Lemieux 2016 Mitochondrion
|Lemieux H, Boemer F, van Galen G, Serteyn D, Amory H, Baise E, Cassart D, van Loon G, Marcillaud-Pitel C, Votion DM (2016) Mitochondrial function is altered in horse atypical myopathy. Mitochondrion 30:35-41.|
Abstract: Equine atypical myopathy in Europe is a fatal rhabdomyolysis syndrome that results from the ingestion of hypoglycin A contained in seeds and seedlings of Acer pseudoplatanus (sycamore maple). Acylcarnitine concentrations in serum and muscle OXPHOS capacity were determined in 15 atypical myopathy cases. All but one acylcarnitine were out of reference range and mitochondrial respiratory capacity was severely decreased up to 49% as compared to 10 healthy controls. The hallmark of atypical myopathy thus consists of a severe alteration in the energy metabolism including a severe impairment in muscle mitochondrial respiration that could contribute to its high death rate.
Copyright © 2016 Elsevier B.V. and Mitochondria Research Society. All rights reserved.
• Keywords: Acer, Acylcarnitines, High-resolution respirometry, Horse, Methylenecyclopropyl acetic acid-CoA, Rhabdomyolysis, Skeletal muscle
Labels: MiParea: Respiration Pathology: Myopathy
Organism: Horse Tissue;cell: Skeletal muscle Preparation: Permeabilized tissue
Coupling state: OXPHOS, ET Pathway: N, S, NS, ROX HRR: Oxygraph-2k