols
O2k-Protocols: Isolation of blood cells for HRR.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Lymphocyte
Platelet
Lica 2018 Stem Cells Dev2018Lica JJ, Grabe GJ, Heldt M, Misiak M, Bloch P, Serocki M, Switalska M, Wietrzyk J, Baginski M, Hellmann A, Borowski E, Skladanowski A (2018) Cell density-dependent cytological stage profile and its application for a screen of cytostatic agents active towards Leukemic Stem Cells. Stem Cells Dev 27:488-513.LEAK
ROUTINE
ET
NHuman
Mouse
Heart
Blood cells
Other cell lines
Kauppila 2018 Nucleic Acids Res2018Kauppila JHK, Bonekamp NA, Mourier A, Isokallio MA, Just A, Kauppila TES, Stewart JB, Larsson NG (2018) Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice. Nucleic Acids Res 46:6642-69.LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaMouse
Kahl 2018 Stroke2018Kahl A, Stepanova A, Konrad C, Anderson C, Manfredi G, Zhou P, Iadecola C, Galkin A (2018) Critical role of flavin and glutathione in complex I-mediated bioenergetic failure in brain ischemia/reperfusion injury. Stroke 49:1223-31.LEAK
OXPHOS
CIVHomogenateMouseNervous system
Szelechowski 2018 Sci Rep2018Szelechowski M, Amoedo N, Obre E, Léger C, Allard L, Bonneu M, Claverol S, Lacombe D, Oliet S, Chevallier S, Le Masson G, Rossignol R (2018) Metabolic reprogramming in amyotrophic lateral sclerosis. Sci Rep 8:3953.LEAK
ROUTINE
ET
F
ROX
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Fibroblast
Quispe 2018 Redox Biol2018Quispe RL, Jaramillo ML, Galant LS, Engel D, Dafre AL, Teixeira da Rocha JB, Radi R, Farina M, de Bem AF (2018) Diphenyl diselenide protects neuronal cells against oxidative stress and mitochondrial dysfunction: Involvement of the glutathione-dependent antioxidant system. Redox Biol 20:118-29.LEAK
ET
ROUTINE
ROXIntact cellsMouseNervous system
Other cell lines
Salin 2018 Integr Comp Biol2018Salin K, Villasevil EM, Anderson GJ, Selman C, Chinopoulos C, Metcalfe NB (2018) The RCR and ATP/O indices can give contradictory messages about mitochondrial efficiency. Integr Comp Biol 58:486-94.LEAK
OXPHOS
N
S
NS
ROX
HomogenateFishesLiver
Giacco 2018 FASEB J2018Giacco A, Delli Paoli G, Senese R, Cioffi F, Silvestri E, Moreno M, Ruoppolo M, Caterino M, Costanzo M, Lombardi A, Goglia F, Lanni A, de Lange P (2018) The saturation degree of fatty acids and their derived acylcarnitines determines the direct effect of metabolically active thyroid hormones on insulin sensitivity in skeletal muscle cells. FASEB J 33:1811-23.LEAK
ET
ROUTINE
ROXIntact cellsRatSkeletal muscle
De Godoy 2018 J Biol Chem2018de Godoy MA, Saraiva LM, de Carvalho LRP, Vasconcelos-Dos-Santos A, Beiral HJV, Ramos AB, Silva LRP, Leal RB, Monteiro VHS, Braga CV, de Araujo-Silva CA, Sinis LC, Bodart-Santos V, Kasai-Brunswick TH, Alcantara CL, Lima APCA, da Cunha-E Silva NL, Galina A, Vieyra A, De Felice FG, Mendez-Otero R, Ferreira ST (2018) Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers. J Biol Chem 293:1957-75.LEAK
ROUTINE
ET
Intact cellsRatNervous system
Dias 2018 Anal Biochem2018Dias C, Lourenco CF, Barbosa RM, Laranjinha J, Ledo A (2018) Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices. Anal Biochem 551:43-50.LEAK
ROUTINE
ET
ROXIntact cellsMouse
Rat
Nervous system
Jang 2018 Intensive Care Med Exp2018Jang DH, MD, Khatri UG, Shortal BP, Kelly M, Lambert DS, Hardy K, Eckmann DM (2018) Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Med Exp 6:4.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHumanBlood cells
Souza 2018 Sci Rep2018Souza RWA, Alves CRR, Medeiros A, Rolim N, Silva GJJ, Moreira JBN, Alves MN, Wohlwend M, Gebriel M, Hagen L, Sharma A, Koch LG, Britton SL, Slupphaug G, Wisløff U, Brum PC (2018) Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. Sci Rep 8:17772.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueRatHeart
Skeletal muscle
Qu 2018 FASEB J2018Qu C, Zhang S, Wang W, Li M, Wang Y, van der Heijde-Mulder M, Shokrollahi E, Hakim MS, Raat NJH, Peppelenbosch MP, Pan Q (2018) Mitochondrial electron transport chain complex III sustains hepatitis E virus replication and represents an antiviral target. FASEB J 33:1008-19.LEAK
ROUTINE
CIV
ROX
Intact cellsHumanLiver
Ejarque 2018 Int J Obes (Lond)2018Ejarque M, Ceperuelo-Mallafré V, Serena C, Maymo-Masip E, Duran X, Díaz-Ramos A, Millan-Scheiding M, Núñez-Álvarez Y, Núñez-Roa C, Gama P, Garcia-Roves PM, Peinado MA, Gimble JM, Zorzano A, Vendrell J, Fernández-Veledo S (2018) Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells. Int J Obes (Lond) 43:1256-68.LEAK
ROUTINE
ET
CIV
ROX
Intact cellsHumanFat
Kong 2018 Proteomics2018Kong D, Tian X, Li Y*, Zhang S, Cheng Y, Huo L, Ma H, Yang Z, Ren L, Zhang M, Zhang W (2018) Revealing the inhibitory effect of ginseng on mitochondrial respiration through synaptosomal proteomics. Proteomics 18:e1700354.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
HomogenateRatNervous system
Ederer 2018 Int J Mol Sci2018Ederer KA, Jin K, Bouslog S, Wang L, Gorman GS, Rowe GC, Abadir P, Raftery D, Moellering D, Promislow D, Jumbo-Lucioni P, De Luca M (2018) Age- and genotype-specific effects of the angiotensin-converting enzyme inhibitor lisinopril on mitochondrial and metabolic parameters in Drosophila melanogaster. Int J Mol Sci 19:3351.LEAK
OXPHOS
NIsolated mitochondriaDrosophila
Girard 2018 mSphere2018Girard RMBM, Crispim M, Alencar MB, Silber AM (2018) Uptake of L-Alanine and its distinct roles in the bioenergetics of Trypanosoma cruzi. mSphere pii:e00338-18.LEAK
ET
Intact cellsProtists
Wang 2018 Mol Med Rep2018Wang B, Li W, Fang H, Zhou H (2018) Hepatitis B virus infection is not associated with fatty liver disease: Evidence from a cohort study and functional analysis. Mol Med Rep 19:320-26.LEAK
ET
Intact cellsHumanLiver
Distefano 2018 J Cachexia Sarcopenia Muscle2018Distefano G, Standley RA, Zhang X, Carnero EA, Yi F, Cornnell HH, Coen PM (2018) Physical activity unveils the relationship between mitochondrial energetics, muscle quality, and physical function in older adults. J Cachexia Sarcopenia Muscle 9:279-94.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Rajasekaran 2018 FASEB J2018Rajasekaran R, Felser A, Nuoffer JM, Dufour JF, St-Pierre MV (2018) The histidine triad nucleotide-binding protein 2 (HINT-2) positively regulates hepatocellular energy metabolism. FASEB J 32:5143-61.LEAK
OXPHOS
ET
N
S
CIV
ROX
Isolated mitochondriaMouseLiver
Lasalvia 2018 PLOS ONE2018Lasalvia M, Scrima R, Perna G, Piccoli C, Capitanio N, Biagi PF, Schiavulli L, Ligonzo T, Centra M, Casamassima G, Ermini A, Capozzi V (2018) Exposure to 1.8 GHz electromagnetic fields affects morphology, DNA-related Raman spectra and mitochondrial functions in human lympho-monocytes. PLOS ONE 13:e0192894.LEAK
ET
Intact cellsHumanLymphocyte
Silaidos 2018 Biol Sex Differ2018Silaidos C, Pilatus U, Grewal R, Matura S, Lienerth B, Pantel J, Eckert GP (2018) Sex-associated differences in mitochondrial function in human peripheral blood mononuclear cells (PBMCs) and brain. Biol Sex Differ 9:34.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
HumanNervous system
Blood cells
Zdralevic 2018 J Biol Chem2018Ždralević M, Brand A, Di Ianni L, Dettmer K, Reinders J, Singer K, Peter K, Schnell A, Bruss C, Decking SM, Koehl G, Felipe-Abrio B, Durivault J, Bayer P, Evangelista M, O'Brien T, Oefner PJ, Renner K, Pouysségur J, Kreutz M (2018) Double genetic disruption of lactate dehydrogenase A and B is required to ablate the 'Warburg effect' restricting tumor growth to oxidative metabolism. J Biol Chem 293:15947-61.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized cells
Intact cells
HumanEndothelial;epithelial;mesothelial cell
Mendes 2018 Mol Neurobiol2018Mendes Lima JP, Rayêe D, Silva-Rodrigues T, Ribeiro Paes Pereira P, Mendonca APM, Rodrigues-Ferreira C, Szczupak D, Fonseca A, Oliveira MF, Souza Lima FR, Lent R, Galina A, Uziel D (2018) Perinatal asphyxia and brain development: mitochondrial damage without anatomical or cellular losses. Mol Neurobiol doi.org/10.1007/s12035-018-1019-7.LEAK
ROUTINE
ET
N
NS
ROX
Intact cellsRatNervous system
Tyagi 2018 Sci Rep2018Tyagi A, Nguyen CU, Chong T, Michel CR, Fritz KS, Reisdorph N, Knaub L, Reusch JEB, Pugazhenthi S (2018) SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. Sci Rep 8:17547.ET
LEAK
OXPHOS
N
NS
HomogenateMouseNervous system
Piel 2018 Intensive Care Med Exp2018Piel S, Ehinger JK, Chamkha I, Frostner EÅ, Sjövall F, Elmér E, Hansson MJ (2018) Bioenergetic bypass using cell-permeable succinate, but not methylene blue, attenuates metformin-induced lactate production. Intensive Care Med Exp 6:22.LEAKS
ROX
Intact cellsHumanPlatelet
Hernandez-Resendiz 2018 J Cell Physiol2018Hernández-Reséndiz I, Gallardo-Pérez JC, López-Macay A, Robledo-Cadena DX, García-Villa E, Gariglio P, Saavedra E, Moreno-Sánchez R, Rodríguez-Enríquez S (2018) Mutant p53R248Q downregulates oxidative phosphorylation and upregulates glycolysis under normoxia and hypoxia in human cervix cancer cells. J Cell Physiol 234:5524-36.LEAKIntact cellsHumanHeLa
Mavroudis 2018 Eur J Cardiothorac Surg2018Mavroudis CD, Karlsson M, Ko T, Hefti M, Gentile JI, Morgan RW, Plyler R, Mensah-Brown KG, Boorady TW, Melchior RW, Rosenthal TM, Shade BC, Schiavo KL, Nicolson SC, Spray TL, Sutton RM, Berg RA, Licht DJ, Gaynor JW, Kilbaugh TJ (2018) Cerebral mitochondrial dysfunction associated with deep hypothermic circulatory arrest in neonatal swine. Eur J Cardiothorac Surg 54:162-68.LEAK
ET
OXPHOS
N
S
CIV
NS
ROX
HomogenatePigNervous system
Vatner 2018 Aging Cell2018Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF (2018) Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14. Aging Cell 17:e12751.LEAK
OXPHOS
N
S
NS
Intact cellsMouseFat
Martins 2018 Oxid Med Cell Longev2018Martins IK, de Carvalho NR, Macedo GE, Rodrigues NR, Ziech CC, Vinadé L, Filho VMB, Menezes IA, Franco J, Posser T (2018) Anacardium microcarpum promotes neuroprotection dependently of AKT and ERK phosphorylation but does not prevent mitochondrial damage by 6-OHDA. Oxid Med Cell Longev 2018:2131895.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateChickenNervous system
Siira 2018 EMBO Rep2018Siira SJ, Rossetti G, Richman TR, Perks K, Ermer JA, Kuznetsova I, Hughes L, Shearwood AJ, Viola HM, Hool LC, Rackham O, Filipovska A (2018) Concerted regulation of mitochondrial and nuclear non-coding RNAs by a dual-targeted RNase Z. EMBO Rep 19:e46198.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseHeart
Lee 2018 Neurol Genet2018Lee RG, Sedghi M, Salari M, Shearwood AJ, Stentenbach M, Kariminejad A, Goullee H, Rackham O, Laing NG, Tajsharghi H, Filipovska A (2018) Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunction. Neurol Genet 4:e276.LEAK
OXPHOS
ET
N
S
CIV
NS
Permeabilized cellsHumanFibroblast
Chicco 2018 J Biol Chem2018Chicco AJ, Le CH, Gnaiger E, Dreyer HC, Muyskens JB, D'Alessandro A, Nemkov T, Hocker AD, Prenni JE, Wolfe LM, Sindt NM, Lovering AT, Subudhi AW, Roach RC (2018) Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics. J Biol Chem 293:6659-71.LEAK
OXPHOS
ET
F
N
S
Permeabilized tissueHumanSkeletal muscle
Carter 2018 J Physiol2018Carter HN, Kim Y, Erlich AT, Zarrin-Khat D, Hood DA (2018) Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity. J Physiol 596:3567-84.LEAK
OXPHOS
N
NS
Permeabilized tissueRatSkeletal muscle
Sowton 2018 Biochem Biophys Res Commun2018Sowton AP, Millington-Burgess SL, Murray AJ, Harper MT (2018) Rapid kinetics of changes in oxygen consumption rate in thrombin-stimulated platelets measured by high-resolution respirometry. Biochem Biophys Res Commun 503:2721-27.LEAKIntact cellsHumanPlatelet
Fischer 2018 BMC Musculoskelet Disord2018Fischer MJ, Horvath G, Krismer M, Gnaiger E, Goebel G, Pesta DH (2018) Evaluation of mitochondrial function in chronic myofascial trigger points - a prospective cohort pilot study using high-resolution respirometry. BMC Musculoskelet Disord 19:388.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Kener 2018 J Vis Exp2018Kener KB, Munk DJ, Hancock CR, Tessem JS (2018) High-resolution respirometry to measure mitochondrial function of intact beta cells in the presence of natural compounds. J Vis Exp 131.LEAK
ET
ROXIntact cellsIslet cell;pancreas;thymus
Rekuviene 2018 Thesis2018Rekuvienė E (2018) Effect of respiratory complex I inhibitors on mitochondrial permeability transition and cell viability during brain ischemia. Doctoral Dissertation 138.LEAK
OXPHOS
N
S
Isolated mitochondriaRatNervous system
McWilliams 2018 Open Biol2018McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar A, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J, Tienari P, Corti O, Dunnett SB, Ganley IG, Suomalainen A, Muqit MMK (2018) Phosphorylation of Parkin at serine 65 is essential for its activation in vivo. Open Biol 8:180108.LEAK
OXPHOS
ET
NHomogenateMouseNervous system
Durand 2018 Blood Purif2018Durand PY, Nicco C, Serteyn D, Attaf D, Edeas M (2018) Microbiota quality and mitochondrial activity link with occurrence of muscle cramps in hemodialysis patients using citrate dialysate: a pilot study. Blood Purif 46:301-8.LEAK
ROUTINE
OXPHOS
ET
S
ROX
Intact cellsHumanPlatelet
Li 2018 Free Radic Biol Med2018Li H, Tang Z, Chu P, Song Y, Yang Y, Sun B, Niu M, Qaed E, Shopit A, Han G, Ma X, Peng J, Hu M, Tang Z (2018) Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways. Free Radic Biol Med 120:228-38.ET
LEAK
ROUTINE
CIVIntact cellsRatNervous system
Other cell lines
Ruas 2018 Sci Rep2018Ruas JS, Siqueira-Santos ES, Rodrigues-Silva E, Castilho RF (2018) High glycolytic activity of tumor cells leads to underestimation of electron transport system capacity when mitochondrial ATP synthase is inhibited. Sci Rep 8:17383.LEAK
ET
ROUTINE
NPermeabilized cells
Intact cells
HumanNervous system
Other cell lines
Reguis Yadao 2018 Thesis2018Reguis Yadao DR (2018) Smooth muscle cell mitochondrial respiration – effects of aerobic training and type I diabetes. Master's Thesis 71.LEAK
OXPHOS
N
NS
ROX
Permeabilized tissueMouseOther cell lines
Paech 2018a Toxicology2018Paech F, Mingard C, Grünig D, Abegg VF, Bouitbir J, Krähenbühl S (2018) Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells. Toxicology 395:34-44.ET
LEAK
OXPHOS
CIV
DQ
N
ROX
S
Isolated mitochondria
Permeabilized cells
Human
Mouse
Liver
Other cell lines
Nielsen 2018 Neurosci Lett2018Nielsen B, Cejvanovic V, Wörtwein G, Hansen AR, Marstal KK, Weimann A, Bjerring PN, Dela F, Poulsen HE, Jørgensen MB (2018) Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue. Neurosci Lett 690:1-5.LEAK
OXPHOS
ET
N
NS
ROX
S
HomogenateRatNervous system
Cardinale 2018 Physiol Rep2018Cardinale DA, Gejl KD, Ørtenblad N, Ekblom B, Blomstrand E, Larsen FJ (2018) Reliability of maximal mitochondrial oxidative phosphorylation in permeabilized fibers from the vastus lateralis employing high-resolution respirometry. Physiol Rep 6. doi: 10.14814/phy2.13611.LEAK
OXPHOS
F
N
Permeabilized tissueHumanSkeletal muscle
Flis 2018 Oxid Med Cell Longev2018Flis DJ, Dzik K, Kaczor JJ, Halon-Golabek M, Antosiewicz J, Wieckowski MR, Ziolkowski W (2018) Swim training modulates skeletal muscle energy metabolism, oxidative stress, and mitochondrial cholesterol content in amyotrophic lateral sclerosis mice. Oxid Med Cell Longev 5940748.LEAK
OXPHOS
NIsolated mitochondriaMouseSkeletal muscle
Santos Bertolini 2018 Thesis2018Santos Bertolini M (2018) Functional study of MICU1 and MICU2 proteins in calcium signaling of Trypanosoma cruzi. Master's Thesis 108.LEAK
OXPHOS
ET
SPermeabilized cellsProtists
Dawson 2018 Acta Physiol (Oxf)2018Dawson NJ, Lyons SA, Henry DA, Scott GR (2018) Effects of chronic hypoxia on diaphragm function in deer mice native to high altitude. Acta Physiol (Oxf) 223:e13030.LEAK
OXPHOS
N
CIV
NS
Permeabilized tissueOther mammalsSkeletal muscle
Hancock 2018 Elife2018Hancock M, Hafstad AD, Nabeebaccus AA, Catibog N, Logan A, Smyrnias I, Hansen SS, Lanner J, Schröder K, Murphy MP, Shah AM, Zhang M (2018) Myocardial NADPH oxidase-4 regulates the physiological response to acute exercise. Elife 7:e41044.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaMouseHeart
Manakov 2018 J Physiol Biochem2018Manakov D, Kolar D, Zurmanova J, Pravenec M, Novotny J (2018) Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36. J Physiol Biochem 74:479-89.ET
LEAK
OXPHOS
F
N
NS
ROX
S
Isolated mitochondriaRatHeart
Logan 2018 Mol Metab2018Logan S, Pharaoh GA, Marlin MC, Masser DR, Matsuzaki S, Wronowski B, Yeganeh A, Parks EE, Premkumar P, Farley JA, Owen DB, Humphries KM, Kinter M, Freeman WM, Szweda LI, Van Remmen H, Sonntag WE (2018) Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes. Mol Metab 9:141-55.LEAK
OXPHOS
N
S
NS
Isolated mitochondriaMouseNervous system
Salin 2018 Funct Ecol2018Salin K, Villasevil EM, Anderson GJ, Auer SK, Selman C, Hartley RC, Mullen W, Chinopoulos C, Metcalfe NB (2018) Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost. Funct Ecol DOI: 10.1111/1365-2435.13125.LEAK
OXPHOS
CIV
NS
ROX
HomogenateFishesLiver
Miklikova 2018 Physiol Res2018Miklíková M, Jarkovská D, Čedíková M, Švíglerová J, Kuncová J, Nalos L, Kubíková T, Liška V, Holubová M, Lysák D, Králíčková M, Vištejnová L, Štengl M (2018) Beneficial effects of mesenchymal stem cells on adult porcine cardiomyocytes in non-contact co-culture. Physiol Res 67:619-31.LEAK
ROUTINE
ET
Intact cellsPigHeart
Cronin 2018 Nature2018Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Latremoliere A, Wirnsberger G, Lametschwandtner G, Busslinger M, Zicha S, Latini A, Robson SC, Waisman A, Andrews N, Costigan M, Channon KM, Weiss G, Kozlov AV, Tebbe M, Johnsson K, Woolf CJ, Penninger JM (2018) The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature 563:564-68.ROUTINE
OXPHOS
ET
LEAK
N
S
Permeabilized cells
Intact cells
MouseLymphocyte
Quispe 2018 Mol Neurobiol2018Quispe RL, Canto RFS, Jaramillo ML, Barbosa FAR, Braga AL, de Bem AF, Farina M (2018) Design, synthesis, and in vitro evaluation of a novel probucol derivative: protective activity in neuronal cells through GPx upregulation. Mol Neurobiol 55:7619-34.LEAK
ROUTINE
ET
ROXIntact cellsMouseNervous system
Other cell lines
De Sales 2018 Molecules2018de Sales NFF, Silva da Costa L, Carneiro TIA, Minuzzo DA, Oliveira FL, Cabral LMC, Torres AG, El-Bacha T (2018) Anthocyanin-rich grape pomace extract (Vitis vinifera L.) from wine industry affects mitochondrial bioenergetics and glucose metabolism in human hepatocarcinoma HepG2 cells. Molecules 23.LEAK
ROUTINE
ET
NIntact cellsHumanLiver
Other cell lines
Kleszczynski 2018 Int J Mol Sci2018Kleszczyński K, Bilska B, Stegemann A, Flis DJ, Ziolkowski W, Pyza E, Luger TA, Reiter RJ, Böhm M, Slominski AT (2018) Melatonin and its metabolites ameliorate UVR-induced mitochondrial oxidative stress in human MNT-1 melanoma cells. Int J Mol Sci 19:E3786.LEAK
OXPHOS
N
NS
Isolated mitochondriaMouseLiver
Cruz 2018 Chem Biol Interact2018Cruz LC, Ecker A, Rodrigues NR, Martins IK, Posser T, Maciel FE, Vargas MA, Barbosa NV, Franco JL (2018) Honey protects against wings posture error and molecular changes related to mitochondrial pathways induced by hypoxia/reoxygenation in adult Drosophila melanogaster. Chem Biol Interact 291:245-52.LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaDrosophila
Wu 2018 Adv Sci2018Wu S, Zhang A, Li S, Chatterjee S, Qi R, Segura-Ibarra V, Ferrari M, Gupte A, Blanco E, Hamilton DJ (2018) Polymer functionalization of isolated mitochondria for cellular transplantation and metabolic phenotype alteration. Adv Sci 1700530.LEAK
OXPHOS
ET
N
ROX
Isolated mitochondriaMouseLiver
Perks 2018 Cell Rep2018Perks KL, Rossetti G, Kuznetsova I, Hughes LA, Ermer JA, Ferreira N, Busch JD, Rudler DL, Spahr H, Schöndorf T, Shearwood AJ, Viola HM, Siira SJ, Hool LC, Milenkovic D, Larsson NG, Rackham O, Filipovska A (2018) PTCD1 is required for 16S rRNA maturation complex stability and mitochondrial ribosome assembly. Cell Rep 23:127-42.LEAK
OXPHOS
ET
N
Gp
S
Isolated mitochondriaMouseHeart
Manoharan 2018 Thesis2018Manoharan N (2018) Characterization of mitochondrial respiration in atlantic salmon (Salmo salar) fed with glutamate and succinate enhanced diet. Master's Thesis 52.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateFishesHeart
Liver
Pamenter 2018 PLoS One2018Pamenter ME, Lau GY, Richards JG (2018) Effects of cold on murine brain mitochondrial function. PLoS One 13:e0208453.LEAK
OXPHOS
ET
N
S
CIV
ROX
Permeabilized tissueMouseNervous system
Astrakhanova 2018 Sovrem Tekhnologii Med2018Astrakhanova ТА, Urazov МD, Usenko АV, Mitroshina ЕV, Mishchenko ТА, Schelchkova NА, Vedunova МV (2018) BDNF-mediated regulation of the brain mitochondria functional state in hypoxia. Sovrem Tekhnologii Med 10:88-94.OXPHOS
LEAK
N
S
Isolated mitochondriaMouseNervous system
Jelenik 2018 Mol Metab2018Jelenik T, Dille M, Müller-Lühlhoff S, Kabra DG, Zhou Z, Binsch C, Hartwig S, Lehr S, Chadt A, Peters EMJ, Kruse J, Roden M, Al-Hasani H, Castañeda TR (2018) FGF21 regulates insulin sensitivity following long-term chronic stress. Mol Metab 16:126-38.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueMouseSkeletal muscle
Francisco 2018 J Neurochem2018Francisco A, Ronchi JA, Navarro CDC, Figueira TR, Castilho RF (2018) Nicotinamide nucleotide transhydrogenase is required for brain mitochondrial redox balance under hampered energy substrate metabolism and high-fat diet. J Neurochem 147:663-77.LEAK
OXPHOS
NIsolated mitochondriaMouseNervous system
Leckey 2018 FASEB J2018Leckey JJ, Hoffman NJ, Parr EB, Devlin BL, Trewin AJ, Stepto NK, Morton JP, Burke LM, Hawley JA (2018) High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB J 32:2979-91.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Toledo 2018 Obesity (Silver Spring)2018Toledo FGS, Dubé JJ, Goodpaster BH, Stefanovic-Racic M, Coen PM, DeLany JP (2018) Mitochondrial respiration is associated with lower energy expenditure and lower aerobic capacity in African American women. Obesity (Silver Spring) 26:903-9.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Singh 2018 Arch Toxicol2018Singh F, Zoll J, Duthaler U, Charles AL, Panajatovic MV, Laverny G, McWilliams TG, Metzger D, Geny B, Krähenbühl S, Bouitbir J (2018) PGC-1β modulates statin-associated myotoxicity in mice. Arch Toxicol 93:487-504.OXPHOS
LEAK
N
S
NS
Permeabilized tissueMouseSkeletal muscle
Stepanova 2018 J Neurochem2018Stepanova A, Konrad C, Manfredi G, Springett R, Ten V, Galkin A (2018) The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A. J Neurochem 148:731-45.LEAK
OXPHOS
N
S
Gp
NS
ROX
Isolated mitochondriaMouseNervous system
Kovalcikova 2018 Thesis2018Kovalčíková J (2018) Functional characterisation of new components of mitochondrial proteome. PhD Thesis p104.LEAK
OXPHOS
ET
N
NS
HomogenateMouse
Rat
Heart
Liver
Kamunde 2018 Free Radic Biol Med2018Kamunde C, Sharaf M, MacDonald N (2018) H2O2 metabolism in liver and heart mitochondria: Low emitting-high scavenging and high emitting-low scavenging systems. Free Radic Biol Med 124:135-48.LEAKN
ROX
Isolated mitochondriaFishesHeart
Liver
Briones-Herrera 2018 Food Chem Toxicol2018Briones-Herrera A, Avila-Rojas SH, Aparicio-Trejo OE, Cristóbal M, León-Contreras JC, Hernández-Pando R, Pinzón E, Pedraza-Chaverri J, Sánchez-Lozada LG, Tapia E (2018) Sulforaphane prevents maleic acid-induced nephropathy by modulating renal hemodynamics, mitochondrial bioenergetics and oxidative stress. Food Chem Toxicol 115:185-97.LEAK
OXPHOS
N
NS
S
Isolated mitochondriaRatKidney
Tetri 2018 Front Physiol2018Tetri LH, Diffee GM, Barton GP, Braun RK, Yoder HE, Haraldsdottir K, Eldridge MW, Goss KN (2018) Sex-specific skeletal muscle fatigability and decreased mitochondrial oxidative capacity in adult rats exposed to postnatal hyperoxia. Front Physiol 9:326.LEAK
OXPHOS
ET
N
S
CIV
ROX
Permeabilized tissueRatSkeletal muscle
Falcao-Tebas 2018 J Physiol2018Falcão-Tebas F, Kuang J, Arceri C, Kerris JP, Andrikopoulos S, Marin EC, McConell GK (2018) Four weeks of exercise early in life reprograms adult skeletal muscle insulin resistance caused by paternal high fat diet. J Physiol 597:121-36.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueRatSkeletal muscle
Hecker 2018 Biochim Biophys Acta2018Hecker M, Sommer N, Foch S, Hecker A, Hackstein H, Witzenrath M, Weissmann N, Seeger W, Mayer K (2018) Resolvin E1 and its precursor 18R-HEPE restore mitochondrial function in inflammation. Biochim Biophys Acta 1863:1016-28.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Jang 2018 J Med Toxicol2018Jang DH, Khatri UG, Mudan A, Love JS, Owiredu S, Eckmann DM (2018) Translational application of measuring mitochondrial functions in blood cells obtained from patients with acute poisoning. J Med Toxicol 14:144-51.LEAK
ROUTINE
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Lymphocyte
Scheiber 2018 J Cardiovasc Transl Res2018Scheiber D, Zweck E, Jelenik T, Horn P, Albermann S, Masyuk M, Boeken U, Saeed D, Kelm M Roden M, Szendroedi J, Westenfeld R (2018) Reduced myocardial mitochondrial ROS production in mechanically unloaded hearts. J Cardiovasc Transl Res 12:107-15.LEAK
OXPHOS
ET
F
N
NS
ROX
Permeabilized tissueHumanHeart
Park 2018 J Clin Invest2018Park H, He A, Tan M, Johnson JM, Dean JM, Pietka TA, Chen Y, Zhang X, Hsu FF, Razani B, Funai K, Lodhi IJ (2018) Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission. J Clin Invest 129:694-711.OXPHOS
ET
LEAK
F
N
S
Permeabilized tissueMouseFat
Gao 2018 Free Radic Biol Med2018Gao JL, Zhao J, Zhu HB, Peng X, Zhu JX, Ma MH, Fu Y, Hu N, Tai Y, Xuan XC, Dong DL (2018) Characterizations of mitochondrial uncoupling induced by chemical mitochondrial uncouplers in cardiomyocytes. Free Radic Biol Med 124:288-98.LEAK
ROUTINE
ET
ROXIntact cellsRatHeart
Keller 2018 Oxid Med Cell Longev2018Keller AC, Knaub LA, Scalzo RL, Hull SE, Johnston AE, Walker LA, Reusch JEB (2018) Sepiapterin improves vascular reactivity and insulin-stimulated glucose in wistar rats. Oxid Med Cell Longev 2018:7363485.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueRatEndothelial;epithelial;mesothelial cell
Woodman 2018 FASEB J2018Woodman AG, Mah R, Keddie D, Noble RMN, Panahi S, Gragasin FS, Lemieux H, Bourque SL (2018) Prenatal iron deficiency causes sex-dependent mitochondrial dysfunction and oxidative stress in fetal rat kidneys and liver. FASEB J 32:3254-63.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenateRatLiver
Kidney
Komlodi 2018 Methods Mol Biol2018Komlodi T, Sobotka O, Krumschnabel G, Bezuidenhout N, Hiller E, Doerrier C, Gnaiger E (2018) Comparison of mitochondrial incubation media for measurement of respiration and hydrogen peroxide production. Methods Mol Biol 1782:137-55.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Human
Mouse
Skeletal muscle
HEK
Einer 2018 Cell Mol Gastroenterol Hepatol2018Einer C, Leitzinger C, Lichtmannegger J, Eberhagen C, Rieder T, Borchard S, Wimmer R, Denk G, Popper B, Neff F, Polishchuk EV, Polishchuk RS, Hauck SM, von Toerne C, Müller JC, Karst U, Baral BS, DiSpirito AA, Kremer AE, Semrau J, Weiss KH, Hohenester S, Zischka H (2018) A high calorie diet aggravates mitochondrial dysfunction and triggers severe liver damage in Wilson disease rats. Cell Mol Gastroenterol Hepatol 7:571-96.LEAK
OXPHOS
ET
SIsolated mitochondriaRatLiver
Musi 2018 Aging Cell2018Musi N, Valentine JM, Sickora KR, Baeuerle E, Thompson CS, Shen Q, Orr ME (2018) Tau protein aggregation is associated with cellular senescence in the brain. Aging Cell 17:e12840.LEAK
OXPHOS
ET
F
N
S
NS
HomogenateMouseNervous system
Zhang 2018 Aging Dis2018Zhang L, Hao J, Zheng Y, Su R, Liao Y, Gong X, Liu L, Wang X (2018) Fucoidan protects dopaminergic neurons by enhancing the mitochondrial function in a rotenone-induced rat model of Parkinson’s disease. Aging Dis 9:590-604.LEAK
OXPHOS
ET
N
S
ROX
Permeabilized tissue
Homogenate
RatNervous system
Coleman 2018 Sci Rep2018Coleman V, Sa-Nguanmoo P, Koenig J, Schulz TJ, Grune T, Klaus S, Kipp AP, Ost M (2018) Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling. Sci Rep 8:2446.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Lee 2018 Reprod Sci2018Lee HC, Lin SC, Wu MH, Tsai SJ (2018) Induction of pyruvate dehydrogenase kinase 1 by hypoxia alters cellular metabolism and inhibits apoptosis in endometriotic stromal cells. Reprod Sci [Epub ahead of print].LEAK
ROUTINE
ROXIntact cellsHumanGenital
Doucet 2018 Mol Pharmacol2018Doucet MS, Jougleux JL, Poirier SJ, Cormier M, Leger JL, Surette ME, Pichaud N, Touaibia M, Boudreau LH (2018) Identification of peracetylated quercetin as a selective 12-lipoxygenase pathway inhibitor in human platelets. Mol Pharmacol 95:139-50.LEAK
ROUTINE
ET
ROXIntact cellsHumanPlatelet
Fuhrmann 2018 Cell Mol Life Sci2018Fuhrmann DC, Wittig I, Dröse S, Schmid T, Dehne N, Brüne B (2018) Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia. Cell Mol Life Sci 75:3051-67.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Isolated mitochondria
Intact cells
Human
Aparicio-Trejo 2018 Free Radic Biol Med2018Aparicio-Trejo OE, Reyes-Fermín LM, Briones-Herrera A, Tapia E, León-Contreras JC, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2018) Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid. Free Radic Biol Med 130:379-96.LEAK
OXPHOS
N
S
NS
ROX
Intact cells
Isolated mitochondria
RatKidney
Boeck 2018 Sci Rep2018Boeck C, Salinas-Manrique J, Calzia E, Radermacher P, von Arnim CAF, Dietrich DE, Kolassa IT, Karabatsiakis A (2018) Targeting the association between telomere length and immunocellular bioenergetics in female patients with Major Depressive Disorder. Sci Rep 8:9419.LEAK
ROUTINE
ET
N
ROX
Intact cellsHumanBlood cells
Treberg 2018 Comp Biochem Physiol B Biochem Mol Biol2018Treberg JR, Braun K, Zacharias P, Kroeker K (2018) Multidimensional mitochondrial energetics: Application to the study of electron leak and hydrogen peroxide metabolism. Comp Biochem Physiol B Biochem Mol Biol 224:121-28.LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaMouse
Rat
Skeletal muscle
Zhang 2018 J Gerontol A Biol Sci Med Sci2018Zhang X, Trevino MB, Wang M, Gardell SJ, Ayala JE, Han X, Kelly DP, Goodpaster BH, Vega RB, Coen PM (2018) Impaired mitochondrial energetics characterize poor early recovery of muscle mass following hind limb unloading in old mice. J Gerontol A Biol Sci Med Sci 73:1313-22.LEAK
OXPHOS
F
N
NS
MouseSkeletal muscle
Burstein 2018 Hum Mol Genet2018Burstein SR, Valsecchi F, Kawamata H, Bourens M, Zeng R, Zuberi A, Milner TA, Cloonan SM, Lutz C, Barrientos A, Manfredi G (2018) In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions. Hum Mol Genet 27:160-77.LEAK
OXPHOS
ET
N
CIV
Isolated mitochondria
Intact cells
Human
Mouse
Heart
Skeletal muscle
Nervous system
HEK
Harmuth 2018 Front Mol Neurosci2018Harmuth T, Prell-Schicker C, Weber JJ, Gellerich F, Funke C, Drießen S, Magg JCD, Krebiehl G, Wolburg H, Hayer SN, Hauser S, Krüger R, Schöls L, Riess O, Hübener-Schmid J (2018) Mitochondrial morphology, function and homeostasis are impaired by expression of an N-terminal calpain cleavage fragment of Ataxin-3. Front Mol Neurosci 11:368.LEAK
ET
ROUTINE
OXPHOS
N
S
Homogenate
Intact cells
MouseFibroblast
Paech 2018b Toxicology2018Paech F, Abegg VF, Duthaler U, Terracciano L, Bouitbir J, Krähenbühl S (2018) Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice. Toxicology 409:13-23.LEAK
OXPHOS
ET
N
S
DQ
CIV
ROX
NS
Isolated mitochondriaMouseLiver
Houghton 2018 Free Radic Biol Med2018Houghton MJ, Kerimi A, Tumova S, Boyle JP, Williamson G (2018) Quercetin preserves redox status and stimulates mitochondrial function in metabolically-stressed HepG2 cells. Free Radic Biol Med 129:296-309.LEAK
ROUTINE
ET
ROXIntact cellsHumanLiver
Lund 2018 Acta Physiol (Oxf)2018Lund MT, Larsen S, Hansen M, Courraud J, Floyd AK, Støckel M, Helge JW, Dela F (2018) Mitochondrial respiratory capacity remains stable despite a comprehensive and sustained increase in insulin sensitivity in obese patients undergoing gastric bypass surgery. Acta Physiol (Oxf) 223:e13032.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Cree-Green 2018 Diabetes2018Cree-Green M, Scalzo RL, Harrall K, Newcomer BR, Schauer IE, Huebschmann AG, McMillin S, Brown MS, Orlicky D, Knaub L, Nadeau KJ, Mcclatchey PM, Bauer TA, Regensteiner JG, Reusch JEB (2018) Supplemental oxygen improves in-vivo mitochondrial oxidative phosphorylation flux in sedentary obese adults with type 2 diabetes. Diabetes 67:1369-79.ET
LEAK
OXPHOS
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Cardinale 2018 Thesis2018Cardinale DA (2018) The significance of mitochondrial respiratory function in regulating oxygen uptake and performance in humans. PhD Thesis 99.LEAK
OXPHOS
F
N
NS
Isolated mitochondria
Permeabilized tissue
HumanSkeletal muscle
Campbell 2018 Free Radic Biol Med2018Campbell MD, Duan J, Samuelson AT, Gaffrey MJ, Wang L, Bammler TK, Moore RJ, White CC, Kavanagh TJ, Voss JG, Szeto HH, Rabinovitch PS, Qian WJ, Marcinek DJ (2018) Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice. Free Radic Biol Med 134:268-81.LEAK
OXPHOS
CIV
N
NS
ROX
S
Permeabilized tissueMouseSkeletal muscle
Karlsson 2018 J Neurotrauma2018Karlsson M, Pukenas B, Chawla S, Ehinger JK, Plyler R, Stolow M, Gabello M, Hugerth M, Elmér E, Hansson MJ, Margulies S, Kilbaugh T (2018) Neuroprotective effects of cyclosporine in a porcine pre-clinical trial of focal traumatic brain injury. J Neurotrauma [Epub ahead of print].LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
HomogenatePigNervous system
Van Den Brink 2018 PLoS Genet2018Van Den Brink DM, Cubizolle A, Chatelain G, Davoust N, Girard V, Johansen S, Napoletano F, Dourlen P, Guillou L, Angebault-Prouteau C, Bernoud-Hubac N, Guichardant M, Brabet P, Mollereau B (2018) Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina. PLoS Genet 14:e1007627.LEAK
OXPHOS
F
N
S
NS
Permeabilized cellsMouseEndothelial;epithelial;mesothelial cell
Fernandes-Siqueira 2018 mSphere2018Fernandes-Siqueira LO, Zeidler JD, Sousa BG, Ferreira T, Da Poian AT (2018) Anaplerotic role of glucose in the oxidation of endogenous fatty acids during Dengue virus infection. mSphere 3.pii: e00458-17.LEAK
ET
F
ROX
Intact cellsHumanLiver
Other cell lines
Ravasz 2018 Biochim Biophys Acta2018Ravasz D, Kacso G, Fodor V, Horvath K, Adam-Vizi V, Chinopoulos C (2018) Reduction of 2-methoxy-1,4-naphtoquinone by mitochondrially-localized Nqo1 yielding NAD+ supports substrate-level phosphorylation during respiratory inhibition. Biochim Biophys Acta 1859:909-24.LEAK
OXPHOS
F
N
DQ
Isolated mitochondriaMouseLiver
Petiz 2018 Chem Biol Interact2018Petiz LL, Pires ADRA, Echevarria A, Rodrigues-Santos CE, Eliane Merlin Rocha M, Acco A, Cadena SMSC (2018) Effects of a new antiprotozoal drug, N,N'-diphenyl-4-methoxy-benzamidine, on energy-linked functions of rat liver mitochondria. Chem Biol Interact 279:34-42.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaRatLiver
Groennebaek 2018 Front Physiol2018Groennebaek T, Jespersen NR, Jakobsgaard JE, Sieljacks P, Wang J, Rindom E, Musci RV, Bøtker HE, Hamilton KL, Miller BF, de Paoli FV, Vissing K (2018) Skeletal muscle mitochondrial protein synthesis and respiration increase with low-load blood flow restricted as well as high-load resistance training. Front Physiol 9:1796.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Reyes 2018 EMBO Mol Med2018Reyes A, Melchionda L, Burlina A, Robinson AJ, Ghezzi D, Zeviani M (2018) Mutations in TIMM50 compromise cell survival in OxPhos-dependent metabolic conditions. EMBO Mol Med 10:e8698.LEAK
ET
ROXIntact cellsHumanFibroblast
Scaini 2018 Eur Neuropsychopharmacol2018Scaini G, Quevedo J, Velligan D, Roberts DL, Raventos H, Walss-Bass C (2018) Second generation antipsychotic-induced mitochondrial alterations: Implications for increased risk of metabolic syndrome in patients with schizophrenia. Eur Neuropsychopharmacol 28:369-80.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsHumanOther cell lines
Lymphocyte
Rivas 2018 Am J Physiol Endocrinol Metab2018Rivas E, Herndon DN, Porter C, Meyer W, Suman OE. (2018) Short-term metformin and exercise training effects on strength, aerobic capacity, glycemic control, and mitochondrial function in children with burn injury.. Am J Physiol Endocrinol Metab. 314(3):E232-E240.LEAK
OXPHOS
Permeabilized tissueHumanSkeletal muscle
Banerjee 2018 Stem Cells Int2018Banerjee A, Lindenmair A, Steinborn R, Dumitrescu SD, Hennerbichler S, Kozlov AV, Redl H, Wolbank S, Weidinger A (2018) Oxygen tension strongly influences metabolic parameters and the release of interleukine-6 of human amniotic mesenchymal stromal cells in vitro. Stem Cells Int 2018:9502451.LEAK
ROUTINE
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Genital
Schiffer 2018 PLoS One2018Schiffer TA, Christensen M, Gustafsson H, Palm F (2018) The effect of inactin on kidney mitochondrial function and production of reactive oxygen species. PLoS One 13:e0207728.LEAK
OXPHOS
N
NS
Isolated mitochondriaRatKidney
Barca 2018 Hum Mol Genet2018Barca E, Ganetzky RD, Potluri P, Juanola-Falgarona M, Gai X, Li D, Jalas C, Hirsch Y, Emmanuele V, Tadesse S, Ziosi M, Akman HO, Chung WK, Tanji K, McCormick E, Place E, Consugar M, Pierce EA, Hakonarson H, Wallace DC, Hirano M, Falk MJ (2018) USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and ATP synthesis. Hum Mol Genet 27:3305-12.LEAK
ROUTINE
OXPHOS
ET
F
N
S
DQ
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Christen 2018 Free Radic Biol Med2018Christen F, Desrosiers V, Dupont-Cyr BA, Vandenberg GW, Le François NR, Tardif JC, Dufresne F, Lamarre SG, Blier PU (2018) Thermal tolerance and thermal sensitivity of heart mitochondria: Mitochondrial integrity and ROS production. Free Radic Biol Med 116:11-8.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaFishesHeart
Ahn 2018 Redox Biol2018Ahn B, Pharaoh G, Premkumar P, Huseman K, Ranjit R, Kinter M, Szweda L, Kiss T, Fulop G, Tarantini S, Csiszar A, Ungvari Z, Van Remmen H (2018) Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass. Redox Biol 17:47-58.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Niu 2018 Cancer Metab2018Niu X, Chen YJ, Crawford PA, Patti GJ (2018) Transport-exclusion pharmacology to localize lactate dehydrogenase activity within cells. Cancer Metab 6:19.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaHumanHeLa
Scalzo 2018 Physiol Rep2018Scalzo RL, Knaub LA, Hull SE, Keller AC, Hunter K, Walker LA, Reusch JEB (2018) Glucagon-like peptide-1 receptor antagonism impairs basal exercise capacity and vascular adaptation to aerobic exercise training in rats. Physiol Rep 6:e13754.LEAK
OXPHOS
ET
F
NS
Other combinations
Permeabilized tissueRatHeart
Wang 2018 Cell Physiol Biochem2018Wang P, Hu Y, Yao D, Li Y (2018) Omi/HtrA2 regulates a aitochondria-dependent apoptotic pathway in a murine model of septic encephalopathy. Cell Physiol Biochem 49:2163-73.LEAK
OXPHOS
N
S
CIV
RatNervous system
Martinez 2018 Arch Biochem Biophys2018Martínez JH, Fuentes F, Vanasco V, Alvarez S, Alaimo A, Cassina A, Coluccio Leskow F, Velazquez F (2018) Alpha-synuclein mitochondrial interaction leads to irreversible translocation and complex I impairment. Arch Biochem Biophys 651:1-12.ET
LEAK
OXPHOS
N
ROX
S
Isolated mitochondriaRatNervous system
Davis 2018 FASEB J2018Davis RAH, Deemer SE, Bergeron JM, Little JT, Warren JL, Fisher G, Smith DL Jr, Fontaine KR, Dickinson SL, Allison DB, Plaisance EP (2018) Dietary R, S-1,3-butanediol diacetoacetate reduces body weight and adiposity in obese mice fed a high-fat diet. FASEB J 33:2409-21.LEAK
OXPHOS
N
NS
Permeabilized tissueMouseSkeletal muscle
Cooper 2018 Exp Physiol2018Cooper MA, McCoin C, Pei D, Thyfault JP, Koestler D, Wright DE (2018) Reduced mitochondrial reactive oxygen species production in peripheral nerves of mice fed a ketogenic diet. Exp Physiol 103:1206-12.OXPHOS
ET
LEAK
F
N
NS
Permeabilized tissueMouseNervous system
Bricambert 2018 Nat Commun2018Bricambert J, Alves-Guerra MC, Esteves P, Prip-Buus C, Bertrand-Michel J, Guillou H, Chang CJ, Vander Wal MN, Canonne-Hergaux F, Mathurin P, Raverdy V, Pattou F, Girard J, Postic C, Dentin R (2018) The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity. Nat Commun 9:2092.ET
LEAK
OXPHOS
N
S
HomogenateMouseLiver
Thrush 2018 Int J Obes (Lond)2018Thrush AB, Antoun G, Nikpay M, Patten DA, DeVlugt C, Mauger JF, Beauchamp BL, Lau P, Reshke R, Doucet É, Imbeault P, Boushel R, Gibbings D, Hager J, Valsesia A, Slack R, Al-Dirbashi OY, Dent R, McPherson R, Harper ME (2018) Diet-resistant obesity is characterized by a distinct plasma proteomic signature and impaired muscle fiber metabolism. Int J Obes (Lond) 42:353-62.LEAK
OXPHOS
ET
F
N
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Larsen 2018 Physiol Rep2018Larsen S, Lundby AM, Dandanell S, Oberholzer L, Keiser S, Andersen AB, Haider T, Lundby C (2018) Four days of bed rest increases intrinsic mitochondrial respiratory capacity in young healthy males. Physiol Rep 6:e13793.OXPHOS
ET
LEAK
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Machado-Neto 2018 Cell Death Dis2018Machado-Neto JA, Fenerich BA, Scopim-Ribeiro R, Eide CA, Coelho-Silva JL, Dechandt CRP, Fernandes JC, Rodrigues Alves APN, Scheucher PS, Simões BP, Alberici LC, de Figueiredo Pontes LL, Tognon CE, Druker BJ, Rego EM, Traina F (2018) Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms. Cell Death Dis 9:311.LEAK
ROUTINE
ET
ROXIntact cellsHuman
Mouse
Other cell lines
Champigny 2018 Mar Drugs2018Champigny CM, Cormier RPJ, Simard CJ, St-Coeur PD, Fortin S, Pichaud N (2018) Omega-3 monoacylglyceride effects on longevity, mitochondrial metabolism and oxidative stress: insights from Drosophila melanogaster. Mar Drugs 16:E453.LEAK
OXPHOS
ET
N
S
NS
ROX
Gp
Permeabilized tissueDrosophila
Pileggi 2018 Free Radic Biol Med2018Pileggi CA, Hedges CP, D'Souza RF, Durainayagam BR, Markworth JF, Hickey AJR, Mitchell CJ, Cameron-Smith D (2018) Exercise recovery increases skeletal muscle H2O2 emission and mitochondrial respiratory capacity following two-weeks of limb immobilization. Free Radic Biol Med 124:241-8.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Kjeld 2018 PLoS One2018Kjeld T, Stride N, Gudiksen A, Hansen EG, Arendrup HC, Horstmann PF, Zerahn B, Jensen LT, Nordsborg N, Bejder J, Halling JF (2018) Oxygen conserving mitochondrial adaptations in the skeletal muscles of breath hold divers. PLoS One 13:e0201401.OXPHOS
ET
LEAK
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Chabi 2018 J Bioenerg Biomembr2018Chabi B, Fouret G, Lecomte J, Cortade F, Pessemesse L, Baati N, Coudray C, Lin L, Tong Q, Wrutniak-Cabello C, Casas F, Feillet-Coudray C (2018) Skeletal muscle overexpression of short isoform Sirt3 altered mitochondrial cardiolipin content and fatty acid composition. J Bioenerg Biomembr 50:131-42.LEAK
OXPHOS
N
S
CIV
NS
Homogenate
Isolated mitochondria
MouseSkeletal muscle
Warnsmann 2018 Mech Ageing Dev2018Warnsmann V, Meyer N, Hamann A, Kögel D, Osiewacz HD (2018) A novel role of the mitochondrial permeability transition pore in (-)-gossypol-induced mitochondrial dysfunction. Mech Ageing Dev 170:45-58.LEAK
OXPHOS
ET
NIsolated mitochondriaFungi
Goncalves 2018 Life Sci2018Gonçalves DF, de Carvalho NR, Leite MB, Courtes AA, Hartmann DD, Stefanello ST, da Silva IK, Franco JL, Soares FAA, Dalla Corte CL (2018) Caffeine and acetaminophen association: Effects on mitochondrial bioenergetics. Life Sci 193:234-41.LEAK
OXPHOS
N
S
NS
ROX
HomogenateMouseLiver
Konopka 2018 Aging Cell2018Konopka AR, Laurin JL, Schoenberg HM, Reid JJ, Castor WM, Wolff CA, Musci RV, Safairad OD, Linden MA, Biela LM, Bailey SM, Hamilton KL, Miller BF (2018) Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults. Aging Cell 18:e12880.ET
LEAK
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueHumanSkeletal muscle
Tai 2018 Acta Pharm Sin B2018Tai Y, Li L, Peng X, Zhu J, Mao X, Qin N, Ma M, Huo R, Bai Y, Dong D (2018) Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells. Acta Pharm Sin B 8:909-18.LEAK
ET
ROXIntact cellsMouseEndothelial;epithelial;mesothelial cell
Dandanell 2018 Scand J Med Sci Sports2018Dandanell S, Meinild-Lundby AK, Andersen AB, Lang PF, Oberholzer L, Keiser S, Robach P, Larsen S, Rønnestad BR, Lundby C (2018) Determinants of maximal whole-body fat oxidation in elite cross-country skiers: role of skeletal muscle mitochondria. Scand J Med Sci Sports 28:2494-504.LEAK
OXPHOS
ET
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Smenes 2018 Interact Cardiovasc Thorac Surg2018Smenes BT, Bækkerud FH, Slagsvold KH, Hassel E, Wohlwend M, Pinho M, Høydal M, Wisløff U, Rognmo Ø, Wahba A (2018) Acute exercise is not cardioprotective and may induce apoptotic signalling in heart surgery: a randomized controlled trial. Interact Cardiovasc Thorac Surg 27:95-101.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanHeart
Boutoual 2018 Scientific Reports2018Boutoual, R., Meseguer, S., Villarroya, M., Martin-Hernandez, E., Errami, M., Martin, M. A., Casado, M., and Armengod, M. E. (2018) Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARgamma-UCP2-AMPK axis. Scientific reports 8, 1163LEAK
ROUTINE
OXPHOS
ET
F
S
Gp
Permeabilized cells
Intact cells
HumanOther cell lines
Fibroblast
Goncalves 2018 Neurotoxicology2018Gonçalves DF, Courtes AA, Hartmann DD, da Rosa PC, Oliveira DM, Soares FAA, Dalla Corte CL (2018) 6-Hydroxydopamine induces different mitochondrial bioenergetics response in brain regions of rat. Neurotoxicology 70:1-11.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueRatNervous system
Burney 2018 Thesis2018Burney E (2018) Characterization of mitochondrial metabolism in L6 rat myoblasts. Bachelor's Thesis p50.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
NS
Other combinations
ROX
Permeabilized cells
Intact cells
RatOther cell lines
Angebault 2018 Sci Signal2018Angebault C, Fauconnier J, Patergnani S, Rieusset J, Danese A, Affortit CA, Jagodzinska J, Mégy C, Quiles M, Cazevieille C, Korchagina J, Bonnet-Wersinger D, Milea D, Hamel C, Pinton P, Thiry M, Lacampagne A, Delprat B, Delettre C (2018) ER-mitochondria cross-talk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome. Sci Signal 11:eaaq1380.LEAK
OXPHOS
N
S
NS
Permeabilized cellsHumanFibroblast
Zhou 2018 Cell Death Dis2018Zhou C, Sun H, Zheng C, Gao J, Fu Q, Hu N, Shao X, Zhou Y, Xiong J, Nie K, Zhou H, Shen L, Fang H, Lyu J (2018) Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth. Cell Death Dis 9:161.LEAK
ROUTINE
ROXIntact cellsHumanIslet cell;pancreas;thymus
Other cell lines
Gonzalez-Freire 2018 Aging Cell2018Gonzalez-Freire M, Scalzo P, D'Agostino J, Moore ZA, Diaz-Ruiz A, Fabbri E, Zane A, Chen B, Becker KG, Lehrmann E, Zukley L, Chia CW, Tanaka T, Coen PM, Bernier M, de Cabo R, Ferrucci L (2018) Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: the Baltimore longitudinal study of aging. Aging Cell 17.LEAK
OXPHOS
NSPermeabilized tissueHumanSkeletal muscle
MacMillan-Crow 2018 Intern Med Rev (Wash D C)2018MacMillan-Crow LA, Mayeux PR (2018) Female mice exhibit less renal mitochondrial injury but greater mortality using a comorbid model of experimental sepsis. Intern Med Rev (Wash D C) 4.OXPHOS
LEAK
N
S
ROX
Permeabilized tissueMouseKidney
Dogan 2018 Cell Metab2018Dogan SA, Cerutti R, Benincá C, Brea-Calvo G, Jacobs HT, Zeviani M, Szibor M, Viscomi C (2018) Perturbed redox signaling exacerbates a mitochondrial myopathy. Cell Metab 28:764-77.LEAK
OXPHOS
N
S
CIV
ROX
Isolated mitochondriaMouseSkeletal muscle
Clere-Jehl 2018 Shock2018Clere-Jehl R, Helms J, Kassem M, Le Borgne P, Delabranche X, Charles AL, Geny B, Meziani F, Bilbault P (2018) Septic shock alters mitochondrial respiration of lymphoid cell-lines and human peripheral blood mononuclear cells: the role of plasma. Shock 51:97-104.LEAK
ROUTINE
ET
Intact cellsHumanBlood cells
Fisher-Wellman 2018 Cell Rep2018Fisher-Wellman KH, Davidson MT, Narowski TM, Lin CT, Koves TR, Muoio DM (2018) Mitochondrial diagnostics: A multiplexed assay platform for comprehensive assessment of mitochondrial energy fluxes. Cell Rep 24:3593-606.LEAK
OXPHOS
F
N
S
Isolated mitochondriaMouseHeart
Skeletal muscle
Remor 2018 Mol Neurobiol2018Remor AP, da Silva RA, de Matos FJ, Glaser V, de Paula Martins R, Ghisoni K, da Luz Scheffer D, Andia DC, Portinho D, de Souza AP, de Oliveira PA, Prediger RD, Torres AI, Linhares RMM, Walz R, Ronsoni MF, Hohl A, Rafacho A, Aguiar AS Jr, De Paul AL, Latini A (2018) Chronic metabolic derangement-induced cognitive deficits and neurotoxicity are associated with REST inactivation. Mol Neurobiol 56:1539-57.LEAK
OXPHOS
NIntact cellsRatNervous system
Lander 2018 J Biol Chem2018Lander N, Chiurillo MA, Bertolini MS, Storey M, Vercesi AE, Docampo R (2018) Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity of Trypanosoma cruzi. J Biol Chem 293:17402-17.LEAK
OXPHOS
ET
N
S
Permeabilized cellsProtists
Banerjee 2018 Cell Transplant2018Banerjee A*, Lindenmair A, Hennerbichler S, Steindorf P, Steinborn R, Kozlov AV, Redl H, Wolbank S, Weidinger A (2018) Cellular and site-specific mitochondrial characterization of vital human amniotic membrane. Cell Transplant 27:3-11.LEAK
ROUTINE
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Genital
Treberg 2018 Redox Biol2018Treberg JR, Braun K, Selseleh P (2018) Mitochondria can act as energy-sensing regulators of hydrogen peroxide availability. Redox Biol 20:483-88.LEAK
OXPHOS
ET
SIsolated mitochondriaRatSkeletal muscle
Hayward 2018 Thesis2018Hayward L (2018) The effect of anoxia on mitochondrial function in a hibernator (Ictidomys tridecemlineatus). Master's Thesis 57.OXPHOS
LEAK
N
NS
Isolated mitochondriaOther mammalsLiver
Casal 2018 J Anim Sci2018Casal A, Garcia-Roche M, Navajas EA, Cassina A, Carriquiry M (2018) Hepatic mitochondrial function in Hereford steers with divergent residual feed intake phenotypes. J Anim Sci 96:4431-43.LEAK
OXPHOS
ET
N
S
ROX
Intact cellsBovinesLiver
Alston 2018 Am J Hum Genet2018Alston CL, Heidler J, Dibley MG, Kremer LS, Taylor LS, Fratter C, French CE, Glasgow RIC, Feichtinger RG, Delon I, Pagnamenta AT, Dolling H, Lemonde H, Aiton N, Bjørnstad A, Henneke L, Gärtner J, Thiele H, Tauchmannova K, Quaghebeur G, Houstek J, Sperl W, Raymond FL, Prokisch H, Mayr JA, McFarland R, Poulton J, Ryan MT, Wittig I, Henneke M, Taylor RW (2018) Bi-allelic mutations in NDUFA6 establish its role in early-onset isolated mitochondrial complex I deficiency. Am J Hum Genet 103:592-601.LEAK
ET
Intact cellsHumanFibroblast
Krug 2018 Thesis2018Krug KP (2018) Adaptation of metabolism and respiratory chain functions in pulmonary arterial vascular muscle cells under chronic hypoxia: especially considering the cytochrome c oxidase subunit 4 isoform 2. Doctoral Dissertation 136.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
ROX
Intact cells
Permeabilized cells
RatOther cell lines
Reutzel 2018 Oxid Med Cell Longev2018Reutzel M, Grewal R, Silaidos C, Zotzel J, Marx S, Tretzel J, Eckert GP (2018) Effects of long-term treatment with a blend of highly purified olive secoiridoids on cognition and brain ATP levels in aged NMRI mice. Oxid Med Cell Longev 2018:4070935.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaMouseNervous system
Ramil 2018 Thesis2018Ramil LR, Gulbinas A, Cesna V (2018) “HIPEC” hyperthermic intraperitoneal chemotherapy. Evaluation of intraperitoneal free cancer cells. Master's Thesis.OXPHOS
LEAK
N
S
Isolated mitochondriaHumanEndothelial;epithelial;mesothelial cell
Christensen 2018 Diabetes Metab Res Rev2018Christensen M, Schiffer TA, Gustafsson H, Krag SP, Nørregaard R, Palm F (2018) Metformin attenuates renal medullary hypoxia in diabetic nephropathy through uncoupling protein-2 inhibition. Diabetes Metab Res Rev 21:e3091.LEAK
OXPHOS
N
NS
Isolated mitochondriaRatKidney
Dabbaghizadeh 2018 PLOS ONE2018Dabbaghizadeh A, Morrow G, Amer YO, Chatelain EH, Pichaud N, Tanguay RM (2018) Identification of proteins interacting with the mitochondrial small heat shock protein Hsp22 of Drosophila melanogaster: Implication in mitochondrial homeostasis. PLOS ONE 13:e0193771.LEAK
ROUTINE
ET
ROXIntact cellsHumanHeLa
Pacheco-Velazquez 2018 Mol Pharm2018Pacheco-Velázquez SC, Robledo-Cadena DX, Hernández-Reséndiz I, Gallardo-Pérez JC, Moreno-Sánchez R, Rodríguez-Enríquez S (2018) Energy metabolism drugs block triple negative breast metastatic cancer cell phenotype. Mol Pharm 15:2151-64.LEAKHumanGenital
Other cell lines
De Moura Alvorcem 2018 Mitochondrion2018De Moura Alvorcem L, Britto R, Parmeggiani B, Glanzel NM, Da Rosa-Junior NT, Cecatto C, Bobermin LD, Amaral AU, Wajner M, Leipnitz G (2018) Evidence that thiol group modification and reactive oxygen species are involved in hydrogen sulfide-induced mitochondrial permeability transition pore opening in rat cerebellum. Mitochondrion 47:141-50.LEAK
OXPHOS
ET
N
S
NS
HomogenateRatNervous system
Bryant 2018 Thesis2018Bryant HJ (2018) The role of mitochondrial uncoupling in temperature responses in Atlantic killifish, Fundulus heteroclitus. Master's Thesis p126.LEAK
OXPHOS
ET
F
S
Isolated mitochondriaFishesNervous system
Liver
Fat
Jang 2018 Shock2018Jang DH, Orloski CJ, Owiredu S, Shofer FS, Greenwood JC, Eckmann DM (2018) Alterations in mitochondrial function in blood cells obtained from patients with sepsis presenting to an emergency department. Shock 51:580-84.LEAK
ROUTINE
ET
ROXHumanBlood cells
Stepanova 2018 J Cereb Blood Flow Metab2018Stepanova A, Konrad C, Guerrero-Castillo S, Manfredi G, Vannucci S, Arnold S, Galkin A (2018) Deactivation of mitochondrial complex I after hypoxia-ischemia in the immature brain. J Cereb Blood Flow Metab [Epub ahead of print].OXPHOS
ET
LEAK
N
S
ROX
Isolated mitochondriaRatNervous system
Martins 2018 Comp Biochem Physiol B Biochem Mol Biol2018Martins EL, Ricardo JC, de-Souza-Ferreira E, Camacho-Pereira J, Ramos-Filho D, Galina A (2018) Rapid regulation of substrate use for oxidative phosphorylation during a single session of high intensity interval or aerobic exercises in different rat skeletal muscles. Comp Biochem Physiol B Biochem Mol Biol 217:40-50.ET
LEAK
OXPHOS
F
N
NS
ROX
Permeabilized tissueRatSkeletal muscle
Braz-Mota 2018 Sci Total Environ2018Braz-Mota S, Campos DF, MacCormack TJ, Duarte RM, Val AL, Almeida-Val VMF (2018) Mechanisms of toxic action of copper and copper nanoparticles in two Amazon fish species: Dwarf cichlid (Apistogramma agassizii) and cardinal tetra (Paracheirodon axelrodi). Sci Total Environ 630:1168-80.LEAK
OXPHOS
ET
N
NS
ROX
FishesLung;gill
Wilmanns 2018 Mol Metab2018Wilmanns JC, Pandey R, Hon O, Chandran A, Schilling JM, Forte E, Wu Q, Cagnone G, Bais P, Philip V, Coleman D, Kocalis H, Archer SK, Pearson JT, Ramialison M, Heineke J, Patel HH, Rosenthal NA, Furtado MB, Costa MW (2018) Metformin intervention prevents cardiac dysfunction in a murine model of adult congenital heart disease. Mol Metab 20:102-14.LEAK
OXPHOS
ET
F
N
NS
ROX
Permeabilized tissueMouseHeart
Zhang 2018 Cardiovasc Diabetol2018Zhang X, Zhang Z, Yang Y, Suo Y, Liu R, Qiu J, Zhao Y, Jiang N, Liu C, Tse G, Li G, Liu T (2018) Alogliptin prevents diastolic dysfunction and preserves left ventricular mitochondrial function in diabetic rabbits. Cardiovasc Diabetol 17:160.OXPHOS
LEAK
NIsolated mitochondriaRabbitHeart
Gam 2018 Acta Diabetol2018Gam CMBF, Mortensen OH, Larsen LH, Poulsen SS, Qvortrup K, Mathiesen ER, Damm P, Quistorff B (2018) Diabetes, myometrium, and mitochondria in pregnant women at term. Acta Diabetol 55:999-1010.LEAK
OXPHOS
F
N
NS
S
Isolated mitochondriaHumanGenital
Sumbalova 2018 Recent Advances Mitochondr Med Coenzyme Q102018Sumbalová Z, Garcia-Souza LF, Cizmarova B, Volani C, Gnaiger E (2018) Analysis of mitochondrial function in human blood cells. In: Recent advances in mitochondrial medicine and Coenzyme Q10. Gvozdjáková A, Cornelissen G, Singh RB eds, Nova Sciences:255-68.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Bradley 2018 Biochim Biophys Acta2018Bradley RM, Bloemberg D, Aristizabal Henao JJ, Hashemi A, Mitchell AS, Fajardo VA, Bellissimo C, Mardian EB, Bombardier E, Paré MF, Moes KA, Stark KD, Tupling AR, Quadrilatero J, Duncan RE (2018) Lpaatδ/Agpat4 deficiency impairs maximal force contractility in soleus and alters fiber type in extensor digitorum longus muscle. Biochim Biophys Acta 1863:700-11.LEAK
OXPHOS
ET
N
S
CIV
NS
Permeabilized tissueMouseSkeletal muscle
Thompson 2018 EMBO Mol Med2018Thompson K, Mai N, Oláhová M, Scialó F, Formosa LE, Stroud DA, Garrett M, Lax NZ, Robertson FM, Jou C, Nascimento A, Ortez C, Jimenez-Mallebrera C, Hardy SA, He L, Brown GK, Marttinen P, McFarland R, Sanz A, Battersby BJ, Bonnen PE, Ryan MT, Chrzanowska-Lightowlers ZM, Lightowlers RN, Taylor RW (2018) OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect. EMBO Mol Med 10:e9060.LEAK
OXPHOS
N
CIV
ROX
Gp
Other combinations
HomogenateDrosophila
Dechandt 2018 Am J Physiol Regul Integr Comp Physiol2018Dechandt CR, Vicentini TM, Lanfredi GP, da Silva RMP Jr, Espreafico EM, de Oliveira JAC, Faça VM, Garcia-Cairasco N, Alberici LC (2018) The highly efficient power house in the Wistar Audiogenic Rat (WAR), an epileptic rat strain. Am J Physiol Regul Integr Comp Physiol 316:R243-R254.LEAK
OXPHOS
ET
N
ROX
Permeabilized tissue
Isolated mitochondria
RatHeart
Skeletal muscle
Liver
Khamoui 2018 J Dev Orig Health Dis2018Khamoui AV, Desai M, Ross MG, Rossiter HB (2018) Sex-specific effects of maternal and postweaning high-fat diet on skeletal muscle mitochondrial respiration. J Dev Orig Health Dis 16:1-8.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Song 2018 Proc Natl Acad Sci U S A2018Song E, Ramos SV, Huang X, Liu Y, Botta A, Sung HK, Turnbull PC, Wheeler MB, Berger T, Wilson DJ, Perry CGR, Mak TW, Sweeney G (2018) Holo-lipocalin-2-derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes. Proc Natl Acad Sci U S A 115:1576-81.LEAK
OXPHOS
ET
N
S
NS
Intact cellsRatHeart
Marinho 2018 Evid Based Complement Alternat Med2018Marinho PC, Vieira AB, Pereira PG, Rabelo K, Ciambarella BT, Nascimento ALR, Cortez E, Moura AS, Guimarães FV, Martins MA, Barquero G, Ferreira RN, de Carvalho JJ (2018) Capybara oil improves hepatic mitochondrial dysfunction, steatosis, and inflammation in a murine model of nonalcoholic fatty liver disease. Evid Based Complement Alternat Med 2018:4956079.LEAK
OXPHOS
Intact cellsMouseLiver
De Lima Junior 2018 EBioMedicine2018De Lima Junior JC, Souza GF, Moura-Assis A, Gaspar RS, Gaspar JM, Rocha AL, Ferrucci DL, Lima TI, Victório SC, Bonfante ILP, Cavaglieri CR, Pareja JC, Brunetto SQ, Ramos CD, Geloneze B, Mori MA, Silveira LR, Segundo GRS, Ropelle ER, Velloso LA (2018) Abnormal brown adipose tissue mitochondrial structure and function in IL10 deficiency. EBioMedicine 39:436-47.LEAK
ET
NIsolated mitochondriaMouseFat
Komlodi 2018 J Bioenerg Biomembr2018Komlódi T, Geibl FF, Sassani M, Ambrus A, Tretter L (2018) Membrane potential and delta pH dependency of reverse electron transport-associated hydrogen peroxide production in brain and heart mitochondria. J Bioenerg Biomembr 10.1007/s10863-018-9766-8.LEAKS
Gp
Isolated mitochondriaGuinea pigHeart
Nervous system
Clarke 2018 Methods Mol Biol2018Clarke KJ, Porter RK (2018) The importance of calcium ions for determining mitochondrial glycerol-3-phosphate dehydrogenase activity when measuring uncoupling protein 1 (UCP1) function in mitochondria isolated from brown adipose tissue. Methods Mol Biol 1782:325-36.LEAKS
Gp
Isolated mitochondriaRatFat
Friederich-Persson 2018 Acta Physiol (Oxf)2018Friederich-Persson M, Persson P, Hansell P, Palm F (2018) Deletion of Uncoupling Protein-2 reduces renal mitochondrial leak respiration, intrarenal hypoxia and proteinuria in a mouse model of type 1 diabetes. Acta Physiol (Oxf) 223:e13058.LEAK
OXPHOS
NIsolated mitochondriaMouseKidney
Lobo-Jarne 2018 Cell Rep2018Lobo-Jarne T, Nývltová E, Pérez-Pérez R, Timón-Gómez A, Molinié T, Choi A, Mourier A, Fontanesi F, Ugalde C, Barrientos A (2018) Human COX7A2L regulates complex III biogenesis and promotes supercomplex organization remodeling without affecting mitochondrial bioenergetics. Cell Rep 25:1786-99.LEAK
OXPHOS
ET
N
S
NS
ROX
Gp
Permeabilized cellsHumanHEK
Other cell lines
Kuehn 2018 Biochem Pharmacol2018Kühn B, Brat C, Fettel J, Hellmuth N, Maucher IV, Bulut U, Hock KJ, Grimmer J, Manolikakes G, Rühl M, Kühn A, Zacharowski K, Matrone C, Urbschat A, Roos J, Steinhilber D, Maier TJ (2018) Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells. Biochem Pharmacol 155:48-60.LEAK
ET
CIVIntact cellsHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Sant'Anna-Silva 2018 Front Oncol2018Sant'Anna-Silva ACB, Santos GC, Campos SPC, Oliveira Gomes AM, Pérez-Valencia JA, Rumjanek FD (2018) Metabolic profile of oral squamous carcinoma cell lines relies on a higher demand of lipid metabolism in metastatic cells. Front Oncol 8:13.LEAK
ROUTINE
ET
ROXIntact cellsHumanOther cell lines
Fibroblast
Becker 2018 EMBO Rep2018Becker C, Kukat A, Szczepanowska K, Hermans S, Senft K, Brandscheid CP, Maiti P, Trifunovic A (2018) CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis. EMBO Rep 19. pii: e45126.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Isolated mitochondriaMouseLiver
Fat
Wang 2018 J Nutr Biochem2018Wang Y, Fouret G, Bonafos B, Blachnio-Zabielska A, Leroy T, Crouzier D, Barea B, Gaillet S, Moro C, Lecomte J, Coudray C, Feillet-Coudray C (2018) Long-term follow-up of muscle lipid accumulation, mitochondrial activity and oxidative stress and their relationship with impaired glucose homeostasis in high fat high fructose diet-fed rats. J Nutr Biochem 64:182-97.OXPHOS
LEAK
N
NS
Isolated mitochondriaRatSkeletal muscle
Urazov 2018 Sovrem Tekhnologii Med2018Urazov MD, Astrakhanova TA, Usenko AV, Mishchenko TA, Schelchkova NA, Kravchenko GA, Vedunova MV, Mitroshina EV (2018) New aspects of central nervous system adaptation to prenatal hypoxia. Sovrem Tekhnologii Med 10:60-68.OXPHOS
LEAK
N
S
NS
Isolated mitochondriaMouseNervous system
Ounpuu 2018 Biochem Cell Biol2018Ounpuu L, Truu L, Shevchuk I, Chekulayev V, Klepinin A, Koit A, Tepp K, Puurand M, Rebane-Klemm E, Käämbre T (2018) Comparative analysis of the bioenergetics of human adenocarcinoma Caco-2 cell line and postoperative tissue samples from colorectal cancer patients. Biochem Cell Biol [Epub ahead of print].LEAK
OXPHOS
CIV
N
ROX
S
Permeabilized cellsHumanEndothelial;epithelial;mesothelial cell
Other cell lines
Haschka 2018 Mov Disord2018Haschka D, Volani C, Stefani A, Tymoszuk P, Mitterling T, Holzknecht E, Heidbreder A, Coassin S, Sumbalova Z, Seifert M, Dichtl S, Theurl I, Gnaiger E, Kronenberg F, Frauscher B, Högl B, Weiss G (2018) Association of mitochondrial iron deficiency and dysfunction with idiopathic restless legs syndrome. Mov Disord 34:114-23.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Lymphocyte
Boutoual 2018 Sci Rep2018Boutoual R, Meseguer S, Villarroya M, Martín-Hernández E, Errami M, Martín MA, Casado M, Armengod ME (2018) Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARγ-UCP2-AMPK axis. Sci Rep 8:1163.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized cells
Intact cells
HumanFibroblast
Kappler 2018 Thesis2018Kappler L (2018) Method development for valid high‐resolution profiling of mitochondria and Omics investigation of mitochondrial adaptions to excess energy intake and physical exercise. Dissertation p181.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Skeletal muscle
Liver
Other cell lines
Hedges 2018 FASEB J2018Hedges CP, Bishop DJ, Hickey AJR (2018) Voluntary wheel running prevents the acidosis-induced decrease in skeletal muscle mitochondrial reactive oxygen species emission. FASEB J 33:4996-5004.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized tissueRatSkeletal muscle
Liu 2018 J Periodontol2018Liu J, Zeng J, Wang X, Zheng M, Luan Q (2018) P53 mediates lipopolysaccharide-induced inflammation in human gingival fibroblasts. J Periodontol 89:1142-51.LEAK
ET
ROXIntact cellsHumanFibroblast
Rocha 2018 J Physiol Biochem2018Rocha C, Koury OH, Scheede-Bergdahl C, Bergdahl A (2018) Cardiac mitochondrial respiration following a low-carbohydrate, high-fat diet in apolipoprotein E-deficient mice. J Physiol Biochem 75:65-72.LEAK
OXPHOS
ET
F
N
CIV
NS
ROX
Permeabilized tissueMouseHeart
Doerrier 2018 Methods Mol Biol2018Doerrier C, Garcia-Souza LF, Krumschnabel G, Wohlfarter Y, Mészáros AT, Gnaiger E (2018) High-Resolution FluoRespirometry and OXPHOS protocols for human cells, permeabilized fibers from small biopsies of muscle, and isolated mitochondria. Methods Mol Biol 1782:31-70.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Intact cells
Human
Mouse
Rat
Saccharomyces cerevisiae
Heart
Skeletal muscle
Endothelial;epithelial;mesothelial cell
Blood cells
HEK
Platelet
Monaco 2018 Am J Physiol Regul Integr Comp Physiol2018Monaco CMF, Miotto PM, Huber JS, van Loon LJC, Simpson JA, Holloway GP (2018) Sodium nitrate supplementation alters mitochondrial H2O2 emission but does not improve mitochondrial oxidative metabolism in the heart of healthy rats. Am J Physiol Regul Integr Comp Physiol 315:R191-R204.LEAK
OXPHOS
N
NS
Permeabilized tissue
Isolated mitochondria
RatHeart
Marie 2018 Cell Death Dis2018Marie M, Bigot K, Angebault C, Barrau C, Gondouin P, Pagan D, Fouquet S, Villette T, Sahel JA, Lenaers G, Picaud S (2018) Light action spectrum on oxidative stress and mitochondrial damage in A2E-loaded retinal pigment epithelium cells. Cell Death Dis 9:287.LEAK
OXPHOS
ET
N
S
NS
Permeabilized cellsEndothelial;epithelial;mesothelial cell
Tripodi 2018 Biochim Biophys Acta Mol Cell Res2018Tripodi F, Castoldi A, Nicastro R, Reghellin V, Lombardi L, Airoldi C, Falletta E, Maffioli E, Scarcia P, Palmieri L, Alberghina L, Agrimi G, Tedeschi G, Coccetti P (2018) Methionine supplementation stimulates mitochondrial respiration. Biochim Biophys Acta Mol Cell Res 1865:1901-13.OXPHOS
LEAK
N
S
Isolated mitochondriaSaccharomyces cerevisiae
Chen 2018 iScience2018Chen YC, Cheng TH, Lin WL, Chen CL, Yang WY, Blackstone C, Chang CR (2018) Srv2 Is a pro-fission factor that modulates yeast mitochondrial morphology and respiration by regulating actin assembly. iScience 11:305-17.LEAK
ROUTINE
ET
ROXIntact cellsSaccharomyces cerevisiae
Kriel 2018 Sci Rep2018Kriel J, Mueller-Nedebock K, Maarman G, Mbizana S, Ojuka E, Klumperman B, Loos B (2018) Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics. Sci Rep 8:10348.LEAK
OXPHOS
ET
ROUTINE
N
ROX
Permeabilized cellsHumanNervous system
Other cell lines
Garcia-Roche 2018 Redox Biol2018García-Roche M, Casal A, Carriquiry M, Radi R, Celia Quijano C, Cassina A (2018) Respiratory analysis of coupled mitochondria in cryopreserved liver biopsies. Redox Biol 17:207-12.LEAK
OXPHOS
ET
N
NS
ROX
S
Permeabilized tissueRat
Bovines
Liver
Real-Hohn 2018 bioRxiv2018Real-Hohn A, Navegantes C, Ramos K, Ramos-Filho D, Cahuê F, Galina A, Salerno V (2018) Hexokinase: a central player in the synergism of high-intensity intermittent exercise and every-other-day intermittent fasting regimen on energy metabolism adaptations. bioRxiv doi: https://doi.org/10.1101/389668.LEAK
OXPHOS
ET
N
NS
Permeabilized tissueRatSkeletal muscle
Fox 2018 Thesis2018Fox JC (2018) FROST450, a novel microtubule targeting agent: resistance and cross-resistance in an ovarian cancer cell line. Bachelor's Thesis 27.LEAK
OXPHOS
ET
N
NS
ROX
Intact cellsHumanGenital
Klepinin 2018 J Bioenerg Biomembr2018Klepinin A, Ounpuu L, Mado K, Truu L, Chekulayev V, Puurand M, Shevchuk I, Tepp K, Planken A, Kaambre T (2018) The complexity of mitochondrial outer membrane permeability and VDAC regulation by associated proteins. J Bioenerg Biomembr 50:339-54.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized cellsMouseHeart
Neuroblastoma
Jelenik 2018 Diabetes2018Jelenik T, Flögel U, Álvarez-Hernández E, Scheiber D, Zweck E, Ding Z, Rothe M, Mastrototaro L, Kohlhaas V, Kotzka J, Knebel B, Müller-Wieland D, Moellendorf S, Gödecke A, Kelm M, Westenfeld R, Roden M, Szendroedi J (2018) Insulin resistance and vulnerability to cardiac ischemia. Diabetes 67:2695-702.LEAK
OXPHOS
F
N
NS
ROX
Permeabilized tissue
Isolated mitochondria
Human
Mouse
Heart
Oemer 2018 Proc Nat Acad Sci U S A2018Oemer G, Lackner L, Muigg K, Krumschnabel G, Watschinger K, Sailer S, Lindner H, Gnaiger E, Wortmann SB, Werner ER, Zschocke J, Keller MA (2018) The molecular structural diversity of mitochondrial cardiolipins. Proc Nat Acad Sci U S A 115:4158-63.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Intact cells
Permeabilized cells
HumanHeLa
Rodrigues 2018 Free Radic Biol Med2018Rodrigues NR, Macedo GE, Martins IK, Gomes KK, de Carvalho NR, Posser T, Franco JL (2018) Short-term sleep deprivation with exposure to nocturnal light alters mitochondrial bioenergetics in Drosophila. Free Radic Biol Med 120:395-406.ET
LEAK
OXPHOS
ROUTINE
CIV
N
NS
ROX
S
Isolated mitochondriaDrosophila
Razak 2018 RUMeS2018Razak SHA, Hassan H, Hakimi NH, Rani NA, Ibrahim NF, Ngah WZW, Makpol S, Damanhuri MHA, Karim NA, Tan JK (2018) Isolation of mitochondria and measurement of oxygen consumption rate by high-resolution respirometry in rat hippocampus. RUMeS 6:11-18.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaRatNervous system
Pape 2018 Nutrients2018Pape JA, Newey CR, Burrell HR, Workman A, Perry K, Bikman BT, Bridgewater LC, Grose JH (2018) Per-Arnt-Sim kinase (PASK) deficiency increases cellular respiration on a standard diet and decreases liver triglyceride accumulation on a western high-fat high-sugar diet. Nutrients 10:1990.OXPHOS
LEAK
NSPermeabilized tissueMouseSkeletal muscle
Liver
Cunatova 2018 Thesis2018Čunátová K (2018) The role of tissue specific isoforms of subunit 4 in assembly and function of cytochrome c oxidase. PhD Thesis p107.ET
LEAK
ROUTINE
CIV
ROX
Intact cellsHumanHEK
Lo 2018 Am J Physiol Renal Physiol2018Lo S, MacMillan-Crow LA, Parajuli N (2018) Renal cold storage followed by transplantation impairs proteasome function and subsequently mitochondrial protein homeostasis. Am J Physiol Renal Physiol 316:F42-F53.OXPHOS
LEAK
N
S
ROX
Permeabilized cellsRatKidney
Other cell lines
Bhaskaran 2018 EMBO Rep2018Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS (2018) Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. EMBO Rep 19. pii: e45009.LEAK
OXPHOS
N
S
NS
MouseFat
Ziegler 2018 Cell2018Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR (2018) Mitophagy in intestinal epithelial cells triggers adaptive immunity during tumorigenesis. Cell 174:88-101.LEAK
ET
Intact cellsMouseEndothelial;epithelial;mesothelial cell
Burtscher 2018 Front Mol Neurosci2018Burtscher J, Bean C, Zangrandi L, Kmiec I, Agostinho A, Scorrano L, Gnaiger E, Schwarzer C (2018) Proenkephalin derived peptides are involved in the modulation of mitochondrial respiratory control during epileptogenesis. Front Mol Neurosci doi:10.3389/fnmol.2018.00351.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
Sprenger 2018 EMBO Mol Med2018Sprenger HG, Wani G, Hesseling A, König T, Patron M, MacVicar T, Ahola S, Wai T, Barth E, Rugarli EI, Bergami M, Langer T (2018) Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med 11:e9288.LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaMouseNervous system
Sokolov 2018 Mitochondrion2018Sokolov EP, Sokolova IM (2018) Compatible osmolytes modulate mitochondrial function in a marine osmoconformer Crassostrea gigas (Thunberg, 1793). Mitochondrion 45:29-37.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Isolated mitochondriaMolluscsLung;gill
Logan 2018 Thesis2018Logan C (2018) Nitrate and nitrite differentially affect respiration in zebrafish during exercise. Honors Baccalaureate of Science in Nutrition p44.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaZebrafishSkeletal muscle
Du 2018 Environ Sci Technol2018Du SNN, McCallum ES, Vaseghi-Shanjani M, Choi JA, Warriner TR, Balshine S, Scott GR (2018) Metabolic costs of exposure to wastewater effluent lead to compensatory adjustments in respiratory physiology in bluegill sunfish. Environ Sci Technol 52:801-11.LEAK
ET
N
S
NS
Isolated mitochondriaFishesLiver
Zimin 2018 Br J Anaesth2018Zimin PI, Woods CB, Kayser EB, Ramirez JM, Morgan PG, Sedensky MM (2018) Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I. Br J Anaesth 120:1019-32.OXPHOS
LEAK
N
S
ROX
Isolated mitochondriaMouseNervous system
Bialas 2018 Int J Chron Obstruct Pulmon Dis2018Białas AJ, Siewiera K, Watała C, Rybicka A, Grobelski B, Kośmider L, Kurek J, Miłkowska-Dymanowska J, Piotrowski WJ, Górski P (2018) Mitochondrial functioning abnormalities observed in blood platelets of chronic smoke-exposed guinea pigs – a pilot study. Int J Chron Obstruct Pulmon Dis 13:3707—17 .LEAK
ROUTINE
ET
ROXIntact cellsGuinea pigPlatelet
Gratl 2018 Thesis2018Gratl A (2018) High-resolution respirometry for measurement of mitochondrial function in PAD patients before and after revascularisation. PhD Thesis 69.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Chou 2018 Int J Cardiol2018Chou CH, Fu TC, Tsai HH, Hsu CC, Wang CH, Wang JS (2018) High-intensity interval training enhances mitochondrial bioenergetics of platelets in patients with heart failure. Int J Cardiol 274:214-20.LEAK
ROUTINE
OXPHOS
ET
F
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanPlatelet
Tsuda 2018 J Cachexia Sarcopenia Muscle2018Tsuda M, Fukushima A, Matsumoto J, Takada S, Kakutani N, Nambu H, Yamanashi K, Furihata T, Yokota T, Okita K, Kinugawa S, Anzai T (2018) Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure. J Cachexia Sarcopenia Muscle 9:844-59.OXPHOS
LEAK
F
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Rodriguez-Nuevo 2018 EMBO J2018Rodríguez-Nuevo A, Díaz-Ramos A, Noguera E, Díaz-Sáez F, Duran X, Muñoz JP, Romero M, Plana N, Sebastián D, Tezze C, Romanello V, Ribas F, Seco J, Planet E, Doctrow SR, González J, Borràs M, Liesa M, Palacín M, Vendrell J, Villarroya F, Sandri M, Shirihai O, Zorzano A (2018) Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency. EMBO J 37.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Permeabilized tissueMouseSkeletal muscle
Gorgey 2018 Eur J Appl Physiol2018Gorgey AS, Witt O, O'Brien L, Cardozo C, Chen Q, Lesnefsky EJ, Graham ZA (2018) Mitochondrial health and muscle plasticity after spinal cord injury. Eur J Appl Physiol 119:315-31.OXPHOS
LEAK
N
S
CIV
NS
Permeabilized tissueHumanSkeletal muscle
Britto 2018 BMC Biol2018Britto FA, Cortade F, Belloum Y, Blaquière M, Gallot YS, Docquier A, Pagano AF, Jublanc E, Bendridi N, Koechlin-Ramonatxo C, Chabi B, Francaux M, Casas F, Freyssenet D, Rieusset J, Giorgetti-Peraldi S, Carnac G, Ollendorff V, Favier FB (2018) Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress. BMC Biol 16:65.LEAK
OXPHOS
F
N
NS
Other combinations
Isolated mitochondria
Permeabilized cells
MouseSkeletal muscle
Kahancova 2018 FEBS Lett2018Kahancova A, Sklenar F, Jezek P, Dlaskova A (2018) Regulation of glucose-stimulated insulin secretion by ATPase Inhibitory Factor 1 (IF1). FEBS Lett 592:999-1009.LEAK
ROUTINE
ET
ROXIntact cellsRatOther cell lines
Stanford 2018 Cell Metab2018Stanford KI, Lynes MD, Takahashi H, Baer LA, Arts PJ, May FJ, Lehnig AC, Middelbeek RJW, Richard JJ, So K, Chen EY, Gao F, Narain NR, Distefano G, Shettigar VK, Hirshman MF, Ziolo MT, Kiebish MA, Tseng YH, Coen PM, Goodyear LJ (2018) 12,13-diHOME: an exercise-induced lipokine that increases skeletal muscle fatty acid uptake. Cell Metab 27:1111-20.LEAK
OXPHOS
ET
F
ROX
Permeabilized tissueHuman
Mouse
Skeletal muscle
Brunetta 2018 Exp Physiol2018Brunetta HS, de Paula GC, de Oliveira J, Martins EL, Dos Santos GJ, Filho AG, Rafacho A, de Bem AF, Nunes EA (2018) Decrement in resting and insulin-stimulated soleus muscle mitochondrial respiration is an early event in diet-induced obesity in mice. Exp Physiol 104:306-21.LEAK
OXPHOS
N
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Ferri 2018 Eur J Appl Physiol2018Ferri A, Panariti A, Miserocchi G, Rocchetti M, Buoli Comani G, Rivolta I, Bishop DJ (2018) Tissue specificity of mitochondrial adaptations in rats after 4 weeks of normobaric hypoxia. Eur J Appl Physiol 118:1641-52.LEAK
OXPHOS
NPermeabilized tissueRatHeart
Skeletal muscle
Farias 2018 Int J Biol Macromol2018Farias CLA, Martinez GR, Cadena SMSC, Mercê ALR, de Oliveira Petkowicz CL, Noleto GR (2018) Cytotoxicity of xyloglucan from Copaifera langsdorffii and its complex with oxovanadium (IV/V) on B16F10 cells. Int J Biol Macromol 121:1019-28.ET
LEAK
ROUTINE
ROXIntact cellsMouseEndothelial;epithelial;mesothelial cell
Scarpelli 2018 J Pineal Res2018Scarpelli P, Almeida GT, Viçoso KL, Lima WR, Pereira LB, Meissner KA, Wrenger C, Rafaello A, Rizzuto R, Pozzan T, Garcia CRS (2018) Melatonin activate FIS1, DYN1 and DYN2 Plasmodium falciparum related-genes for mitochondria fission: mitoemerald-GFP as a tool to visualize mitochondria structure. J Pineal Res 66:e12484.LEAK
ROUTINE
ET
Intact organism
Ko 2018 Pflugers Arch2018Ko TH, Marquez JC, Kim HK, Jeong SH, Lee S, Youm JB, Song IS, Seo DY, Kim HJ, Won DN, Cho KI, Choi MG, Rhee BD, Ko KS, Kim N, Won JC, Han J (2018) Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts. Pflugers Arch 470:263-75.LEAK
OXPHOS
N
ROX
Isolated mitochondriaRatHeart
Kulkarni 2018 Haematologica2018Kulkarni PP, Tiwari A, Singh N, Gautam D, Sonkar VK, Agarwal V, Dash D (2018) Aerobic glycolysis fuels platelet activation: small-molecule modulators of platelet metabolism as anti-thrombotic agents. Haematologica 104:806-18.LEAK
ROUTINE
ET
ROXIntact cellsHumanPlatelet
Cecatto 2018 J Cell Biochem2018Cecatto C, Wajner A, Vargas CR, Wajner SM, Amaral AU, Wajner M (2018) High vulnerability of the heart and liver to 3-hydroxypalmitic acid-induced disruption of mitochondrial functions in intact cell systems. J Cell Biochem 119:7678-86.LEAK
OXPHOS
ET
NIntact cells
Permeabilized cells
RatHeart
Nervous system
Liver
Okerblom 2018 Proc Biol Sci2018Okerblom J, Fletes W, Patel HH, Schenk S, Varki A, Breen EC (2018) Human-like Cmah inactivation in mice increases running endurance and decreases muscle fatigability: implications for human evolution. Proc Biol Sci 285:20181656.LEAK
OXPHOS
N
NS
Permeabilized tissueMouseSkeletal muscle
Zhang 2018 J Mol Cell Cardiol2018Zhang G, Sheng M, Wang J, Teng T, Sun Y, Yang Q, Xu Z (2018) Zinc improves mitochondrial respiratory function and prevents mitochondrial ROS generation at reperfusion by phosphorylating STAT3 at Ser727. J Mol Cell Cardiol 118:169-82.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Permeabilized cells
Isolated mitochondria
MouseHeart
Valentine 2018 J Gerontol A Biol Sci Med Sci2018Valentine JM, Li ME, Shoelson SE, Zhang N, Reddick RL, Musi N (2018) NFκB regulates muscle development and mitochondrial function. J Gerontol A Biol Sci Med Sci [Epub ahead of print].LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueMouseSkeletal muscle
Rundle 2018 Environ Sci Technol2018Rundle K, Sharaf M, Stevens D, Kamunde C, Van Den Heuvel MR (2018) Oil sands-derived naphthenic acids are oxidative uncouplers and impair electron transport in isolated mitochondria. Environ Sci Technol 52:10803-11.LEAK
OXPHOS
ET
N
ROX
Isolated mitochondriaFishesLiver
Mancini 2017 Thesis2018Mancini G (2017) Colesterol dietético e doença de Alzheimer em modelos experimentais: avaliação da resposta sináptica, mitocondrial e comportamental. Doctoral Thesis p118.LEAK
ET
ROUTINE
ROXIntact cellsMouseNervous system
JanssenDuijghuijsen 2018 Thesis2018JanssenDuijghuijsen LM (2018) Good, Bad, or Risky? Intestinal permeability to protein: Human and in vitro studies. Doctoral Thesis p154.LEAK
ROUTINE
ET
ROXIntact cellsHumanEndothelial;epithelial;mesothelial cell
Hedges 2018 J Appl Physiol (1985)2018Hedges CP, Woodhead JST, Wang HW, Mitchell CJ, Cameron-Smith D, Hickey AJR, Merry TL (2018) Peripheral blood mononuclear cells do not reflect skeletal muscle mitochondrial function or adaptation to high-intensity interval training in healthy young men. J Appl Physiol (1985) 126:454-61.LEAK
OXPHOS
ET
N
CIV
NS
ROX
Permeabilized tissue
Intact cells
HumanSkeletal muscle
Blood cells
Lymphocyte
Rossignoli 2018 J Nutr Biochem2018Rossignoli CP, Dechandt CRP, Souza AO, Sampaio IH, Vicentini TM, Teodoro BG, Neto MPC, Ferrari GD, Couto-Lima CA, Alberici LC (2018) Effects of intermittent dietary supplementation with conjugated linoleic acid and fish oil (EPA/DHA) on body metabolism and mitochondrial energetics in mice. J Nutr Biochem 60:16-23.ET
LEAK
OXPHOS
N
S
Isolated mitochondria
Permeabilized cells
MouseFat
Liver
Nervous system
Skeletal muscle
Arnoux 2018 Elife2018Arnoux I, Willam M, Griesche N, Krummeich J, Watari H, Offermann N, Weber S, Narayan Dey P, Chen C, Monteiro O, Buettner S, Meyer K, Bano D, Radyushkin K, Langston R, Lambert JJ, Wanker E, Methner A, Krauss S, Schweiger S, Stroh A (2018) Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease. Elife 7:e38744.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseNervous system
MitoEAGLE blood cells 12018MitoEAGLE blood cells group (2018) An interlaboratory guide through procedures for mitochondrial respiratory studies with intact and permeabilized peripheral blood mononuclear cells and platelets. - Updated: 2018-02-23LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Intact cells
Permeabilized cells
HumanBlood cells
Platelet
Dela 2018 Acta Physiol (Oxf)2018Dela F, Ingersen A, Andersen NB, Nielsen MB, Petersen HHH, Hansen CN, Larsen S, Wojtaszewski J, Helge JW (2018) Effects of one-legged high-intensity interval training on insulin-mediated skeletal muscle glucose homeostasis in patients with type 2 diabetes. Acta Physiol (Oxf) 226:e13245.OXPHOS
LEAK
N
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Meinild Lundby 2018 Acta Physiol (Oxf)2018Meinild Lundby AK, Jacobs RA, Gehrig S, de Leur J, Hauser M, Bonne TC, Flück D, Dandanell S, Kirk N, Kaech A, Ziegler U, Larsen S, Lundby C (2018) Exercise training increases skeletal muscle mitochondrial volume density by enlargement of existing mitochondria and not de novo biogenesis. Acta Physiol (Oxf) 222, e12905.OXPHOS
LEAK
ET
NS
F
N
CIV
Permeabilized tissueHumanSkeletal muscle
Schiffer 2018 Am J Physiol Renal Physiol2018Schiffer TA, Gustafsson H, Palm F (2018) Kidney outer medulla mitochondria are more efficient compared with cortex mitochondria as a strategy to sustain ATP production in a suboptimal environment. Am J Physiol Renal Physiol 315:F677-F681.LEAK
OXPHOS
N
NS
Isolated mitochondriaRatKidney
Matsumoto 2018 Circulation2018Matsumoto J, Takada S, Kinugawa S, Furihata T, Nambu H, Kakutani N, Tsuda M, Fukushima A, Yokota T, Tanaka S, Takahashi H, Watanabe M, Hatakeyama S, Matsumoto M, Nakayama KI, Otsuka Y, Sabe H, Tsutsui H, Anzai T (2018) Brain-derived neurotrophic factor improves limited exercise capacity in mice with heart failure. Circulation 138:2064-66.LEAK
ET
N
S
NS
Permeabilized tissueMouseSkeletal muscle
Holland 2018 Cell Death Dis2018Holland OJ, Cuffe JSM, Dekker Nitert M, Callaway L, Kwan Cheung KA, Radenkovic F, Perkins AV (2018) Placental mitochondrial adaptations in preeclampsia associated with progression to term delivery. Cell Death Dis 9:1150.LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueHumanGenital
Stein 2018 Cell Rep2018Stein CS, Jadiya P, Zhang X, McLendon JM, Abouassaly GM, Witmer NH, Anderson EJ, Elrod JW, Boudreau RL (2018) Mitoregulin: A lncRNA-encoded microprotein that supports mitochondrial supercomplexes and respiratory efficiency. Cell Rep 23:3710-20.LEAK
OXPHOS
F
N
Permeabilized tissueHumanHeart
Skeletal muscle
Martinez-Palma 2018 Neurotherapeutics2018Martínez-Palma L, Miquel E, Lagos-Rodríguez V, Barbeito L, Cassina A, Cassina P (2018) Mitochondrial modulation by dichloroacetate reduces toxicity of aberrant glial cells and gliosis in the SOD1G93A rat model of amyotrophic lateral sclerosis. Neurotherapeutics 16:203-15.LEAK
ET
ROXIntact cellsRatNervous system
Blunsom 2018 Biochim Biophys Acta2018Blunsom NJ, Gomez-Espinosa E, Ashlin TG, Cockcroft S (2018) Mitochondrial CDP-diacylglycerol synthase activity is due to the peripheral protein, TAMM41 and not due to the integral membrane protein, CDP-diacylglycerol synthase 1. Biochim Biophys Acta 1863:284-98.LEAK
ROUTINE
ET
ROXIntact cellsRatHeart
Lima 2018 Biochem Cell Biol2018Lima T, Silveira L (2018) A microplate assay for measuring cell death in C2C12 cells. Biochem Cell Biol 96:702-6.LEAK
ET
FIntact cellsMouseSkeletal muscle
Other cell lines
Weisz 2018 Hum Mol Genet2018Weisz ED, Towheed A, Monyak RE, Toth MS, Wallace DC, Jongens TA (2018) Loss of Drosophila FMRP leads to alterations in energy metabolism and mitochondrial function. Hum Mol Genet 27:95-106.OXPHOS
ET
LEAK
N
S
NS
ROX
Isolated mitochondriaDrosophilaSkeletal muscle
Havird 2018 bioRxiv2018Havird JC, Noe GR, Link L, Torres A, Logan DC, Sloan DB, Chicco AJ (2018) Assessing mitochondrial function in angiosperms with highly divergent mitochondrial genomes. bioRxiv doi: https://doi.org/10.1101/448902.LEAK
OXPHOS
N
S
CIV
NS
Isolated mitochondriaPlants
Lu 2018 Cell Rep2018Lu Z, Cui Y, Wei X, Gao P, Zhang H, Wei X, Li Q, Sun F, Yan Z, Zheng H*, Yang G, Liu D, Zhu Z (2018) Deficiency of PKD2L1 (TRPP3) exacerbates pathological cardiac hypertrophy by augmenting NCX1-mediated mitochondrial calcium overload. Cell Rep 24:1639-52.LEAK
OXPHOS
ET
N
S
NS
ROX
Isolated mitochondriaMouseHeart
Pardo 2018 FASEB J2018Pardo R, Vilà M, Cervela L, de Marco M, Gama-Pérez P, González-Franquesa A, Statuto L, Vilallonga R, Simó R, Garcia-Roves PM, Villena JA (2018) Calorie restriction prevents diet-induced insulin resistance independently of PGC-1-driven mitochondrial biogenesis in white adipose tissue. FASEB J 33:2343-58.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseFat
Chung 2018 J Exp Biol2018Chung DJ, Sparagna GC, Chicco AJ, Schulte PM (2018) Patterns of mitochondrial membrane remodeling parallel functional adaptations to thermal stress. J Exp Biol 221. pii: jeb174458.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Isolated mitochondriaFishesLiver
Kauppila 2018 Thesis2018Kauppila JHK (2018) Generating mammalian mitochondrial disease models with mitochondrial DNA mutations. PhD Thesis p120.LEAK
OXPHOS
ET
N
S
Isolated mitochondriaMouseHeart
Liver
Deschaseaux 2018 US Patent2018Deschaseaux F, Guilloton F, Muller S, Sensebe L, Casteilla L, Carriere-Pazat A (2018) Method for obtaining human brown/beige adipocytes . US Patent US20180216070A1.LEAK
ROUTINE
ET
ROXIntact cellsHumanFat
Merz 2018 Intensive Care Med Exp2018Merz T, Wepler M, Nußbaum B, Vogt J, Calzia E, Wang R, Szabo C, Radermacher P, McCook O (2018) Cystathionine-γ-lyase expression is associated with mitochondrial respiration during sepsis-induced acute kidney injury in swine with atherosclerosis. Intensive Care Med Exp 6:43.ET
LEAK
OXPHOS
F
N
NS
ROX
S
HomogenatePigKidney
Rubio-Villena 2018 Hum Mol Genet2018Rubio-Villena C, Viana R, Bonet J, Garcia-Gimeno MA, Casado M, Heredia M, Sanz P (2018) Astrocytes: new players in progressive myoclonus epilepsy of Lafora type. Hum Mol Genet 27:1290-1300.LEAK
ROUTINE
ET
ROXMouseNervous system
Bytautiene 2018 J Dev Orig Health Dis2018Bytautiene Prewit E, Porter C, La Rosa M, Bhattarai N, Yin H, Gamble P, Kechichian T, Sidossis LS (2018) Adipose tissue uncoupling protein 1 levels and function are increased in a mouse model of developmental obesity induced by maternal exposure to high-fat diet. J Dev Orig Health Dis 9:401-8.LEAKF
N
Permeabilized tissueMouseFat
Song 2018 J Cell Physiol2018Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z (2018) Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo. J Cell Physiol 234:777-88.LEAK
ET
ROXIntact cellsHumanIslet cell;pancreas;thymus
Laouafa 2018 Adv Exp Med Biol2018Laouafa S, Roussel D, Marcouiller F, Soliz J, Bairam A, Joseph V (2018) Role of estradiol receptor beta (ERβ) on arterial pressure, respiratory chemoreflex and mitochondrial function in young and aged female mice. Adv Exp Med Biol 1071:115-27.LEAK
OXPHOS
ET
N
S
CIV
ROX
Permeabilized tissueMouseNervous system
Touat 2018 J Clin Invest2018Touat M, Sourisseau T, Dorvault N, Chabanon RM, Garrido M, Morel D, Krastev DB, Bigot L, Adam J, Frankum JR, Durand S, Pontoizeau C, Souquère S, Kuo MS, Sauvaigo S, Mardakheh F, Sarasin A, Olaussen KA, Friboulet L, Bouillaud F, Pierron G, Ashworth A, Lombès A, Lord CJ, Soria JC, Postel-Vinay S (2018) DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade. J Clin Invest 128:1671-87.LEAK
ROUTINE
ET
HumanLung;gill
Other cell lines
Ryan 2018 JCI Insight2018Ryan TE, Yamaguchi DJ, Schmidt CA, Zeczycki TN, Shaikh SR, Brophy P, Green TD, Tarpey MD, Karnekar R, Goldberg EJ, Sparagna GC, Torres MJ, Annex BH, Neufer PD, Spangenburg EE, McClung JM (2018) Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants. JCI Insight 3:123235.OXPHOS
LEAK
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Hughey 2018 J Biol Chem2018Hughey CC, Trefts E, Bracy DP, James FD, Donahue EP, Wasserman DH (2018) Glycine N-methyltransferase deletion in mice diverts carbon flux from gluconeogenesis to pathways that utilize excess methionine cycle intermediates. J Biol Chem 293:11944-54.LEAK
ROUTINE
ET
Intact cellsMouseLiver
Efimova 2018 Thesis2018Efimova I (2018) Structural composition and functional properties of mitochondrial FoF1 ATP synthase on models of specific subunits deficiencies. PhD Thesis 94.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized cellsHumanHEK
Li 2018 Gene2018Li Y, Wen S, Li D, Xie J, Wei X, Li X, Liu Y, Fang H, Yang Y, Lyu J (2018) SURF1 mutations in Chinese patients with Leigh syndrome: Novel mutations, mutation spectrum, and the functional consequences. Gene 674:15-24.LEAK
ROUTINE
Intact cellsHumanBlood cells
Trewin 2018 Am J Physiol Regul Integr Comp Physiol2018Trewin AJ, Parker L, Shaw CS, Hiam D, Garnham AP, Levinger I, McConell GK, Stepto NK (2018) Acute HIIE elicits similar changes in human skeletal muscle mitochondrial H2O2 release, respiration and cell signaling as endurance exercise even with less work. Am J Physiol Regul Integr Comp Physiol 315:R1003-R1016.ET
LEAK
OXPHOS
N
NS
ROX
S
Permeabilized tissueHumanSkeletal muscle
Sirsat 2018 Comp Biochem Physiol A Mol Integr Physiol2018Sirsat SKG, Dzialowski EM (2018) Ontogeny of skeletal and cardiac muscle mitochondria oxygen fluxes in two breeds of chicken. Comp Biochem Physiol A Mol Integr Physiol 215:20-7.LEAK
OXPHOS
N
S
CIV
NS
ROX
Permeabilized tissueBirdsHeart
Skeletal muscle
Walczak 2018 FASEB J2018Walczak J, Dębska-Vielhaber G, Vielhaber S, Szymański J, Charzyńska A, Duszyński J, Szczepanowska J (2018) Distinction of sporadic and familial forms of ALS based on mitochondrial characteristics. FASEB J 33:4388-403.OXPHOS
LEAK
ROUTINE
N
S
Permeabilized cellsHumanFibroblast
Davila 2018 Elife2018Davila A, Liu L, Chellappa K, Redpath P, Nakamaru-Ogiso E, Paolella LM, Zhang Z, Migaud ME, Rabinowitz JD, Baur JA (2018) Nicotinamide adenine dinucleotide is transported into mammalian mitochondria. Elife 7:e33246.LEAK
OXPHOS
ET
NIsolated mitochondriaMouseSkeletal muscle
Liver
Holloway 2018 Cell Rep2018Holloway GP, Holwerda AM, Miotto PM, Dirks ML, Verdijk LB, van Loon LJC (2018) Age-associated impairments in mitochondrial ADP sensitivity contribute to redox stress in senescent human skeletal muscle. Cell Rep 22:2837–48.OXPHOS
ET
LEAK
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Tillmans 2018 Thesis2018Tillmans F (2018) Effect of normobaric hypoxia on leukemic vell lines in vitro. Dissertation p92.LEAK
ROUTINE
ET
N
S
NS
ROX
Intact cells
Permeabilized cells
HumanOther cell lines
Lymphocyte
Eimre 2018 Oxid Med Cell Longev2018Eimre M, Paju K, Peet N, Kadaja L, Tarrend M, Kasvandik S, Seppet J, Ivask M, Orlova E, Kõks S (2018) Increased mitochondrial protein levels and bioenergetics in the musculus rectus femoris of Wfs1-deficient mice. Oxid Med Cell Longev 2018:3175313.OXPHOS
LEAK
N
S
CIV
ROX
Permeabilized tissueMouseSkeletal muscle
MitoFit Open Seminar 2017-07-142017-07-14
MitoFit
Innsbruck AT, 2017 Jul 14. MitoFit Open Seminar on immune cell bioenergetics.
Investigating the role of mitochondria in healthy and psychopathological aging.
LEAK
ROUTINE
ET
Intact cellsHumanBlood cells
Jang 2017 Clin Toxicol (Phila)2017Jang DH, Kelly M, Hardy K, Lambert DS, Shofer FS, Eckmann DM (2017) A preliminary study in the alterations of mitochondrial respiration in patients with carbon monoxide poisoning measured in blood cells. Clin Toxicol (Phila) 55:579-84.LEAK
ROUTINE
OXPHOS
ET
F
S
CIV
NS
ROX
Intact cellsBlood cells
Yeh 2017 Thesis2017Yeh A (2017) Modulation of mitochondrial function as an indicator for sublethal effects of contaminants of emerging concern. Dissertation p117.LEAK
OXPHOS
ET
N
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Human
Fishes
Liver
Dahlke 2017 Glob Chang Biol2017Dahlke FT, Leo E, Mark FC, Pörtner HO, Bickmeyer U, Frickenhaus S, Storch D (2017) Effects of ocean acidification increase embryonic sensitivity to thermal extremes in Atlantic cod, Gadus morhua. Glob Chang Biol 23(4):1499-1510.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateFishes
Holland 2017 Placenta2017Holland OJ, Hickey AJR, Alvsaker A, Moran S, Hedges C, Chamley LW, Perkins AV (2017) Changes in mitochondrial respiration in the human placenta over gestation. Placenta 57:102-12.LEAK
ROUTINE
OXPHOS
F
N
CIV
NS
ROX
Permeabilized cells
Intact cells
Genital
Scrima 2017 PLOS ONE2017Scrima R, Menga M, Pacelli C, Agriesti F, Cela O, Piccoli C, Cotoia A, De Gregorio A, Gefter JV, Cinnella G, Capitanio N (2017) Para-hydroxyphenylpyruvate inhibits the pro-inflammatory stimulation of macrophage preventing LPS-mediated nitro-oxidative unbalance and immunometabolic shift. PLOS ONE 12:e0188683.LEAK
ROUTINE
ET
ROXIntact cellsHuman
Mouse
Endothelial;epithelial;mesothelial cell
Blood cells
Fibroblast
Macrophage-derived
Asiri 2017 Thesis2017Asiri A (2017) Effects of asiatic acid on neurite outgrowth in Neuro-2a cells. Master's Thesis p42.LEAK
ROUTINE
ET
Intact cellsMouseNervous system
McFarlane 2017 Am J Physiol Regul Integr Comp Physiol2017McFarlane SV, Mathers KE, Staples JF (2017) Reversible temperature-dependent differences in brown adipose tissue respiration during torpor in a mammalian hibernator. Am J Physiol Regul Integr Comp Physiol 312:R434-42.LEAK
ROUTINE
OXPHOS
F
N
Isolated mitochondria
Intact cells
Other mammalsFat
Volani 2017 Metallomics2017Volani C, Doerrier C, Demetz E, Haschka D, Paglia G, Lavdas AA, Gnaiger E, Weiss G (2017) Dietary iron loading negatively affects liver mitochondrial function. Metallomics 9:1634-44.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouseLiver
Linden 2016 Am J Physiol Gastrointest Liver Physiol2017Linden MA, Fletcher JA, Meers GM, Thyfault JP, Laughlin MH, Rector RS (2017) A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats. Am J Physiol Gastrointest Liver Physiol 311:G387-95.OXPHOS
ET
LEAK
N
NS
Isolated mitochondriaRatLiver
Nabben 2017 Am J Physiol Regul Integr Comp Physiol2017Nabben M, Schmitz JP, Ciapaite J, Le Clercq CM, van Riel NA, Haak HR, Nicolay K, de Coo IF, Smeets HJ, Praet SF, van Loon LJ, Prompers JJ (2017) Dietary nitrate does not reduce oxygen cost of exercise or improve muscle mitochondrial function in mitochondrial myopathy patients. Am J Physiol Regul Integr Comp Physiol 312:689-701.LEAK
OXPHOS
ET
F
N
S
Permeabilized tissueHumanSkeletal muscle
De Carvalho 2017 Toxicol Research2017de Carvalho NR, Rodrigues NR, Macedo GE, Boligon AA, de Campos MM, Posser T, Cunha FAB, Coutinho HD, Klamt F, Bristot IJ, Merritt TJS, Franco JL (2017) Eugenia uniflora leaves essential oil promotes mitochondrial dysfunction in Drosophila melanogaster through the inhibition of oxidative phosphorylation. Toxicol Research 6:526-34 .LEAK
OXPHOS
ET
F
N
NS
ROX
S
Isolated mitochondriaDrosophila
Mahalingam 2017 J Physiol2017Mahalingam S, McClelland GB, Scott GR (2017) Evolved changes in the intracellular distribution and physiology of muscle mitochondria in high-altitude native deer mice. J Physiol 595:4785-801.LEAK
OXPHOS
N
CIV
NS
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Goedecke 2017 JMIR Res Protoc2017Goedecke JH, Mendham AE, Clamp L, Nono Nankam PA, Fortuin-de Smidt MC, Phiri L, Micklesfield LK, Keswell D, Woudberg NJ, Lecour S, Alhamud A, Kaba M, Lutomia FM, van Jaarsveld PJ, de Villiers A, Kahn SE, Chorell E, Hauksson J, Olsson T (2017) An exercise intervention to unravel the mechanisms underlying insulin resistance in a cohort of black South African women: Protocol for a randomized controlled trial. JMIR Res Protoc 03/10/2017:9098.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Fat
Chavanelle 2017 Sci Rep2017Chavanelle V, Boisseau N, Otero YF, Combaret L, Dardevet D, Montaurier C, Delcros G, Peltier SL, Sirvent P (2017) Effects of high-intensity interval training and moderate-intensity continuous training on glycaemic control and skeletal muscle mitochondrial function in db/db mice. Sci Rep 7:204.ET
LEAK
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueMouseSkeletal muscle
Correa 2017 Crit Care2017Corrêa TD, Pereira AJ, Brandt S, Vuda M, Djafarzadeh S, Takala J, Jakob SM (2017) Time course of blood lactate levels, inflammation, and mitochondrial function in experimental sepsis. Crit Care 21:105.LEAK
OXPHOS
N
S
CIV
Isolated mitochondriaPigNervous system
Bal 2017 J Biol Chem2017Bal NC, Singh S, Reis FCG, Maurya SK, Pani S, Rowland LA, Periasamy M (2017) Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice. J Biol Chem 292:16616-25.LEAK
OXPHOS
N
NS
Permeabilized tissueMouseSkeletal muscle
Fat
Bernardinelli 2017 PLoS One2017Bernardinelli E, Costa R, Scantamburlo G, To J, Morabito R, Nofziger C, Doerrier C, Krumschnabel G, Paulmichl M, Dossena S (2017) Mis-targeting of the mitochondrial protein LIPT2 leads to apoptotic cell death. PLoS One 12(6):e0179591.LEAK
ROUTINE
ET
ROXIntact cellsHumanKidney
Ounpuu 2017 Biochim Biophys Acta2017Ounpuu L, Klepinin A, Pook M, Teino I, Peet N, Paju K, Tepp K, Chekulayev V, Shevchuk I, Koks S, Maimets T, Kaambre T (2017) 2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. Biochim Biophys Acta 1861:2146-54.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
ROX
CIV
Permeabilized cells
Intact cells
HumanStem cells
Schmidt 2017 J Vasc Surg2017Schmidt CA, Ryan TE, Lin CT, Inigo MM, Green TD, Brault JJ, Spangenburg EE, McClung JM (2017) Diminished force production and mitochondrial respiratory deficits are strain-dependent myopathies of subacute limb ischemia. J Vasc Surg 65:1504-1514.OXPHOS
ET
LEAK
N
S
CIV
NS
Permeabilized tissue
Isolated mitochondria
MouseSkeletal muscle
Dechandt 2017 J Bioenerg Biomembr2017Dechandt CRP, Zuccolotto-Dos-Reis FH, Teodoro BG, Fernandes AMAP, Eberlin MN, Kettelhut IC, Curti C, Alberici LC (2017) Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes. J Bioenerg Biomembr 49:399-411.LEAK
ROUTINE
ET
F
N
ROX
Permeabilized cells
Intact cells
RatLiver
Jespersen 2017 J Physiol2017Jespersen NR, Yokota T, Støttrup NB, Bergdahl A, Paelestik KB, Povlsen JA, Dela F, Bøtker HE (2017) Pre-ischaemic mitochondrial substrate constraint by inhibition of malate-aspartate shuttle preserves mitochondrial function after ischaemia-reperfusion. J Physiol 595:3765-80.LEAK
OXPHOS
F
N
NS
ROX
S
Permeabilized tissueRatHeart
Buck 2017 PLOS ONE2017Buck E, Zügel M, Schumann U, Merz T, Gumpp AM, Witting A, Steinacker JM, Landwehrmeyer GB, Weydt P, Calzia E, Lindenberg KS (2017) High-resolution respirometry of fine-needle muscle biopsies in pre-manifest Huntington's disease expansion mutation carriers shows normal mitochondrial respiratory function. PLOS ONE 12:e0175248.LEAK
OXPHOS
ET
F
N
S
NS
ROX
HomogenateHuman
Mouse
Heart
Skeletal muscle
Nervous system
Liver
Rontoyanni 2017 Shock2017Rontoyanni VG, Malagaris I, Herndon DN, Rivas E, Capek KD, Delgadillo AD, Bhattarai N, Elizondo A, Voigt CD, Finnerty CC, Suman OE, Porter C (2017) Skeletal muscle mitochondrial function is determined by burn severity, sex and sepsis, and is associated with glucose metabolism and functional capacity in burned children. Shock 50:141-48.LEAK
OXPHOS
F
N
NS
Permeabilized tissueHumanSkeletal muscle
Thomas 2017 Thesis2017Thomas NO (2017) Age-related decrease in resilience against acute redox cycling agents: critical role of declining GSH-dependent detoxification capacity. Dissertation p141.LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized cells
Intact cells
RatLiver
Torres 2017 Cell Metab2017Torres MJ, Kew KA, Ryan TE, Pennington ER, Lin CT, Buddo KA, Fix AM, Smith CA, Gilliam LA, Karvinen S, Lowe DA, Spangenburg EE, Zeczycki TN, Shaikh SR, Neufer PD (2017) 17β-estradiol directly lowers mitochondrial membrane microviscosity and improves bioenergetic function in skeletal muscle. Cell Metab 27:167-79.OXPHOS
ET
LEAK
F
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Yang 2017 Cell Death Dis2017Yang N, Weinfeld M, Lemieux H, Montpetit B, Goping IS (2017) Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis. Cell Death Dis 8:e2587.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized cells
Intact cells
Saccharomyces cerevisiae
Human
Lymphocyte
Crouch 2017 PLOS ONE2017Crouch ML, Knowels G, Stuppard R, Ericson NG, Bielas JH, Marcinek DJ, Syrjala KL (2017) Cyclophosphamide leads to persistent deficits in physical performance and in vivo mitochondria function in a mouse model of chemotherapy late effects. PLOS ONE 12:e0181086.LEAK
OXPHOS
ET
N
NS
Permeabilized tissueMouseSkeletal muscle
Ortega 2017 Biol Reprod2017Ortega MS, Wohlgemuth S, Tribulo P, Siqueira LG, Null DJ, Cole JB, Da Silva MV, Hansen PJ (2017) A single nucleotide polymorphism in COQ9 affects mitochondrial and ovarian function and fertility in Holstein cows. Biol Reprod 96:652-63.LEAK
ROUTINE
ET
ROXBovinesBlood cells
Li 2017 Oxid Med Cell Longev2017Li CJ, Chen PK, Sun LY, Pang CY (2017) Enhancement of mitochondrial transfer by antioxidants in human mesenchymal stem cells. Oxid Med Cell Longev 2017:8510805.ET
LEAK
ROUTINE
ROXIntact cellsHumanFat
Gusdon 2017 Exp Gerontol2017Gusdon AM, Callio J, Distefano G, O'Doherty RM, Goodpaster BH, Coen PM, Chu CT (2017) Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. Exp Gerontol 90:1-13.LEAK
OXPHOS
N
S
Isolated mitochondriaMouseNervous system
Lou 2017 Physiol Rep2017Lou PH, Lucchinetti E, Scott KY, Huang Y, Gandhi M, Hersberger M, Clanachan AS, Lemieux H, Zaugg M (2017) Alterations in fatty acid metabolism and sirtuin signaling characterize early type-2 diabetic hearts of fructose-fed rats. Physiol Rep 5 pii: e13388.LEAK
OXPHOS
F
N
CIV
NS
RatHeart
Anderson 2017 Cell Metab2017Anderson KA, Huynh FK, Fisher-Wellman K, Stuart JD, Peterson BS, Douros JD, Wagner GR, Thompson JW, Madsen AS, Green MF, Sivley RM, Ilkayeva OR, Stevens RD, Backos DS, Capra JA, Olsen CA, Campbell JE, Muoio DM, Grimsrud PA, Hirschey MD (2017) SIRT4 is a lysine deacylase that controls leucine metabolism and insulin secretion. Cell Metab 25:838-55.OXPHOS
LEAK
F
N
NS
Other combinations
Isolated mitochondriaMouseHeart
Liver
Selwood 2017 US Patent2017Selwood D, Baker D, Szabadkai G, Duchen MR, Hill JM, Warne JND (2017) Quinolium conjugates of cyclosporin . US Patent US20170349632 A1.LEAK
OXPHOS
ET
N
ROX
Isolated mitochondriaMouseLiver
Canevarolo 2017 Thesis2017Canevarolo RR (2017) Resistência ao metotrexato está diretamente associada à concentração de glutationa em linhagens de leucemia linfoide aguda. Dissertation p159.LEAK
ROUTINE
ET
Intact cellsHumanMacrophage-derived
Xu 2017 J Hum Genet2017Xu B, Li X, Du M, Zhou C, Fang H, Lyu J, Yang Y (2017) Novel mutation of ND4 gene identified by targeted next-generation sequencing in patient with Leigh syndrome. J Hum Genet 62:291-7.LEAK
ROUTINE
Intact cellsHumanBlood cells
Platelet
Du 2017 Evolution2017Du SNN, Khajali F, Dawson NJ, Scott GR (2017) Hybridization increases mitochondrial production of reactive oxygen species in sunfish. Evolution 71:1643-52.ET
LEAK
OXPHOS
N
NS
ROX
S
Isolated mitochondriaFishesLiver
Sobotka 2017 Thesis2017Sobotka O (2017) Pharmacological and metabolic influence on liver mitochondrial functions. PhD Thesis p127.LEAK
OXPHOS
ET
F
N
NS
Homogenate
Isolated mitochondria
Intact cells
Mouse
Rat
Liver
Porras 2017 Stem Cells2017Porras DP, Abbaszadeh M, Bhattacharya D, D'Souza NC, Edjiu NR, Perry CG, Scimè A (2017) p107 determines a metabolic checkpoint required for adipocyte lineage fates. Stem Cells 35:1378-91.OXPHOS
LEAK
F
N
Intact cellsMouseFat
Fibroblast
Rezania 2017 Thromb Res2017Rezania S, Puskarich MA, Petrusca DN, Neto-Neves EM, Rondina MT, Kline JA (2017) Platelet hyperactivation, apoptosis and hypercoagulability in patients with acute pulmonary embolism. Thromb Res 155:106-15.LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Platelet
Carraro 2017 Mol Cell Endocrinol2017Carraro RS, Souza GF, Solon C, Razolli DS, Chausse B, Barbizan R, Victorio SC, Velloso LA (2017) Hypothalamic mitochondrial abnormalities occur downstream of inflammation in diet-induced obesity. Mol Cell Endocrinol 460:238-45.LEAK
OXPHOS
N
ROX
Permeabilized tissueMouseNervous system
Cavalcanti-de-Albuquerque 2017 Mol Neurobiol2017Cavalcanti-de-Albuquerque JP, de Souza Ferreira E, de Carvalho DP, Galina A (2017) Mitochondria-bound hexokinase (mt-HK) activity differ in cortical and hypothalamic synaptosomes: differential role of mt-HK in H2O2 depuration. Mol Neurobiol 55:5889-5900.LEAK
OXPHOS
N
S
Gp
ROX
Intact cellsRatNervous system
De Velasco 2017 Br J Nutr2017de Velasco PC, Chicaybam G, Ramos-Filho DM, Dos Santos RMAR, Mairink C, Sardinha FLC, El-Bacha T, Galina A, Tavares-do-Carmo MDG (2017) Maternal intake of trans-unsaturated or interesterified fatty acids during pregnancy and lactation modifies mitochondrial bioenergetics in the liver of adult offspring in mice. Br J Nutr 118:41-52.ET
LEAK
OXPHOS
N
NS
ROX
Isolated mitochondriaMouseLiver
Rouet 2017 US Patent2017Rouet P, Smih F (2017) ApoO for use in method for treating cancer and various pathophysiological situations. US Patent US20170035842 A1.LEAK
ET
ROXIsolated mitochondriaHuman
Mouse
Heart
Liver
Uzhachenko 2017 Aging (Albany NY)2017Uzhachenko R, Boyd K, Olivares-Villagomez D, Zhu Y, Goodwin JS, Rana T, Shanker A, Tan WJ, Bondar T, Medzhitov R, Ivanova AV (2017) Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis. Aging (Albany NY) 9:627-49.LEAK
ET
ROUTINE
ROXIntact cellsMouseKidney
Endothelial;epithelial;mesothelial cell
Fibroblast
Phillips 2017 Cancer Res2017Phillips CM, Zatarain JR, Nicholls ME, Porter C, Widen SG, Thanki K, Johnson P, Jawad MU, Moyer MP, Randall JW, Hellmich JL, Maskey M, Qiu S, Wood TG, Druzhyna N, Szczesny B, Módis K1, Szabo C, Chao C, Hellmich MR. (2017) Upregulation of Cystathionine-β-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis.. Cancer Res. 77(21):5741-5754.LEAK
ROUTINE
ET
Intact cellsHumanEndothelial;epithelial;mesothelial cell
Merz 2017 Intensive Care Med Exp2017Merz T, Vogt JA, Wachter U, Calzia E, Szabo C, Wang R, Radermacher P, McCook O (2017) Impact of hyperglycemia on cystathionine-γ-lyase expression during resuscitated murine septic shock. Intensive Care Med Exp 5:30.LEAK
OXPHOS
ET
F
N
S
NS
ROX
HomogenateMouseLiver
Nogueira 2017 Free Radic Biol Med2017Nogueira NP, Saraiva FMS, Oliveira MP, Mendonca APM, Inacio JDF, Almeida-Amaral EE, Menna-Barreto RF, Laranja GAT, Lopes Torres EJ, Oliveira MF, Paes MC (2017) Heme modulates Trypanosoma cruzi bioenergetics inducing mitochondrial ROS production. Free Radic Biol Med 108:183-91.LEAK
ROUTINE
OXPHOS
ET
SIntact organism
Permeabilized cells
Protists
Koning 2017 J Cereb Blood Flow Metab2017Koning G, Leverin AL, Nair S, Schwendimann L, Ek J, Carlsson Y, Gressens P, Thornton C, Wang X*, Mallard C, Hagberg H (2017) Magnesium induces preconditioning of the neonatal brain via profound mitochondrial protection. J Cereb Blood Flow Metab 39:1038-55.LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaRat
Alves 2017 Free Radic Biol Med2017Alves de Souza CE, Alves de Souza HM, Stipp MC, Corso CR, Galindo CM, Cardoso CR, Dittrich RL, de Souza Ramos EA, Klassen G, Carlos RM, Correia Cadena SMS, Acco A (2017) Ruthenium complex exerts antineoplastic effects that are mediated by oxidative stress without inducing toxicity in Walker-256 tumor-bearing rats. Free Radic Biol Med 110:228-39.LEAK
ROUTINE
ROXRat
Mueller 2017 Orphanet J Rare Dis2017Mueller SM, Gehrig SM, Petersen JA, Frese S, Mihaylova V, Ligon-Auer M, Khmara N, Nuoffer JM, Schaller A, Lundby C, Toigo M, Jung HH (2017) Effects of endurance training on skeletal muscle mitochondrial function in Huntington disease patients. Orphanet J Rare Dis 12:184.LEAK
OXPHOS
ET
F
N
S
CIV
NS
ROX
Permeabilized tissueHumanSkeletal muscle
... further results



Publications in the MiPMap


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» Abstracts: LEAK
Sort in ascending/descending order by a click on one of the small symbols in squares below.
 YearReferenceCouplingPathwayPreparationOrganismTissue;cell
Kandel 2019 Biophys J2019Kandel SM, Tomar N, Zheleznova N, Audi SH, Cowley Jr AW, Dash RK (2019) Calcium stimulation of mitochondrial respiration is substrate dependent and tissue specific. Biophys J.LEAK
OXPHOS
F
N
S
Isolated mitochondriaRatHeart
Kidney
Lelcu 2019 MiP20192019
Theia Lelcu
Assessment of platelet respiration in blood malignancies: a pilot study in children and adults.
LEAK
OXPHOS
ET
N
NS
ROX
Permeabilized cellsHumanPlatelet
Evinova 2019 MiPschool Coimbra2019
MiPsociety
High resolution respirometry of neuroblastoma SK-N-SH and SH-SY 5Y cell lines.
LEAK
ROUTINE
ET
NIntact cellsHumanNeuroblastoma
Hatokova 2019 MiPschool Coimbra2019
MiPsociety
Influence the passage number on a respiration of SH-SY 5Y cells.
LEAK
ROUTINE
ET
Intact cellsHumanNeuroblastoma
Dominguez-Amorocho 2019 MiP20192019
MiPsociety
Role of Sirtuin 1/3 in CD4+ T cells activation and differentiation in obese and transplanted animals.
LEAK
ET
OXPHOS
ROXMouseLymphocyte
Goncalves Debora 2019 MiPschool Coimbra2019
MiPsociety
Aging effects on mitochondrial control factors in Pink1 knockout Drosophila melanogaster.
LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateDrosophila
Van der Ende 2019 MiPschool Coimbra2019
Miranda van der Ende
Mitochondrial respiration in muscle tissue of colon cancer patients.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Kramer 2019 Abstract IOC1412019Kramer P, Distefano G, Monte J, Mills A, Edmunds L, Jurczak M, Cummings SR, Kritchevsky S, Newman AB, Hepple RT, Goodpaster B, Coen PM, Molina A (2019) The Study of Muscle, Mobility, and Aging (SOMMA): A multi-institutional respirometry study. Mitochondr Physiol Network 24.02.LEAK
OXPHOS
ET
N
CIV
NS
ROX
HumanSkeletal muscle
Garcia-Roves 2019 MiPschool Coimbra2019
Pablo Garcia-Roves
Generating reference values on mitochondrial respiration in permeabilized muscle fibers.
LEAK
OXPHOS
ET
N
S
CIV
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Minuzzi 2019 MiPschool Coimbra2019
MiPsociety
A pilot study on mitochondrial function of mouse skin using high-resolution respirometry.
LEAK
OXPHOS
ET
F
N
S
Permeabilized tissueMouseEndothelial;epithelial;mesothelial cell
Betiu 2019 MiP20192019
MiPsociety
Cell-permeable succinate improves amiodarone-induced mitochondrial complex I and II inhibition in human platelets.
LEAK
ET
ROXPermeabilized cells
Intact cells
HumanPlatelet
Timohhina 2019 MiP20192019
Natalja Timohhina
Metabolic effects of mitochondria-targeted antioxidant peptides in colorectal cancer cells.
LEAK
OXPHOS
ET
ROXHumanEndothelial;epithelial;mesothelial cell
Garcia 2019 MiPschool Coimbra2019
Geovana Garcia
Functional interactions between the Drosophila melanogaster mitochondrial glycerol-3-phosphate dehydrogenase and a xenotopically expressed alternative oxidase.
LEAK
OXPHOS
N
Gp
Drosophila
Lemieux 2019 MiP20192019
Hélène Lemieux
Partial prevention of oxidative stress damage to mitochondria with photobiomodulation.
LEAK
OXPHOS
ET
N
S
CIV
NS
Other invertebrates
Aid-Vanakova 2019 MiP20192019
MiPsociety
Adaptation of muscle OXPHOS in developing glucose intolerance - Wfs1 mice model.
LEAK
OXPHOS
N
S
MouseSkeletal muscle
Heart
Beleza 2019 MiPschool Coimbra2019
Jorge Beleza
Gestational exercise counteracts the deleterious consequences imposed by diabetes mellitus developed during pregnancy on 16 weeks old male offspring liver mitochondrial function.
LEAK
OXPHOS
N
S
RatLiver
Kuka 2018 MiP20182018
MiPsociety
The discovery of methyl-GBB - acylcarnitine lowering as an effective strategy to treat cardiometabolic diseases.
LEAK
OXPHOS
RatHeart
Schoepf 2018 33rd Annual EAU Congress Copenhagen2018Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue.LEAK
OXPHOS
ET
F
N
NS
Other combinations
ROX
Permeabilized cells
Permeabilized tissue
HumanGenital
Acuna-Castroviejo 2018 MiP20182018
Dario Acuna-Castroviejo
Mitochondria, melatonin, and neuroinflammation in Parkinson's disease. Acuna-Castroviejo_Presentation
LEAK
OXPHOS
NMouseNervous system
Gnaiger 2018 AussieMit2018Komlodi T, Sobotka O, Doerrier C, Gnaiger E (2018) Mitochondrial H2O2 production is low under tissue normoxia but high at in-vitro air-level oxygen pressure - comparison of LEAK and OXPHOS states. AussieMit 2018 Melbourne AU.LEAK
ROUTINE
OXPHOS
NSIsolated mitochondria
Intact cells
Mouse
Saccharomyces cerevisiae
Heart
Nervous system
Gnaiger 2018 MiPschool Tromso A12018
Erich Gnaiger
Mitochondrial states and rates: 1. Electron transfer pathways and respiratory control. 2. Coupling control.
LEAK
ET
OXPHOS
F
N
S
Gp
DQ
CIV
NS
Other combinations
Doerrier 2018 EBEC20182018
Carolina Anneliese Doerrier
Respiratory mapping of mitochondrial pathways for establishing a database of mitochondrial physiology.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
Blood cells
HEK
Platelet
Sobotka 2018 MiP20182018
Ondrej Sobotka
Measurement of ROS production under hypoxia and unexpected methodological pitfalls of Amplex UltraRed assay.
LEAK
OXPHOS
Isolated mitochondriaMouse
Saccharomyces cerevisiae
Heart
Nervous system
Garcia-Souza 2018 Life Sciences Meeting 2018 Innsbruck AT2018A respirometric cell viability test for peripheral-blood mononuclear cells and platelets.ET
LEAK
ROUTINE
SIntact cellsHumanBlood cells
Platelet
Porter 2018 MiP2018b2018
MiPsociety
Skeletal muscle mitochondrial thermogenesis in hypermetabolic humans.
LEAK
OXPHOS
Komlodi 2018 AussieMit2018Komlodi T, Hunger M, Moore AL, Gnaiger E (2018) Electron transfer at the Q-junction: new perspectives from combined measurement of mitochondrial O2 flux, H2O2 flux, and coenzyme Q redox state. AussieMit 2018 Melbourne AU.LEAK
OXPHOS
S
Gp
Isolated mitochondriaMouseNervous system
Garipi 2018 MiPschool Tromso E22018Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS productionLEAK
ROUTINE
OXPHOS
ET
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Han 2018 MiP20182018
MiPsociety
Mitochondrial functional changes elicited by a single near-infrared (670nm) exposure. Han_Presentation
LEAK
ROUTINE
ET
HumanKidney
HEK
Doerrier 2018 MiP2018a2018
Carolina Anneliese Doerrier
Inter-laboratory harmonization of protocols for mitochondrial function evaluation in permeabilized muscle fibers.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueMouseSkeletal muscle
Doerrier 2018 ESCI20182018
Carolina Anneliese Doerrier
High-resolution respirometry, two techniques combined in one to explore mitochondrial function in health and disease
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
ROX
CIV
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Skeletal muscle
Nervous system
Blood cells
HEK
Nemec 2018 MiP20182018
Michal Nemec
Aerobic/strength exercise intervention modulates skeletal muscle mitochondrial function in seniors.
LEAKF
N
NS
Other combinations
Permeabilized tissueHumanSkeletal muscle
Harper 2018 MiPschool Tromso D12018
Mary-Ellen Harper
OXPHOS efficiency in skeletal and cardiac muscles: Proton leaks, ROS and glutathione redox.
LEAKHeart
Skeletal muscle
Bovard 2018 IOC1342018Integrative determinants of oxygen uptake and biomolecular markers of exercise training.LEAKHumanSkeletal muscle
Meszaros 2018 EBEC20182018Tissue- and substrate-specific patterns in the oxygen kinetics of mitochondrial respiration.ET
LEAK
OXPHOS
NIsolated mitochondriaMouseHeart
Liver
Nervous system
Doerrier 2018 MiP2018c2018
Carolina Doerrier
Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation.
LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Meszaros 2018 Mt Med Hinxton2018High-resolution mitochondrial oxygen kinetics as diagnostic tool in Complex IV impairments.LEAK
OXPHOS
ET
N
CIV
NS
Isolated mitochondriaMouseHeart
Nervous system
Liver
Evinova 2018 MiP20182018
MiPsociety
High-resolution respirometry of neuroblastoma SH-SY 5Y cell line.
LEAK
ROUTINE
ET
Intact cellsHumanOther cell lines
Neuroblastoma
Kovalev 2018 EMBS2018Kovalev A, Sokolova I, Sukhotin A (2018) Allometry of mitochondrial respiration in mussels. EMBS.LEAK
OXPHOS
ET
CIVIsolated mitochondriaMolluscsLiver
Islet cell;pancreas;thymus
McMaster 2018 Am J Obstet Gynecol2018Preeclampsia is associated with placental mitochondrial dysfunction.LEAK
ROUTINE
OXPHOS
ET
NIsolated mitochondriaHuman
Krajcova 2018 ICO1342018Skeletal muscle bioenergetics in critically ill patients: effect of early rehabilitation on mitochondrial functions and insulin resistance during and 6 months after critical illness.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateHumanSkeletal muscle
Gnaiger 2018 EBEC20182018The protonmotive force under pressure: an isomorphic analysis.LEAK
Bastos Sant'Anna Silva 2018 MiPschool Tromso C42018
Ana Bastos Sant'Anna
Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function.
LEAK
ROUTINE
OXPHOS
ET
S
ROX
Intact cellsHumanGenital
Pchelin 2018 IOC1302018Activation of heterodimeric receptor to erythropoietin with its agonist CdEPO regulates brain mitochondrial bioenergetics after local acute ischemia/reperfusion in C57BL/6 mice.LEAKNIsolated mitochondriaMouseNervous system
Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT2018Cellular succinate transport and mitochondrial respiratory function in prostate cancer.ROUTINE
LEAK
OXPHOS
ET
S
ROX
Permeabilized cells
Intact cells
HumanHEK
Genital
Li 2018 IBEC2018Li C, Li N, Zhang Y (2018) UPRmt and mitophagy are selectively activated depending on muscle fiber types in insulin resistant rats. IBEC.LEAK
OXPHOS
RatSkeletal muscle
Chang 2018 Life Sciences Meeting 2018 Innsbruck AT2018pH dependence of mitochondrial respiration and H2O2 production in oral cancer cells – a pilot study.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cellsHumanHEK
Kidney
Ravasz 2018 Abstract The evolving concept of mitochondria2018Vast pools of endogenous quinones sustain NADH oxidation by Complex I during anoxia, supporting substrate-level phosphorylation in mouse liver mitochondriaLEAK
OXPHOS
NIsolated mitochondriaMouseLiver
Avram 2018 MiP20182018
MiPsociety
Cell-permeable succinate bypasses statin-induced mitochondrial complex I inhibition in human platelets. Avram_Presentation
LEAK
ET
SPermeabilized cells
Intact cells
HumanPlatelet
Krajcova 2018 MiPschool Tromso E22018
Adela Krajcova
High-resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle.
LEAK
OXPHOS
ET
N
NS
ROX
HomogenateHumanHeart
Komlodi 2018 EBEC20182018Electron supply to the Q-junction: assessment of mitochondrial respiration, H2O2 flux and the redox state of the Q-pool.LEAK
OXPHOS
S
Gp
Isolated mitochondriaMouseNervous system
Michalak 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Mitochonrial respiration in intact peripheral blood mononuclear cells in patients with extrapyramidal syndromes.
LEAK
ROUTINE
OXPHOS
ET
ROXIntact cellsHumanBlood cells
Giampieri 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
Strawberry extract protects human dermal fibroblasts against oxidative stress and improves mitochondrial functionality.
LEAKROXFibroblast
Markova 2017 MiP20172017
Michaela Markova
Porcine sepsis and associated myocardial depression.
LEAK
OXPHOS
N
S
CIV
NS
ROX
PigHeart
Keppner 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
Different respiratory states to determine LEAK and uncoupled respiration in the SUIT protocol: effect and consequences.
LEAK
OXPHOS
ET
N
NS
Permeabilized cellsBlood cells
Doerrier 2017 MiPschool C22017
DoerrierC.JPG
Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
HEK
Calabria 2017 MiP20172017
Elisa Calabria
Age and frailty related changes in PBMCs mitochondrial function and whole body physiology.
LEAK
ET
SPermeabilized cellsHumanBlood cells
Bento 2017 MITOEAGLE Obergurgl2017
Guida Bento Foto.JPG
Isolation of human urine-derived stem cells for mitochondrial function profile assessment.
LEAK
ET
ROXIntact cellsHumanStem cells
Chabi 2017 MITOEAGLE Obergurgl2017
ChabiB.JPG
Optimization of permeabilized fibers preparation for mitochondrial respiration measurements using Design of Experiments methodology.
LEAKNSPermeabilized tissueMouseSkeletal muscle
Gnaiger 2017 MiP20172017
Erich Gnaiger
Protonmotive force and chemiosmotic pressure: a generalization of non-ohmic flux control of the proton leak.
LEAK
Doerrier 2017 Abstract MitoEAGLE Barcelona2017
COST Action MitoEAGLE
SUIT reference protocol for comparative mitochondrial physiology.
LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
Permeabilized cells
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Nervous system
HEK
Krajcova 2017 MITOEAGLE Obergurgl2017
Krajcova A
Developing a method of assessing mitochondrial functions in homogenates of human heart muscle.
LEAK
OXPHOS
ET
N
NS
HomogenateHuman
Michalak 2017 MiP20172017
MiPsociety
The effect of anticoagulants on mitochondrial respiration in intact peripheral blood mononuclear cells.
LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Siewiera 2017 MiPschool Obergurgl2017
Karolina Siewiera
Blood platelets as bioenergetic markers of brain damage in STZ-diabetes.
LEAK
ROUTINE
ET
Intact cellsRatBlood cells
Platelet
Nemec 2017 MiP20172017
Michal Nemec
Three-month exercise modulates skeletal muscle mitochondria function in patients with mild cognitive impairment.
LEAKN
NS
Permeabilized tissueHumanSkeletal muscle
Lin 2017 FASEB J2017Mitochondrial respiration is fiber-type specific in skeletal muscles.LEAK
ROUTINE
N
NS
Permeabilized tissueRatSkeletal muscle
Juhasz 2017 MiPschool Obergurgl2017
Juhasz L.jpg
Blockade of N-methyl-D-aspartate receptors improves polymicrobial sepsis-evoked mitochondrial dysfunction in rats.
LEAK
OXPHOS
N
S
HomogenateRatLiver
Reboredo-Rodriguez 2017 MiPschool Obergurgl2017
Reboredo-Rodriguez Patricia
Protective effect of a polyphenol-rich strawberry extract on oxidative and endoplasmic reticulum stresses in HepG2 cell line.
LEAK
ET
ROXHumanLiver
Irving 2017 MiP20172017
Brian Irving
Impact of acute exercise on PBMC respiratory function and methodological considerations.
LEAK
ROUTINE
OXPHOS
ET
N
NS
ROX
Blood cells
Amick 2017 MiPschool Obergurgl2017
Amick picture.jpg
Bioenergetic profiling of mitochondria isolated from three distinct brain regions relevant to AD pathology in non-human primates.
LEAK
OXPHOS
F
N
Isolated mitochondriaOther mammalsNervous system
Waldauf 2017 MITOEAGLE Obergurgl2017
COST Action MitoEAGLE
Effect of propofol on energy metabolism in an in vitro model of human skeletal muscle homogenates.
LEAK
OXPHOS
ET
F
N
S
CIV
NS
HomogenateHumanSkeletal muscle
Rybacka-Mossakowska 2017 MiP20172017
MiPsociety
Mitochondrial respiration in intact peripheral blood mononuclear cells in multiple sclerosis patients.
LEAK
ROUTINE
ET
ROXIntact cellsHumanBlood cells
Komlodi 2017 MiPschool Obergurgl2017
Timea Komlodi
Electron pressure exerted by convergent succinate- and glycerophosphate-pathways to the Q-junction regulate reversed electron transfer to Complex I and H2O2 production.
LEAK
OXPHOS
N
S
Gp
Other combinations
ROX
Isolated mitochondriaMouseNervous system
Cizmarova 2017 MiP20172017
Beate Cizmarova
PBMC cryopreservation and evaluation for functional mitochondrial diagnosis.
LEAK
ROUTINE
ET
Intact cellsHumanBlood cells
Chowdhury 2017 Blood2017Importance of mitochondrial metabolism as a selective therapeutic approach in chronic lymphocytic leukemia patients.LEAKROXIntact cellsHumanLymphocyte
Gnaiger 2017 Abstract MitoEAGLE Barcelona2017
COST Action MitoEAGLE
Quality first: a paradigm shift in mt-respiratory control towards global connection.
LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueHuman
Mouse
Heart
Genital
Hellgren 2017 MiPschool Obergurgl2017
Kim Hellgren IMG 4885.JPG
Effect of prenatal hypoxia on adult mitochondrial respiration and ROS production.
LEAK
ROUTINE
ET
NHomogenateMouseHeart
Karavyraki 2017 MiPschool Obergurgl2017
KaravyrakiMarilena.jpg
Mitochondrial function and morphology linked to metabolic differences in normal, dysplastic and cancerous oral cells.
LEAKROXIntact cellsHuman
Iyer 2017 MiP20172017
Iyer Shilpa
Bioenergetic profiling of patient derived human fibroblasts for mitochondrial diseases. Iyer_Presentation
LEAK
ROUTINE
HumanFibroblast
Markova 2017 MiPschool Obergurgl2017
Michaela Markova
Mitochondrial respiration in the rat left heart ventricle after inhibition of pyruvate dehydrogenase kinase.
LEAK
OXPHOS
N
S
CIV
NS
ROX
HomogenateRatHeart
Afrin 2017 MiPschool Obergurgl2017
AfrinS.jpg
Induction of mitochondrial dysfunction by Manuka honey as a strategy for prevention of colon cancer in vitro model: a rising role on reactive oxygen species, apoptosis, and cell metabolism.
LEAKROX
Han 2017 MiP20172017
MiPsociety
Metabolic syndrome differentially impacts the retina and underlying retinal pigment epithelium cells.
LEAK
OXPHOS
S
CIV
NS
RatNervous system
Komlodi 2017 Abstract MITOEAGLE Barcelona2017
COST Action MitoEAGLE
Succinate dehydrogenase regulation via oxaloacetate in brain mitochondria.
OXPHOS
LEAK
ET
N
S
Isolated mitochondria
Homogenate
Guinea pig
Mouse
Nervous system
Kidney
Heart
Liver
Hoel 2017 MiPschool Obergurgl2017
Hoel Fredrik
A study on mitochondrial stress responses due to OXPHOS inhibition.
LEAKROXHumanNervous system
Siewiera 2017 MiP20172017
Karolina Siewiera
Changes in blood platelet and brain mitochondrial respiration during short and long-lasting STZ-induced diabetes.
LEAK
ET
NHomogenate
Intact cells
RatNervous system
Blood cells
Platelet
Distefano 2017 MiPschool Obergurgl2017
Giovanna Distefano
Effects of calorie restriction-induced weight loss and exercise on skeletal muscle mitochondrial energetics of older obese subjects.
LEAK
OXPHOS
ET
F
NS
Permeabilized tissueHumanSkeletal muscle
MitoFit Open Seminar 2017-07-142017
MitoFit
Innsbruck AT, 2017 Jul 14. MitoFit Open Seminar on immune cell bioenergetics.
Investigating the role of mitochondria in healthy and psychopathological aging.
LEAK
ROUTINE
ET
Intact cellsHumanBlood cells
Komlodi 2017 MiP20172017
Timea Komlodi
H2O2 production under hypoxia in brain and heart mitochondria: does O2 concentration matter?
LEAK
OXPHOS
N
NS
Isolated mitochondriaMouseHeart
Nervous system
Meszaros 2017 MiPschool Obergurgl2017
Andras Meszaros
(Very) High-resolution respirometry – a deep dive into oxygen dependence of mitochondrial respiration.
LEAK
OXPHOS
N
S
Isolated mitochondriaMouseLiver
Nervous system
Kidney
Krylova 2017 MiPschool Obergurgl2017
KrylovaT.jpg
High-resolution respirometry in diagnostic of mitochondrial complex I deficiency.
LEAK
ROUTINE
ET
N
S
Intact cells
Permeabilized cells
Endothelial;epithelial;mesothelial cell
Fibroblast
Doerrier 2017 MiP2017 WG22017
Carolina Anneliese Doerrier
Upper limit of OXPHOS capacity in permeabilized myofibers: effect of oxygen, ADP and blebbistatin in MiR05Cr and Buffer Z.
LEAK
OXPHOS
ET
N
NS
Permeabilized tissueMouseSkeletal muscle
Hartmann 2017 Abstract MITOEAGLE Barcelona2017
COST Action MITOEAGLE
Mitochondrial respiration of isolated peripheral blood mononuclear cells in an experimental porcine brain injury model.
LEAK
ROUTINE
ET
Intact cellsHuman
Pig
Blood cells
Gasparrini 2017 MiPschool Obergurgl2017
COST Action MitoEAGLE
Anti-inflammatory effects of strawberry and honey extracts in RAW 264.7 macrophages stressed with LPS.
LEAKROXMouseMacrophage-derived
Kovalcikova 2017 MiP20172017
Kovalcikova Jana
Mitochondrial protein TMEM70: key role in the biogenesis of ATP synthase verified in a mouse knockout model.
LEAK
OXPHOS
MouseHeart
Liver
O'Brien 2017 Abstract IOC1222017PPARα independent effects of nitrate supplementation on skeletal muscle mitochondrial function in hypoxia.LEAK
OXPHOS
FMouseSkeletal muscle
Gnaiger 2017 MiPschool A12017
Gnaiger Erich.jpg
Elemental steps towards understanding mitochondrial core energy metabolism: coupling control.
LEAK
ROUTINE
OXPHOS
ET
ROXIntact cells
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Meszaros 2017 MiP20172017
Andras Meszaros
Mitochondrial oxygen kinetics as a sensitive diagnostic tool to determine apparent cytochrome c oxidase excess capacity.
LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaMouseNervous system
Liver
Kidney
Nogueras 2017 MiPschool Obergurgl2017
Lara Nogueras.jpg
Mitochondrial dysfunction in peripheral blood mononuclear cells from multiple sclerosis patients.
LEAK
ROUTINE
ET
ROXIntact cellsBlood cells
Ukropec 2017 MITOEAGLE Obergurgl2017
COST Action MitoEAGLE
Could functional state of muscle mitochondria reflect exercise-induced changes in insulin sensitivity, glucose tolerance and cognitive performance in individuals with mild cognitive impairment?
LEAK
OXPHOS
ET
F
N
S
Gp
NS
Permeabilized cellsSkeletal muscle
Doerrier 2017 MiP2017 C12017
Carolina Anneliese Doerrier
Effects of warm ischemia on cardiac mitochondria to detect specific targets by high-resolution respirometry (HRR)
LEAK
ET
F
N
S
CIV
NS
Isolated mitochondriaMouseHeart
Volani 2016 Abstract MitoFit Science Camp 20162016Effects of iron imbalances on mitochondrial activity in mouse liver homogenate and permabilized rat PBMCs.LEAK
OXPHOS
ET
N
S
HomogenateMouse
Rat
Liver
Blood cells
Lymphocyte
Volani 2016 Abstract Mito Xmas Meeting Innsbruck2016Effects of systemic iron perturbations on mitochondrial activity and on cellular metabolism in vivo.LEAK
ROUTINE
OXPHOS
ET
N
S
HomogenateMouseLiver
Chicco 2016b Abstract MitoFit Science Camp 20162016OXPHOS coupling efficiency of permeabilized muscle fibers predicts metabolic efficiency of subjects exercising at 5260 m.LEAK
OXPHOS
ET
F
N
Permeabilized tissueHumanSkeletal muscle
Cecatto 2016 Abstract IOC1162016Cecatto C, Silva JC, Wajner A, Godoy KS, Ribeiro, RT, Amaral AU, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca2+ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver. Mitochondr Physiol Network 21.11LEAK
OXPHOS
ET
F
N
CIV
Other combinations
Permeabilized tissue
Isolated mitochondria
RatNervous system
Liver
Krumschnabel 2016a Abstract MitoFit Science Camp 20162016O2k-Protocols: Mitochondrial preparations for HRR.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Homogenate
Isolated mitochondria
MouseHeart
Krumschnabel 2016b Abstract MitoFit Science Camp 20162016O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.LEAK
OXPHOS
ET
N
S
NS
ROX
HumanKidney
HEK
Davies 2016 Abstract Proceedings of The Physiological Society2016Development of mitochondrial function in the cortex and cerebellum of the ovine fetus.LEAK
OXPHOS
N
S
NS
HomogenateBovinesNervous system
Herminghaus 2016 Abstract MitoFit Science Camp 20162016Sterile laparotomy time-dependently modulates hepatic but not colonic mitochondrial function similar to moderate abdominal sepsis.LEAK
OXPHOS
N
NS
RatLiver
Endothelial;epithelial;mesothelial cell
Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck2016Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry.LEAK
OXPHOS
ET
F
N
S
NS
ROX
MouseNervous system
Doerrier 2016 Abstract MitoFit Science Camp 20162016Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
ROX
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Human
Mouse
Heart
Blood cells
HEK
Platelet
Bezuidenhout 2016b Abstract MitoFit Science Camp 20162016Analysis and comparison of mitochondrial function using cooling plate or ice during mechanical separation of mouse skeletal muscle fibers.LEAK
OXPHOS
ET
N
S
ROX
Permeabilized tissueMouseSkeletal muscle
Madlala 2016 Abstract MitoFit Science Camp 20162016Fructose-induced defects in selected mitochondrial enzymes is detected by respirometry using glutamate&malate but not pyruvate&malate substrates.LEAK
OXPHOS
ET
NPermeabilized cellsHumanLiver
Laner 2016 Abstract Mito Xmas Meeting Innsbruck2016OXPHOS and ET capacity in permeabilized fibers of canine superathletes.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Laner 2016 Abstract MitoFit Science Camp 20162016OXPHOS and ET-capacity in permeabilized fibers of canine superathletes. Analysis of HRR data presenting unexpected challenges.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Lamberti 2016 Abstract MitoFit Science Camp 20162016Development of a reference sample for HRR.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
HumanKidney
HEK
Krajcova 2016 Abstract MitoFit Science Camp 20162016Mitochondrial pathogenesis of propofol infusion syndrome in an in vitro model of human skeletal muscle.LEAK
ET
FHomogenateHumanSkeletal muscle
Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck2016Searching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry.LEAK
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Isolated mitochondriaMouseHeart
Sparagna 2016 Abstract IOC1092016Sparagna GC (2016) Measuring cardiac mitochondrial function in pediatric patients before and after implantation of a left ventricular assist device. Mitochondr Physiol Network 21.01.LEAK
OXPHOS
N
S
NS
HumanHeart
Sumbalova 2016b Abstract MitoFit Science Camp 20162016Human blood cells: isolation and HRR.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
NS
Other combinations
ROX
Permeabilized cells
Intact cells
HumanBlood cells
Lymphocyte
Platelet
Calzia 2016 Abstract MitoFit Science Camp 20162016Mitochondrial respiration shows tissue- and strain-specific aging in short- and long-lived N. furzeri strains.LEAK
OXPHOS
ET
NSFishesHeart
Skeletal muscle
Nervous system
Liver
Schoepf 2016 Abstract Mito Xmas Meeting Innsbruck2016Mitochondrial function in primary prostate cancer.ET
LEAK
OXPHOS
N
Other combinations
S
Permeabilized tissueHuman
Gnaiger 2016 Abstract UMDF20162016Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells.LEAK
OXPHOS
ET
F
N
NS
Permeabilized cells
Permeabilized tissue
HumanEndothelial;epithelial;mesothelial cell
Genital
Other cell lines
Fibroblast
Sobotka 2016 Abstract IOC1162016Sobotka O, Kucera O, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11ET
LEAK
OXPHOS
CIV
F
Gp
N
NS
Other combinations
ROX
S
Isolated mitochondriaRatLiver
Doerrier 2015 Abstract MiPschool Greenville 20152015"Succinate paradox" study by high resolution respirometry combined with fluorometry and spectrofluorometry: NextGen-O2k.LEAK
OXPHOS
SIsolated mitochondriaMouseHeart
Galina 2015 Abstract MiP20152015High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles.LEAKN
S
ROX
Permeabilized tissueRatSkeletal muscle
Maarman 2015 Abstract MiPschool Cape Town 20152015Characterisation of mitochondrial function in a model of pulmonary hypertension-induced right ventricular failure.LEAK
OXPHOS
N
S
NS
Isolated mitochondriaRatHeart
Doerrier 2015 Abstract MiP20152015Simultaneous measurement of mitochondrial respiration, hydrogen peroxide production, and NADH autofluorescence to assess mitochondrial function.LEAK
OXPHOS
SIsolated mitochondriaMouseHeart
Smenes 2015 Abstract IOC1002015Smenes BT, Baekkerud FH, Hassel E, Wohlwend M, Slagsvold KH, Rognmo O, Wahba A (2015) Mitochondrial function in patients exercising prior to coronary surgery – A single blinded randomized controlled trial. Mitochondr Physiol Network 20.01.LEAK
ROUTINE
ET
N
S
HumanSkeletal muscle
Karabatsiakis 2015 Abstract MiP20152015Mitochondrial respiration of peripheral blood mononuclear cells in patients with borderline personality disorder.LEAK
ROUTINE
OXPHOS
ET
ROXHumanBlood cells
Funk 2015 Abstract MiPschool Greenville 20152015Isolated mitochondria from liver and brain of long-lived growth hormone receptor gene disrupted mice demonstrate reduced respiration rates.LEAK
OXPHOS
Isolated mitochondriaMouseNervous system
Liver
Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHuman
Mouse
Skeletal muscle
Ojuka 2015 Abstract MiPschool Cape Town 20152015Use of malate or carnitine as co-substrates for assessment of fatty acid oxidation.LEAK
OXPHOS
ET
Permeabilized cells
Permeabilized tissue
Isolated mitochondria
Renshaw 2015 Abstract MiP20152015Mitochondrial responses to thermal stress: is the ability to withstand anoxia-induced stress associated with cross-tolerance to thermal stress?LEAK
OXPHOS
ET
N
S
HomogenateFishesNervous system
Gnaiger 2015 Abstract MiPschool Cape Town 20152015The functional design of the electron transfer system (ETS) and mitochondrial respiratory control.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Permeabilized cells
Permeabilized tissue
Homogenate
Isolated mitochondria
Ali 2015 Abstract MiP20152015Mitochondrial function and ROS homeostasis in young mouse heart and brain: the sex factor!LEAK
OXPHOS
ET
HomogenateMouseHeart
Nervous system
Rutkai 2015 Abstract MiPschool Greenville 20152015Sex-differences in mitochondrial respiration is mediated by nitric oxide in rat cerebral arteries.LEAK
ROUTINE
ET
RatEndothelial;epithelial;mesothelial cell
Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Chavanelle 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
F
N
Permeabilized tissueMouseSkeletal muscle
Ali 2015 Abstract MiPschool Cape Town 20152015Early gender-related dimorphism in heart and brain mitochondria function and ROS dynamics.LEAK
OXPHOS
ET
MouseHeart
Nervous system
Sumbalova 2015 Abstract MiP20152015High-resolution measurement of mitochondrial membrane potential and respiration – comparison of potentiometric and fluorometric methods.LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaMouseNervous system
Laner 2015 Abstract MiPschool Cape Town 20152015The Oroboros Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Isolated mitochondria
Intact cells
Mouse
Saccharomyces cerevisiae
Heart
Sleiman 2015 Abstract MiP20152015Mitochondrial respiration in sequential biospies from skeletal muscles during hemorrhagic shock and over the course of 48h of reperfusion in pigs.LEAK
OXPHOS
ET
N
S
HomogenatePigSkeletal muscle
Blecha 2015 Abstract MiP20152015Modulation of mitochondrial electron transport chain activity differentially regulates cell death in proliferating and quiescent cells.LEAK
ET
ROX
Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion Forum2015Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion ForumLEAK
OXPHOS
ET
FPermeabilized tissueHuman
Rat
Skeletal muscle
Dyrstad 2015 Abstract MiPschool London 20152015Activation of epithelial to mesenchymal transition (EMT) regulates stemness and metabolic reprogramming in mammary epithelial cells.LEAK
ROUTINE
ET
N
ROX
HumanEndothelial;epithelial;mesothelial cell
Other cell lines
Laner 2015 Abstract MiP20152015Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueDogSkeletal muscle
Ost 2015 Abstract IOC1002015Ost M (2015) “Mitokines” and the organismal role of mitochondrial function in energy homeostasis & metabolism. Mitochondr Physiol Network 20.01.LEAK
OXPHOS
Permeabilized tissueMouseSkeletal muscle
Fibroblast
Weidgang 2015 Abstract MiP20152015Mitochondrial respiration in homogenized biopsies from kidney, liver, heart and diaphragm from mice after blunt thoracic trauma and hemorrhagic shock. Effects of a novel hydrogen sulfide donor AP39.LEAK
OXPHOS
ET
N
S
HomogenateMouseHeart
Skeletal muscle
Liver
Kidney
Calzia 2015 Abstract MiP20152015Mitochondrial respiration in homogenized small tissue biopsies from the M. Vastus lateralis of patients with Huntington's Disease before and after cycling exercise.LEAK
OXPHOS
ET
N
S
ROX
HumanSkeletal muscle
Sheldon 2015 Abstract MiPschool Greenville 20152015eNOS is required to preserve hepatic mitochondrial function in western diet-induced nonalcoholic fatty liver disease.LEAK
OXPHOS
ET
N
NS
MouseLiver
Salin 2015 Abstract MiP20152015Individual variation in whole-organism performance is related to mitochondrial properties at high temperatures.LEAKFishesSkeletal muscle
Liver
Gnaiger 2015 Abstract MiPschool Cape Town 2015 II2015On coupling control of mitochondrial respiration. What is wrong with the RCR?LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Devaux 2015 Abstract MiP20152015Mitochondrial complexes I and II behave differently in two anoxia-tolerant species: adaptive mitochondrial plasticity may be related to the ability to undergo metabolic depression.ET
LEAK
OXPHOS
N
S
HomogenateFishesNervous system
Van Dyk 2015 Abstract MiPschool Cape Town 20152015Optimization of selected cell lines for use on the Seahorse extracellular flux analyzer.LEAK
ROUTINE
ET
N
ROX
Isolated mitochondriaHumanOther cell lines
Fibroblast
Gnaiger 2015 Abstract MiP20152015Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Permeabilized cells
Intact cells
HumanHEK
El-Bacha 2014 Abstract MiP20142014Cytotoxicity of grape pomace extract (Vitis vinifera L.) from Brazilian wine industry in human hepatocarcinoma HepG2 cells.LEAK
ROUTINE
ET
Intact cellsHumanLiver
Zorzano 2014 Abstract MiP20142014Metabolic implications of mitofusin 2 dysfunction.LEAK
OXPHOS
MouseSkeletal muscle
Bristot 2014 Abstract MiP20142014High-resolution respirometry and bioenergetics evaluation in fibroblasts derived from patients with TP53 germline mutations.LEAK
OXPHOS
Intact cellsHumanFibroblast
Herminghaus 2014 Abstract MiP20142014Severity of polymicrobial sepsis modulates mitochondrial function in rat liver.LEAK
OXPHOS
N
S
Isolated mitochondriaRatLiver
Porter 2014 Abstract IOC952014Porter C (2014) The impact of resistance exercise training on skeletal muscle mitochondrial respiration in healthy young adults. Mitochondr Physiol Network 19.10LEAK
OXPHOS
ET
Permeabilized tissueHumanSkeletal muscle
Power 2014 Abstract MiP20142014The hot heart: cardiac mitochondrial energetics during hyperthermia.LEAK
OXPHOS
Isolated mitochondriaRatHeart
Jezek 2014 Abstract MiP20142014Mitochondrial cristae morphology changes: from Hackenbrock to hypoxia.LEAK
OXPHOS
Isolated mitochondriaOther cell lines
Laner 2014 Abstract MiP20142014Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibers.LEAK
ROUTINE
OXPHOS
ET
N
NS
Permeabilized tissueDogSkeletal muscle
Schoepf 2014 Abstract MiP20142014OXPHOS analysis in small prostate biopsies.LEAK
OXPHOS
ET
N
S
CIV
NS
Permeabilized tissueHumanGenital
Krumschnabel 2014 Abstract MiP20142014Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production.LEAK
OXPHOS
ET
N
S
NS
Homogenate
Isolated mitochondria
MouseNervous system
Paes 2014 Abstract IOC 2014-04 Schroecken2014Paes MC, Saraiva FMS, Nogueira NP, Laranja GAT, Coelho MGP, Oliveira MF (2014) Heme increases mitochondrial membrane potential and ROS production in Trypanosoma cruzi epimastigotes. Mitochondr Physiol Network 19.02.LEAK
OXPHOS
ET
S
Other combinations
Permeabilized cells
Oxidase;biochemical oxidation
Protists
Karabatsiakis 2014 Abstract IOC962014Karabatsiakis A (2014) Consequences of depression on respiratory activity in peripheral blood mononuclear cells. Mitochondr Physiol Network 19.11.LEAK
ROUTINE
ET
Intact cellsHumanBlood cells
Lymphocyte
Sparks 2014 Abstract MiP20142014NAMPT remodels substrate metabolism in skeletal muscle.LEAK
OXPHOS
N
S
Permeabilized tissueMouseSkeletal muscle
Mendonca 2014 Abstract IOC 2014-04 Schroecken2014Mendonca AP, Rodrigues MF, Amoedo ND, Oliveira MF (2014) Effects of iron on mitochondrial physiology of central nervous system cell lines. Mitochondr Physiol Network 19.02.LEAK
OXPHOS
ET
Nervous system
Other cell lines
Neuroblastoma
Lai 2014 Abstract1 MiP20142014Improved isolation of high quality subsarcolemmal and interfibrillar mitochondria from skeletal muscle.LEAK
OXPHOS
NIsolated mitochondriaRat
Dog
Heart
Skeletal muscle
Fibroblast
Doerrier 2014 Abstract SECF2014Evaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice.LEAK
OXPHOS
ET
N
S
NS
ROX
Permeabilized tissue
Isolated mitochondria
MouseHeart
Volodina 2014 Abstract MiP20142014Multipotent stromal cells injection improves rat liver regeneration through activation of mitochondrial functions after subtotal hepatectomy.LEAK
OXPHOS
ET
N
NS
Isolated mitochondriaRatLiver
Alberici 2014 Abstract MiP20142014Effects of long-chain acyl-CoA synthetase 6 knockdown in primary skeletal muscle cells metabolism.LEAK
ROUTINE
ET
Intact cellsRatSkeletal muscle
Shabalina 2013 Abstract IOC792013Shabalina IG (2013) Enhanced Complex I but low Complex II substrate-derived ROS production rates in mice, prematurely aging due to enhanced mitochondrial DNA mutation rate. Mitochondr Physiol Network 18.07LEAK
OXPHOS
ET
N
S
NS
Isolated mitochondriaMouseHeart
Skeletal muscle
Liver
Pichaud 2013 Abstract MiP20132013Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
Gp
CIV
NS
ROX
Permeabilized tissueDrosophila
Hexapods
Skeletal muscle
Gnaiger 2013 Abstract ASMRM2013Gnaiger E(2013) Loss of mitochondrial competence and degenerative disease: cause and effect. Abstract ASMRM-Seoul.LEAK
OXPHOS
Human
Camacho-Pereira 2013 Abstract IOC752013Camacho-Pereira J (2013) CD38 as a regulator of mitochondrial function. Mitochondr Physiol Network 18.03.ET
LEAK
OXPHOS
ROUTINE
N
NS
S
Intact cells
Isolated mitochondria
Permeabilized cells
MouseHEK
Liver
Macrophage-derived
Schulte 2013 Abstract MiP20132013Chung DJ, Schulte PM, Richards JG (2013) The effect of low-temperature acclimation on mitochondrial function in the common killifish (Fundulus heteroclitus), a top-down elasticity analysis. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
Isolated mitochondriaFishesLiver
Scott 2013 Abstract MiP20132013Scott GR, Mahalingam S, McClelland GB(2013) Mitochondrial adaptations to hypoxia in high-altitude birds and mammals. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
Isolated mitochondria
Enzyme
Other mammals
Birds
Skeletal muscle
Hickey 2013 Abstract MiP20132013Hickey AJ, Iftikar FI, MacDonald J, Baker D (2013) Mitochondria in a changing climate? The role of mitochondrial in hyperthermic heart failure in different fish species. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
CIV
NS
Permeabilized tissueOther mammals
Fishes
Heart
Volska 2013 Abstract MiP20132013Volska K, Makrecka-Kuka M, Svalbe B, Dambrova M (2013) The inhibitor of L-carnitine biosynthesis protects brain mitochondria against anoxia-reoxygenation injury. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
NIsolated mitochondriaRatNervous system
Amoedo 2013 Abstract MiP20132013Amoêdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08.ET
LEAK
OXPHOS
ROUTINE
N
ROX
S
Enzyme
Intact cells
Permeabilized cells
MouseEndothelial;epithelial;mesothelial cell
Other cell lines
Quistorff 2013 Abstract MiP20132013Quistorff B (2013) With type 2 diabetes mitochondrial dysfunction develops earlier in liver than in skeletal muscle. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
F
S
Other combinations
RatSkeletal muscle
Liver
Gnaiger 2013 Abstract Mito20132013Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Conserved mitochondrial coupling efficiency and adaptive substrate control in Inuit and Caucasians: adaptation and acclimatization to the Arctic winter.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Menze 2013 Abstract MiP20132013Menze MA, Marunde MA, Samarajeewa DA, Anderson J, Li S, Hand SC (2013) Group1 LEA protein ameliorates inhibition of mitochondrial respiration in Drosophila melanogaster Kc167 cells and isolated mitochondria. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
NIntact organism
Intact cells
Permeabilized cells
Isolated mitochondria
Enzyme
Drosophila
Artemia
Crustaceans
Hexapods
Other cell lines
CHO
HEK
Macrophage-derived
Korzeniewski 2013 Abstract MiP20132013Korzeniewski B (2013) Regulation of oxidative phosphorylation during work transitions in different tissues results from its kinetic properties. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
Heart
Skeletal muscle
Krumschnabel 2013 Abstract MiP20132013Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
NS
ROX
HomogenateMouse
Fishes
Heart
Nervous system
Liver
Irving 2013 Abstract MiP20132013Irving BA, Stahl R, Kane CJ, Chernousov M, Argyropoulos G, Carey D (2013) Sex differences in murine mitochondrial oxidative capacity following a 24 week high-fat diet. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
NS
Permeabilized tissue
Homogenate
MouseSkeletal muscle
Liver
Fat
Cavalcanti de Albuquerque 2013 Abstract MiP20132013Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
S
Gp
NS
ROX
Intact organism
Permeabilized tissue
RatSkeletal muscle
Borutaite 2013 Abstract MiP20132013Borutaite V, Jablonskiene G, Arandarcikaite O (2013) Mitochondrial response to heart and brain ischemia. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
N
S
Isolated mitochondriaPig
Rat
Heart
Nervous system
Rodrigues 2013 Abstract MiP20132013Rodrigues MF, Amoedo ND, Rumjanek FD (2013) Studies of bioenergetics alterations in breast cancer lines induced by histone desacetylase inhibitors. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
ET
ROXIntact cellsGenital
DeLany 2013 TOS2013Skeletal muscle mitochondrial respiration is lower in African American compared to Caucasian women and is associated with resting metabolic rate and cardiorespiratory fitness.LEAK
OXPHOS
Permeabilized tissueHumanSkeletal muscle
Gnaiger 2013 Abstract MiP20132013Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Biochemical coupling efficiency in permeabilized fibers from arm and leg muscle in Inuit versus Caucasians: A functional test of the uncoupling hypothesis in Greenland. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized tissueHumanSkeletal muscle
Kotwica 2013 Abstract MiP20132013Kotwica AO, Horscroft JA, Murray AJ(2013) Mitochondrial respiration in heart and soleus of ob/ob mice. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
F
N
S
Permeabilized tissueMouseHeart
Skeletal muscle
Pecina 2013 Abstract MiP20132013Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
Gp
NS
Other combinations
ROX
Permeabilized cells
Homogenate
HumanBlood cells
Lymphocyte
Garcia-Roves 2013 Abstract MiP20132013Garcia-Roves PM, Gonzalez-Franquesa A, Martinez-Navarro L, Fernandez-Ruiz R (2013) Metabolic flexibility before and after lifestyle intervention in a diet-induced type 2 diabetes animal model. Mitochondr Physiol Network 18.08.ET
LEAK
OXPHOS
CIV
N
NS
S
Homogenate
Permeabilized cells
Permeabilized tissue
MouseFat
Islet cell;pancreas;thymus
Liver
Nervous system
Skeletal muscle
Galina 2013 Abstract MiP20132013Galina A, Messeder DJM, Camacho-Pereira J, Pereira da Silva AP, Rodrigues-Ferreira C (2013) Effects of antitumor alkylating agent 3-bromopyruvate on energy transducing pathways in hepatoma HepG2, liver mitochondria and SERCA: Is there any role for mitochondrial hexokinase activity? Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
Permeabilized cells
Isolated mitochondria
Enzyme
Intact cells
RatSkeletal muscle
Nervous system
Liver
Other cell lines
Calzia 2013 Abstract MiP20132013Calzia E, Wagner K, Wagner F, Groeger M, Matallo J, McCook O, Wachter U, Vogt J, Radermacher P (2013) Studying mitochondrial effects of sulfide. Does the species matter? Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
Pig
Mouse
Liver
Salin 2013 Abstract MiP20132013Salin K, Luquet E, Rey B, Roussel D, Voituron Y (2013) Mitochondrial functioning, a proximate mechanism underlying the pace-of- life? Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
S
CIV
Isolated mitochondria
Enzyme
Oxidase;biochemical oxidation
Other mammals
Amphibians
Liver
Hendricks 2013 Abstract MiP20132013Hendricks E, Nathan BP, Menze MA (2013) Bioenergetics of permeabilized and intact nerve cell terminals from ApoE deficient and wild type mice. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Intact cells
Permeabilized cells
Isolated mitochondria
MouseNervous system
Oliveira MF 2013 Abstract MiP20132013Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
F
N
S
Gp
CIV
ROX
Intact organism
Intact organ
Permeabilized cells
Permeabilized tissue
Homogenate
Intact cells
Human
Drosophila
Hexapods
Other invertebrates
Skeletal muscle
Neuroblastoma
Garcia-Souza 2013 Abstract IOC802013Garcia-Souza LF (2013) Thrombin trigger mitochondrial functional remodeling in human platelets. Mitochondr Physiol Network 18.09.LEAK
ROUTINE
ET
Intact cellsHumanBlood cells
Jezek 2013 Abstract MiP20132013Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08.LEAK
ROUTINE
OXPHOS
ET
N
S
ROX
Isolated mitochondria
Intact cells
MouseLung;gill
Islet cell;pancreas;thymus
Kressig 2013 Abstract IOC792013Kressig F (2013) et al. Mechanism of increased pulmonary vascular remodeling in UCP2 k/o mice. Mitochondr Physiol Network 18.07LEAKIsolated mitochondria
Permeabilized cells
MouseLung;gill
Other cell lines
Chicco 2013 Abstract MiP20132013Chicco AJ, Le CH, Schlater A, Kanatous S (2013) Comparative muscle mitochondrial physiology of the northern elephant seal. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
Other combinations
Permeabilized tissueHuman
Other mammals
Skeletal muscle
Slinde 2013 Abstract MiP20132013Slinde E, Egelandsdal B, Olsen RE (2013) Respiration of tissue and mitochondria from Atlantic salmon (Salmo salar, L) liver, muscle, heart, brain and blood. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
ROX
Permeabilized tissue
Isolated mitochondria
Other mammals
Fishes
Heart
Liver
Blood cells
Gomez Rodriguez 2013 Abstract IOC752013Gomez Rodriguez A (2013) ß-adrenergic receptor signaling interruption with two β-blockers (atenolol or nebivolol) can modify different oxidative stress related parameters linked to longevity in mouse liver. Mitochondr Physiol Network 18.03.LEAKIsolated mitochondriaMouseLiver
Palm 2013 Abstract MiP20132013Palm F, Hansell P, Friederich-Persson M (2013) Role of mitochondrial function for the onset and progression of kidney disease. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
Intact organ
Intact cells
Isolated mitochondria
Mouse
Rat
Kidney
Laner 2013 ASMRM2013Laner V, Gradl P, Eigentler A, Fontana-Ayoub M, Fasching M, Gnaiger E (2013) The Oroboros O2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. ASMRM2013.LEAK
OXPHOS
ET
N
S
NS
HomogenateMouseHeart
Hand 2013 Abstract MiP20132013Hand SC, Patil Y (2013) Defense against ATP depletion during the energy-limited state of diapause. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
N
S
Intact organism
Homogenate
Isolated mitochondria
Enzyme
Artemia
Crustaceans
Skulachev 2013 Abstract MiP20132013Skulachev VP (2013) SkQ1, the first mitochondria-targeted medicine available in drugstores. Mitochondr Physiol Network 18.08.LEAK
ET
Intact organism
Isolated mitochondria
SMP
Intact cells
Human
Mouse
Horse
Dog
Rabbit
Fishes
Other invertebrates
Fungi
Plants
Heart
Skeletal muscle
Nervous system
Kidney
Islet cell;pancreas;thymus
Other cell lines
HeLa
Fibroblast
Stem cells
Dzialowski 2013 Abstract MiP20132013Dzialowski EM, Ream S, Duquaine A, Sirsat TS, Goy Sirsat SK (2013) Mitochondrial function and the development of endothermy in the precocial Pekin duck (Anas pekin). Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ET
F
N
S
NS
Intact organism
Permeabilized tissue
BirdsSkeletal muscle
Szibor 2013 Abstract MiP20132013Szibor M, Heidler J, Gizatullina Z, Salwig I, Dhandapani PK, Wittig I, Rustin P (2013) Expression of Ciona intestinalis alternative oxidase in mouse. Mitochondr Physiol Network 18.08.LEAK
OXPHOS
ROXIsolated mitochondria
Oxidase;biochemical oxidation
MouseHeart
Skeletal muscle
Nervous system
Liver
Lung;gill
Towheed 2012 Abstract IOC722012Towheed A (2012) Elucidating pathogenesis of ATP synthase dysfunction in a Drosophila model of mitochondrial encephalomyopathy. Mitochondr Physiol Network 17.13.LEAK
ROUTINE
OXPHOS
ET
N
S
NS
Intact organism
Permeabilized tissue
Drosophila
Hexapods
Rodrigues 2012 Abstract IOC722012Rodrigues MF, Amoedo ND, Rumjanek FD (2012) Studies of bioenergetics alterations in breast cancer lines induced by sodium butyrate. Mitochondr Physiol Network 17.13.LEAK
ROUTINE
ET
Horscroft 2012 Abstract IOC722012Horscroft JA, Kotwica AO, Ashmore T, Colleoni F, Morash AJ, Gilbert E, Gnaiger E, Martin DS, Murray AJ (2012) Mitochondrial function at altitude in lowland Europeans and highland Sherpas. Mitochondr Physiol Network 17.13.LEAK
OXPHOS
ET
N
NS
HumanSkeletal muscle
Hepple 2012 Abstract Bioblast2012Hepple RT, Picard M, Taivassalo T (2012) Is latent mitochondrial dysfunction in aging muscle exposed through mitochondrial isolation? Mitochondr Physiol Network 17.12.LEAK
OXPHOS
Permeabilized tissue
Isolated mitochondria
Skeletal muscle
Kamath 2012 Abstract IOC722012Kamath VG, Lizenby ZJ, Adusumilli VRKR, Hsiung CH, McKee EE (2012) Measuring mitochondrial OXPHOS as a nucleoside reverse transcriptase inhibitor induced cardiac toxicity endpoint. Mitochondr Physiol Network 17.13.LEAK
OXPHOS
ET
Isolated mitochondriaRat
Doerrier 2012 Abstract Bioblast2012Doerrier C, Garcia JA, Escames G, Acuna-Castroviejo D (2012) Treatment with melatonin prevents myocardial mitochondrial dysfunction in experimental sepsis in mice. Mitochondr Physiol Network 17.12.LEAK
OXPHOS
ET
N
S
NS
Permeabilized tissueMouseHeart
Horvath 2012 Abstract Bioblast2012Horvath G, Eigentler A, Gnaiger E, Tretter L (2012) Respiratory substrate effects on mitochondrial membrane potential - experiments with mouse cardiac muscle homogenate. Mitochondr Physiol Network 17.12.ET
LEAK
OXPHOS
N
NS
S
HomogenateMouseHeart
Amoedo 2012 Abstract Bioblast2012Amoedo ND, Rodrigues MF, Pereira SAS, Melo FH, Jasiulionis MG, Galina A, Rumjanek FD (2012) Mitochondrial function and bioenergetics during malignant transformation and metastasis. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
OXPHOS
ET
SIntact cellsMouseOther cell lines
Harper 2012 Abstract Bioblast2012Harper ME, Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, Van IJcken W Frank Grosveld F, Dekemp RA, Boushel RC, Rudnicki MA (2012) Metabolic effects of microRNA-133 and its antagomir in mice. Mitochondr Physiol Network 17.12.LEAKIntact organism
Permeabilized cells
MouseSkeletal muscle
Fat
Dzialowski 2012 Abstract IOC722012Dzialowski EM, Sirsat T, Goy S (2012) T3: Does it really make the alligator go “Tick, Tock”? Mitochondr Physiol Network 17.13.LEAK
OXPHOS
N
S
NS
Isolated mitochondriaReptilesHeart
Skeletal muscle
Albertini 2012 Abstract Bioblast2012Albertini E, Koziel R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
ET
Intact cellsEndothelial;epithelial;mesothelial cell
HUVEC
Labieniec-Watala 2012 Abstract Bioblast2012Labieniec-Watala M, Siewiera K, Watala C (2012) Seasonal fluctuations affect the physiology of laboratory animals – facts and artifacts from the perspective of heart mitochondrial respiratory response to tested compounds. Mitochondr Physiol Network 17.12.LEAK
OXPHOS
ET
N
S
NS
Homogenate
Isolated mitochondria
Mouse
Rat
Heart
Liver
Fibroblast
Jacobs 2012 Abstract Bioblast2012Jacobs R, Lundby C (2012) Mitochondria express enhanced quality as well as quantity in parallel with aerobic fitness across recreationally active individuals up to elite athletes. Mitochondr Physiol Network 17.12.LEAK
OXPHOS
ET
F
N
S
NS
Permeabilized cellsHumanSkeletal muscle
Mark 2012 Abstract Bioblast2012Mark FC, Strobel A, Poertner HO (2012) Ocean warming and acidification – when fish mitochondria turn sour. Mitochondr Physiol Network 17.12.LEAK
ROUTINE
OXPHOS
N
S
CIV
NS
Permeabilized tissue
Isolated mitochondria
FishesHeart
Liver
Gnaiger 2011 Abstract SMRM-Hyderabad2011Gnaiger E, Wright-Paradis C, Sondergaard H, Calbet J, Damsgaard R, Munck-Andersen T, Saltin B, Boushel RC (2011) Conserved mitochondrial coupling and adaptive substrate control in Inuit and Caucasians: Acclimatization to active life styles in the Arctic winter. Abstract SMRM-Hyderabad.LEAK
OXPHOS
Human
Sumbalova 2011 Abstract Mitochondrial Medicine2011Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago.LEAK
OXPHOS
ET
N
S
NS
Homogenate
Isolated mitochondria
MouseNervous system
Pesta 2011Abstract Mitochondrial Medicine-Training2011Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibers. Abstract Mitochondrial Medicine Chicago.LEAK
OXPHOS
ET
F
N
S
NS
ROX
Permeabilized tissueHumanSkeletal muscle
Pesta 2010 MiP Abstract2010Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via 31P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010.LEAK
OXPHOS
ET
F
N
S
NS
Human
Borutaite MiP20102010Borutaite V, Cizas P, Morkuniene R, Budvytyte R (2010) Effect of beta amyloid oligomers on neuronal viability and mitochondrial functions.LEAKIsolated mitochondriaRatNervous system



MitoPedia concepts: Respiratory state, SUIT state, Recommended 


MitoPedia methods: Respirometry 


MitoPedia topics: EAGLE