LV Riga Liepins E

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LV Riga Liepins E

Oroboros O2k-Network

O2k-Network
O2k-Network Lab Latvian Institute of Organic SynthesisLaboratory of Pharmaceutical Pharmacology
Address Aizkraukles Street 21, LV-1006
City Riga
State/Prov
Country Latvia
Weblink http://www.osi.lv/en/
Contact Liepins Edgars, Dambrova Maija
Team Volska Kristine, Stelfa Gundega, Korzh Stanislava, Videja Melita
Team previous Makrecka-Kuka Marina
Status 5 Power-O2k 2015-
Oroboros Events IOC158, MiPschool 2018, MitoEAGLE 2018 LV, MitoEAGLE 2017 CZ, MitoEAGLE 2017 ES, MitoEAGLE 2016 IT, MitoFit Science Camp 2016, IOC109, IOC105, IOC95, MiP2014, MiP2013
Topics


O2k-Publications

 PublishedReference
Al-Sabri 2024 Sci Rep2024Al-Sabri MH, Ammar N, Korzh S, Alsehli AM, Hosseini K, Fredriksson R, Mwinyi J, Williams MJ, Boukhatmi H, SchiΓΆth HB (2024) Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes. https://doi.org/10.1038/s41598-024-53446-w
Liepinsh 2024 Br J Pharmacol2024Liepinsh E, Zvejniece L, Clemensson L, Ozola M, Vavers E, Cirule H, Korzh S, Skuja S, Groma V, Briviba M, Grinberga S, Liu W, Olszewski P, Gentreau M, Fredriksson R, Dambrova M, SchiΓΆth HB (2024) Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial Ξ²-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver. Br J Pharmacol [Epub ahead of print]. https://doi.org/10.1111/bph.16363
Zvejniece 2023 Biomed Pharmacother2023Zvejniece L, Svalbe B, Vavers E, Ozola M, Grinberga S, Gukalova B, Sevostjanovs E, Liepinsh E, Dambrova M (2023) Decreased long-chain acylcarnitine content increases mitochondrial coupling efficiency and prevents ischemia-induced brain damage in rats.
Liepinsh 2021 Free Radic Biol Med2021Liepinsh E, Kuka J, Vilks K, Svalbe B, Stelfa G, Vilskersts R, Sevostjanovs E, Goldins NR, Groma V, Grinberga S, Plaas M, Makrecka-Kuka M, Dambrova M (2021) Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage. Free Radic Biol Med 177:370-80.
Makrecka-Kuka 2020 Cardiovasc Drugs Ther2020Makrecka-Kuka Marina, Korzh Stanislava, Videja Melita, Vilks Karlis, Cirule Helena, Kuka Janis, Dambrova Maija, Liepinsh Edgars (2020) Empagliflozin protects cardiac mitochondrial fatty acid metabolism in a mouse model of diet-induced lipid overload. Cardiovasc Drugs Ther 34:791-97.
Liepinsh 2020 Physiol Rep2020Liepinsh E, Makarova E, Plakane L, Konrade I, Liepins K, Videja M, Sevostjanovs E, Grinberga S, Makrecka-Kuka M, Dambrova M (2020) Low-intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults. Physiol Rep 8:e14489.
Allen 2020 Commun Biol2020Allen ME, Pennington ER, Perry JB, Dadoo S, Makrecka-Kuka M, Dambrova M, Moukdar F, Patel HD, Han X, Kidd GK, Benson EK, Raisch TB, Poelzing S, Brown DA, Shaikh SR (2020) The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats. Commun Biol 3:389.
Kupats 2020 Oxid Med Cell Longev2020Kupats E, Stelfa G, Zvejniece B, Grinberga S, Vavers E, Makrecka-Kuka M, Svalbe B, Zvejniece L, Dambrova M (2020) Mitochondrial-protective effects of R-phenibut after experimental traumatic brain injury. Oxid Med Cell Longev 2020:9364598.
Makrecka-Kuka 2020 Sci Rep2020Makrecka-Kuka M, Dimitrijevs P, Domracheva I, Jaudzems K, Dambrova M, Arsenyan P (2020) Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production. https://doi.org/10.1038/s41598-020-78620-8.
Perry 2019 J Mol Cell Cardiol2019Perry JB, Davis GN, Allen ME, Makrecka-Kuka M, Dambrova M, Grange RW, Shaikh SR, Brown DA (2019) Cardioprotective effects of idebenone do not involve ROS scavenging: Evidence for mitochondrial complex I bypass in ischemia/reperfusion injury. J Mol Cell Cardiol 135:160-171.
Makrecka-Kuka 2017 Toxicol Lett2017Makrecka-Kuka M, Volska K, Antone U, Vilskersts R, Grinberga S, Bandere D, Liepinsh E, Dambrova M (2017) Trimethylamine N-oxide impairs pyruvate and fatty acid oxidation in cardiac mitochondria. Toxicol Lett 267:32-8.
Liepinsh 2016 Biochem J2016Liepinsh E, Makrecka-Kuka M, Volska K, Kuka J, Makarova E, Antone U, Sevostjanovs E, Vilskersts R, Strods A, Tars K, Dambrova M (2016) Long-chain acylcarnitines determine ischaemia/reperfusion-induced damage in heart mitochondria. Biochem J 473:1191-202.
MiPNet20.16 IOC105 Riga2015-08-27
O2k-Network
Riga LV, 2015 Aug 27. Oroboros O2k-Workshop on high-resolution respirometry (HRR) and O2k-Fluorometry - innovabalt, IOC105.
Makrecka-Kuka 2015 Biomolecules2015Makrecka-Kuka M, Krumschnabel G, Gnaiger E (2015) High-resolution respirometry for simultaneous measurement of oxygen and hydrogen peroxide fluxes in permeabilized cells, tissue homogenate and isolated mitochondria. https://doi.org/10.3390/biom5031319

O2k-Abstracts

 PublishedReference
Cecatto 2023 BPS2023 San Diego2023
Sabine Schmitt
Cecatto C, Schmitt Sabine, Cardoso L, Videja M, Dambrova M, Makrecka-Kuka M, Liepinsh E, Gnaiger E (2023) Contribution of fatty acid oxidation to respiratory control in brain mitochondria. 67th Annual Meeting of the Biophysical Society.
Kidere 2018 MiP20182018
Dita Kidere
Cytoplasmic hybrid cells as a model to characterize the effect of the mtDNA mutations on the OXPHOS system.
Stelfa 2018 MiP20182018
MiPsociety
Neuroprotective compound R-phenibut protects brain mitochondria against anoxia-reoxygenation damage in vitro.
Kuka 2018 MiP20182018
MiPsociety
The discovery of methyl-GBB - acylcarnitine lowering as an effective strategy to treat cardiometabolic diseases.
Volska 2018 MiP20182018
Kristina Volska
The mechanisms of long-chain acylcarnitine accumulation during ischemia.
Kidere 2018 MiPschool Tromso E22018
Dita Kidere
Cytoplasmic hybrid cells as a model to characterize the OXPHOS system: control sample with glutamate metabolism defect.
Makrecka-Kuka 2018 MiPschool Tromso E12018
Marina Makrecka-Kuka
Cardiac fatty acid oxidation: from in vitro to in vivo.
Makrecka-Kuka 2017 MiP20172017
Marina Makrecka-Kruka
Heart, brain and kidneys: who will survive? Tissue-specific changes in mitochondrial function in the experimental model of endotoxemia.

IOC105 O2k-Workshop 2015-08-27


Visiting scientist in the Oroboros O2k-Laboratory

O2k-Network
Marina Makrecka-Kuka: Visiting scientist at the Oroboros O2k-Laboratory from March 12 to 29 2018
Kristine Volska: Visiting scientist at the Oroboros O2k-Laboratory from March 01 to April 01 2016
Marina Makrecka-Kuka: Visiting scientist at the Oroboros O2k-Laboratory within the framework of FP7 from August until October 2014
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