Lopez-Lluch 2010 Mech Ageing Dev

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Lopez-Lluch G, Rodriguez-Aguilera JC, Santos-Ocana C, Navas P (2010) Is coenzyme Q a key factor in aging? Mech Ageing Dev 131:225-35.

» PMID:20193705

Lopez-Lluch G, Rodriguez-Aguilera JC, Santos-Ocana C, Navas P (2010) Mech Ageing Dev

Abstract: Coenzyme Q (Q) is a key component for bioenergetics and antioxidant protection in the cell. During the last years, research on diseases linked to Q-deficiency has highlighted the essential role of this lipid in cell physiology. Q levels are also affected during aging and neurodegenerative diseases. Therefore, therapies based on dietary supplementation with Q must be considered in cases of Q deficiency such as in aging. However, the low bioavailability of dietary Q for muscle and brain obligates to design new mechanisms to increase the uptake of this compound in these tissues. In the present review we show a complete picture of the different functions of Q in cell physiology and their relationship to age and age-related diseases. Furthermore, we describe the problems associated with dietary Q uptake and the mechanisms currently used to increase its uptake or even its biosynthesis in cells. Strategies to increase Q levels in tissues are indicated.

Bioblast editor: Komlodi T

Cited by

  • Komlodi et al (2021) Simultaneous measurement of respiration and redox state of the Coenzyme Q pool in mitochondrial preparations. Bioenerg Commun 2021.3 doi:10.26124/bec:2021-0003


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